Overexpression of activating transcription factor 3 exerts suppressive effects in HepG2 cells.

abstract：:Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is requ...

journal_title：Molecular medicine reports

authors： Wu L,Sun Y,Wan J,Luan T,Cheng Q,Tan Y

更新日期：2017-07-01 00:00:00

abstract：:The present study investigated the role of microRNA (miR)‑146a in a diabetic nephropathy (DN) model, and its molecular mechanism. DN mice were given intraperitoneal injections of streptozotocin (55 mg/kg/day) for 5 consecutive days as an in vivo DN model. The HK‑2 human kidney cell line were exposed to 45% D‑glucose a...

journal_title：Molecular medicine reports

authors： Wan RJ,Li YH

更新日期：2018-03-01 00:00:00

abstract：:Hypothermia is an effective neuroprotective treatment for brain injury caused by intracerebral hemorrhage (ICH). It is reported to reduce brain edema and neuronal cell death. Thrombin, a coagulation protease released from blood clots, is critical in brain edema formation following ICH. Protease activated receptor‑1 (P...

journal_title：Molecular medicine reports

authors： Gao D,Ding F,Lei G,Luan G,Zhang S,Li K,Wang D,Zhang L,Dai D

更新日期：2015-04-01 00:00:00

abstract：:Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. However, the effect of PKE as a cancer drug ...

journal_title：Molecular medicine reports

authors： Park BH,Jung KH,Son MK,Seo JH,Lee HS,Lee JH,Hong SS

更新日期：2013-01-01 00:00:00

abstract：:Hypoxemia and hypercarbia resulting from a lack of surfactant is considered to be the primary mechanism underlying neonatal respiratory distress syndrome (NRDS). Surfactant replacement therapy may mitigate the symptoms of the disease by decreasing the surface tension of alveoli and facilitating inflation. However, sur...

journal_title：Molecular medicine reports

authors： Mei H,Zhang Y,Liu C,Zhang Y,Liu C,Song D,Xin C,Wang J,Josephs-Spaulding J,Zhu Y,Tang F

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to investigate the effects of cinobufacini injection on the proliferation and expression of topoisomerases in human HepG-2 hepatocarcinoma cells. The cells were divided into a control group and an experimental group, in which 0.105, 0.21, 0.42 mg/l cinobufacini was injected. Cell proliferation ...

journal_title：Molecular medicine reports

authors： Liu Y,Ban LY,Su X,Gao S,Liu JW,Cui XN

更新日期：2015-07-01 00:00:00

abstract：:Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of endometriosis, a...

journal_title：Molecular medicine reports

authors： Albertsen HM,Matalliotaki C,Matalliotakis M,Zervou MI,Matalliotakis I,Spandidos DA,Chettier R,Ward K,Goulielmos GN

更新日期：2019-03-01 00:00:00

abstract：:Longdan Xiegan Tang (LXT) is a mixture of herbal extracts commonly used in traditional Chinese medicine that may exert immunomodulatory effects for the treatment of autoimmune diseases. However, the detailed mechanisms that mediate the actions of LXT are unclear. The present study induced an experimental autoimmune uv...

journal_title：Molecular medicine reports

authors： Tang K,Guo D,Zhang L,Guo J,Zheng F,Si J,Bi H

更新日期：2016-09-01 00:00:00

abstract：:Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The...

journal_title：Molecular medicine reports

authors： Lyu ZK,Li CL,Jin Y,Liu YZ,Zhang X,Zhang F,Ning LN,Liang ES,Ma M,Gao W,Zhang MX,Liu DS

更新日期：2017-11-01 00:00:00

abstract：:Multinucleated cells are present in impaired spermatogenesis and in the senescent testis. Following accumulating evidence from our previous studies on the identification of multinucleated cells during normal testicle development, the current study further investigated the possible mechanism and role of these multinucl...

journal_title：Molecular medicine reports

authors： Luo L,Li Y,Yang Y,He Y,Wang Y,Xu Z,Zhang Y

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of hepatitis B virus X protein (HBx) on the expression of DNA methyltransferase (DNMT)3A/3B and suppressors of cytokine signaling‑1 (SOCS‑1), as well as promoter CpG island methylation of the SOCS‑1 gene. Stable hepatocyte cell lines expressing the HBx gene (p...

journal_title：Molecular medicine reports

authors： Fu X,Song X,Li Y,Tan D,Liu G

更新日期：2016-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a type of movement disorder caused by loss of dopamine‑producing neurons in the midbrain. In order to identify the synergistic microRNA (miRNA) pattern in PD, miRNA and mRNA double expression profiles of PD were downloaded. Differentially expressed miRNA and mRNA were identified [P<0.01, fo...

journal_title：Molecular medicine reports

authors： Hao B,Chen X,Dai D,Zou C,Wu X,Chen J

更新日期：2015-02-01 00:00:00

abstract：:Accumulating evidence has revealed that the mammalian heart possesses a measurable capacity for renewal. Neonatal mice retain a regenerative capacity over a short time-frame (≤6 days), but this capacity is lost by 7 days of age. In the present study, differential gene expression profiling of mouse cardiac tissue was p...

journal_title：Molecular medicine reports

authors： Liu M,Zhu JG,Yu ZB,Song GX,Shen YH,Liu YQ,Zhu C,Qian LM

更新日期：2014-06-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline in cognitive function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In the present study, we tested the hypothesis that Toll-lik...

journal_title：Molecular medicine reports

authors： Wang Y,He H,Li D,Zhu W,Duan K,Le Y,Liao Y,Ou Y

更新日期：2013-04-01 00:00:00

abstract：:The cooperation and communication between different cell signaling transduction pathways are considered critical in the development of various types of cancer as well as drug resistance. There is evidence of crosstalk between the G protein-coupled receptor 30 (GPR30), the newly discovered estrogen receptor (ER), and t...

journal_title：Molecular medicine reports

authors： Ruan SQ,Wang SW,Wang ZH,Zhang SZ

更新日期：2012-07-01 00:00:00

abstract：:The aim of this study was to detect class Ⅰ, II and III integrons using multiplex PCR, and to analyze the role that these integrons play in mediating multidrug-resistant Staphylococcus aureus (SA). The sensitivity of SA to 20 types of antibiotics was examined using the K-B method. A...

journal_title：Molecular medicine reports

authors： Ren C,Zhao Y,Shen Y

更新日期：2013-03-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation ...

journal_title：Molecular medicine reports

authors： Liu P,Jiang W,Zhao J,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to identify candidate microRNAs (miRNAs) involved in the progression of renal fibrosis. Dataset GSE42716 of miRNAs extracted from kidneys from mice with unilateral ureteral obstruction (UUO), and mice without UUO was downloaded from the Gene Expression Omnibus database. The Limma packa...

journal_title：Molecular medicine reports

authors： Xin G,Zhou G,Zhang X,Wang W

更新日期：2017-09-01 00:00:00

abstract：:Studies using animal models have demonstrated that probiotics may have a beneficial role in the prevention of colorectal cancer (CRC); however, the underlying mechanism of the beneficial effects of interventional probiotic treatment on gut microbiota has remained elusive. In the present study, pyrosequencing of the V3...

journal_title：Molecular medicine reports

authors： Gao Z,Guo B,Gao R,Zhu Q,Wu W,Qin H

更新日期：2015-10-01 00:00:00

abstract：:Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulat...

journal_title：Molecular medicine reports

authors： Jia Z,Lin L,Huang S,Zhu Z,Huang W,Huang Z

更新日期：2017-08-01 00:00:00

abstract：:Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, and is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action of IL‑8 regarding the ability to promote proliferation and to inhibit apoptosis in prostate cancer. Here, the aim of the present...

journal_title：Molecular medicine reports

authors： Guo Y,Zang Y,Lv L,Cai F,Qian T,Zhang G,Feng Q

更新日期：2017-12-01 00:00:00

abstract：:In the last 30 years, the 5-year-survival rate of patients with osteosarcoma has not improved as a result of the low prevalence and large tumor heterogeneity. Therefore, the development of novel drugs for the treatment of osteosarcoma is urgently required. The present study aimed to identify potential novel drugs for ...

journal_title：Molecular medicine reports

authors： Zou Y,Yang J,Jiang D

更新日期：2015-11-01 00:00:00

abstract：:Paraquat (PQ) poisoning‑induced pulmonary fibrosis is one of the primary causes of mortality in patients with PQ poisoning. The potential mechanism of PQ‑induced pulmonary fibrosis was thought to be mediated by inflammation. Recently, bone marrow‑derived mesenchymal stem cells (BMSCs) have been considered as a potenti...

journal_title：Molecular medicine reports

authors： Chen J,Si L,Zhou L,Deng Y

更新日期：2019-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to 'seed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby 'seed sequences' may compromise or enhance miRNA/mRNA interaction leading to either 'loss‑of‑function' or 'gain‑of‑function...

journal_title：Molecular medicine reports

authors： Zhao Y,Li X,Zhu S

更新日期：2016-09-01 00:00:00

abstract：:Irinotecan (CTP-11) is a topoisomerase I inhibitor used in the treatment of colorectal cancer and non-small cell lung cancer (NSCLC). Despite an initial response to therapy, resistance to irinotecan reduces its efficacy. We isolated irinotecan-resistant human NSCLC A549 cells, termed A549/CTP-11R cells. A549/CTP-11R c...

journal_title：Molecular medicine reports

authors： Ikeda R,Vermeulen LC,Lau E,Jiang Z,Pomplun M,Kolesar JM

更新日期：2010-11-01 00:00:00

abstract：:Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer‑associated mortality in the world. However, its mechanisms of occurrence and development have not been clearly elucidated. Furthermore, there is no effective tumor marker for GC. Using DNA microarray analysis, the present stu...

journal_title：Molecular medicine reports

authors： Duan S,Gong B,Wang P,Huang H,Luo L,Liu F

更新日期：2018-10-01 00:00:00

abstract：:Gonadotrophin‑releasing hormone (GnRH) agonists (GnRHa) have been widely used to induce a state of downregulation for in vitro fertilization, and its direct effects on the pituitary are well known. However, the effects of GnRHa on the expression of anti‑mullerian hormone (AMH) by follicles in varying stages in vivo re...

journal_title：Molecular medicine reports

authors： Huang J,Wang X,Li Z,Ma R,Xiao W

更新日期：2015-09-01 00:00:00

abstract：:Gabapentin (GBP) and pregabalin (PGB) exert antinociceptive effects on chronic nociceptive responses with neuropathic or inflammatory conditions. Furthermore, it is considered that GBP and PGB exhibit anti‑inflammatory effects by modulating the substance P (SP)‑mediated neurokinin‑1 receptor (NK1R; a SP receptor) resp...

journal_title：Molecular medicine reports

authors： Yamaguchi K,Kumakura S,Someya A,Iseki M,Inada E,Nagaoka I

更新日期：2017-11-01 00:00:00

abstract：:Findings of previous studies have revealed that intestinal mucosal mast cells (IMMCs) are involved in small intestinal ischemia‑reperfusion injury (IIRI). However, time-course changes of mast cell counts and mast cell function in this process remain unclear. The present study aimed to observe the number of IMMCs and t...

journal_title：Molecular medicine reports

authors： Ge M,Gan X,Liu D,Zhang W,Gao W,Huang P,Hei Z

更新日期：2013-08-01 00:00:00

abstract：:Hypoxic exposure results in the vascular dysfunction and reduction of vasomotor responses and thus disrupts or reduces blood flow in the resistance arteries. Connexin (Cx)-mediated gap junctional intercellular communication (GJIC) serves a critical role in the regulation of vasomotor tone and the synchronized contract...

journal_title：Molecular medicine reports

authors： Liu H,Li XZ,Peng M,Ji W,Zhao L,Li L,Zhang L,Si JQ,Ma KT

更新日期：2017-04-01 00:00:00