Fibroblast activation protein α in tumor microenvironment: recent progression and implications (review).

abstract：:The content stability of commonly used control genes is considered to vary significantly in different independent experimental systems, either in the expression of RNA expression or in the level of DNA content. The present study aimed to examine a panel of six common control genes, including β‑globin (HBB), telomerase...

journal_title：Molecular medicine reports

authors： Yang Q,Li X,Ali HA,Yu S,Zhang Y,Wu M,Gao S,Zhao G,Du Z,Zhang G

更新日期：2015-11-01 00:00:00

abstract：:To determine the effect of thymosin α1 (Tα1) on the phenotypic and functional maturation of HL‑60 cells, freeze‑thaw antigen‑loaded dendritic cells (DCs) were derived from peripheral blood mononuclear cells (PBMCs) of children with acute lymphoblastic leukemia (ALL). The DCs were generated from the PBMC samples that w...

journal_title：Molecular medicine reports

authors： Li X,Liu X,Zhao Y,Zhong R,Song A,Sun L

更新日期：2015-10-01 00:00:00

abstract：:Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic loosening of prostheses. In the present study a lentiviral vector was constructed to silence macrophage colony stimulating factor (M‑CSF) and receptor activator of nuclear factor κ‑B ligand (RANKL) genes, which synergistically...

journal_title：Molecular medicine reports

authors： Zhang Y,Jiang P,Li W,Liu X,Lu Y,Huang Z,Song K

更新日期：2017-12-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a triterpenoid saponin isolated from the tuber of Bolbostemma paniculatum (Maxim) Franquet, serves an universal suppressive role in multiple cancer types, including lung cancer. However, the mechanism involved in non‑small cell lung cancer (NSCLC) cells by which TBMS1 elicits its antitumor effec...

journal_title：Molecular medicine reports

authors： Shi H,Bi H,Sun X,Dong H,Jiang Y,Mu H,Liu G,Kong W,Gao R,Su J

更新日期：2018-03-01 00:00:00

abstract：:Isorhamnetin (ISH) is a flavonoid primarily obtained from the fruit of Hippophae rhamnoides L., which possesses anti‑inflammatory properties. However, the effect of ISH on the expression of inflammatory mediators in response to interleukin (IL)‑1β stimulation has not been elucidated. The present study investigated the...

journal_title：Molecular medicine reports

authors： Li J,Wu R,Qin X,Liu D,Lin F,Feng Q

更新日期：2017-10-01 00:00:00

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to investigate the effect of SOX2 on odontoblast differentiation of dental pulp stem cells (DPSCs), and to examine the potential application of DPSCs on dental restoration. SRY‑box 2 (SOX2) overexpression in human DPSCs (DPSCs‑SOX2) was established by retroviral infection. The empty vector‑infe...

journal_title：Molecular medicine reports

authors： Yang Y,Zhao Y,Liu X,Chen Y,Liu P,Zhao L

更新日期：2017-12-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00

abstract：:The aim of the present study was to explore the survival of pig-rhesus corneal xenografts following donor bone marrow transplantation (BMT). Wuzhishan pigs were used as donors and rhesus monkeys as recipients for corneal xenotransplantation. Twelve rhesus monkeys were divided into t...

journal_title：Molecular medicine reports

authors： Jie Y,Liu L,Pan Z,Wang L

更新日期：2013-03-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:The present study aimed to investigate genes and transcription factors (TFs) that may contribute to neuroblastoma (NB) development. The GSE78061 dataset that included 25 human NB cell lines and four retinal pigment epithelial cell lines was used to analyze differentially expressed genes (DEGs) between groups. Function...

journal_title：Molecular medicine reports

authors： Liu J,Li Y

更新日期：2019-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small non‑coding RNA molecules, which serve an important function in the development of multidrug resistance in cancer through the post‑transcriptional regulation of gene expression and RNA silencing. In the present study, the functional effects of miR‑197 were analyzed in chemo‑resis...

journal_title：Molecular medicine reports

authors： Xiong HL,Zhou SW,Sun AH,He Y,Li J,Yuan X

更新日期：2015-10-01 00:00:00

abstract：:Triptolide is known to exert anti-inflammatory and immunomodulatory activities; however, its impact on intestinal fibrosis has not been previously examined. Based on our previous studies of the suppressive activity of triptolide on human colonic subepithelial myofibroblasts and the therapeutic efficacy of triptolide i...

journal_title：Molecular medicine reports

authors： Tao Q,Wang B,Zheng Y,Li G,Ren J

更新日期：2015-08-01 00:00:00

abstract：:Constitutive photomorphogenic 1 (COP1) belongs to the COP‑de-etiolated (DET)‑fusca (FUS) protein family and has been demonstrated to suppress prostate adenocarcinomas and other types of tumor, such as liver and gastric cancer. The present study investigated the expression of COP1 and its downstream factor, ets variant...

journal_title：Molecular medicine reports

authors： Ta L,Xuan C,Xing N,Zhu X

更新日期：2016-08-01 00:00:00

abstract：:The present study aimed to reveal the potential genes associated with the pathogenesis of intervertebral disc degeneration (IDD) by analyzing microarray data using bioinformatics. Gene expression profiles of two regions of the intervertebral disc were compared between patients with IDD and controls. GSE70362 containin...

journal_title：Molecular medicine reports

authors： Guo W,Zhang B,Li Y,Duan HQ,Sun C,Xu YQ,Feng SQ

更新日期：2017-12-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Subsequently to the publication of this article, the authors have realized that Fig. 4 contained some incorrectly incorporated data panels; specifically, the A‑d, B‑b and B‑c panels did not display the correct data. The revised version of Fig. 4 featuring the correct data for the A‑d, B‑b and B‑c panels is shown on th...

journal_title：Molecular medicine reports

authors： Cheng L,Song J,Li G,Liu Y,Wang Y,Meng X,Sun G,Sun X

更新日期：2019-11-01 00:00:00

abstract：:Gastric cancer (GC) has one of the highest mortality rates among all types of cancer in the world. At present, an efficient treatment for GC remains elusive. Studies have demonstrated that microRNAs (miRs) are abnormally expressed in cancer, and that these serve important roles in the development and metastasis of var...

journal_title：Molecular medicine reports

authors： Yin Y,Li X,Guo Z,Zhou F

更新日期：2019-11-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a type of chronic inflammatory disturbance that affects a number of individuals worldwide; the precise mechanism is unclear and treatment is frequently insufficient to maintain patients in remission. Saccharomyces boulardii is a thermophilic, non‑pathogenic yeast that may be adminis...

journal_title：Molecular medicine reports

authors： Zhou H,Zhang HJ,Guan L,Zhang YN,Li Y,Sun MJ

更新日期：2018-12-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:Calcium dyshomeostasis is an important pathology of memory impairment. However, the mechanism of how calcium dyshomeostasis impairs neurons has remained elusive. The aim of the present study was to reveal the influence of calcium dyshomeostasis on the expression of calcium memory‑associated proteins and the ability of...

journal_title：Molecular medicine reports

authors： Zhou X,Yang Z,Han L,Li X,Feng M,Zhang T,Luo H,Zhu L,Zhang J,Zhang Q,Hu Q

更新日期：2015-10-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) infection has been shown to stimulate autophagy. We have demonstrated that the inhibition of phosphoinositide 3‑kinase (PI3K)/protein kinase B/mammalian target of rapamycin complex (mTORC) signaling pathway could affect the autophagic reaction induced by CVB3 infection in our previous study. H...

journal_title：Molecular medicine reports

authors： Chang H,Tian L,Chen J,Tang A,Li C,Li Z,Yang Z

更新日期：2018-07-01 00:00:00

abstract：:Previous studies have reported that the Rho-associated coiled-coil containing protein kinase 2 (ROCKII) and glycogen synthase kinase‑3β (GSK)‑3β signaling pathways are involved in axonal regeneration. The present study investigated the effects of the combined application of Y27632 (a ROCKII inhibitor) and 4-benzyl-2‑m...

journal_title：Molecular medicine reports

authors： Zhang G,Lei F,Zhou Q,Feng D,Bai Y

更新日期：2016-12-01 00:00:00

abstract：:An outbreak of hepatitis C virus (HCV) infections, for which the risk factor was unknown, was previously identified in North Guangdong, China. In the present study, a total of 736 local residents were surveyed regarding their lifetime risk factors for HCV infection. Serum anti‑HCV antibodies and HCV RNA were examined ...

journal_title：Molecular medicine reports

authors： Shao X,Luo Q,Cai Q,Zhang F,Zhu J,Liu Y,Zhao Z,Gao Z,Zhang X

更新日期：2016-11-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of the BCR‑ABL1 fusion gene, a constitutively active, oncogenic tyrosine kinase that is responsible for the clinical features of CML. Tyrosine kinase inhibitors, such as imatinib, have markedly altered the treatment of CML. Ho...

journal_title：Molecular medicine reports

authors： Mehlig LM,Garve C,Tauer JT,Suttorp M,Bauer A

更新日期：2015-04-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer among women worldwide. However, there is insufficient research that focuses on the expression and molecular mechanisms of microRNA (miR)‑204‑5p in BC. In the current study, data were downloaded from the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO) and the U...

journal_title：Molecular medicine reports

authors： Cai KT,Liu AG,Wang ZF,Jiang HW,Zeng JJ,He RQ,Ma J,Chen G,Zhong JC

更新日期：2019-02-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and malignant brain tumor of the adult central nervous system and is associated with poor prognosis. The present study aimed to identify the hub genes in GBM in order to improve the current understanding of the underlying mechanism of GBM. The RNA‑seq data were download...

journal_title：Molecular medicine reports

authors： Chen X,Pan Y,Yan M,Bao G,Sun X

更新日期：2020-08-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is the most prevalent form of primary cardiomyopathy in humans and is a leading cause of heart failure and sudden cardiac death. Genetic abnormalities have been demonstrated to be a major contributor to the development of DCM. However, DCM is a genetically heterogeneous disease, and the ge...

journal_title：Molecular medicine reports

authors： Zhou YM,Dai XY,Huang RT,Xue S,Xu YJ,Qiu XB,Yang YQ

更新日期：2016-10-01 00:00:00

abstract：:Macrophage polarization serves an important role in immune regulation that is regulated by T‑cell immunoglobulin‑mucin‑3 (Tim‑3). The objective of the present study was to explore the role of 1,25‑dihydroxy‑vitamin D3 [1,25(OH)2D3] in macrophage polarization. Plasmid transfection techniques were applied to prepare RAW...

journal_title：Molecular medicine reports

authors： Liang S,Cai J,Li Y,Yang R

更新日期：2019-05-01 00:00:00