MicroRNA-635 inhibits the malignancy of osteosarcoma by inducing apoptosis.

abstract：:The aim of the current study was to investigate the role of phospholipase C (PLC)γ/protein kinase C (PKC)/C‑kinase‑activated protein phosphatase‑1 (CPI‑17) signaling pathways in uterine smooth muscle during parturition. Samples of uterine tissue were collected from pregnant patients who underwent a caesarean section f...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-01-01 00:00:00

abstract：:Currently, the role of tumor endothelial marker 8 (TEM8) in the occurrence, development, invasion and metastasis of lung cancer and its mechanism are poorly understood. The present study aimed to investigate the effects of TEM8 on proliferation, apoptosis, migration and invasion of XWLC‑05 lung cancer cells. The expre...

journal_title：Molecular medicine reports

authors： Gong Q,Liu C,Wang C,Zhuang L,Zhang L,Wang X

更新日期：2018-01-01 00:00:00

abstract：:N-acetyl cysteine (NAC) has been extensively reported to exert neuroprotective effects on the central nervous system. Oxidative stress may contribute to the underlying mechanisms causing Alzheimer's disease (AD). The effect of NAC against oxidative stress injury was investigated in a cellular model of AD in the presen...

journal_title：Molecular medicine reports

authors： Wu W,Liu BH,Xie CL,Xia XD,Zhang YM

更新日期：2018-05-01 00:00:00

abstract：:In recent years hydrogen sulfide (H2S) has demonstrated vasculoprotective effects against cell death, which suggests its promising therapeutic potential for numerous types of disease. Additionally, a protective effect of exogenous H2S in HG‑induced injuries in HUVECs was demonstrated, suggesting a potential protective...

journal_title：Molecular medicine reports

authors： Lin J,Li X,Lin Y,Huang Z,Wu W

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to investigate the possible role of cytotoxic T lymphocytes (CTL) and mononuclear macrophages in the pathogenic processes of experimental animals. To construct a chronic experimental allergic encephalomyelitis (EAE) model, an artificially synthesized myelin oligodendrocyte glycoprotein...

journal_title：Molecular medicine reports

authors： Zhou X,Li X,Feng M,Zhang Q,Yang Z

更新日期：2015-11-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role ...

journal_title：Molecular medicine reports

authors： Zhu W,Zhuang P,Song W,Duan S,Xu Q,Peng M,Zhou J

更新日期：2017-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is important for the proliferation and differentiation of gastric mucosal cells. Betacellulin (BTC) is a novel ligand for EGFR Since their role is unclear in the ulcer healing process, we investigated their expression. Gastric ulcers in 30 Sprague-Dawley rats were induced by ace...

journal_title：Molecular medicine reports

authors： Choi GH,Park HS,Kim KR,Choi HN,Jang KY,Chung MJ,Kang MJ,Lee DG,Moon WS

更新日期：2008-07-01 00:00:00

abstract：:Endothelial dysfunction and impaired endothelial regenerative capacity are key contributors to the high incidence of cardiovascular disease in patients with chronic kidney disease (CKD). Uremic toxins are associated with this pathogenesis. Previous studies have revealed that a uremic toxin, para‑cresol (p‑cresol), exe...

journal_title：Molecular medicine reports

authors： Pan L,Ye X,Ding J,Zhou Y

更新日期：2017-04-01 00:00:00

abstract：:Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer, autoimmune diseas...

journal_title：Molecular medicine reports

authors： Shi Y,Xu X,Luan P,Kou W,Li M,Yu Q,Zhuang J,Xu Y,Peng W,Jian W

更新日期：2020-12-01 00:00:00

abstract：:Non‑alcoholic steatohepatitis (NASH) is a common clinicopathological condition. Currently, the pathogenesis of NASH remains unknown, and no optimal therapy option currently exists. It has previously been demonstrated that diallyl disulfide (DADS) was capable of attenuating liver dysfunction, as DADS supplementation ha...

journal_title：Molecular medicine reports

authors： Zhang N,Wang Y,Zhang J,Liu B,Li G,Xin S,Xu K

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to investigate the combination of certain serological markers (Forns' index; FI), FibroScan® and acoustic radiation force impulse elastography (ARFI) in the assessment of liver fibrosis in patients with hepatitis B, and to explore the impact of inflammatory activity and steatosis on th...

journal_title：Molecular medicine reports

authors： Dong DR,Hao MN,Li C,Peng Z,Liu X,Wang GP,Ma AL

更新日期：2015-06-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:The corticotropin-releasing factor (CRF) family is involved in modulating gastrointestinal motility, sensitivity and inflammation. CRF signalling exerts an important role in inflammatory bowel disease (IBD), predominantly by activating CRF receptors. The aim of the present study was to investigate the function of CRF ...

journal_title：Molecular medicine reports

authors： Chen H,Shi H,Liu Y,Ren X,He S,Chang X,Yin Y

更新日期：2018-01-01 00:00:00

abstract：:The apoptosis of alveolar epithelial cells is important in seawater aspiration‑induced acute lung injury (ALI). The present study aimed to investigate whether epigallocatechin-3-gallate (EGCG) is able to suppress apoptosis in alveolar epithelial cells in seawater aspiration‑induced ALI in vivo and in vitro, and the po...

journal_title：Molecular medicine reports

authors： Liu W,Dong M,Bo L,Li C,Liu Q,Li Z,Jin F

更新日期：2016-01-01 00:00:00

abstract：:Tissue-engineered bone substitutes are frequently used to repair bone defects. Adipose-derived stem cells (ASCs) are a promising source of cells for repairing bone tissue, however, insufficient osteogenic potency remains the main obstacle for their application. The present study aimed to enhance the osteogenic potency...

journal_title：Molecular medicine reports

authors： Wang Z,Zhang D,Hu Z,Cheng J,Zhuo C,Fang X,Xing Y

更新日期：2015-09-01 00:00:00

abstract：:Runt-related transcription factor 2 (RUNX2) is a vital regulatory factor that controls osteoblast-specific gene expression; however, RUNX2‑regulated genes in human mesenchymal stem cells (hMSCs) remain to be fully elucidated. In the present study, chromatin immunoprecipitation (ChIP)-on-chip analysis of RUNX2 in hMSCs...

journal_title：Molecular medicine reports

authors： Xiong J,Hu Z,Wang T,Xu X,Liu J,Wu P,Che X,Li W

更新日期：2016-08-01 00:00:00

abstract：:Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome...

journal_title：Molecular medicine reports

authors： Syeed N,Syed Sameer A,Hamid A,Shah ZA,Afroze D,Rasool R,Siddiqi MA

更新日期：2010-09-01 00:00:00

abstract：:The present study aimed to investigate changes at the transcript level that are associated with spontaneous astrocytoma progression, and further, to discover novel targets for glioma diagnosis and therapy. GSE4290 microarray data downloaded from Gene Expression Omnibus were used to identify the differentially expresse...

journal_title：Molecular medicine reports

authors： Hu G,Wei B,Wang L,Wang L,Kong D,Jin Y,Sun Z

更新日期：2015-08-01 00:00:00

abstract：:Constitutive photomorphogenic 1 (COP1) belongs to the COP‑de-etiolated (DET)‑fusca (FUS) protein family and has been demonstrated to suppress prostate adenocarcinomas and other types of tumor, such as liver and gastric cancer. The present study investigated the expression of COP1 and its downstream factor, ets variant...

journal_title：Molecular medicine reports

authors： Ta L,Xuan C,Xing N,Zhu X

更新日期：2016-08-01 00:00:00

abstract：:Millions of infants and children are exposed to anesthesia every year during medical care. Sevoflurane is a volatile anesthetic that is frequently used for pediatric anesthesia. However, previous reports have suggested that the administration of sevoflurane promotes neurodegeneration, raising concerns regarding the sa...

journal_title：Molecular medicine reports

authors： Wang LY,Tang ZJ,Han YZ

更新日期：2016-10-01 00:00:00

abstract：:Bone mesenchymal stem cells (BMSCs) have been an area of interest in biomedical research and tissue engineering due to their diverse differentiation abilities. In osteogenesis, bone morphogenetic proteins (BMPs), particularly BMP‑2, are important. However, the effect of BMP‑2 on the osteogenetic capacity of BMSCs rema...

journal_title：Molecular medicine reports

authors： Sun J,Li J,Li C,Yu Y

更新日期：2015-09-01 00:00:00

abstract：:Autogenous microfat grafting is widely used to augment depressed deformities or for other cosmetic purposes. Since the microfat survival rate is unpredictable due to absorption and calcification, previously cryopreserved fat is widely used for secondary procedures. Sphingosylphosphorylcholine (SPC) is a lysophospholip...

journal_title：Molecular medicine reports

authors： Bae YC,Choi CW,Nam KW,Song JS,Lee JW

更新日期：2016-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhib...

journal_title：Molecular medicine reports

authors： Xu YY,Chen L,Zhou JM,Wu YY,Zhu YY

更新日期：2013-10-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent stem cells derived from early stage embryos. It remains unclear whether inhibiting the Wnt/β‑catenin signaling pathway using dickkopf Wnt signaling pathway inhibitor 1 (DKK1) impacts on the differentiation potential of mouse ESCs in vitro and in vivo. In the present study, i...

journal_title：Molecular medicine reports

authors： Ou L,Fang L,Tang H,Qiao H,Zhang X,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:Allergen extracts are commonly utilized for diagnosis and immunotherapy; however, the stability of protease‑rich extracts is important for a precise diagnosis and treatment efficacy. The present study determines the optimal conditions for the storage of German cockroach allergen extract. Cockroach extracts were recons...

journal_title：Molecular medicine reports

authors： Jeong KY,Lee J,Yuk JE,Park KH,Lee JH,Kim JD,Park JW

更新日期：2020-02-01 00:00:00

abstract：:Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying mechanism remains unclear. CB2 serves a protective role in various pathological states through the activation of autophagy. Therefore, the present study a...

journal_title：Molecular medicine reports

authors： Mao Y,Huang Y,Zhang Y,Wang C,Wu H,Tian X,Liu Y,Hou B,Liang Y,Rong H,Gu X,Ma Z

更新日期：2019-12-01 00:00:00

abstract：:The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interf...

journal_title：Molecular medicine reports

authors： Liu T,Wu X,Wang Y,Hou X,Jiang G,Wu T,Xie H,Xie M

更新日期：2017-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are single‑stranded RNA species that constitute a class of non‑coding RNAs, and are emerging as key regulators of gene expression. Since each miRNA is capable of regulating multiple genes, miRNAs are attractive markers for studies of coordinated gene expression. In this study, we investigated miRNA ...

journal_title：Molecular medicine reports

authors： Lee HY,Han SS,Rhee H,Park JH,Lee JS,Oh YM,Choi SS,Shin SH,Kim WJ

更新日期：2015-03-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00