Role of inflammation in the initiation and maintenance of atrial fibrillation and the protective effect of atorvastatin in a goat model of aseptic pericarditis.

abstract：:NIN1/RPN12 binding protein 1 homolog (Saccharomyces cerevisiae) (NOB1) encodes a chaperone protein that joins the 20S proteasome with the 19S regulatory particle in the nucleus and facilitates the biogenesis of the 26S proteasome, which plays a role in maintaining cellular homeostasis by controlling protein degradatio...

journal_title：Molecular medicine reports

authors： Chen B,Liu J,Wu D,Qin Y,Peng C,Li C,Wang J

更新日期：2014-06-01 00:00:00

abstract：:Besides known prognostic factors in breast cancer, disseminated tumor cells are regarded as a surrogate marker for minimal residual disease in breast cancer. Their prognostic significance is comparable to that of lymph node status. However, the mechanism by which the primary tumor directs cells to disseminate into lym...

journal_title：Molecular medicine reports

authors： Kasimir-Bauer S,Heubner M,Otterbach F,Kimmig R,Siffert W,Adamzik M

更新日期：2009-07-01 00:00:00

abstract：:Potassium channels can be affected by epileptic seizures and serve a crucial role in the pathophysiology of epilepsy. Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone‑lysine N‑methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing. Insight i...

journal_title：Molecular medicine reports

authors： Zhang SP,Zhang M,Tao H,Luo Y,He T,Wang CH,Li XC,Chen L,Zhang LN,Sun T,Hu QK

更新日期：2018-01-01 00:00:00

abstract：:The present study hypothesized that caffeic acid (3,4‑dihydroxycinnamic acid; CaA) may exert antidepressant‑like effects in rats with chronic unpredictable mild stress via epigenetic mechanisms, such as DNA methylation and hydroxymethylation. The chronic unpredictable mild stress (CUMS) model was used to analyze the e...

journal_title：Molecular medicine reports

authors： Hu J,Cao S,Zhang Z,Wang L,Wang D,Wu Q,Li L

更新日期：2020-12-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The most significant histological property of AF is atrial fibrosis, but the underlying mechanism is not clear. In this study we investigated the expression of miR-133 and miR-30, anti-fibrotic microRNAs (miRNAs), in chronic AF in canines. A tot...

journal_title：Molecular medicine reports

authors： Li H,Li S,Yu B,Liu S

更新日期：2012-06-01 00:00:00

abstract：:Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' ...

journal_title：Molecular medicine reports

authors： Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

更新日期：2008-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a type of chronic inflammatory disturbance that affects a number of individuals worldwide; the precise mechanism is unclear and treatment is frequently insufficient to maintain patients in remission. Saccharomyces boulardii is a thermophilic, non‑pathogenic yeast that may be adminis...

journal_title：Molecular medicine reports

authors： Zhou H,Zhang HJ,Guan L,Zhang YN,Li Y,Sun MJ

更新日期：2018-12-01 00:00:00

abstract：:Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR‑141 is suppressed in sorted...

journal_title：Molecular medicine reports

authors： Gao X,Zhu X,Sun Y,Liu J

更新日期：2017-07-01 00:00:00

abstract：:Family with sequence similarity 172, member A (FAM172A), was cloned from human aortic tissues and confirmed in our previous study in 2009, however, its functions remain to be fully elucidated. In our previous studies, the protein expression of FAM172A in human aortic smooth muscle cells was found to be upregulated by ...

journal_title：Molecular medicine reports

authors： Li MF,Zhang R,Guo MG,Li LX,Lu HK,Lu JX,Jia WP

更新日期：2016-01-01 00:00:00

abstract：:B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...

journal_title：Molecular medicine reports

authors： Jia R,Jiao Z,Xu X,Wang J,Zhou Y,Song X,Ge S,Fan X

更新日期：2011-01-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Due to the rising abuse of ketamine usage in recent years, ketamine‑induced urinary tract syndrome has received increasing attention. The present study aimed to investigate the molecular mechanism underlying ketamine‑associated cystitis in a mouse model. Female C57BL/6 mice were randomly divided into two groups: One g...

journal_title：Molecular medicine reports

authors： Shen CH,Wang ST,Wang SC,Lin SM,Lin LC,Dai YC,Liu YW

更新日期：2019-04-01 00:00:00

abstract：:microRNAs (miRNAs) are small, highly conserved, non-coding RNAs that regulate gene expression at the post‑transcriptional level. The expression of these small RNA genes is tightly regulated during development, differentiation and apoptosis of normal cells, however, they are often deregulated in various types of cancer...

journal_title：Molecular medicine reports

authors： Liang G,Li G,Wang Y,Lei W,Xiao Z

更新日期：2014-03-01 00:00:00

abstract：:Kallikrein-related peptidase 14 (KLK14) is a member of the tissue kallikrein family of proteases, which are associated with the pathogenesis of malignant tumors and are over-expressed in ovarian carcinoma. However, the mechanism through which KLK14 is implicated in ovarian cancer remains unclear. The aim of the presen...

journal_title：Molecular medicine reports

authors： Zhang R,Shi H,Chen Z,Feng W,Zhang H,Wu K

更新日期：2012-01-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most important causes of end‑stage renal disease. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus, which possesses various pharmacological activities. AS‑IV prevents podocyte apoptosis and ameliorates renal injury in DN; however, few studies have focu...

journal_title：Molecular medicine reports

authors： Yao XM,Liu YJ,Wang YM,Wang H,Zhu BB,Liang YP,Yao WG,Yu H,Wang NS,Zhang XM,Peng W

更新日期：2016-06-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by fibrosis of the skin and visceral organs, and peripheral circulatory disturbance. α2‑antiplasmin (α2AP) is the major circulating inhibitor of plasmin and is a key regulator of fibrinolysis. It has been demonstrated that the e...

journal_title：Molecular medicine reports

authors： Niwa H,Kanno Y,Shu E,Seishima M

更新日期：2020-10-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of cardiovascular diseases, including in cardiac fibrosis. The present study aimed to investigate the biological role and underlying mechanisms of the induction of cardiac fibroblasts by the lncRNA, RNA component of mitochondrial RNA pr...

journal_title：Molecular medicine reports

authors： Zhang SY,Huang SH,Gao SX,Wang YB,Jin P,Lu FJ

更新日期：2019-10-01 00:00:00

abstract：:Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure ...

journal_title：Molecular medicine reports

authors： Xu B,Xu H,Cao H,Liu X,Qin C,Zhao Y,Han X,Li H

更新日期：2017-08-01 00:00:00

abstract：:Circulating tumor cells (CTCs) are tumor cells present in the bloodstream, which originate from tumor sites, and are ultimately responsible for metastasis or relapse in several types of cancer. However, to the best of our knowledge, only a few studies have investigated these extremely rare cells in esophageal squamous...

journal_title：Molecular medicine reports

authors： Zhang Y,Li J,Wang L,Meng P,Zhao J,Han P,Xia J,Xu J,Wang L,Shen F,Zheng A,Zhou F,Fan R

更新日期：2019-08-01 00:00:00

abstract：:Atorvastatin (Lipitor™) is a lipid‑lowering agent that is widely used in the treatment of cardiovascular diseases. Previous research has largely focused on its cholesterol‑lowering effects; however, a limited number of studies have investigated the actions of atorvastatin on vascular endothelial cells. In the present ...

journal_title：Molecular medicine reports

authors： Zhao WB,Fu H,Chang F,Liu J,Wang J,Li F,Zhao J

更新日期：2019-03-01 00:00:00

abstract：:The present study aimed to reveal the underlying mechanism of angiotensin II (AngII)‑induced cardiac remodeling and to identify potential therapeutic targets for prevention. Rat cardiac fibroblasts (CFs) were cultured with 10 nM AngII for 12 h, and CFs without AngII were used as the control. Following RNA isolation fr...

journal_title：Molecular medicine reports

authors： Shu J,Liu Z,Jin L,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Biliary atresia (BA) is an infantile disease resulting from a severe cholangiopathy, which can obstruct extrahepatic bile ducts, disrupt bile flow and lead to end‑stage cirrhosis. The current study aimed to develop a genetic method to investigate the pathogenesis of BA. The gene expression profile of BA (GSE46967) was...

journal_title：Molecular medicine reports

authors： You Z,Wen J,Cheng L,Ye H,Li B

更新日期：2015-09-01 00:00:00

abstract：:In the pathophysiology of osteoarthritis (OA), articular cartilage degeneration exhibits a significant role. Vascular endothelial growth factor (VEGF) is considered to be an effective angiogenic factor and a crucial regulator of articular cartilage degeneration in the development of OA. Therefore, the present study ai...

journal_title：Molecular medicine reports

authors： Deng S,Zhou JL,Peng H,Fang HS,Liu F,Weng JQ

更新日期：2018-05-01 00:00:00

abstract：:Peripheral artery disease (PAD) is a common manifestation of atherosclerosis. A number of emerging risk factors, including oxidative stress biomarkers, free radicals and heat shock proteins, may add to the established risk factors for cardiovascular disease (CVD). The present study assessed surrogate markers of oxidat...

journal_title：Molecular medicine reports

authors： Signorelli SS,Li Volsi G,Fiore V,Mangiafico M,Barbagallo I,Parenti R,Rizzo M,Li Volti G

更新日期：2016-10-01 00:00:00

abstract：:Adoptive transfer of bone marrow‑derived mesenchymal stem cells (BMSCs) significantly alleviates smoking‑induced chronic obstructive pulmonary disease (COPD) in rats. Considering the critical roles of T cells during COPD development, the present study aimed to further identify the molecular mechanisms underlying the a...

journal_title：Molecular medicine reports

authors： Li X,Xu J,Li P

更新日期：2020-05-01 00:00:00

abstract：:Macrophages can be polarized into the inflammatory M1 lineage or the immunomodulatory M2 lineage, depending on the differential tissue microenvironment signaling, specific pathogens or cytokine stimulation. Tumor necrosis factor α‑induced protein 8‑like protein 2 (TIPE2) has been demonstrated to negatively regulate in...

journal_title：Molecular medicine reports

authors： Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to investigate the protective effect of erythropoietin (EPO) against acute myocardial injury and its underlying mechanisms. Mice (n=146) were randomly divided in a double‑blind manner into four groups, sham, Rocephin, EPO and sepsis, and mortality was observed on the seventh day after cecal l...

journal_title：Molecular medicine reports

authors： Zhang X,Dong S,Qin Y,Bian X

更新日期：2015-05-01 00:00:00

abstract：:FW523-3, a new lipopeptide compound, was recently isolated and purified from the culture broth of a marine Micromonospora chalcea. FW523-3 was shown to inhibit the proliferation of certain cancer cells. However, the spectra and the underlying mechanism of its antitumor activity are unclear. In this study, the MTT and ...

journal_title：Molecular medicine reports

authors： Xie JJ,Zhou F,Li EM,Jiang H,Du ZP,Lin R,Fang DS,Xu LY

更新日期：2011-07-01 00:00:00

abstract：:To investigate the role of microRNA (miR)‑149 in the cardiac differentiation of mouse bone marrow mesenchymal stem cells (MSCs) in vitro, MSCs were infected with a lentivirus overexpressing miR‑149 and the effect on cardiac differentiation was determined. The quantitative polymerase chain reaction results demonstrated...

journal_title：Molecular medicine reports

authors： Lu M,Xu L,Wang M,Guo T,Luo F,Su N,Yi S,Chen T

更新日期：2018-06-01 00:00:00

abstract：:Genistein is an important chemopreventive agent against atherosclerosis and cancer. However, whether genistein is effective in the treatment of lung cancer, and its underlying mechanism, remains to be determined. The present study demonstrated that genistein treatment of A549 lung cancer cells decreased viability in a...

journal_title：Molecular medicine reports

authors： Zhang J,Su H,Li Q,Li J,Zhao Q

更新日期：2017-04-01 00:00:00