Activation of Toll-like receptor 7 regulates the expression of IFN-λ1, p53, PTEN, VEGF, TIMP-1 and MMP-9 in pancreatic cancer cells.

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:The aim of the present study was to examine the protective effects and mechanism of sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in the SH‑SY5Y human neuroblastoma cell line. MPP+ cytotoxicity and the protective effects of VAPs on the SH‑SY5Y cells were determined using an...

journal_title：Molecular medicine reports

authors： Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

更新日期：2017-10-01 00:00:00

abstract：:Twenty‑three clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The producti...

journal_title：Molecular medicine reports

authors： Zhang J,Hu DK,Wang DG,Liu Y,Liu CB,Yu LH,Qu Y,Luo XH,Yang JH,Yu J,Liu SC,Li XY

更新日期：2013-11-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:Glioma is the most common malignant and fatal primary tumor in the central nervous system in adults. Recent data has suggested a profound role for microRNAs (miRs) in cancer progression. The present study demonstrated, via quantitative polymerase chain reaction (qPCR) analysis, that miR-203 expression was markedly low...

journal_title：Molecular medicine reports

authors： Tang G,Wu J,Xiao G,Huo L

更新日期：2015-04-01 00:00:00

abstract：:Human interferon α (IFN-α) and erythropoietin (EPO) have been used for a variety of purposes in clinical medicine. Human IFN-α has been used to treat several types of viral infection and cancer, as well as renal anemia, via stimulation of erythrocyte formation in the bone marrow. Transgenic cattle are excellent candid...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Hwang I,Lee JY,Shin TY,Hyun SH,Hwang WS,Jeung EB

更新日期：2013-02-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and pathological processes. H2S-donating drugs have been tested to conjugate the beneficial effects of H2S with other pharmaceutical properties. It has been shown that the endogenous cystathionine-γ-lyase (CSE)/H2S pathway partici...

journal_title：Molecular medicine reports

authors： Xie YH,Zhang N,Li LF,Zhang QZ,Xie LJ,Jiang H,Li LP,Hao N,Zhang JX

更新日期：2014-10-01 00:00:00

abstract：:The present study was conducted to determine whether the activation of TRESK in the dorsal root ganglion (DRG) by the TRESK gene recombinant adenovirus vector inhibits the capsaicin-evoked substance P (SP) release using a radioimmunoassay. TRESK is an outwardly rectifying K+ current...

journal_title：Molecular medicine reports

authors： Zhou J,Yao SL,Yang CX,Zhong JY,Wang HB,Zhang Y

更新日期：2012-04-01 00:00:00

abstract：:As a member of the cysteine protease family, cathepsin S (CTSS) serves an important role in diseases such as cancer, arthritis and atherosclerosis. Nevertheless, its role in renal fibrosis is unknown. In the present study, the effects of CTSS on renal fibrosis in mild (group M) and severe (group S) hydronephrosis were...

journal_title：Molecular medicine reports

authors： Yao X,Cheng F,Yu W,Rao T,Li W,Zhao S,Zhou X,Ning J

更新日期：2019-07-01 00:00:00

abstract：:Functional appliances correct dental malocclusion, partly by exerting an indirect mechanical stimulus on the condylar cartilage, initiating novel bone formation in the condyle. Angiopoietin is involved in the angiogenesis associated with novel bone formation. This study aimed to determine the expression of angiopoieti...

journal_title：Molecular medicine reports

authors： Jing Z,Gu Z,Feng J

更新日期：2013-10-01 00:00:00

abstract：:Previous studies have demonstrated the effects of hyperuricemia on the damage to target organs, including the kidneys, joints and the heart. However, it is unclear whether hyperuricemia results in damage to the intestines. The aim of the present study was to investigate intestinal barrier dysfunction in a mouse model ...

journal_title：Molecular medicine reports

authors： Guo Y,Li H,Liu Z,Li C,Chen Y,Jiang C,Yu Y,Tian Z

更新日期：2019-10-01 00:00:00

abstract：:Wilms tumor (WT) is the most common type of renal malignancy in children. Survival rates are low and high‑risk WT generally still carries a poor prognosis. To better elucidate the pathogenesis and tumorigenic pathways of high‑risk WT, the present study presents an integrated analysis of RNA expression profiles of high...

journal_title：Molecular medicine reports

authors： Wang X,Song P,Huang C,Yuan N,Zhao X,Xu C

更新日期：2019-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurological disorder that results from brain cell death; however, not all brain regions are simultaneously affected to the same extent. Despite single biomarkers for AD having been determined on a genome‑wide scale, the differential co‑expression in gene pairs betwe...

journal_title：Molecular medicine reports

authors： Yu L,Qian S,Wei S

更新日期：2018-08-01 00:00:00

abstract：:Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a derm...

journal_title：Molecular medicine reports

authors： Guo J,Guo S,Wang Y,Yu Y

更新日期：2017-10-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

journal_title：Molecular medicine reports

authors： Zhou MK,Liu XJ,Zhao ZG,Cheng YM

更新日期：2015-04-01 00:00:00

abstract：:Liver-intestine cadherin (LI-cadherin), a novel member of the cadherin family, has been associated with the ability of a tumor to acquire an aggressive phenotype in several types of cancer. However, the exact function of LI-cadherin in the process of tumor invasion and metastasis remains predominantly unknown. To expl...

journal_title：Molecular medicine reports

authors： Yu Q,Shen W,Zhou H,Dong W,Gao D

更新日期：2016-05-01 00:00:00

abstract：:Multinucleated cells are present in impaired spermatogenesis and in the senescent testis. Following accumulating evidence from our previous studies on the identification of multinucleated cells during normal testicle development, the current study further investigated the possible mechanism and role of these multinucl...

journal_title：Molecular medicine reports

authors： Luo L,Li Y,Yang Y,He Y,Wang Y,Xu Z,Zhang Y

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to investigate the hypotheses that cytomegalovirus (CMV) may trigger idiopathic pulmonary fibrosis (IPF) in a susceptible host and/or that the presence of CMV may alter IPF in response to a well-defined trigger of pulmonary fibrosis. A mouse model of murine CMV (MCMV) infection was est...

journal_title：Molecular medicine reports

authors： Li Y,Gao J,Wang G,Fei G

更新日期：2016-08-01 00:00:00

abstract：:Liver fibrosis is the common outcome of almost all cases of chronic liver disease. The hallmark of liver fibrosis is the activation of hepatic stellate cells (HSCs). microRNA‑34a (miR‑34a), which regulates a plethora of target proteins involved in the cell cycle, apoptosis, differentiation and cellular development, is...

journal_title：Molecular medicine reports

authors： Li X,Chen Y,Wu S,He J,Lou L,Ye W,Wang J

更新日期：2015-02-01 00:00:00

abstract：:Low‑density lipoprotein receptors (LDLRs) may serve a role in the diabetogenic effect of statins; however, the effects of statins on LDLR expression and its regulation in the pancreas and islets have yet to be determined. To exclude the long‑term effects of treatment with atorvastatin, which allows mice to adapt, male...

journal_title：Molecular medicine reports

authors： Yu Q,Wang F,Meng X,Gong Y,Wang Y,Xu C,Wang S

更新日期：2018-09-01 00:00:00

abstract：:Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV) infection. Previous studies have identified that the occurrence, relapse and cancerization of CA is relevant to immune imbalance caused by immune hypofunction or immunoregulatory dysfunction. However, to date, the s...

journal_title：Molecular medicine reports

authors： Shi YJ,Yang J,Yang W

更新日期：2013-08-01 00:00:00

abstract：:Through searching for anti‑neuroinflammatory metabolites from Nardostachys jatamansi extracts, nardostachin was revealed to exert anti‑neuroinflammatory effects against lipopolysaccharide (LPS)‑induced overproduction of nitric oxide and prostaglandin E2 in BV2 and rat primary microglial cells. Furthermore, nardostachi...

journal_title：Molecular medicine reports

authors： Kim DC,Park JS,Yoon CS,Kim YC,Oh H

更新日期：2021-01-01 00:00:00

abstract：:Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compres...

journal_title：Molecular medicine reports

authors： Cui W,Wang H,Cheng Y,Ma X,Lei Y,Ruan X,Shi L,Lv M

更新日期：2019-01-01 00:00:00

abstract：:Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. However, its effect on proliferation and clinical parameters in HCC require further elucidation. The present study aimed to investigate LOXL2 expression in HCC from in vitro and clinical asp...

journal_title：Molecular medicine reports

authors： Wu L,Zhang Y,Zhu Y,Cong Q,Xiang Y,Fu L

更新日期：2016-09-01 00:00:00

abstract：:Excessive accumulation of β-amyloid (Aβ) has been proposed as a pivotal event in the pathogenesis of Alzheimer's disease. Possible mechanisms underlying Aβ-induced neuronal cytotoxicity include oxidative stress and apoptosis. Reactive oxygen species (ROS) have been proposed to be involved in the apoptotic mechanism of...

journal_title：Molecular medicine reports

authors： Xie X,Wang HT,Li CL,Gao XH,Ding JL,Zhao HH,Lu YL

更新日期：2010-07-01 00:00:00

abstract：:Macrophage cholesterol efflux is important in maintaining cellular lipid homeostasis and preventing the formation of lipid‑laden foam cells. Although radioactive [3H]‑cholesterol is widely used as a tracer in cholesterol efflux assays, the lengthy and labor‑intensive assay procedure, and the radioactivity disposal pro...

journal_title：Molecular medicine reports

authors： Song W,Wang W,Wang Y,Dou L,Chen L,Yan X

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical application of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for the detection of malignant lesions. A total of 132 patients with increased levels of blood tumor markers but without a prior history of malignancy were examined. The results of FDG...

journal_title：Molecular medicine reports

authors： Zhan HW,Xu W,Ye XJ,Zhao CL,Zhang H,Li J,Yao Q,Zhang LJ

更新日期：2009-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) regulate several physiological and pathological processes, but their role in visceral lipid deposition has not been explored. In the present study, human preadipocytes from visceral fat tissue (HPA‑v) were induced to form adipocytes, and the circRNA expression profiles in HPA‑v and adipocytes ...

journal_title：Molecular medicine reports

authors： Sun W,Sun X,Chu W,Yu S,Dong F,Xu G

更新日期：2020-02-01 00:00:00

abstract：:In order to examine how implanted bone marrow stromal cells (BMSCs) encourage peripheral nerve regeneration, the present study investigated the interaction of BMSCs and Schwann cells (SCs) using an indirect in vitro co‑culture model. SCs and BMSCs were obtained from adult Sprague‑Dawley rats. The passaged BMSCs were C...

journal_title：Molecular medicine reports

authors： Zhou LN,Cui XJ,Su KX,Wang XH,Guo JH

更新日期：2015-10-01 00:00:00

abstract：:Diabetes has been identified to be a risk factor for Alzheimer's disease (AD). Vildagliptin, a novel oral hypoglycemic agent, has been demonstrated to exert protective effects on the pancreas and cardiovascular system. The present study examined the potential protective effects of vildagliptin on neurons in an AD rat ...

journal_title：Molecular medicine reports

authors： Ma QH,Jiang LF,Mao JL,Xu WX,Huang M

更新日期：2018-03-01 00:00:00