Endoplasmic reticulum protein 29 is involved in endoplasmic reticulum stress in islet beta cells.

abstract：:Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP). However, the mechanism underlying the effect of resistin in the aggravation of AP remains to be elucidated. The aim of the present study was to investigate the...

journal_title：Molecular medicine reports

authors： Jiang CY,Wang W

更新日期：2017-01-01 00:00:00

abstract：:Heng-Gu-Gu-Shang-Yu-He-Ji, also known as OsteoKing, is used as a herbal Traditional Chinese Medicine for the treatment of bone disease, including femoral head necrosis and osteoarthritis. However, whether OsteoKing has anti-osteoporotic properties has remained to be elucidated. The purpose of the present study was the...

journal_title：Molecular medicine reports

authors： Dai L,Wu H,Yu S,Zhao H,Xue L,Xu M,Shen Z,Hu M

更新日期：2015-07-01 00:00:00

abstract：:Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem ce...

journal_title：Molecular medicine reports

authors： Song K,Gu T,Shuang F,Tang J,Ren D,Qin J,Hou S

更新日期：2015-09-01 00:00:00

abstract：:The purpose of this study was to assess the efficacy and predictive biomarkers of combination docetaxel-trastuzumab in a neoadjuvant setting by means of a phase II trial. Women with histologically-confirmed advanced invasive breast cancer whose tumours overexpressed HER-2 received 4 cycles of docetaxel (70 mg/m2 every...

journal_title：Molecular medicine reports

authors： Kurosumi M,Tabei T,Sano M,Honma K,Yanagita Y,Yamamoto N,Inoue K,Sato N,Kimura M

更新日期：2008-01-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumour and the second leading cause of cancer‑related death in children and adolescents. Microwave ablation has an excellent therapeutic effect on bone tumours by instantaneously increasing the temperature in the tumour; however, there is a risk of damaging the surroundin...

journal_title：Molecular medicine reports

authors： Chen L,Wang M,Lin Z,Yao M,Wang W,Cheng S,Li B,Zhang Y,Yin Q

更新日期：2020-08-01 00:00:00

abstract：:Despite increasing evidence to suggest that microRNA (miR)-146a and miR-181b are involved in the regulation of immune responses and tumor progression, their roles in silicosis remain to be fully elucidated. Therefore, the present study examined the roles of miR‑146a and miR‑181b in inflammatory responses, and their ef...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang F,Lan Y,Zhou D,Ren X,Zhao L,Zhang Q

更新日期：2015-10-01 00:00:00

abstract：:The present study aimed to investigate the functional effects of microRNA‑195 on ovarian cancer cells and the underling mechanism involved. Reverse transcription‑quantitative polymerase chain reaction was used to measure the expression of microRNA‑195 in patients with ovarian cancer. Cell proliferation and apoptosis w...

journal_title：Molecular medicine reports

authors： Chen J

更新日期：2018-08-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Caudal type homeobox transcription factor 2 (CDX2) is important in intestinal cell fate specification and multiple lines of evidence have substantiated that CDX2 is important in carcinogenesis of the digestive tract. The CDX2 regulatory network is intricate and remains to be fully elucidated in gastric cancer. The aim...

journal_title：Molecular medicine reports

authors： Wei W,Li L,Wang X,Yan L,Cao W,Zhan Z,Zhang X,Yu H,Xie Y,Xiao Q

更新日期：2015-07-01 00:00:00

abstract：:The costs of spinal cord injury and its complications are high in personal, social and financial terms. Complications include bladder cancer, for which the risk is 16-28 times higher than that of the general population, There is currently little consensus regarding the cause of this discrepancy. As microRNAs are stabl...

journal_title：Molecular medicine reports

authors： Wang T,Liu Y,Yuan W,Zhang L,Zhang Y,Wang Z,Zhou X,Zhou H,Chu T,Hao Y,Liu B,Zhao X,Lu L,Feng S,Kong X

更新日期：2015-08-01 00:00:00

abstract：:Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compres...

journal_title：Molecular medicine reports

authors： Cui W,Wang H,Cheng Y,Ma X,Lei Y,Ruan X,Shi L,Lv M

更新日期：2019-01-01 00:00:00

abstract：:Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibrobla...

journal_title：Molecular medicine reports

authors： Zi F,He J,He D,Li Y,Yang L,Cai Z

更新日期：2015-05-01 00:00:00

abstract：:The aim of the present study was to investigate the molecular mechanism of nasopharyngeal carcinoma (NPC) primary tumor development through the identification of key genes using bioinformatics approaches. Using the GSE53819 microarray dataset, acquired from the Gene Expression Omnibus database, differentially expresse...

journal_title：Molecular medicine reports

authors： An F,Zhang Z,Xia M

更新日期：2015-10-01 00:00:00

abstract：:GLI family zinc finger 3 (Gli3), as the upstream transcriptional activator of hedgehog signaling, has previously been demonstrated to participate in the process of liver fibrosis. The present study aimed to investigate the potential functions of microRNA (miR)‑200a and Gli3 in the progression of liver fibrosis. The ex...

journal_title：Molecular medicine reports

authors： Li L,Ran J,Li L,Chen G,Zhang S,Wang Y

更新日期：2020-04-01 00:00:00

abstract：:Androgens are essential for the development of the prostate and prostate cancer. We examined androgen-regulated gene expression in the human prostate. Samples from benign and malignant prostate tissue and samples containing prostate tissue obtained from prostate cancer patients thre...

journal_title：Molecular medicine reports

authors： Vaarala MH,Hirvikoski P,Kauppila S,Paavonen TK

更新日期：2012-09-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:Intimal hyperplasia appears to differ after implanting a drug-eluting stent (DES) with a biodegradable or a permanent polymer. The aim of the present study was to compare biodegradable with permanent polymer DES, since the available data are limited. One hundred patients with de novo coronary artery stenosis were incl...

journal_title：Molecular medicine reports

authors： Tian F,Chen Y,Liu C,Jin Q,Chen L,Sun Z,Liu H,Guo J,Gai L

更新日期：2013-04-01 00:00:00

abstract：:Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed by professional antigen presenting cells (APCs), epithelial cells, vascular endothelium and tumor cells. IDO‑mediated catabolic products, which are addition...

journal_title：Molecular medicine reports

authors： Wu H,Gong J,Liu Y

更新日期：2018-04-01 00:00:00

abstract：:In the present study, the effect of fatty acid synthase (FASN) inhibition on cell invasion and migration in vitro was investigated. A recombinant plasmid containing a microRNA targeting the FASN gene was used to inhibit FASN expression in U2‑OS cells. Cell migration and invasion were investigated using wound healing a...

journal_title：Molecular medicine reports

authors： Liu ZL,Mao JH,Peng AF,Yin QS,Zhou Y,Long XH,Huang SH

更新日期：2013-02-01 00:00:00

abstract：:Chronic microglial activation endangers neuronal survival through the release of various pro-inflammatory and neurotoxic factors. As such, negative regulators of microglial activation have been considered as potential therapeutic candidates to reduce the risk of neurodegeneration associated with inflammation. Uncaria ...

journal_title：Molecular medicine reports

authors： Jung HY,Nam KN,Woo BC,Kim KP,Kim SO,Lee EH

更新日期：2013-01-01 00:00:00

abstract：:Down syndrome (DS) is the most common birth defect in children. To investigate the mechanisms of DS, the present study analyzed the bisulfite‑sequencing (seq) data GSE42144, which was downloaded from the Gene Expression Omnibus. GSE42144 included DNA methylation data of three DS samples and three control samples, and ...

journal_title：Molecular medicine reports

authors： Zhang J,Zhou W,Liu Y,Li N

更新日期：2016-11-01 00:00:00

abstract：:The pathogenesis of Graves' ophthalmopathy (GO) remains to be entirely elucidated. The present study aimed to determine the association between phenotypic expression of the MTHFR gene and susceptibility to GO in patients with Graves' disease (GD). A prospective case‑controlled study was conducted with 122 patients wit...

journal_title：Molecular medicine reports

authors： Lee JY,Kim NK,Cho YW,Lew H

更新日期：2016-09-01 00:00:00

abstract：:The present study aimed to investigate the antifibrogenic effects of genistein (GEN) on the kidney in streptozotocin (STZ)‑induced diabetic rats and to determine the associated mechanisms. Rats were randomized into four groups: Normal control (N), STZ (S), L (STZ + low‑dose GEN) and H (STZ + high‑dose GEN). After 8 we...

journal_title：Molecular medicine reports

authors： Jia Q,Yang R,Liu XF,Ma SF,Wang L

更新日期：2019-01-01 00:00:00

abstract：:Osteoblasts produce various types of cytokines under pathological conditions and control osteoclast differentiation. Tumor necrosis factor-α (TNF-α) has been demonstrated to exert complex effects in osteoblasts under local inflammatory conditions, including in periodontal and periapical diseases. Interleukin-34 (IL-34...

journal_title：Molecular medicine reports

authors： Yu Y,Yang D,Qiu L,Okamura H,Guo J,Haneji T

更新日期：2014-09-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

journal_title：Molecular medicine reports

authors： Zhou MK,Liu XJ,Zhao ZG,Cheng YM

更新日期：2015-04-01 00:00:00

abstract：:The proliferation and differentiation of cardiac fibroblasts (CFs) is central to cardiac fibrosis. Betulinic acid (BA) is an active compound isolated from the bark of the birch tree Betula spp. (Betulaceae) and has been shown to attenuate hepatic fibrosis. However, the effect of BA on the high glucose‑induced fibrosis...

journal_title：Molecular medicine reports

authors： Jiang L,Chen FX,Zang ST,Yang QF

更新日期：2017-11-01 00:00:00

abstract：:Semaphorin 6B is a member of the semaphorin family of signaling proteins, which is implicated in a variety of biological processes, such as axon guidance and muscle regeneration. PPARα is known to be a regulator of semaphorin 6B in human cancer cell lines. In this study, we examined the effect of fenofibrate as a PPAR...

journal_title：Molecular medicine reports

authors： Murad H,Kasies F,Azroony R,Alya G,Madania A

更新日期：2011-05-01 00:00:00

abstract：:Congenital heart disease (CHD), and cleft lip and palate (CLP) are currently the most common types of structural malformation in infants. Various methods have been used to identify the disease‑associated genes. However, targeted next‑generation sequencing (NGS) is not yet considered an option for routine use. Thus, th...

journal_title：Molecular medicine reports

authors： Bu H,Liu L,Hu S,Tan Z,Zhao T

更新日期：2019-05-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:Previous studies have demonstrated that metformin (Met) may reduce the risk of cancer development. In the present study, the anti-cancer effects of Met in A498 cells were investigated. It was found that Met inhibited A498 cell proliferation in a time- and dose-dependent manner, as well as induced the activation of AMP...

journal_title：Molecular medicine reports

authors： Fang Z,Xu X,Zhou Z,Xu Z,Liu Z

更新日期：2014-06-01 00:00:00