Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated mortality in the 21st century. microRNA (miR)‑23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR‑23b in HCC remains unclear. The present study revealed a neg...

journal_title：Molecular medicine reports

authors： Jiang T,Huang Z,Zhang S,Zou W,Xiang L,Wu X,Shen Y,Liu W,Zeng Z,Zhao A,Zhou S,Zeng Q

更新日期：2018-08-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most important causes of end‑stage renal disease. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus, which possesses various pharmacological activities. AS‑IV prevents podocyte apoptosis and ameliorates renal injury in DN; however, few studies have focu...

journal_title：Molecular medicine reports

authors： Yao XM,Liu YJ,Wang YM,Wang H,Zhu BB,Liang YP,Yao WG,Yu H,Wang NS,Zhang XM,Peng W

更新日期：2016-06-01 00:00:00

abstract：:The present study aimed to investigate the effect of epigallocatechin gallate (EGCG) on airway inflammation in mice with bronchial asthma, and the regulatory mechanism of transforming growth factor (TGF)‑β1 signaling pathway, so as to provide theoretical basis for research and development of a novel drug for clinical ...

journal_title：Molecular medicine reports

authors： Shan L,Kang X,Liu F,Cai X,Han X,Shang Y

更新日期：2018-08-01 00:00:00

abstract：:The increasing burden of diabetes in low and middle‑income countries is attributable to both genetic and epigenetic factors. Environmental‑ and lifestyle‑associated changes are also considered to be important contributors to this disease. The resultant co‑morbidities arising from micro‑and macrovascular changes in dia...

journal_title：Molecular medicine reports

authors： Yu Z,Zhang W,Zhang X,Xu D,Wang N

更新日期：2020-08-01 00:00:00

abstract：:Lung fibrosis is associated with inflammation, apoptosis and oxidative damage. The transcription factor nuclear factor erythroid 2‑related factor‑2 (Nrf2) prevents damage to cells from oxidative stress by regulating the expression of antioxidant proteins. Sulforaphane (SFN), an Nrf2 activator, additionally regulates e...

journal_title：Molecular medicine reports

authors： Yan B,Ma Z,Shi S,Hu Y,Ma T,Rong G,Yang J

更新日期：2017-06-01 00:00:00

abstract：:Small‑cell lung cancer (SCLC) is a type of lung cancer with early metastasis, and high recurrence and mortality rates. The molecular mechanism is still unclear and further research is required. The aim of the present study was to examine the pathogenesis and potential molecular markers of SCLC by comparing the differe...

journal_title：Molecular medicine reports

authors： Mao Y,Xue P,Li L,Xu P,Cai Y,Chu X,Jiang P,Zhu S

更新日期：2019-09-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but devastating malignancy. Up to 90% of patients presenting with CCA have no identifiable risk factors. The base excision repair (BER) pathway has a principal role in the repair of mutations caused by oxidized or reduced bases. The MutY homolog (MUTYH, MYH) is one of the key protein...

journal_title：Molecular medicine reports

authors： You SH,Wang X,Huang S,Wang M,Ji GZ,Xia JR,Fan ZN

更新日期：2013-01-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral cancer associated with high malignancy. Circular RNAs (circRNAs) are a form of non‑coding RNA with stable and conserved expression in mammalian cells. The aim of the present study was to investigate circRNAs expression profiles in TSCC, and examin...

journal_title：Molecular medicine reports

authors： Wei T,Ye P,Yu GY,Zhang ZY

更新日期：2020-04-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by fibrosis of the skin and visceral organs, and peripheral circulatory disturbance. α2‑antiplasmin (α2AP) is the major circulating inhibitor of plasmin and is a key regulator of fibrinolysis. It has been demonstrated that the e...

journal_title：Molecular medicine reports

authors： Niwa H,Kanno Y,Shu E,Seishima M

更新日期：2020-10-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Bone injury following radiotherapy has been confirmed by epidemiological and animal studies. However, the underlying mechanism remains to be elucidated and no preventive or curative solution has been identified for this bone loss. The present study aimed to investigate the irradiation‑altered osteogenesis and adipogen...

journal_title：Molecular medicine reports

authors： Wang Y,Zhu G,Wang J,Chen J

更新日期：2016-01-01 00:00:00

abstract：:Intrauterine adhesions (IUA) may be caused by endometrial stromal cell proliferation, increases in myofibroblasts or increases in extracellular matrix secretion. However, the specific mechanisms underlying the development of IUA have yet to be elucidated. The present study identified that angiotensin (Ang) II is capab...

journal_title：Molecular medicine reports

authors： Shan T,Zhang L,Zhao C,Chen W,Zhang Y,Li G

更新日期：2014-06-01 00:00:00

abstract：:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β...

journal_title：Molecular medicine reports

authors： Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding J

更新日期：2014-07-01 00:00:00

abstract：:Excessive bone resorption mediated by osteoclasts may lead to the risk of various lytic bone diseases. In the present study, the effects of I‑BET151, a bromodomain and extra terminal domain protein inhibitor, on osteoclastogenesis in RAW264.7 cells and the underlying mechanism of this process was investigated. Cells w...

journal_title：Molecular medicine reports

authors： Cheng J,Zheng J,Guo N,Zi F

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate whether brain death (BD) induces the activation of endoplasmic reticulum stress (ERS) and protein phosphatase 2A (PP2A), and reveal the possible association with BD‑induced liver cell apoptosis. A total of 30 healthy adult male Sprague‑Dawley rats were randomized into three group...

journal_title：Molecular medicine reports

authors： Lan J,Zhong Z,Wang Y,Xiong Y,Ye Q

更新日期：2020-02-01 00:00:00

abstract：:A previous study has demonstrated a progression in the nerve regeneration by polyaniline/cellulose (PANI/RC), although the underlying mechanism was not elucidated. In the present study, regenerated nerves were investigated, using histological techniques, functional assays and western blot analysis. The triceps surae m...

journal_title：Molecular medicine reports

authors： Fan L,Xiong Y,Fu Z,Xu D,Wang L,Chen Y,Xia H,Peng N,Ye S,Wang Y,Zhang L,Ye Q

更新日期：2017-11-01 00:00:00

abstract：:Cytokines and their intercellular signals regulate the multipotency of mesenchymal stem cells (MSCs). The present study established the MSC lines SG‑2, ‑3, and ‑5 from the bone marrow of green fluorescent protein (GFP)‑transgenic mice. These cell lines clearly expressed mouse MSC markers Sca‑1 and CD44, and SG‑2 and ‑...

journal_title：Molecular medicine reports

authors： Sawada S,Chosa N,Takizawa N,Yokota J,Igarashi Y,Tomoda K,Kondo H,Yaegashi T,Ishisaki A

更新日期：2016-03-01 00:00:00

abstract：:Acute lung injury (ALI) is a common, costly and potentially lethal disease with characteristics of alveolar‑capillary membrane disruption, pulmonary edema and impaired gas exchange due to increased apoptosis and pulmonary inflammation. There is no effective and specific therapy for ALI; however, mesenchymal stem cells...

journal_title：Molecular medicine reports

authors： Chen XX,Tang L,Han ZH,Wang WJ,Meng JG

更新日期：2019-03-01 00:00:00

abstract：:Gliomas are the most common type of primary brain tumor. Using current standard treatment regimens, the prognosis of patients with gliomas remains poor, which is predominantly due to the resistance of glioma cells to chemotherapy. The organ microenvironment has been implicated in the pathogenesis and survival of tumor...

journal_title：Molecular medicine reports

authors： Lin Q,Liu Z,Ling F,Xu G

更新日期：2016-02-01 00:00:00

abstract：:Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to inves...

journal_title：Molecular medicine reports

authors： Cai F,Cai L,Zhou Z,Pan X,Wang M,Chen S,Luis MAF,Cen C,Biskup E

更新日期：2019-05-01 00:00:00

abstract：:The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by ...

journal_title：Molecular medicine reports

authors： Takara K,Matsubara M,Yamamoto K,Minegaki T,Takegami S,Takahashi M,Yokoyama T,Okumura K

更新日期：2012-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common type of brain cancer; it usually recurs and patients have a short survival time. The present study aimed to construct a gene expression classifier and to screen key genes associated with GBM prognosis. GSE7696 microarray data set included samples from 10 recurrent GBM t...

journal_title：Molecular medicine reports

authors： Yang H,Jin L,Sun X

更新日期：2019-03-01 00:00:00

abstract：:Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

journal_title：Molecular medicine reports

authors： Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

更新日期：2014-12-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is associated with an aggressive clinical history, high risk of recurrence and metastasis, and shorter patient survival due to lack of targeted therapy. In the present study, UNC0638, a chemical G9a inhibitor, was identified to suppress TNBC cell invasion and migration in vitro at ...

journal_title：Molecular medicine reports

authors： Liu XR,Zhou LH,Hu JX,Liu LM,Wan HP,Zhang XQ

更新日期：2018-02-01 00:00:00

abstract：:Arsenic trioxide (As2O3; ATO), a compound which is characterized by its ability to function as a potent anticancer agent, has been investigated in a variety of carcinomas. B7‑H4, a transmembrane protein, may inhibit the function of the T cell effector, and therefore, may be useful in investigating different types of t...

journal_title：Molecular medicine reports

authors： Cui L,Gao B,Cao Z,Chen X,Zhang S,Zhang W

更新日期：2016-03-01 00:00:00

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:Prolonged treatment with tyrosine kinase inhibitors (TKI) including imatinib (IMA) or nilotinib (NIL), induces severe disturbances of bone metabolism in patients with chronic myeloid leukaemia. As vitamin D3 (VD3) is involved in the complex cycle of bone remodelling, the present study investigated in vitro, the influe...

journal_title：Molecular medicine reports

authors： Kroschwald L,Suttorp M,Tauer JT,Zimmermann N,Günther C,Bauer A

更新日期：2018-01-01 00:00:00

abstract：:Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang M,Jiang M,Nong G

更新日期：2020-08-01 00:00:00

abstract：:Transgelin 2 (TAGLN2) is a cytoskeletal protein of the calponin family. Abnormal expression of TAGLN2 was observed in various types of cancer. Our previous study reported that TAGLN2 expression was reduced in lymph node‑positive breast cancer patients; however, the role of TAGLN2 in breast cancer metastasis remains un...

journal_title：Molecular medicine reports

authors： Yang L,Hong Q,Xu SG,Kuang XY,Di GH,Liu GY,Wu J,Shao ZM,Yu SJ

更新日期：2019-11-01 00:00:00