Putative role of the mTOR/4E-BP1 signaling pathway in the carcinogenesis and progression of gastric cardiac adenocarcinoma.

abstract：:Reamed intramedullary nailing (RIN) is a surgical method of choice for treatment of diaphyseal fractures. This procedure affects the biological environment of bone tissue locally and systemically. This study investigated the influence of RIN on mesenchymal stem cells (MSCs) in patients with long bone fractures. The ax...

journal_title：Molecular medicine reports

authors： Sperelakis I,Tsitoura E,Koutoulaki C,Mastrodimou S,Tosounidis TH,Dimitriou H,Spandidos DA,Antoniou KM,Kontakis G

更新日期：2020-09-01 00:00:00

abstract：:Lactate is an important metabolite in cellular metabolism and fluctuates in certain disease conditions including cancer and immune diseases. It was hypothesized that a decrease in lactate would modulate the inflammatory response elicited by lipopolysaccharides (LPS) in macrophages. When RAW 264.7 macrophages were trea...

journal_title：Molecular medicine reports

authors： Song YJ,Kim A,Kim GT,Yu HY,Lee ES,Park MJ,Kim YJ,Shim SM,Park TS

更新日期：2019-01-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β...

journal_title：Molecular medicine reports

authors： Ma X,Wang L,Zhao H,Pang N,Zhang F,Jiang T,Liu X,Mamuti W,Wen H,Ding J

更新日期：2014-07-01 00:00:00

abstract：:Malignant glioma is the most common type of cancer in the central nervous system, with highly invasive characteristics. The Rho-associated protein kinase (ROCK1) has been found to act as key regulator of actin cytoskeleton reorganization, a process closely associated with cancer cell invasion. microRNA-145 (miRNA-145)...

journal_title：Molecular medicine reports

authors： Wan X,Cheng Q,Peng R,Ma Z,Chen Z,Cao Y,Jiang B

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to examine the protective effects and mechanism of sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in the SH‑SY5Y human neuroblastoma cell line. MPP+ cytotoxicity and the protective effects of VAPs on the SH‑SY5Y cells were determined using an...

journal_title：Molecular medicine reports

authors： Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

更新日期：2017-10-01 00:00:00

abstract：:Endothelial cell injury caused by reactive oxygen species (ROS) plays a critical role in the pathogenesis of atherosclerosis. Therefore, phytochemicals or antioxidants that inhibit the production of ROS have clinical value for the treatment of atherosclerosis. Rhein is one of the most important active components of rh...

journal_title：Molecular medicine reports

authors： Zhong XF,Huang GD,Luo T,Deng ZY,Hu JN

更新日期：2012-05-01 00:00:00

abstract：:Runt-related transcription factor 2 (RUNX2) is a vital regulatory factor that controls osteoblast-specific gene expression; however, RUNX2‑regulated genes in human mesenchymal stem cells (hMSCs) remain to be fully elucidated. In the present study, chromatin immunoprecipitation (ChIP)-on-chip analysis of RUNX2 in hMSCs...

journal_title：Molecular medicine reports

authors： Xiong J,Hu Z,Wang T,Xu X,Liu J,Wu P,Che X,Li W

更新日期：2016-08-01 00:00:00

abstract：:Microglia‑mediated neuroinflammation is key in the pathogenesis of Alzheimer's disease (AD). Several studies have suggested that NADPH oxidase contributes to microglia‑mediated neuroinflammation. Resveratrol, which is a natural polyphenolic compound, exerts neuroprotective effects in AD due to its anti‑inflammatory pr...

journal_title：Molecular medicine reports

authors： Yao Y,Li J,Niu Y,Yu JQ,Yan L,Miao ZH,Zhao XX,Li YJ,Yao WX,Zheng P,Li WQ

更新日期：2015-10-01 00:00:00

abstract：:Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death. Dietary or pharmaceutical augmentation of the endogenous antioxidant defense capacity is a potential means by which to...

journal_title：Molecular medicine reports

authors： Lin P,Tian XH,Yi YS,Jiang WS,Zhou YJ,Cheng WJ

更新日期：2015-11-01 00:00:00

abstract：:Skeletal myogenesis is a highly ordered and complex biological process that is mediated by numerous regulatory factors. In previous studies, it has been demonstrated that microRNAs (miRs) and long non‑coding RNAs (lncRNAs) serve key roles in skeletal myogenesis. The present study showed that the expression levels of m...

journal_title：Molecular medicine reports

authors： Zhao X,Gu H,Wang L,Zhang P,Du J,Shen L,Jiang D,Wang J,Li X,Zhang S,Li M,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:The present study aimed to examine whether fms‑related tyrosine kinase 3 ligand (Flt3L) protects the organs of mice with multiorgan dysfunction syndrome (MODS). Male C57BL/6 mice were randomly assigned to normal control, MODS and Flt3L treatment groups. The mouse models of MODS were established using intraperitoneal z...

journal_title：Molecular medicine reports

authors： Tian G,Lu J,Guo H,Liu Q,Wang H

更新日期：2015-06-01 00:00:00

abstract：:The present study aimed to screen several differentially expressed genes (DEGs) and differentially expressed microRNAs (miRNAs) for two types of mesenchymal stem cell (MSC) differentiation. Bone morphogenetic protein 6 (BMP‑6) and dexamethasone were used to induce MSCs towards osteoblastic differentiation or adipocyti...

journal_title：Molecular medicine reports

authors： Xu X,Jiang H,Li X,Wu P,Liu J,Wang T,Zhou X,Xiong J,Li W

更新日期：2017-04-01 00:00:00

abstract：:Millions of infants and children are exposed to anesthesia every year during medical care. Sevoflurane is a volatile anesthetic that is frequently used for pediatric anesthesia. However, previous reports have suggested that the administration of sevoflurane promotes neurodegeneration, raising concerns regarding the sa...

journal_title：Molecular medicine reports

authors： Wang LY,Tang ZJ,Han YZ

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to assess the therapeutic effects of atorvastatin on cerebral vessel autoregulation and to explore the underlying mechanisms in a rabbit model of subarachnoid hemorrhage (SAH). A total of 48 healthy male New Zealand rabbits (weight, 2‑2.5 kg) were randomly allocated into SAH, Sham or S...

journal_title：Molecular medicine reports

authors： Chen JH,Wu T,Yang LK,Chen L,Zhu J,Li PP,Hu X,Wang YH

更新日期：2018-01-01 00:00:00

abstract：:Reduced β2 glycoprotein I (β2GPI) has been demonstrated to exhibit a beneficial effect in diabetic atherosclerosis and retinal neovascularization. However, the effect of reduced β2GPI on vascular disorders in diabetic mellitus (DM) remains to be elucidated. The present study established a high glucose‑induced injury m...

journal_title：Molecular medicine reports

authors： Zhang JY,Ma J,Yu P,Tang GJ,Li CJ,Yu DM,Zhang QM

更新日期：2017-10-01 00:00:00

abstract：:Post‑cardiac arrest myocardial dysfunction (PAMD) is a leading cause of death in patients undergoing resuscitation patients following cardiac arrest (CA). Although prostaglandin E1 (PGE1) is a clinical drug used to mitigate ischemia injury, its effect on PAMD remains unknown. In the present study, the protective effec...

journal_title：Molecular medicine reports

authors： Su C,Fan X,Xu F,Wang J,Chen Y

更新日期：2021-02-01 00:00:00

abstract：:Activation of renin-angiotensin system (RAS) is one of the pathological mechanisms associated with myocardial ischemia-reperfusion injury following resuscitation. The present study aimed to determine whether erythropoietin (EPO) improves post‑resuscitation myocardial dysfunction and how it affects the renin‑angiotensi...

journal_title：Molecular medicine reports

authors： Zhou H,Huang J,Zhu L,Cao Y

更新日期：2018-04-01 00:00:00

abstract：:Macrophage cholesterol efflux is important in maintaining cellular lipid homeostasis and preventing the formation of lipid‑laden foam cells. Although radioactive [3H]‑cholesterol is widely used as a tracer in cholesterol efflux assays, the lengthy and labor‑intensive assay procedure, and the radioactivity disposal pro...

journal_title：Molecular medicine reports

authors： Song W,Wang W,Wang Y,Dou L,Chen L,Yan X

更新日期：2015-10-01 00:00:00

abstract：:An increasing number of microRNAs (miRNAs) have been identified as diagnostic and prognostic biomarkers, as well as additional therapeutic tools, in skeletal diseases. Recent studies have established the pathophysiological role of miR‑214, using human osteoporotic bone specimens. However, miR‑214 expression levels and...

journal_title：Molecular medicine reports

authors： Wang X,Sun J,Fu C,Wang D,Bi Z

更新日期：2014-12-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent stem cells derived from early stage embryos. It remains unclear whether inhibiting the Wnt/β‑catenin signaling pathway using dickkopf Wnt signaling pathway inhibitor 1 (DKK1) impacts on the differentiation potential of mouse ESCs in vitro and in vivo. In the present study, i...

journal_title：Molecular medicine reports

authors： Ou L,Fang L,Tang H,Qiao H,Zhang X,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:The authors initially performed reverse transcription‑quantitative polymerase chain reaction to determine the expression profile of KDM5A in ovarian cancer tissues and adjacent normal tissue. Compared with adjacent normal tissue, it was identified that KDM5A was highly expressed in ovarian cancer tissues. Moreover, hu...

journal_title：Molecular medicine reports

authors： Feng T,Wang Y,Lang Y,Zhang Y

更新日期：2017-09-01 00:00:00

abstract：:Receptor interacting protein kinase 4 (RIPK4) is a serine/threonine kinase that plays an important role in the regulation of cell proliferation, invasion and metastasis in several malignancies; however, its clinical significance and biological function in osteosarcoma (OS) remains unknown. In the present study, the RI...

journal_title：Molecular medicine reports

authors： Yi Z,Pu Y,Gou R,Chen Y,Ren X,Liu W,Dong P

更新日期：2020-03-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Diabetes mellitus is known to cause kidney impairment; however, the mechanism remains elusive. The aim of this study was to investigate the role of C/EBP homologous protein (CHOP), an important protein in endoplasmic reticulum stress‑mediated mesangial cell apoptosis in hyperglycemia. Mesangial cells were cultured in ...

journal_title：Molecular medicine reports

authors： He D,Li J,Zhao J,Fei J,Zhang X

更新日期：2013-02-01 00:00:00

abstract：:The present study investigated the synergic effects and potential mechanisms of action of Astragalus polysaccharides (APS) combined with Crataegus flavonoids (CF) in the treatment of type 1 diabetes. Diabetes was induced by intraperitoneal injection of 100 mg/kg streptozotocin in mice. Normal and untreated diabetic co...

journal_title：Molecular medicine reports

authors： Cui K,Zhang S,Jiang X,Xie W

更新日期：2016-06-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL), the most frequently occurring type of lymphoid malignancy, has been demonstrated to be associated with mutations of Ten‑Eleven Translocation (TET). In order to explore the association between DLBCL and TET mutations, the present study analyzed the gene expression and methylation ...

journal_title：Molecular medicine reports

authors： Liu P,Jiang W,Zhao J,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:Oxyresveratrol (ORES) is a natural phenolic compound with multiple biological functions including antioxidation, anti‑inflammation and neuroprotection; however, the inhibitory effect of ORES on osteosarcoma remains largely unknown. The present study aimed to determine the effects of ORES on osteosarcoma cell Saos‑2. C...

journal_title：Molecular medicine reports

authors： Lv T,Jian Z,Li D,Ao R,Zhang X,Yu B

更新日期：2020-12-01 00:00:00

abstract：:Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present study aimed to examine the potential therapeutic effects of SSd on carbon tetrachloride (CCl4)‑induced acute hepatocellular injury in the HL‑77...

journal_title：Molecular medicine reports

authors： Lin L,Que R,Shen Y,Chen Y,Yan N,Li Y

更新日期：2018-06-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00