Abstract:
:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological characteristics including surface markers, proliferation capacity, tumorigenicity and immunogenicity were analyzed by flow cytometric analysis, ELISA and co‑culture with human lymphocytes, respectively. The results indicated that all four types of stem cells obtained from different sources expressed MSC surface markers, and they did not show tumorigenicity either in vivo or in vitro. Stem cells from SHED exhibited the strongest proliferation capacity. Umbilical cord‑derived MSCs displayed the strongest immunomodulatory ability, while bone marrow MSCs exhibited the best antigen‑presenting potential in response to interferon‑γ stimulation. These results provide information on MSCs derived from different tissues, which may be helpful in their clinical application.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BHdoi
10.3892/mmr.2018.9501subject
Has Abstractpub_date
2018-12-01 00:00:00pages
4969-4977issue
6eissn
1791-2997issn
1791-3004journal_volume
18pub_type
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