miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3.

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:The present study hypothesized that caffeic acid (3,4‑dihydroxycinnamic acid; CaA) may exert antidepressant‑like effects in rats with chronic unpredictable mild stress via epigenetic mechanisms, such as DNA methylation and hydroxymethylation. The chronic unpredictable mild stress (CUMS) model was used to analyze the e...

journal_title：Molecular medicine reports

authors： Hu J,Cao S,Zhang Z,Wang L,Wang D,Wu Q,Li L

更新日期：2020-12-01 00:00:00

abstract：:Lipids extracted from Halocynthia roretzi contain n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, as well as carotenoids. The aim of the present study was to evaluate the effect of H. roretzi lipids on white adipose tissue (WAT) weight and high blood glucose levels in diabetic/o...

journal_title：Molecular medicine reports

authors： Mikami N,Hosokawa M,Miyashita K

更新日期：2010-05-01 00:00:00

abstract：:ABO genotyping is commonly used in several situations, including blood transfusion, personal identification and disease detection. The present study developed a novel method for ABO genotyping, using loop‑mediated isothermal amplification (LAMP). This method allows the simultaneous determination of six ABO genotypes u...

journal_title：Molecular medicine reports

authors： Zhang C,Zhu J,Yang J,Wan Y,Ma T,Cui Y

更新日期：2015-10-01 00:00:00

abstract：:Sphincter of Oddi dysfunction (SOD) is a benign obstructive disorder predominantly resulting from spasms of the SO. Pharmacological therapies aim to induce SO relaxation; the hypercholesterolemic (HC) rabbit is the only SOD model available for study. In the present study, SO muscle strips, intracellular calcium ion co...

journal_title：Molecular medicine reports

authors： Wang F,Yang Y,Ji X,Tao X,Wang Y,Wang C

更新日期：2019-06-01 00:00:00

abstract：:The authors of the above article wish to retract their paper. Subsequently to its publication, in addition to certain irreconcilable differences in opinion shared among the authors, they have realized that, in their analysis of the role of peroxisome proliferator‑activated receptor γ in brain microvascular endothelial...

journal_title：Molecular medicine reports

authors： Xu M,Yang X,Zeng Q,He H,Lu P,Huang G

更新日期：2018-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of sufentanil on sepsis-induced acute lung injury (ALI), and identify the potential molecular mechanisms underlying its effect. In order to achieve this, a rat sepsis model was established. Following treatment with sufentanil, the lung wet/dry (W/D) weight ratio was c...

journal_title：Molecular medicine reports

authors： Hu Q,Wang Q,Han C,Yang Y

更新日期：2020-11-01 00:00:00

abstract：:Vitamin A deficiency (VAD) caused by malnutrition and certain intestinal diseases induces visual impairments, including night blindness and photoreceptor cell dysfunction as indicated by reduced a‑ and b‑waves in an electroretinogram (ERG). The effects of VAD on the inner retinal layer cells, including amacrine and ga...

journal_title：Molecular medicine reports

authors： Kakiuchi D,Uehara T,Shiotani M,Nakano-Ito K,Suganuma A,Aoki T,Tsukidate K,Sawada K

更新日期：2015-02-01 00:00:00

abstract：:Adipocytes have been demonstrated to promote the progression of various tumors through modulation of cancer cell metabolism. However, their role in lung cancer progression remains undetermined. In the present study, adipocytes and lung adenocarcinoma A549 cells were cultured in a Transwell co‑culture system. Cancer ce...

journal_title：Molecular medicine reports

authors： Li FF,Zhang H,Li JJ,Cao YN,Dong X,Gao C

更新日期：2018-08-01 00:00:00

abstract：:Damage of retinal ganglion cells (RGCs) is the major consequence of glaucoma and regeneration of RGCs is extremely difficult once the damage has occurred. Retinal stem cells (RSCs) are considered an ideal choice for RGC regeneration. Pigmented cells from the ciliary margin (PCMs) have great retinal differentiation pot...

journal_title：Molecular medicine reports

authors： Li Y,He X,Li J,Ni F,Sun Q,Zhou Y

更新日期：2017-06-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the fun...

journal_title：Molecular medicine reports

authors： You DG,Lee HR,Kim WK,Kim HJ,Lee GY,Yoo YD

更新日期：2017-12-01 00:00:00

abstract：:Ephrin type‑A receptor 2 (EphA2) is a receptor tyrosine kinase that is associated with cancer cell metastasis. There has been little investigation into its impact on the regulation of sensitivity to paclitaxel in nasopharyngeal carcinoma (NPC). In the present study, upregulation of EphA2 expression enhanced the surviv...

journal_title：Molecular medicine reports

authors： Wang Y,Liu Y,Li G,Su Z,Ren S,Tan P,Zhang X,Qiu Y,Tian Y

更新日期：2015-02-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is toxic against transformed tumor cells. Cornification is the terminal differentiation of keratinocytes and a specific form of programmed cell death caused by TRAIL that occurs in keratinocytes. Apoptosis can also be triggered when TRAIL induces expressi...

journal_title：Molecular medicine reports

authors： Kim SW,Park SY

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in...

journal_title：Molecular medicine reports

authors： Liu Y,Li F,Zhang L,Wu J,Wang Y,Yu H

更新日期：2017-11-01 00:00:00

abstract：:Viral myocarditis (VM), a severe clinical condition characterized by cardiac inflammation, is most frequently induced as a result of coxsackievirus infection. Evidence suggests that microRNAs may have significant roles in the progression of cardiac injury during coxsackievirus infection. Concurrently, microRNA (miR)-2...

journal_title：Molecular medicine reports

authors： Chen ZG,Liu H,Zhang JB,Zhang SL,Zhao LH,Liang WQ

更新日期：2015-07-01 00:00:00

abstract：:Functional appliances correct dental malocclusion, partly by exerting an indirect mechanical stimulus on the condylar cartilage, initiating novel bone formation in the condyle. Angiopoietin is involved in the angiogenesis associated with novel bone formation. This study aimed to determine the expression of angiopoieti...

journal_title：Molecular medicine reports

authors： Jing Z,Gu Z,Feng J

更新日期：2013-10-01 00:00:00

abstract：:Uveal melanoma (UM) represents the most frequent primary tumor of the eye. Despite the development of new drugs and screening programs, the prognosis of patients with UM remains poor and no effective prognostic biomarkers are yet able to identify high‑risk patients. Therefore, in the present study, microRNA (miRNA or ...

journal_title：Molecular medicine reports

authors： Falzone L,Romano GL,Salemi R,Bucolo C,Tomasello B,Lupo G,Anfuso CD,Spandidos DA,Libra M,Candido S

更新日期：2019-04-01 00:00:00

abstract：:Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the ...

journal_title：Molecular medicine reports

authors： Yue XJ,Guo Y,Yang HJ,Feng ZW,Li T,Xu YM

更新日期：2016-08-01 00:00:00

abstract：:Micro (mi)RNAs are short non‑coding RNA molecules, which post‑transcriptionally regulate gene expression and exert key roles in cell growth, differentiation and apoptosis. In the present study, the mechanism and the function of miR‑1915‑3p in the apoptotic regulation of lung cancer cell lines (NCI‑H441 and NCI‑H1650) ...

journal_title：Molecular medicine reports

authors： Xu C,Li H,Zhang L,Jia T,Duan L,Lu C

更新日期：2016-01-01 00:00:00

abstract：:Human forkhead box P3 (FOXP3)+ cluster of differentiation (CD)25+CD4+ regulatory T cells (Tregs) are a type of T cell that express CD4, CD25 and FOXP3, which are critical for maintaining immune homeostasis. The present study aimed to determine the mechanisms underlying Treg function. The GSE11292 dataset was downloade...

journal_title：Molecular medicine reports

authors： Bai X,Shi H,Yang M,Wang Y,Sun Z,Xu S

更新日期：2018-03-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common multifactorial disorder characterized by hyperandrogenism, insulin resistance and chronic oligoanovulation. In addition, a number of females with PCOS have ovaries with multiple cysts, an irregular or no menstrual cycle and an imbalance of female hormones compared with norm...

journal_title：Molecular medicine reports

authors： Park JH,Li L,Baek KH

更新日期：2015-09-01 00:00:00

abstract：:Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether SNPs in genes invol...

journal_title：Molecular medicine reports

authors： Azevedo AP,Silva SN,Reichert A,Lima F,Júnior E,Rueff J

更新日期：2018-12-01 00:00:00

abstract：:The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). The study included 91 females with PCOS and 99 healthy controls. Phenotypic hypera...

journal_title：Molecular medicine reports

authors： Baldani DP,Skrgatic L,Cerne JZ,Oguic SK,Gersak BM,Gersak K

更新日期：2015-05-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) has a structure similar to heparan sulfate, which exerts anti‑inflammatory effects via inhibiting elastase (Ela) activity. Release of Ela along the glomerular capillary wall may induce glomerular injury and proteinuria. The present study aimed to investigate the influence of LMWH on...

journal_title：Molecular medicine reports

authors： Zhai S,Hu L,Zhong L,Tao Y,Wang Z

更新日期：2017-12-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:Circular RNAs (circRNAs) regulate several physiological and pathological processes, but their role in visceral lipid deposition has not been explored. In the present study, human preadipocytes from visceral fat tissue (HPA‑v) were induced to form adipocytes, and the circRNA expression profiles in HPA‑v and adipocytes ...

journal_title：Molecular medicine reports

authors： Sun W,Sun X,Chu W,Yu S,Dong F,Xu G

更新日期：2020-02-01 00:00:00

abstract：:The aim of the present study was to predict and identify B‑cell epitopes for mouse tumor necrosis factor‑α (mTNF‑α). DNAStar and BcePred software were used to predict B‑cell epitopes for mTNF‑α. A predicted eight‑branch multiple antigenic polypeptide (MAP) was synthesized and used to immunize BALB/c mice, combined wit...

journal_title：Molecular medicine reports

authors： Zhang J,Cui Y,Wu Y,Wang H,Ke J

更新日期：2017-09-01 00:00:00

abstract：:Glucocorticoid receptor (GR) function is essential for glucocorticoid action on various effector cells. The aim of the present study was to investigate the mRNA expression profiles of GRα and GRβ in peripheral blood mononuclear cells (PBMC) and examine the association between the expression levels of the GR isoforms a...

journal_title：Molecular medicine reports

authors： Mei B,Chen Y,Liu W,Li L,Wang C

更新日期：2015-03-01 00:00:00