Serum levels of CXCR3 ligands predict T cell-mediated acute rejection after kidney transplantation.

abstract：:The aim of the present study was to compare the phosphatidylinositol 3-kinase (PI3KCA)-AKT serine/threonine kinase (AKT) pathway in circulating tumor cells (CTCs) and corresponding cancerous tissues. Stemness‑like circulating tumor cells (slCTCs) and CTCs in epithelial-mesenchymal transition (EMT) have been implicated...

journal_title：Molecular medicine reports

authors： Bredemeier M,Kasimir-Bauer S,Kolberg HC,Herold T,Synoracki S,Hauch S,Edimiris P,Bankfalvi A,Tewes M,Kimmig R,Aktas B

更新日期：2017-05-01 00:00:00

abstract：:The purpose of the present study was to evaluate distinct metabolic features of meningiomas to distinguish them from other brain lesions using proton magnetic resonance spectroscopy. The study was performed on 17 meningiomas, 24 high-grade gliomas and 9 metastases. Elevated signal intensity at 3.8 ppm observed in low ...

journal_title：Molecular medicine reports

authors： Kousi E,Tsougos I,Fountas K,Theodorou K,Tsolaki E,Fezoulidis I,Kapsalaki E

更新日期：2012-04-01 00:00:00

abstract：:Ubiquitin‑specific‑processing protease 34 (USP34) is a deubiquitinase that is involved in the pathogenesis of various cancers. Its roles in diffuse large B‑cell lymphoma (DLBCL) are unknown. The present study aimed to determine the level of USP34 expression and to explore its association with clinicopathological featu...

journal_title：Molecular medicine reports

authors： Li C,Huang L,Lu H,Wang W,Chen G,Gu Y,Zhou Q,Peng Z,Feng Z

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present study was to identify miRNAs that were differentially expressed in hepatocellular carcinoma (HCC) by comparing normal and cancer tissue samples and to analyze the correlation of the target genes and HCC. The gene expression profile of GSE31383 was downloaded from the Gene Expression Omnibus data...

journal_title：Molecular medicine reports

authors： Han K,Li J,Zhao H,Liang P,Huang X,Zheng L,Li Y,Yang T,Wang L

更新日期：2014-07-01 00:00:00

abstract：:Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative, anti-inflammatory and immunoregulatory bioactivities. The present study was performed to examine the effect of quercetin on hu...

journal_title：Molecular medicine reports

authors： Chen FY,Cao LF,Wan HX,Zhang MY,Cai JY,Shen LJ,Zhong JH,Zhong H

更新日期：2015-01-01 00:00:00

abstract：:Pioglitazone may have potential benefits as an alternative therapeutic treatment for patients with Alzheimer's disease (AD), particularly in individuals that also have comorbid diabetes; however, the mechanisms of action remain unclear. The present study aimed to explore the effects of pioglitazone on amyloid β, isofo...

journal_title：Molecular medicine reports

authors： Yang S,Chen Z,Cao M,Li R,Wang Z,Zhang M

更新日期：2017-05-01 00:00:00

abstract：:Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of endometriosis, a...

journal_title：Molecular medicine reports

authors： Albertsen HM,Matalliotaki C,Matalliotakis M,Zervou MI,Matalliotakis I,Spandidos DA,Chettier R,Ward K,Goulielmos GN

更新日期：2019-03-01 00:00:00

abstract：:The present study aimed to investigate the role of Bruton's tyrosine kinase (BTK) in the pathogenesis of lung injury induced by trauma‑hemorrhagic shock (THS), and to examine the pulmonary protective effects of BTK inhibition. Male Sprague‑Dawley rats were divided into four groups (n=12/group): i) A Sham group, which ...

journal_title：Molecular medicine reports

authors： Liu X,Zhang J,Han W,Wang Y,Liu Y,Zhang Y,Zhou D,Xiang L

更新日期：2017-07-01 00:00:00

abstract：:Despite increasing evidence to suggest that microRNA (miR)-146a and miR-181b are involved in the regulation of immune responses and tumor progression, their roles in silicosis remain to be fully elucidated. Therefore, the present study examined the roles of miR‑146a and miR‑181b in inflammatory responses, and their ef...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang F,Lan Y,Zhou D,Ren X,Zhao L,Zhang Q

更新日期：2015-10-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231 and MCF-7 breast cancer cells. The flo...

journal_title：Molecular medicine reports

authors： Chen A,Wang D,Liu X,He S,Yu Z,Wang J

更新日期：2012-09-01 00:00:00

abstract：:The present study aimed to investigate the effects of the long non‑coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) on proliferation, apoptosis and the inflammatory response of osteoarthritic chondrocytes (OACs) and its associated mechanism of action. Primary chondrocytes were isolated from cartilage tis...

journal_title：Molecular medicine reports

authors： Ji Q,Qiao X,Liu Y,Wang D,Yan J

更新日期：2020-03-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis accelerated by hyperglycemia. Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, was upregulated in aorta media from diabetic mice al...

journal_title：Molecular medicine reports

authors： Chen GP,Zhang XQ,Wu T,Han J,Ye D

更新日期：2017-05-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human re...

journal_title：Molecular medicine reports

authors： Zhu BB,Wang H,Chi YF,Wang YM,Yao XM,Liu S,Qiu H,Fang J,Yin PH,Zhang XM,Peng W

更新日期：2018-01-01 00:00:00

abstract：:Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TG...

journal_title：Molecular medicine reports

authors： Liu S,Chen S,Zeng J

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that inhibit the expression of target protein-coding genes, most often at the post-transcriptional level. miRNAs are often found to be misregulated in human cancer and they can act as potent oncogenes or tumor suppressor genes. In this study, we found that a germline mutati...

journal_title：Molecular medicine reports

authors： Shang H,Wang T,Shang F,Huang KM,Li YQ

更新日期：2014-10-01 00:00:00

abstract：:The ZIC genes comprise a family of transcriptional factors associated with neural tube defects (NTDs) in mice and with holoprosencephaly in humans. An allelic variant of ZIC2, a CAC repeat within the first exon, was reported in association with an increased risk of non-syndromic NTDs in patients with a Hispanic ethnic...

journal_title：Molecular medicine reports

authors： Costa-Lima MA,Meneses HN,El-Jaick KB,Amorim MR,Castilla EE,Orioli IM

更新日期：2008-05-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in...

journal_title：Molecular medicine reports

authors： Liu Y,Li F,Zhang L,Wu J,Wang Y,Yu H

更新日期：2017-11-01 00:00:00

abstract：:Besides known prognostic factors in breast cancer, disseminated tumor cells are regarded as a surrogate marker for minimal residual disease in breast cancer. Their prognostic significance is comparable to that of lymph node status. However, the mechanism by which the primary tumor directs cells to disseminate into lym...

journal_title：Molecular medicine reports

authors： Kasimir-Bauer S,Heubner M,Otterbach F,Kimmig R,Siffert W,Adamzik M

更新日期：2009-07-01 00:00:00

abstract：:Irinotecan (CTP-11) is a topoisomerase I inhibitor used in the treatment of colorectal cancer and non-small cell lung cancer (NSCLC). Despite an initial response to therapy, resistance to irinotecan reduces its efficacy. We isolated irinotecan-resistant human NSCLC A549 cells, termed A549/CTP-11R cells. A549/CTP-11R c...

journal_title：Molecular medicine reports

authors： Ikeda R,Vermeulen LC,Lau E,Jiang Z,Pomplun M,Kolesar JM

更新日期：2010-11-01 00:00:00

abstract：:Upregulated gene 11 (URG11) represents a gene upregulated by hepatitis B virus X protein and is involved in the biological processes of multifarious tumors. The present study aimed to investigate the protective effects and regulatory mechanisms of URG11 in benign prostatic hyperplasia (BPH). URG11, Ras homolog family ...

journal_title：Molecular medicine reports

authors： Zhang G,Zhu F,Han G,Li Z,Yu Q,Li Z,Li J

更新日期：2018-07-01 00:00:00

abstract：:Histone deacetylase 9 (HDAC9) is involved in a variety of malignant tumors, and leads to malignant tumor development and poor prognosis. However, the association between HDAC9 expression, and the prognosis and clinicopathological features of patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear. The pr...

journal_title：Molecular medicine reports

authors： Li H,Li X,Lin H,Gong J

更新日期：2020-02-01 00:00:00

abstract：:The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been revealed, which explain opposing expression patterns in different types of cancer, the specific function of SIRT2 in ovarian cancer remains...

journal_title：Molecular medicine reports

authors： Du Y,Wu J,Zhang H,Li S,Sun H

更新日期：2017-04-01 00:00:00

abstract：:Isoflurane is a commonly used inhaled anesthetic, which induces apoptosis of SH‑SY5Y cells in a dose‑ and time‑dependent manner; however, the underlying mechanisms remain unknown. The authors of the present study hypothesized that a mutation in β‑amyloid precursor protein (APP), which is a gene associated with familia...

journal_title：Molecular medicine reports

authors： Liu X,Song S,Wang Q,Yuan T,He J

更新日期：2016-12-01 00:00:00

abstract：:Blood stasis syndrome (BSS), additionally called Eohyul, is a basic pathological concept in Traditional Korean Medicine. Do In Seung Gi‑Tang (DISGT) is herbal medicine used for the treatment of BSS. It primarily treats metabolic diseases (MDs) including obesity, hypertension, diabetes mellitus and gynecological diseas...

journal_title：Molecular medicine reports

authors： Shim EH,Lee MS,Lee JA,Lee H

更新日期：2017-06-01 00:00:00

abstract：:The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B and ZHX2, all of which are ...

journal_title：Molecular medicine reports

authors： Wang J,Liu D,Liang X,Gao L,Yue X,Yang Y,Ma C,Liu J

更新日期：2013-11-01 00:00:00

abstract：:One of the major reasons for failure after total joint arthroplasty is aseptic loosening of the implant. At articulating surfaces, defined as the interface between implant and surrounding bone cement, wear particles can be generated and released into the periprosthetic tissue, resulting in inflammation and osteolysis....

journal_title：Molecular medicine reports

authors： Jonitz-Heincke A,Lochner K,Schulze C,Pohle D,Pustlauk W,Hansmann D,Bader R

更新日期：2016-08-01 00:00:00

abstract：:The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 ...

journal_title：Molecular medicine reports

authors： Jia G,Zao M,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Cholangiocarcinoma is an intractable carcinoma originating from the bile duct epithelium. To gain an understanding of the cell biology of cholangiocarcinoma, in vitro cell culture is valuable. However, well‑characterized cell lines are limited. In the present study, the morphology of the TK cholangiocarcinoma cell lin...

journal_title：Molecular medicine reports

authors： Akiyoshi K,Kamada M,Akiyama N,Suzuki M,Watanabe M,Fujioka K,Ikeda K,Mizuno S,Manome Y

更新日期：2014-04-01 00:00:00

abstract：:Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer‑associated mortality in the world. However, its mechanisms of occurrence and development have not been clearly elucidated. Furthermore, there is no effective tumor marker for GC. Using DNA microarray analysis, the present stu...

journal_title：Molecular medicine reports

authors： Duan S,Gong B,Wang P,Huang H,Luo L,Liu F

更新日期：2018-10-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydro...

journal_title：Molecular medicine reports

authors： Zhai X,Chen X,Lu J,Zhang Y,Sun X,Huang Q,Wang Q

更新日期：2017-03-01 00:00:00