Anti‑breast cancer activity of selected 1,3,5‑triazines via modulation of EGFR‑TK.

abstract：:The tumor suppressor protein LKB1 is a serine/threonine kinase that plays a critical role in cell proliferation, and its inactivation has been linked to tumorigenesis in various cancer types. Current understanding of the LKB1 function is largely restricted to results from experiments on LKB1‑deficient cancer cells, wh...

journal_title：Molecular medicine reports

authors： Liang X,Wang P,Gao Q,Tao X

更新日期：2014-03-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of death and nervous system damage in neonates. The aim of the present study was to investigate the effect of the Toll‑like receptor 4 (TLR4) antagonist TAK‑242 on HIE. The Rice‑Vannucci method was used for ligation of the left common carotid art...

journal_title：Molecular medicine reports

authors： Jiang L,Xu Z,Li H,Wu M,Wang F,Liu S,Tao J,Feng X

更新日期：2020-08-01 00:00:00

abstract：:LL‑37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL‑37 may modulate various inflammatory reactions. The authors previously revealed that LL‑37 improves the survival of a murine cecal ligation and puncture (CLP)...

journal_title：Molecular medicine reports

authors： Hosoda H,Nakamura K,Hu Z,Tamura H,Reich J,Kuwahara-Arai K,Iba T,Tabe Y,Nagaoaka I

更新日期：2017-10-01 00:00:00

abstract：:NORAD (non‑coding RNA activated by DNA damage) is a long non‑coding RNA (lncRNA) that is upregulated and promotes cell progression in various human types of cancer; however, its function in non‑small cell lung cancer (NSCLC) remains unclear. The present study investigated the regulatory function and underlying mechani...

journal_title：Molecular medicine reports

authors： Gao W,Weng T,Wang L,Shi B,Meng W,Wang X,Wu Y,Jin L,Fei L

更新日期：2019-06-01 00:00:00

abstract：:The baseline concentration of C-reactive protein (CRP) has been associated with a wide array of human diseases. In epidemiological studies and in the clinic, CRP is typically measured as a pentamer, composed of 5 identical CRP subunits. The present study aimed to determine whether other isoforms were present in the bl...

journal_title：Molecular medicine reports

authors： Li Q,Xu W,Xue X,Wang Q,Han L,Li W,Lv S,Liu D,Richards J,Shen Z,Ma L,Song Q

更新日期：2016-12-01 00:00:00

abstract：:Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with t...

journal_title：Molecular medicine reports

authors： Pérez PM,Moore-Carrasco R,González DR,Fuentes EQ,Palomo IG

更新日期：2012-05-01 00:00:00

abstract：:Esculin is a derivative of coumarin, which is also an active ingredient of ash bark, and has antibacterial, anti-inflammatory, anti‑allergy and skin protective effects. The underlying mechanism and protective effects of esculin on cognitive impairment in experimental diabetic nephropathy (DN) was investigated in the p...

journal_title：Molecular medicine reports

authors： Song Y,Wang X,Qin S,Zhou S,Li J,Gao Y

更新日期：2018-05-01 00:00:00

abstract：:Prostate cancer is the second most common disease of the male reproductive system. Berberine is a quaternary ammonium salt that is extracted from plants. The aim of the current study was to explore the antitumor activity of berberine in prostate cancer cells and identify the underlying mechanism of its effects. PC3 hu...

journal_title：Molecular medicine reports

authors： Lu W,Du S,Wang J

更新日期：2015-05-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have therapeutic potential for repairing tissue damage and are involved in immune regulation. MSCs are predominantly isolated from bone marrow (BM), adipose tissue or placental tissue. Further to these well‑known sources, the isolation of MSCs from human tonsils was previously reported...

journal_title：Molecular medicine reports

authors： Ryu JH,Park M,Kim BK,Kim YH,Woo SY,Ryu KH

更新日期：2016-10-01 00:00:00

abstract：:Abnormal paired box 9 (PAX9) expression is associated with tumorigenesis, cancer development, invasion and metastasis. The present study investigated the prognostic significance of PAX9 in esophageal squamous cell carcinoma (ESCC) and its role in predicting radiation sensitivity. A total of 52.8% (121/229) ESCC tissue...

journal_title：Molecular medicine reports

authors： Tan B,Wang J,Song Q,Wang N,Jia Y,Wang C,Yao B,Liu Z,Zhang X,Cheng Y

更新日期：2017-07-01 00:00:00

abstract：:Malignant mesothelioma (MM) is a highly aggressive neoplasm, which is associated with asbestos exposure. The dysregulated phosphatidylinositol 3-kinase (PI3K)-AKT pathway plays an important role in cell proliferation, survival and motility in various cancers. In this study, we analyzed the activation status and underl...

journal_title：Molecular medicine reports

authors： Suzuki Y,Murakami H,Kawaguchi K,Tanigushi T,Fujii M,Shinjo K,Kondo Y,Osada H,Shimokata K,Horio Y,Hasegawa Y,Hida T,Sekido Y

更新日期：2009-03-01 00:00:00

abstract：:Toll‑like receptor 3 (TLR3) can react with double stranded RNA and is involved in the inflammatory response to respiratory syncytial virus (RSV) infection. Also, oxidative stress has been reported to be involved in RSV infection. However, the correlation between oxidative stress and TLR3 activation during RSV infectio...

journal_title：Molecular medicine reports

authors： Wang MM,Lu M,Zhang CL,Wu X,Chen JX,Lv WW,Sun T,Qiu H,Huang SH

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of sorafenib combined with silencing of activating transcription factor 2 (ATF2) in hepatocellular carcinoma (HCC) cells and to assess the underlying molecular mechanisms. Huh‑7 HCC cell line was selected for the present study. Small interfering RNA (siRNA)‑...

journal_title：Molecular medicine reports

authors： Luo L,Cai L,Luo L,Tang Z,Meng X

更新日期：2018-06-01 00:00:00

abstract：:The present study investigated the role of microRNA (miR)‑146a in a diabetic nephropathy (DN) model, and its molecular mechanism. DN mice were given intraperitoneal injections of streptozotocin (55 mg/kg/day) for 5 consecutive days as an in vivo DN model. The HK‑2 human kidney cell line were exposed to 45% D‑glucose a...

journal_title：Molecular medicine reports

authors： Wan RJ,Li YH

更新日期：2018-03-01 00:00:00

abstract：:Recent epidemiological studies and animal experiments have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX), the first oxidase in the process of prostaglandin production from arachidonic acid, is the principal target of NSAIDs. Due to i...

journal_title：Molecular medicine reports

authors： Matsuyama M,Yoshimura R

更新日期：2009-07-01 00:00:00

abstract：:Glucocorticoids (GCs) are important stress hormones, which are used as a concomitant medication during malignant tumor chemotherapy. Clinical and preclinical studies have linked GCs to melanoma growth and progression. However, the effects and mechanism of action of GCs on the adhesion and survival of melanoma cells ar...

journal_title：Molecular medicine reports

authors： Huang GX,Qi MF,Li XL,Tang F,Zhu L

更新日期：2018-02-01 00:00:00

abstract：:Human forkhead box P3 (FOXP3)+ cluster of differentiation (CD)25+CD4+ regulatory T cells (Tregs) are a type of T cell that express CD4, CD25 and FOXP3, which are critical for maintaining immune homeostasis. The present study aimed to determine the mechanisms underlying Treg function. The GSE11292 dataset was downloade...

journal_title：Molecular medicine reports

authors： Bai X,Shi H,Yang M,Wang Y,Sun Z,Xu S

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between brain-derived neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke depression (PSD) rats and to explore the mechanism(s) involved in the process of cognitive impairment. A rat model of focal ce...

journal_title：Molecular medicine reports

authors： Zhang ZH,Wu LN,Song JG,Li WQ

更新日期：2012-10-01 00:00:00

abstract：:Activation of renin-angiotensin system (RAS) is one of the pathological mechanisms associated with myocardial ischemia-reperfusion injury following resuscitation. The present study aimed to determine whether erythropoietin (EPO) improves post‑resuscitation myocardial dysfunction and how it affects the renin‑angiotensi...

journal_title：Molecular medicine reports

authors： Zhou H,Huang J,Zhu L,Cao Y

更新日期：2018-04-01 00:00:00

abstract：:Liver fibrosis is the common outcome of almost all cases of chronic liver disease. The hallmark of liver fibrosis is the activation of hepatic stellate cells (HSCs). microRNA‑34a (miR‑34a), which regulates a plethora of target proteins involved in the cell cycle, apoptosis, differentiation and cellular development, is...

journal_title：Molecular medicine reports

authors： Li X,Chen Y,Wu S,He J,Lou L,Ye W,Wang J

更新日期：2015-02-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades its own long-lived proteins and damaged organelles. Ataxia telangiectasia mutated (ATM) has recently been shown to upregulate the process of autophagy. Previous studies showed...

journal_title：Molecular medicine reports

authors： Qased AB,Yi H,Liang N,Ma S,Qiao S,Liu X

更新日期：2013-02-01 00:00:00

abstract：:Osteosarcoma is a malignant bone tumor which is found most commonly in adolescents and young adults. Local perfusion thermochemotherapy has long been proposed as an alternative strategy for the treatment of osteosarcoma. As a standard anticancer drug, paclitaxel plays a significant ...

journal_title：Molecular medicine reports

authors： Huang T,Gong WH,Li XC,Zou CP,Jiang GJ,Li XH,Feng DP

更新日期：2012-11-01 00:00:00

abstract：:Prostate cancer (PCa) is the second most common cancer amongst males worldwide. In the current study, microarray datasets GSE3325 and GSE6919 from the Gene Expression Omnibus database were screened to identify candidate genes that are associated with the progression of PCa. A total of 273 differentially expressed gene...

journal_title：Molecular medicine reports

authors： Li S,Hou J,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen...

journal_title：Molecular medicine reports

authors： Ding H,Luo Y,Hu K,Huang H,Liu P,Xiong M,Zhu L,Yi J,Xu Y

更新日期：2020-11-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer mortality worldwide and patients occasionally develop local recurrence or distant metastasis soon after curative resection. Reports of new therapeutic strategies for lung squamous cell carcinoma (SqCC) are extremely rare, while selective anti...

journal_title：Molecular medicine reports

authors： Masuda R,Kijima H,Imamura N,Aruga N,Nakamura Y,Masuda D,Takeichi H,Kato N,Nakagawa T,Tanaka M,Inokuchi S,Iwazaki M

更新日期：2012-11-01 00:00:00

abstract：:Previous genome-wide association studies have demonstrated that single nucleotide polymorphisms in T‑box (TBX)5 are associated with increased susceptibility to atrial fibrillation (AF), and a recent study has causally linked a TBX5 mutation to atypical Holt-Oram syndrome and paroxysmal AF. However, the prevalence and ...

journal_title：Molecular medicine reports

authors： Guo DF,Li RG,Yuan F,Shi HY,Hou XM,Qu XK,Xu YJ,Zhang M,Liu X,Jiang JQ,Yang YQ,Qiu XB

更新日期：2016-05-01 00:00:00

abstract：:Receptor interacting protein kinase 4 (RIPK4) is a serine/threonine kinase that plays an important role in the regulation of cell proliferation, invasion and metastasis in several malignancies; however, its clinical significance and biological function in osteosarcoma (OS) remains unknown. In the present study, the RI...

journal_title：Molecular medicine reports

authors： Yi Z,Pu Y,Gou R,Chen Y,Ren X,Liu W,Dong P

更新日期：2020-03-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be responsible for tumor recurrence, metastasis and the high mortality rate of cancer patients. Isolation and identification of CSCs is crucial for basic and preclinical studies. However, as there are currently no universal markers for the isolation and identification of CSCs i...

journal_title：Molecular medicine reports

authors： Wang L,Guo H,Lin C,Yang L,Wang X

更新日期：2014-06-01 00:00:00

abstract：:Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rat...

journal_title：Molecular medicine reports

authors： Lufrano M,Jacob A,Zhou M,Wang P

更新日期：2013-08-01 00:00:00

abstract：:Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC‑803 and SGC‑7901) in vitro, and to determine whether the apoptosis‑relat...

journal_title：Molecular medicine reports

authors： Liu H,Zhou Y,Tang L

更新日期：2017-09-01 00:00:00