Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema.

Abstract:

:Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 (PGE2) and of two proteins regulated by these, interleukin-1β (IL-1β) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The thickness of paw edema induced in vivo in mice by carrageenan administration was effectively reduced by the AT extract. Translocation of the nuclear factor-κB (NF-κB) subunit 65 (p65) into the nucleus and phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-related kinase (ERK) were inhibited by the AT extract. Our results indicated that a methanol extract of AT downregulates the inflammatory response by blocking phosphorylation of MEK and ERK and activation of NF-κB. To the best of our knowledge, this is the first study of anti-inflammatory effects of an AT extract, and demonstrates its potential in the treatment of inflammatory diseases.

journal_name

Mol Med Rep

authors

Kim HS,Park JW,Kwon OK,Kim JH,Oh SR,Lee HK,Bach TT,Quang BH,Ahn KS

doi

10.3892/mmr.2014.1941

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

1388-94

issue

4

eissn

1791-2997

issn

1791-3004

journal_volume

9

pub_type

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