MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma.

abstract：:The purpose of this study was to assess the efficacy and predictive biomarkers of combination docetaxel-trastuzumab in a neoadjuvant setting by means of a phase II trial. Women with histologically-confirmed advanced invasive breast cancer whose tumours overexpressed HER-2 received 4 cycles of docetaxel (70 mg/m2 every...

journal_title：Molecular medicine reports

authors： Kurosumi M,Tabei T,Sano M,Honma K,Yanagita Y,Yamamoto N,Inoue K,Sato N,Kimura M

更新日期：2008-01-01 00:00:00

abstract：:Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV) infection. Previous studies have identified that the occurrence, relapse and cancerization of CA is relevant to immune imbalance caused by immune hypofunction or immunoregulatory dysfunction. However, to date, the s...

journal_title：Molecular medicine reports

authors： Shi YJ,Yang J,Yang W

更新日期：2013-08-01 00:00:00

abstract：:Gonadotrophin‑releasing hormone (GnRH) agonists (GnRHa) have been widely used to induce a state of downregulation for in vitro fertilization, and its direct effects on the pituitary are well known. However, the effects of GnRHa on the expression of anti‑mullerian hormone (AMH) by follicles in varying stages in vivo re...

journal_title：Molecular medicine reports

authors： Huang J,Wang X,Li Z,Ma R,Xiao W

更新日期：2015-09-01 00:00:00

abstract：:Tumor angiogenesis is important in the growth and metastasis of malignant tumors. In our previous study, we demonstrated that an arginine-arginine-leucine (RRL) peptide is a tumor endothelial cell-specific binding sequence that may be used as a molecular probe for the imaging of malignant tumors in vivo. The aim of th...

journal_title：Molecular medicine reports

authors： Zhao Q,Yan P,Yin L,Li L,Chen XQ,Ma C,Wang RF

更新日期：2013-04-01 00:00:00

abstract：:Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two‑herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hy...

journal_title：Molecular medicine reports

authors： Ye S,Gu Y,Xu Y,Fan W,Wang X,Chen S,Cai S,Lv S,Tong Y,Cai J

更新日期：2014-09-01 00:00:00

abstract：:Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR‑141 is suppressed in sorted...

journal_title：Molecular medicine reports

authors： Gao X,Zhu X,Sun Y,Liu J

更新日期：2017-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and Angiotensin II (Ang-II) are important in glomerulosclerosis, which is one of the main causes of chronic kidney disease. Previous studies have demonstrated that angiotensin type 1 receptor blocker (ARB) can inhibit the synthesis of VEGF mediated by Ang‑II and can effectivel...

journal_title：Molecular medicine reports

authors： Liu X,Zhang H,Wang Q,Yu K,Wang R,Sun J

更新日期：2015-09-01 00:00:00

abstract：:The pathogenesis of Graves' ophthalmopathy (GO) remains to be entirely elucidated. The present study aimed to determine the association between phenotypic expression of the MTHFR gene and susceptibility to GO in patients with Graves' disease (GD). A prospective case‑controlled study was conducted with 122 patients wit...

journal_title：Molecular medicine reports

authors： Lee JY,Kim NK,Cho YW,Lew H

更新日期：2016-09-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)‑542‑3p is a tumor suppressor in multiple types of cancer. However, whether and how miR‑542‑3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the curre...

journal_title：Molecular medicine reports

authors： Sun J,Deng Y,Shi J,Yang W

更新日期：2020-01-01 00:00:00

abstract：:To determine the effect of thymosin α1 (Tα1) on the phenotypic and functional maturation of HL‑60 cells, freeze‑thaw antigen‑loaded dendritic cells (DCs) were derived from peripheral blood mononuclear cells (PBMCs) of children with acute lymphoblastic leukemia (ALL). The DCs were generated from the PBMC samples that w...

journal_title：Molecular medicine reports

authors： Li X,Liu X,Zhao Y,Zhong R,Song A,Sun L

更新日期：2015-10-01 00:00:00

abstract：:Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP co...

journal_title：Molecular medicine reports

authors： He J,Feng C,Sun J,Lu K,Chu T,Zhou Y,Pan Y

更新日期：2018-04-01 00:00:00

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:The aim of the present study was to investigate the apoptosis of human ovarian cancer cell lines, A2780 and CP70, induced by a novel curcumin analogue, B19. The proliferation of cells was detected with methyl thiazolyl tetrazolium (MTT) assay and apoptosis was examined by flow cytom...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang HQ,Zhu GH,Wang YH,Yu XC,Zhu XB,Liang G,Xiao J,Li XK

更新日期：2012-03-01 00:00:00

abstract：:MicroRNAs (miRs) are small non‑coding RNA molecules that regulate gene expression at the post‑transcriptional level. Aberrant expression of miR‑9 has been reported to be involved in the tumorigenesis and progression of various malignancies. However, its role in prostate cancer (PC) has not been completely clarified. I...

journal_title：Molecular medicine reports

authors： Sang Z,Jiang X,Guo L,Yin G

更新日期：2019-05-01 00:00:00

abstract：:Asparaginase like 1 (ASRGL1) protein belongs to the N‑terminal nucleophile group, cleaving the isoaspartyl‑dipeptides and L‑asparagine by adding water. It tends to be overexpressed in cancerous tumors including ovarian cancer and breast tumors. The present study assessed the potential ability of ASRGL1 as a molecular ...

journal_title：Molecular medicine reports

authors： Lv XF,Hong HQ,Liu L,Cui SH,Ren CC,Li HY,Zhang XA,Zhang LD,Wei TX,Liu JJ,Xing WY,Fu H,Yan SJ

更新日期：2018-07-01 00:00:00

abstract：:The present study aimed to identify potentially important biomarkers associated with polycystic ovary syndrome (PCOS) by integrating DNA methylation with transcriptome profiling. The transcription (E‑MTAB‑3768) and methylation (E‑MTAB‑3777) datasets were retrieved from ArrayExpress. Paired transcription and methylatio...

journal_title：Molecular medicine reports

authors： Liu L,He D,Wang Y,Sheng M

更新日期：2020-05-01 00:00:00

abstract：:Chronic microglial activation endangers neuronal survival through the release of various pro-inflammatory and neurotoxic factors. As such, negative regulators of microglial activation have been considered as potential therapeutic candidates to reduce the risk of neurodegeneration associated with inflammation. Uncaria ...

journal_title：Molecular medicine reports

authors： Jung HY,Nam KN,Woo BC,Kim KP,Kim SO,Lee EH

更新日期：2013-01-01 00:00:00

abstract：:Mutations in the optic atrophy 1 gene (OPA1) are associated with autosomal dominant optic atrophy and 20% of patients demonstrate extra-ocular manifestations. In addition to these autosomal dominant cases, only a few syndromic cases have been reported thus far with compound heterozygous OPA1 mutations, suggestive of e...

journal_title：Molecular medicine reports

authors： Lee J,Jung SC,Hong YB,Yoo JH,Koo H,Lee JH,Hong HD,Kim SB,Chung KW,Choi BO

更新日期：2016-07-01 00:00:00

abstract：:Genetically modified mesenchymal stem cells have been used in attempts to increase the expression of interleukin‑1 receptor antagonist (IL‑1Ra); however, the attempts thus far have been unsuccessful. The aim of the present study was to investigate whether the lentivirus transduced IL‑1Ra gene was able to be stably exp...

journal_title：Molecular medicine reports

authors： He T,Chi G,Tian B,Tang T,Dai K

更新日期：2015-09-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among females and the adenosine triphosphate (ATP) binding cassette E1 (ABCE1) gene is a member of the ATP‑binding cassette (ABC) family. Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis. However, little...

journal_title：Molecular medicine reports

authors： Huang B,Zhou H,Lang X,Liu Z

更新日期：2014-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analys...

journal_title：Molecular medicine reports

authors： Zuo N,Li Y,Liu N,Wang L

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of neuropeptide Y (NPY) on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor glutamate receptor 2 (GluR2) subunit in epileptiform discharge hippocampal neurons. Hippocampal neurons were harvested from neonatal Sprague‑Dawley rats aged <24 h and ...

journal_title：Molecular medicine reports

authors： Bu W,Zhao WQ,Li WL,Dong CZ,Zhang Z,Li QJ

更新日期：2017-07-01 00:00:00

abstract：:Connexin 43 (Cx43) is the main gap junction protein in astrocytes and exerts the same effects on growth inhibition in astrocytoma and glioma as microRNA-146a (miR-146a) in glioma. β2-adrenergic receptor (AR) signaling modulates Cx43 expression in myocytes via components downstream of protein kinase A (PKA) and exchang...

journal_title：Molecular medicine reports

authors： Khaksarian M,Mostafavi H,Soleimani M,Karimian SM,Ghahremani MH,Joghataee MT,Khorashadizadeh M,Aligholi H,Attari F,Hassanzadeh G

更新日期：2015-08-01 00:00:00

abstract：:Infantile hemangioma (IH) is one of the most common vascular tumors that occurs during childhood, but its pathogenesis is currently not completely understood. Even though lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) plays vital roles in tumorigenesis of malignant tumors, its roles in IH remain unclear. The...

journal_title：Molecular medicine reports

authors： Yu L,Shu H,Xing L,Lv MX,Li L,Xie YC,Zhang Z,Zhang L,Xie YY

更新日期：2020-10-01 00:00:00

abstract：:Inflammation is a potent promoter of tumor metastasis. The aim of the present study was to explore the function of systemic inflammation in the formation of lung metastasis of breast cancer cells in a mouse model. BALB/c mice were injected intraperitoneally with lipopolysaccharide (LPS) in order to establish an inflam...

journal_title：Molecular medicine reports

authors： Li S,Xu X,Jiang M,Bi Y,Xu J,Han M

更新日期：2015-06-01 00:00:00

abstract：:Prenatal clinical detection of thalassemia involves gap‑PCR and reverse dot blot (RDB) analysis of fetal DNA acquired through invasive methods. The present study aimed to develop a non‑invasive prenatal diagnostic method for thalassemia based on next‑generation sequencing (NGS). A total of eight families with proband ...

journal_title：Molecular medicine reports

authors： Yang X,Ye Y,Fan D,Lin S,Li M,Hou H,Zhang J,Yang X

更新日期：2020-08-01 00:00:00

abstract：:Methyl‑CpG‑binding protein 2 (MeCP2) is a transcriptional repressor that has been implicated in tumor onset and progression. Compared with normal and other tumorous tissue, MeCP2 is highly expressed in well‑differentiated adenocarcinoma and mucinous adenocarcinoma tissues, particularly at the invasion site of colorect...

journal_title：Molecular medicine reports

authors： Song N,Li K,Wang Y,Chen Z,Shi L

更新日期：2016-01-01 00:00:00

abstract：:We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's antic...

journal_title：Molecular medicine reports

authors： Xie J,Que W,Liu H,Liu M,Yang A,Chen M

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life‑threatening disease induced by the excessive proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Formononetin (FMN) is a natural isoflavone with numerous cardioprotective properties, which can inhibit the proliferation and induce the apo...

journal_title：Molecular medicine reports

authors： Cai C,Xiang Y,Wu Y,Zhu N,Zhao H,Xu J,Lin W,Zeng C

更新日期：2019-12-01 00:00:00

abstract：:Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), le...

journal_title：Molecular medicine reports

authors： Kim HS,Park JW,Kwon OK,Kim JH,Oh SR,Lee HK,Bach TT,Quang BH,Ahn KS

更新日期：2014-04-01 00:00:00