Pulsed electromagnetic fields alleviate streptozotocin‑induced diabetic muscle atrophy.

abstract：:The present study investigated the effect of certain 1,3,5‑triazine derivatives on epidermal growth factor receptor‑tyrosine kinase (EGFR‑TK). The results suggested that 1,3,5‑triazine derivatives exhibited optimal drug likeness via molinspiration and proved to be effective drug candidates as potential anticancer agen...

journal_title：Molecular medicine reports

authors： Yan W,Zhao Y,He J

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hyster...

journal_title：Molecular medicine reports

authors： Li Y,Hong L,Liu C,Min J,Hong S,Hu M,Zhao Y,Yang Q,Tang J,He S

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

journal_title：Molecular medicine reports

authors： Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

更新日期：2015-11-01 00:00:00

abstract：:Recent studies have reported structural and functional abnormalities in multiple brain regions of classical trigeminal neuralgia (CTN) patients. Differences in spontaneous neuronal activity between CTN patients and healthy subjects, however, remain unknown. The aim of the present study was to investigate alterations i...

journal_title：Molecular medicine reports

authors： Chen Y,Xiang CQ,Liu WF,Jiang N,Zhu PW,Ye L,Li B,Lin Q,Min YL,Su T,He LC,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑...

journal_title：Molecular medicine reports

authors： Xue Y,Li Z,Wang Y,Zhu X,Hu R,Xu W

更新日期：2020-10-01 00:00:00

abstract：:The present study aimed to determine the role of arginase (Arg) in pulmonary arterial hypertension (PAH). In vitro, human pulmonary artery smooth muscle cells (HPASMCs) were cultured under hypoxic conditions with, or without, the Arg inhibitor, S‑(2‑boronoethyl)‑l‑cysteine (BEC), for 48 h, following which the prolifer...

journal_title：Molecular medicine reports

authors： Jiang W,Sun B,Song X,Zheng Y,Wang L,Wang T,Liu S

更新日期：2015-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhib...

journal_title：Molecular medicine reports

authors： Xu YY,Chen L,Zhou JM,Wu YY,Zhu YY

更新日期：2013-10-01 00:00:00

abstract：:The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli ...

journal_title：Molecular medicine reports

authors： Cho BH,Jung YH,Kim DJ,Woo BH,Jung JE,Lee JH,Choi YW,Park HR

更新日期：2018-02-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

journal_title：Molecular medicine reports

authors： Liao X,Zhou Z,Zhang X

更新日期：2020-08-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)‑542‑3p is a tumor suppressor in multiple types of cancer. However, whether and how miR‑542‑3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the curre...

journal_title：Molecular medicine reports

authors： Sun J,Deng Y,Shi J,Yang W

更新日期：2020-01-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be responsible for tumor recurrence, metastasis and the high mortality rate of cancer patients. Isolation and identification of CSCs is crucial for basic and preclinical studies. However, as there are currently no universal markers for the isolation and identification of CSCs i...

journal_title：Molecular medicine reports

authors： Wang L,Guo H,Lin C,Yang L,Wang X

更新日期：2014-06-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:Connexin 43 (Cx43) is the main gap junction protein in astrocytes and exerts the same effects on growth inhibition in astrocytoma and glioma as microRNA-146a (miR-146a) in glioma. β2-adrenergic receptor (AR) signaling modulates Cx43 expression in myocytes via components downstream of protein kinase A (PKA) and exchang...

journal_title：Molecular medicine reports

authors： Khaksarian M,Mostafavi H,Soleimani M,Karimian SM,Ghahremani MH,Joghataee MT,Khorashadizadeh M,Aligholi H,Attari F,Hassanzadeh G

更新日期：2015-08-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the primary causes of cancer‑associated mortality worldwide. However, the potential molecular mechanism of CRC progression remains unknown. Long non‑coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to be involved in the development and progression of a variet...

journal_title：Molecular medicine reports

authors： Wang Y,Fu J,Yang L,Liang Z

更新日期：2021-01-01 00:00:00

abstract：:The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interf...

journal_title：Molecular medicine reports

authors： Liu T,Wu X,Wang Y,Hou X,Jiang G,Wu T,Xie H,Xie M

更新日期：2017-08-01 00:00:00

abstract：:In order to investigate the pathogenic targets and associated biological process of Alzheimer's disease in the present study, mRNA expression profiles (GSE28146) and microRNA (miRNA) expression profiles (GSE16759) were downloaded from the Gene Expression Omnibus database. In GSE28146, eight control samples, and Alzhei...

journal_title：Molecular medicine reports

authors： Jia Y,Nie K,Li J,Liang X,Zhang X

更新日期：2016-11-01 00:00:00

abstract：:Advanced glycosylation end-product specific receptor (AGER) is a multi-ligand cell surface receptor abnormally expressed in lung cancer, and is a member of the immunoglobulin superfamily. Therefore, this study aimed to explore the effect of AGER on the biological behavior of non‑small cell lung cancer (NSCLC) H1299 ce...

journal_title：Molecular medicine reports

authors： Wang Q,Zhu W,Xiao G,Ding M,Chang J,Liao H

更新日期：2020-08-01 00:00:00

abstract：:Protein 4.1N (4.1N) is a member of the protein 4.1 family and is essential for the regulation of cell adhesion, motility and signaling. Previous studies have suggested that 4.1N may serve a tumor suppressor role. However, the molecular mechanisms remain unclear. In the current study, the role of 4.1N in the downregula...

journal_title：Molecular medicine reports

authors： Zhang L,Hu A,Li M,Zhang H,Ren C,An X,Liu C

更新日期：2016-01-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family, which is hypothesized to regulate cell cycle progression in tumor cells. However, whether CDKN3 is a potential therapeutic target for breast cancer remains to be elucidated. The present in vitro study aimed to inves...

journal_title：Molecular medicine reports

authors： Deng M,Wang J,Chen Y,Zhang L,Xie G,Liu Q,Zhang T,Yuan P,Liu D

更新日期：2016-08-01 00:00:00

abstract：:Intracranial aneurysm (IA) is a devastating disease, the pathogenesis of which remains to be elucidated. The present study aimed to determine the molecular mechanism of IA and to identify potential therapeutic targets using bioinformatics analysis. The GSE54083 dataset, which includes data from patients with ruptured ...

journal_title：Molecular medicine reports

authors： Wei L,Wang Q,Zhang Y,Yang C,Guan H,Chen Y,Sun Z

更新日期：2018-01-01 00:00:00

abstract：:The study investigated the effects and underlying mechanisms of silent information regulation of transcription 1 (Sirt1) action on apoptosis in chondrocytes and degradation of the extracellular matrix. Cartilage tissue samples were derived from knee arthroplasty of patients with osteoarthritis (OA). The three groups w...

journal_title：Molecular medicine reports

authors： He DS,Hu XJ,Yan YQ,Liu H

更新日期：2017-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in asthma is unclear. The objective of the present study was to e...

journal_title：Molecular medicine reports

authors： Yu B,Yao L,Liu C,Tang L,Xing T

更新日期：2019-05-01 00:00:00

abstract：:Following the publication of this article, the authors have realized that an error was made with the description of the first and fourth listed affiliation addresses: "North China University of Science and of Technology", should have been written as "North China University of Science and Technology". This error also a...

journal_title：Molecular medicine reports

authors： Bao Z,Hao J,Li Y,Feng F

更新日期：2020-06-01 00:00:00

abstract：:Uveal melanoma (UM) is characterized by high metastasis and poor prognosis. A more improved understanding of the metastatic mechanism in UM cells is essential for the design of molecular therapy. Grb2‑associated binder 2 (Gab2) has been reported to serve important roles in the progression of various types of human can...

journal_title：Molecular medicine reports

authors： Chen M,Li Y,Sun X,Zhang B,Li W,Wang S,Zhu X,Li F,Shi L

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to reveal the potential genes associated with the pathogenesis of intervertebral disc degeneration (IDD) by analyzing microarray data using bioinformatics. Gene expression profiles of two regions of the intervertebral disc were compared between patients with IDD and controls. GSE70362 containin...

journal_title：Molecular medicine reports

authors： Guo W,Zhang B,Li Y,Duan HQ,Sun C,Xu YQ,Feng SQ

更新日期：2017-12-01 00:00:00

abstract：:Cisplatin is a first generation platinum‑based chemotherapeutic agent, however, the extensive application of cisplatin inevitably results in drug resistance, which is a major obstacle in cancer chemotherapy. The aim of the present study was to investigate the efficiency of reversing cisplatin‑resistance with the use o...

journal_title：Molecular medicine reports

authors： Ma S,Tan W,Du B,Liu W,Li W,Che D,Zhang G

更新日期：2016-04-01 00:00:00

abstract：:Our previous study demonstrated that treatment with Tribulus terrestris (TT) extracts (120 mg/kg) promoted the muscle weight gain and performance of rats undergoing high intensity exercise. The present study was designed to explore the mechanisms underlying the effect of treatment with TT extracts and the involvement ...

journal_title：Molecular medicine reports

authors： Wu Y,Yang H,Wang X

更新日期：2017-09-01 00:00:00

abstract：:Metabolic syndrome arises from a combination of disorders that increase the risk of cardiovascular disease and diabetes. In previous studies, it was observed that overexpression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) induced obesity and the insulin resistance that accompanies metabolic syndrome in roden...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Jeong YH,Hwang WS,Jeung EB

更新日期：2013-09-01 00:00:00