Effects of GnRH agonists on the expression of developmental follicular anti-mullerian hormone in varying follicular stages in cyclic mice in vivo.

abstract：:Electroacupuncture (EA) has been documented as a form of therapy for chronic sinusitis (CRS). The present study aimed to assess the effects of EA combined with interleukin‑10 (IL‑10) overexpression on CRS in mice, and to investigate the associated mechanisms. A mouse model of CRS was established by the administration ...

journal_title：Molecular medicine reports

authors： Zhou L,Hong J,Wan Z,Lu X,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:Flavopiridol (FP) exerts antitumoral effects by triggering tumor cell cycle arrest and cytotoxicity in human breast cancer cell lines. The potent antitumor activity of FP is through its inhibition of cyclin‑dependent kinases; however, this may not be the only mechanism of action. The present study aimed to investigate...

journal_title：Molecular medicine reports

authors： Wang S,Wang K,Wang H,Han J,Sun H

更新日期：2017-12-01 00:00:00

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages ...

journal_title：Molecular medicine reports

authors： Zhong Y,Feng J,Fan Z,Li J

更新日期：2018-04-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpres...

journal_title：Molecular medicine reports

authors： Liu X,Tang Z,Zhang Y,Hu J,Li D,Zang G,Yu Y

更新日期：2012-08-01 00:00:00

abstract：:Post‑cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in patients undergoing resuscitation patients following cardiac arrest (CA). Although prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury, its effect on PAMD remains unknown. In the present study, the protective effec...

journal_title：Molecular medicine reports

authors： Su C,Fan X,Xu F,Wang J,Chen Y

更新日期：2021-02-01 00:00:00

abstract：:In order to examine how implanted bone marrow stromal cells (BMSCs) encourage peripheral nerve regeneration, the present study investigated the interaction of BMSCs and Schwann cells (SCs) using an indirect in vitro co‑culture model. SCs and BMSCs were obtained from adult Sprague‑Dawley rats. The passaged BMSCs were C...

journal_title：Molecular medicine reports

authors： Zhou LN,Cui XJ,Su KX,Wang XH,Guo JH

更新日期：2015-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) results in inflammation, and glucocorticoids have been proven to be effective inhibitors of ICH‑induced inflammation. However, the precise underlying mechanisms of ICH‑induced inflammation and glucocorticoid function remain largely undefined. Using a mouse ICH model, the present study de...

journal_title：Molecular medicine reports

authors： Xu HF,Fang XY,Zhu SH,Xu XH,Zhang ZX,Wang ZF,Zhao ZQ,Ding YJ,Tao LY

更新日期：2016-10-01 00:00:00

abstract：:Molecular biologists have identified a number of genes and microRNAs (miRs) associated with chronic myelogenous leukemia (CML). However, their underlying mechanisms in CML remain unclear. In the present study, three regulatory networks of genes and miRs were constructed to elucidate the underlying mechanisms of CML. T...

journal_title：Molecular medicine reports

authors： Wang K,Xu Z,Wang N,Tian Y,Sun X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:Damage of retinal ganglion cells (RGCs) is the major consequence of glaucoma and regeneration of RGCs is extremely difficult once the damage has occurred. Retinal stem cells (RSCs) are considered an ideal choice for RGC regeneration. Pigmented cells from the ciliary margin (PCMs) have great retinal differentiation pot...

journal_title：Molecular medicine reports

authors： Li Y,He X,Li J,Ni F,Sun Q,Zhou Y

更新日期：2017-06-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is one of the highly malignant tumors and a serious threat to human health. The aim of the present study was to explore the underlying molecular mechanisms of SCLC. mRNA microarray datasets GSE6044 and GSE11969 were downloaded from Gene Expression Omnibus database, and the differentially ...

journal_title：Molecular medicine reports

authors： Wen P,Chidanguro T,Shi Z,Gu H,Wang N,Wang T,Li Y,Gao J

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in...

journal_title：Molecular medicine reports

authors： Liu Y,Li F,Zhang L,Wu J,Wang Y,Yu H

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to identify any association between bone morphogenetic protein‑7 (BMP‑7) and the expression of the transcriptional co‑repressor Ski‑related novel protein N (SnoN), in addition to alterations in tubulointerstitial fibrosis, during the development and progression of diabetic nephropathy (DN). Str...

journal_title：Molecular medicine reports

authors： Wang Y,Xiao Y,Li S,Shi L,Liu L,Zhang Y,Shi M,Guo B

更新日期：2017-09-01 00:00:00

abstract：:Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)‑induced cardiotoxicity. However, how apoptosis and oxidative stress arise in DOX‑induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical lysosomal cysteine protease that is associated with apoptosis, inf...

journal_title：Molecular medicine reports

authors： Liu C,Cai Z,Hu T,Yao Q,Zhang L

更新日期：2020-12-01 00:00:00

abstract：:The aim of this study was to detect class Ⅰ, II and III integrons using multiplex PCR, and to analyze the role that these integrons play in mediating multidrug-resistant Staphylococcus aureus (SA). The sensitivity of SA to 20 types of antibiotics was examined using the K-B method. A...

journal_title：Molecular medicine reports

authors： Ren C,Zhao Y,Shen Y

更新日期：2013-03-01 00:00:00

abstract：:Previous studies have confirmed that exposure to particulate matter with a diameter of ≤2.5 µm (PM2.5) is associated with inflammation. PM2.5 decreases cardiac cell viability and increases apoptosis through overproduction of reactive oxygen species (ROS). In the present study, the role of PM2.5 in ECs was investigated...

journal_title：Molecular medicine reports

authors： Chen S,Wu X,Hu J,Dai G,Rong A,Guo G

更新日期：2017-09-01 00:00:00

abstract：:High density lipoproteins (HDL) are heterogeneous particles regarding their size and composition. They have vital functions in reverse cholesterol transport (RCT). RCT occurs when lipid-free apolipoprotein AI recruits cholesterol and phospholipid to form nascent HDL particles. Adenosine triphosphate‑binding cassette t...

journal_title：Molecular medicine reports

authors： Zhou L,Li C,Gao L,Wang A

更新日期：2015-09-01 00:00:00

abstract：:Induction of cardiomyocyte proliferation, the most promising approach to reverse myocardial attrition, has been gaining importance as a therapy for cardiovascular disease. Hypoxia and macrophages were previously independently reported to promote cardiomyocyte proliferation in mice. However, whether hypoxia promotes ca...

journal_title：Molecular medicine reports

authors： Liu B,Zhang HG,Zhu Y,Jiang YH,Luo GP,Tang FQ,Jian Z,Xiao YB

更新日期：2017-06-01 00:00:00

abstract：:Bone injury following radiotherapy has been confirmed by epidemiological and animal studies. However, the underlying mechanism remains to be elucidated and no preventive or curative solution has been identified for this bone loss. The present study aimed to investigate the irradiation‑altered osteogenesis and adipogen...

journal_title：Molecular medicine reports

authors： Wang Y,Zhu G,Wang J,Chen J

更新日期：2016-01-01 00:00:00

abstract：:Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, the present study was designed to elucidate the neuroprotective effects of theaflavin on cerebral I/R injury ...

journal_title：Molecular medicine reports

authors： Li R,Li X,Wu H,Yang Z,Fei L,Zhu J

更新日期：2019-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) exert regulatory functions on various biological processes in cancer cells, including proliferation, apoptosis and mobility. Prostate cancer-associated transcript 1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer, however, the effect of PCAT‑1 in hepatocell...

journal_title：Molecular medicine reports

authors： Wen J,Xu J,Sun Q,Xing C,Yin W

更新日期：2016-05-01 00:00:00

abstract：:Cardiomyopathies have been indicated to be one of the leading causes of heart failure. Though it was indicated that genetic defects, viral infection and trace element deficiency were among the causes of cardiomyopathy, the etiology has remained to be fully elucidated. Cardiomyocytes require large amounts of energy to ...

journal_title：Molecular medicine reports

authors： Liu Z,Cai H,Dang Y,Qiu C,Wang J

更新日期：2016-02-01 00:00:00

abstract：:Dysregulation of collagen type XII α1 chain (COL12A1) has been found in several cancer types and could be involved in tumor progression. However, its clinical significance in gastric cancer (GC) remains under exploration. Online databases (Gene Expression Omnibus and UALCAN), reverse transcription‑quantitative PCR and...

journal_title：Molecular medicine reports

authors： Jiang X,Wu M,Xu X,Zhang L,Huang Y,Xu Z,He K,Wang H,Wang H,Teng L

更新日期：2019-10-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by ace...

journal_title：Molecular medicine reports

authors： Choi GH,Park HS,Kim KR,Choi HN,Jang KY,Chung MJ,Kang MJ,Lee DG,Moon WS

更新日期：2008-07-01 00:00:00

abstract：:N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α (NT‑PGC‑1α) is an alternative splice variant of PGC‑1α. NT‑PGC‑1α exhibits stronger anti‑obesity effects in adipose tissue than PGC‑1α; however, NT‑PGC‑1α has not yet been investigated in neonatal rat cardiomyocytes (NRCMs). The present s...

journal_title：Molecular medicine reports

authors： Liu Z,Hua J,Cai W,Zhan Q,Lai W,Zeng Q,Ren H,Xu D

更新日期：2018-08-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:BCL6ZF is a novel transcript of BCL6, which lacks the first two zinc fingers of BCL6. It has been established that BCL6 acts as a sequence‑specific transcriptional repressor, however, the functions of BCL6ZF remain undefined. By generating stably overexpressed BCL6 and BCL6ZF in NCI‑H1299 lung cancer cells, it was fou...

journal_title：Molecular medicine reports

authors： Fu X,Hao Y,Mao Y,Qian Y,Qian Z,Li T,He D,Xiao X

更新日期：2015-05-01 00:00:00

abstract：:Nerve growth factor (NGF) is expressed in the human corneal epithelium and stroma. It is an efficient therapy for human corneal ulcers caused by neurotropic disease. However, little is known about the molecular mechanism of NGF in healing human corneal epithelial diseases. Numerous microRNAs (miRNAs) are expressed in ...

journal_title：Molecular medicine reports

authors： Wu D,Qian T,Hong J,Li G,Shi W,Xu J

更新日期：2017-10-01 00:00:00