IL‑8 promotes proliferation and inhibition of apoptosis via STAT3/AKT/NF‑κB pathway in prostate cancer.

abstract：:Postmenopausal osteoporosis (OPM) is a common type of osteoporosis in females. It is a systemic, chronic bone disease that presents as microstructure degradation of osseous tissue, decreased bone mineral density and increased osteopsathyrosis caused by hypoovarianism and reduced estrogen levels in the body following m...

journal_title：Molecular medicine reports

authors： Qiu J,Huang G,Na N,Chen L

更新日期：2018-05-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common multifactorial disorder characterized by hyperandrogenism, insulin resistance and chronic oligoanovulation. In addition, a number of females with PCOS have ovaries with multiple cysts, an irregular or no menstrual cycle and an imbalance of female hormones compared with norm...

journal_title：Molecular medicine reports

authors： Park JH,Li L,Baek KH

更新日期：2015-09-01 00:00:00

abstract：:The present study investigated the effect of certain 1,3,5‑triazine derivatives on epidermal growth factor receptor‑tyrosine kinase (EGFR‑TK). The results suggested that 1,3,5‑triazine derivatives exhibited optimal drug likeness via molinspiration and proved to be effective drug candidates as potential anticancer agen...

journal_title：Molecular medicine reports

authors： Yan W,Zhao Y,He J

更新日期：2018-11-01 00:00:00

abstract：:Moscatilin is a bibenzyl derivative extracted from the Dendrobium aurantiacum var. denneanum, which has traditionally been used as an immunomodulatory treatment in China. The present study was designed to determine whether moscatilin is a pro‑apoptotic agent in pancreatic cancer, and to elucidate the underlying mechan...

journal_title：Molecular medicine reports

authors： Zhang L,Fang Y,Xu XF,Jin DY

更新日期：2017-03-01 00:00:00

abstract：:Ezrin is involved in maintaining cell structure and cell motility. Expression levels of the ezrin gene correlate with numerous human malignancies. The aim of this study was to explore the role of ezrin in tumor progression and the prognostic evaluation of colorectal adenocarcinoma (CRA). The levels of ezrin protein in...

journal_title：Molecular medicine reports

authors： Lin LJ,Chen LT

更新日期：2013-07-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning of Japan and is available throughout the world. The two main raw ingredients of soy sauce are soybean and wheat, both of which are established food allergens. The present study examined the degradation and removal of soybean allergens in soy sauce by immunoblotting with a...

journal_title：Molecular medicine reports

authors： Magishi N,Yuikawa N,Kobayashi M,Taniuchi S

更新日期：2017-08-01 00:00:00

abstract：:Previous studies have demonstrated that calcium channel blockers have protective effects on damaged brains. In the present study, the protective effect of the calcium channel blocker nicardipine against rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells was investigated...

journal_title：Molecular medicine reports

authors： Park HJ,Kim HJ

更新日期：2013-03-01 00:00:00

abstract：:In the present study a rat model of oval cell‑mediated liver regeneration was constructed to examine the molecular mechanisms of matrine in oval cell‑mediated liver regeneration and the effects of matrine on hepatic function and the expression of OV6 protein and recombination signal sequence‑binding protein Jκ (RBP‑Jκ...

journal_title：Molecular medicine reports

authors： Yang ZY,Wang L,Hou YX,Wang XB

更新日期：2013-05-01 00:00:00

abstract：:Human immunodeficiency virus‑1 (HIV‑1) infection severely damages the gut‑associated lymphoid tissue (GALT), the immune system and the gut barrier, which leads to accelerating the disease progression for patients with acquired immune deficiency syndrome (AIDS). Dysregulation of microRNAs (miRNAs) may contribute to thi...

journal_title：Molecular medicine reports

authors： Xu Y,Wang HW,Luo HY,Shu R,Liu J,Sun L,Han XF,Lin N,Wang TH,Zeng YJ,Wang KH

更新日期：2017-12-01 00:00:00

abstract：:B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...

journal_title：Molecular medicine reports

authors： Jia R,Jiao Z,Xu X,Wang J,Zhou Y,Song X,Ge S,Fan X

更新日期：2011-01-01 00:00:00

abstract：:The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains...

journal_title：Molecular medicine reports

authors： Du Y,Wu J,Zhang H,Li S,Sun H

更新日期：2017-04-01 00:00:00

abstract：:The present study investigated the role of the c‑Jun N‑terminal kinase (JNK)/transforming growth factor‑β (TGF‑β)/Smad3 pathway in endoplasmic reticulum stress (ERS)‑mediated renal interstitial fibrosis, which would be beneficial for chronic kidney disease (CKD) therapy. In human renal biopsy tissue, the expression le...

journal_title：Molecular medicine reports

authors： Liu Y,Shen P,Zhou Y,Tang L,Chai H

更新日期：2019-07-01 00:00:00

abstract：:The mortality rate of ovarian cancer is the highest of all gynecological malignancies. Telmisartan is a commonly used clinical angiotensin receptor blocker, which has antihypertensive, anti‑inflammatory and antithrombotic effects. In the present study, it was investigated whether telmisartan could exert anticancer eff...

journal_title：Molecular medicine reports

authors： Pu Z,Zhu M,Kong F

更新日期：2016-01-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and sec...

journal_title：Molecular medicine reports

authors： Zheng W,Guan J

更新日期：2018-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) regulate several physiological and pathological processes, but their role in visceral lipid deposition has not been explored. In the present study, human preadipocytes from visceral fat tissue (HPA‑v) were induced to form adipocytes, and the circRNA expression profiles in HPA‑v and adipocytes ...

journal_title：Molecular medicine reports

authors： Sun W,Sun X,Chu W,Yu S,Dong F,Xu G

更新日期：2020-02-01 00:00:00

abstract：:Previous genome-wide association studies have demonstrated that single nucleotide polymorphisms in T‑box (TBX)5 are associated with increased susceptibility to atrial fibrillation (AF), and a recent study has causally linked a TBX5 mutation to atypical Holt-Oram syndrome and paroxysmal AF. However, the prevalence and ...

journal_title：Molecular medicine reports

authors： Guo DF,Li RG,Yuan F,Shi HY,Hou XM,Qu XK,Xu YJ,Zhang M,Liu X,Jiang JQ,Yang YQ,Qiu XB

更新日期：2016-05-01 00:00:00

abstract：:The early diagnosis of acute rejection is crucial for graft survival after kidney transplantation. The interferon-γ (IFNγ)-CXCR3-chemokine-dependent inflammatory loop plays a pivotal role in the recruitment of T lymphocytes during acute rejection. Previously published studies have typically focused on the CXCR3 recept...

journal_title：Molecular medicine reports

authors： Huang H,Xu X,Yao C,Cai M,Qian Y,Wang X,Shi B

更新日期：2014-01-01 00:00:00

abstract：:CD44 is closely linked to breast cancer progression; however, the regulatory functions of microRNAs (miRs) in breast cancer have yet to be fully elucidated. In order to investigate the regulation of CD44 by miRs in breast cancer, the present study isolated CD44+ and CD44- breast cancer cells by flow cytometry, reveali...

journal_title：Molecular medicine reports

authors： Yang Z,Chen D,Nie J,Zhou S,Wang J,Tang Q,Yang X

更新日期：2016-06-01 00:00:00

abstract：:Fine particulate matter (PM2.5) has been linked to exacerbation of allergic airway inflammation in mice. However, the mechanism underlying exposure to PM2.5 and subsequent and adverse effects remains to be fully elucidated. Therefore, the present study aimed to investigate the effects of PM2.5 by different levels on a...

journal_title：Molecular medicine reports

authors： Liu Y,Feng GZ,Du Q,Jin XX,Du XR

更新日期：2017-10-01 00:00:00

abstract：:Krüppel-like factors (KLFs) regulate a wide variety of cellular functions and modulate pathological processes. In the present study, a post‑translational mechanism of microRNAs (miRs) was investigated in H2O2-induced human cardiomyocyte (HCM) injury. In H2O2‑cultured HCM cells, reactive oxygen species and apoptotic ce...

journal_title：Molecular medicine reports

authors： Zhang X,Liu F,Wang Q,Geng Y

更新日期：2017-10-01 00:00:00

abstract：:microRNAs (miRNAs) are small, non‑coding RNAs involved in multiple biological pathways by regulating post-transcriptional gene expression. Previously, autophagy has been reported to suppress the progression of non-small cell lung cancer (NSCLC). However, how miRNAs regulate autophagy in NSCLC remains to be elucidated....

journal_title：Molecular medicine reports

authors： Wei J,Ma Z,Li Y,Zhao B,Wang D,Jin Y,Jin Y

更新日期：2015-01-01 00:00:00

abstract：:Many studies have reported that lutein may exert its biological activities, including anti‑inflammation, anti‑oxidase and anti‑apoptosis, through effects on reactive oxygen species (ROS). Thus, lutein may prevent the damaging activities of ROS in cells. The current study investigated the effect of lutein against sever...

journal_title：Molecular medicine reports

authors： Tan D,Yu X,Chen M,Chen J,Xu J

更新日期：2017-10-01 00:00:00

abstract：:The primary cause of breast cancer‑associated mortality is the formation of distant metastasis. During the metastatic process, single tumor cells dissolve from the primary tumor site and undergo various changes in cell adhesion and motility properties. The tumor cells invade the blood stream and travel to different si...

journal_title：Molecular medicine reports

authors： Andergassen U,Schlenk K,Jeschke U,Sommer H,Kölbl A

更新日期：2018-08-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis-inducing ligand (TRAIL) is well known as a transmembrane cytokine and has been proposed as one of the most effective anti‑cancer therapeutic agents, owing to its efficiency to selectively induce cell death in a variety of tumor cells. Suppression of autophagy flux has been incre...

journal_title：Molecular medicine reports

authors： Nazim UM,Yin H,Park SY

更新日期：2019-02-01 00:00:00

abstract：:Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem ce...

journal_title：Molecular medicine reports

authors： Song K,Gu T,Shuang F,Tang J,Ren D,Qin J,Hou S

更新日期：2015-09-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:Early reports suggest that nuclear factor IA (NFIA) is important in the pathogenesis of glioma. Our previous study demonstrated that the long non‑coding RNA (lncRNA), RP5‑833A20.1, suppressed the expression of NFIA in THP‑1 macrophage-derived foam cells. However, the effect and possible mechanism of RP5‑833A20.1 on gl...

journal_title：Molecular medicine reports

authors： Kang CM,Hu YW,Nie Y,Zhao JY,Li SF,Chu S,Li HX,Huang QS,Qiu YR

更新日期：2016-12-01 00:00:00

abstract：:Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melano...

journal_title：Molecular medicine reports

authors： Chen J,Wu F,Shi Y,Yang D,Xu M,Lai Y,Liu Y

更新日期：2019-08-01 00:00:00

abstract：:Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticanc...

journal_title：Molecular medicine reports

authors： Dexheimer GM,Becker Delving LKO,de Oliveira HS,Biolchi V,Goettert MI,Pozzobon A

更新日期：2017-05-01 00:00:00