Do In Seung Gi‑Tang extract suppresses adipocyte differentiation in 3T3‑L1 cells.

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:Ovarian cancer is the most frequent cause of death among gynecological cancers. In the present study, the anti‑cancer effect of liriopesides B, a steroidal saponin from Liriope spicata var. prolifera, against A2780 cells was investigated. Transwell chambers were adopted to assess its effect on cell invasion and chemot...

journal_title：Molecular medicine reports

authors： Yu H,Wang H,Yin Y,Wang Z

更新日期：2020-09-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analys...

journal_title：Molecular medicine reports

authors： Zuo N,Li Y,Liu N,Wang L

更新日期：2017-11-01 00:00:00

abstract：:Moscatilin is a bibenzyl derivative extracted from the Dendrobium aurantiacum var. denneanum, which has traditionally been used as an immunomodulatory treatment in China. The present study was designed to determine whether moscatilin is a pro‑apoptotic agent in pancreatic cancer, and to elucidate the underlying mechan...

journal_title：Molecular medicine reports

authors： Zhang L,Fang Y,Xu XF,Jin DY

更新日期：2017-03-01 00:00:00

abstract：:This study aimed to explore the effects of microbubble concentration, gene dosage, cell-microbubble mixing mode and fetal bovine serum (FBS) on gene delivery. 293T cells were transfected with Sonovue microbubbles carrying the hAng-1 gene via ultrasound irradiation. Various ultrasound exposure parameters and microbubbl...

journal_title：Molecular medicine reports

authors： Zhou Q,Chen JL,Chen Q,Wang X,Deng Q,Hu B,Guo RQ

更新日期：2012-12-01 00:00:00

abstract：:Matrilin-2 (matn2) contains a unique domain, between the second von Willebrand factor A (vWFA) domain and the C-terminal coiled-coil domain, with no sequence homology with other family members. Complementary DNA (cDNA) sequence analysis of matn2 expression in both mice and humans re...

journal_title：Molecular medicine reports

authors： Li L,Zhang L,Shao Y,Wang G,Gong R,Wang Z,Peng J,Wang S,Genochio D,Zhao B,Luo J

更新日期：2012-11-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) is correlated with insulin resistance and islet‑cell function. In the present study, the sub‑cellular localization and role of ER protein 29 (Erp29) were investigated in an in vitro ERS model of islet beta cells. The INS‑1 islet cell line was treated with various concentrations of tu...

journal_title：Molecular medicine reports

authors： Gao J,Zhang Y,Wang L,Xia L,Lu M,Zhang B,Chen Y,He L

更新日期：2016-01-01 00:00:00

abstract：:Neutrophilic airway inflammation in chronic lung infections caused by Pseudomonas aeruginosa (PA) is associated with T helper (Th)17 responses. Suppressor of cytokine signaling 3 (SOCS3) is the major negative modulator of Th17 function through the suppression of signal transducer and activator of transcription (STAT)3...

journal_title：Molecular medicine reports

authors： Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M

更新日期：2017-07-01 00:00:00

abstract：:The tumorigenesis and maintenance of a cancer cells is dependent upon the collaboration of multiple signaling pathways. Signal transducer and activator of transcription 3 (STAT3) and β-catenin are at the center of multiple cancer-associated signaling pathways; therefore, simultaneously targeting STAT3 and β-catenin ma...

journal_title：Molecular medicine reports

authors： Wang XH,Liu MN,Huang P,Xu J,Liu AY,Chen J,Lv CQ,Xu RL

更新日期：2015-08-01 00:00:00

abstract：:The authors of the above article wish to retract their paper. Subsequently to its publication, in addition to certain irreconcilable differences in opinion shared among the authors, they have realized that, in their analysis of the role of peroxisome proliferator‑activated receptor γ in brain microvascular endothelial...

journal_title：Molecular medicine reports

authors： Xu M,Yang X,Zeng Q,He H,Lu P,Huang G

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of high mobility group protein B1 (HMGB1), which is expressed in the serum of patients with sepsis, on vascular endothelial permeability. Sera from patients with sepsis were used to treat endothelial cells (ECs), and the effect on endothelial permeability was...

journal_title：Molecular medicine reports

authors： Zheng YJ,Xu WP,Ding G,Gao YH,Wang HR,Pan SM

更新日期：2016-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that currently has no standard treatment. The present study aimed to evaluate the effects of Lycium ruthenicum extract (LRE) on high‑fat diet (HFD)-induced NAFLD, and elucidate the underlying molecular mechanisms. To determine the hepatoprotective effe...

journal_title：Molecular medicine reports

authors： Lin J,Zhang Y,Wang X,Wang W

更新日期：2015-09-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpres...

journal_title：Molecular medicine reports

authors： Liu X,Tang Z,Zhang Y,Hu J,Li D,Zang G,Yu Y

更新日期：2012-08-01 00:00:00

abstract：:The aim of the present study was to investigate the role of tetramethylpyrazine (TMP), one of the alkaloids isolated from the Chinese herb Chuanxiong, on the proliferation and migration of brain endothelial cells. A different dosage of TMP was employed to stimulate the mouse microvascular cell line bEnd.3 in vitro. TM...

journal_title：Molecular medicine reports

authors： Zhang M,Gao F,Teng F,Zhang C

更新日期：2014-07-01 00:00:00

abstract：:Nutrients are known to display pharmacologic activity against viruses and to exert cooperative effects in cells. To study the influence of nutrient cooperation on HIV production in chronically infected T lymphocytes, we evaluated the individual and combined effects of nutrients on HIV-1 reverse transcriptase (RT) rele...

journal_title：Molecular medicine reports

authors： Jariwalla RJ,Gangapurkar B,Pandit A,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2010-05-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis. Mucin 5ac (MUC5AC) is a major component of airway mucus. Annexin II (ANXII) has been reported to be expressed in various c...

journal_title：Molecular medicine reports

authors： Xu R,Li Q,Zhou X,Perelman JM,Kolosov VP

更新日期：2014-01-01 00:00:00

abstract：:GLI family zinc finger 3 (Gli3), as the upstream transcriptional activator of hedgehog signaling, has previously been demonstrated to participate in the process of liver fibrosis. The present study aimed to investigate the potential functions of microRNA (miR)‑200a and Gli3 in the progression of liver fibrosis. The ex...

journal_title：Molecular medicine reports

authors： Li L,Ran J,Li L,Chen G,Zhang S,Wang Y

更新日期：2020-04-01 00:00:00

abstract：:The loss of neurotrophic factor support has been shown to contribute to the development of the central nervous system. Glial cell line‑derived neurotrophic factor (GDNF), a potent neurotrophic factor, is closely associated with apoptosis and exerts neuroprotective effects on numerous populations of cells. However, the...

journal_title：Molecular medicine reports

authors： Cui W,Zhang Y,Lu D,Ren M,Yuan G

更新日期：2016-01-01 00:00:00

abstract：:Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. However, its effect on proliferation and clinical parameters in HCC require further elucidation. The present study aimed to investigate LOXL2 expression in HCC from in vitro and clinical asp...

journal_title：Molecular medicine reports

authors： Wu L,Zhang Y,Zhu Y,Cong Q,Xiang Y,Fu L

更新日期：2016-09-01 00:00:00

abstract：:Adrenomedullin (ADM), initially identified in human pheochromocytoma, participates in a wide range of physiological and pathological processes, including vasorelaxation, angiogenesis and apoptosis. Recent studies have reported that ADM protected tumor cells against apoptotic cell de...

journal_title：Molecular medicine reports

authors： Kim JY,Park WD,Lee S,Park JH

更新日期：2012-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection induces not only chronic liver disease, but also extrahepatic manifestations such as thyroid disease and oral cancer. Thyroid dysfunction is also a complication known to be associated with interferon (IFN) therapy for HCV infection. We report on a 69-year-old Japanese man who develope...

journal_title：Molecular medicine reports

authors： Nagao Y,Hiromatsu Y,Nakashima T,Sata M

更新日期：2008-09-01 00:00:00

abstract：:Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure ...

journal_title：Molecular medicine reports

authors： Xu B,Xu H,Cao H,Liu X,Qin C,Zhao Y,Han X,Li H

更新日期：2017-08-01 00:00:00

abstract：:Recent epidemiological studies and animal experiments have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX), the first oxidase in the process of prostaglandin production from arachidonic acid, is the principal target of NSAIDs. Due to i...

journal_title：Molecular medicine reports

authors： Matsuyama M,Yoshimura R

更新日期：2009-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common type of brain cancer; it usually recurs and patients have a short survival time. The present study aimed to construct a gene expression classifier and to screen key genes associated with GBM prognosis. GSE7696 microarray data set included samples from 10 recurrent GBM t...

journal_title：Molecular medicine reports

authors： Yang H,Jin L,Sun X

更新日期：2019-03-01 00:00:00

abstract：:Embryonic stem cells (ESCs) have unlimited expansion potential and the ability to differentiate into all somatic cell types for regenerative medicine and disease model studies. Octamer‑binding transcription factor 4 (OCT4), encoded by the POU domain, class 5, transcription factor 1 gene, is a transcription factor vita...

journal_title：Molecular medicine reports

authors： She S,Wei Q,Kang B,Wang YJ

更新日期：2017-11-01 00:00:00

abstract：:Obesity has a negative effect on ovarian functions, which is reported to increase the risk of infertility. The mechanism underlying obesity‑induced infertility is not yet clear. The present study established a high‑fat diet (HFD)‑induced obesity mouse model to elucidate the mechanisms underlying the effect of HFD‑indu...

journal_title：Molecular medicine reports

authors： Wu Y,Zhang Z,Liao X,Qi L,Liu Y,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Benign thyroid nodules are among the most common endocrine disorders. Recent advances in diagnostic imaging and pathology have significantly contributed to better risk stratification of thyroid nodules. However, current treatment options, beyond surgical approaches are limited. The following placebo-controlled study p...

journal_title：Molecular medicine reports

authors： Stancioiu F,Mihai D,Papadakis GZ,Tsatsakis A,Spandidos DA,Badiu C

更新日期：2019-09-01 00:00:00

abstract：:Neuroinflammation and microglial activation are two important hallmarks of neurodegenerative diseases. Continuous microglial activation may cause the release of several cytotoxic molecules, including many cytokines that are involved in the inflammatory process. Therefore, attenuating inflammation caused by activated m...

journal_title：Molecular medicine reports

authors： Mendonca P,Taka E,Soliman KFA

更新日期：2019-08-01 00:00:00

abstract：:Chronic iron overload may result in hepatic fibrosis and even neoplastic transformation due to a burst of reactive oxygen species (ROS). Mitochondria have been proposed to be important in the production of ROS. The purpose of this study was to investigate the role of the mitochondrial permeability transition pore (mPT...

journal_title：Molecular medicine reports

authors： Liu D,He H,Yin D,Que A,Tang L,Liao Z,Huang Q,He M

更新日期：2013-04-01 00:00:00

abstract：:The present study observed and compared the biological behaviour of HepG2 cells prior and subsequent to the overexpression of activating transcription factor 3 (ATF3). Experiments investigating the cytological function by which ATF3 affects liver cancer cells were also performed. MTT, Transwell and flow cytometry assa...

journal_title：Molecular medicine reports

authors： Li X,Zang S,Cheng H,Li J,Huang A

更新日期：2019-02-01 00:00:00