ROCK1, a novel target of miR-145, promotes glioma cell invasion.

abstract：:Owing to an oversight during the proof checking stage, the above article has been published with the incorrect author listed for correspondence. The first author, Chao Huang, is listed as the corresponding author, although he was only intended to have been temporarily assigned to handle queries during the pre-press st...

journal_title：Molecular medicine reports

authors： Huang C,Liu H,Gong X,Wen B,Chen D,Liu J,Hu F

更新日期：2016-12-01 00:00:00

abstract：:Electroacupuncture (EA) has been documented as a form of therapy for chronic sinusitis (CRS). The present study aimed to assess the effects of EA combined with interleukin‑10 (IL‑10) overexpression on CRS in mice, and to investigate the associated mechanisms. A mouse model of CRS was established by the administration ...

journal_title：Molecular medicine reports

authors： Zhou L,Hong J,Wan Z,Lu X,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role and regulatory mechanism of long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 (FTH1P3) in glioma development. The expression of FTH1P3 in low‑ and high‑grade glioma tissues was investigated using reverse transcription‑quantitative polymeras...

journal_title：Molecular medicine reports

authors： Zhang Y,Li Y,Wang J,Lei P

更新日期：2018-11-01 00:00:00

abstract：:The development of pharmaceutical agents possessing anti‑invasive and anti‑metastatic abilities, as well as apoptotic activity, is important in decreasing the incidence and recurrence of oral cancer. Cancer cells are known to acquire invasiveness not only through epigenetic changes, but also from inflammatory stimuli ...

journal_title：Molecular medicine reports

authors： Cho BH,Jung YH,Kim DJ,Woo BH,Jung JE,Lee JH,Choi YW,Park HR

更新日期：2018-02-01 00:00:00

abstract：:We wish to retract our article entitled 'Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy' published in Molecular Medicine Reports 13: 4273-4278, 2016. The article was submitted by the first author, Xinhong Liu, without the prior knowledge of the corre...

journal_title：Molecular medicine reports

authors： Liu X,Wu H,Gong J,Wang T,Yan C

更新日期：2016-07-01 00:00:00

abstract：:Mineralized bone matrix constituted with collagenous and non-collagenous proteins was synthesized by osteoblasts differentiated from mesenchymal stem cells. Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, promotes cell migration and proliferation, and suppresses the inflammatory response. R...

journal_title：Molecular medicine reports

authors： Choi BD,Lee SY,Jeong SJ,Lim DS,Cha HJ,Chung WG,Jeong MJ

更新日期：2016-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and malignant brain tumor of the adult central nervous system and is associated with poor prognosis. The present study aimed to identify the hub genes in GBM in order to improve the current understanding of the underlying mechanism of GBM. The RNA‑seq data were download...

journal_title：Molecular medicine reports

authors： Chen X,Pan Y,Yan M,Bao G,Sun X

更新日期：2020-08-01 00:00:00

abstract：:The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported ...

journal_title：Molecular medicine reports

authors： Xu CW,Cai XY,Shao Y,Li Y,Shi MW,Zhang LY,Wang L,Zhang YP,Wang LP,Tian YW

更新日期：2015-09-01 00:00:00

abstract：:Hepatoblastoma (HB) is the most common type of pediatric liver malignancy, which predominantly occurs in young children (aged <5 years), and continues to be a therapeutic challenge in terms of metastasis and drug resistance. As a new pattern of tumor blood supply, vasculogenic mimicry (VM) is a channel structure lined...

journal_title：Molecular medicine reports

authors： Zhang F,Zhang CM,Li S,Wang KK,Guo BB,Fu Y,Liu LY,Zhang Y,Jiang HY,Wu CJ

更新日期：2018-01-01 00:00:00

abstract：:The hyper-responsiveness of plasma cortisol to vasopressin has been reported in patients with ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) and in certain cases of Cushing's adenomas with overexpression of V1a receptors in the adrenal gland. We previously reported a high prevalence of the ...

journal_title：Molecular medicine reports

authors： Suzuki S,Uchida D,Koide H,Suyama K,Tanaka T,Noguchi Y,Saito Y,Tatsuno I

更新日期：2009-01-01 00:00:00

abstract：:Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotec...

journal_title：Molecular medicine reports

authors： Dai H,Jia G,Lu M,Liang C,Wang Y,Wang H

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

journal_title：Molecular medicine reports

authors： Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

更新日期：2015-11-01 00:00:00

abstract：:Chronic microglial activation endangers neuronal survival through the release of various pro-inflammatory and neurotoxic factors. As such, negative regulators of microglial activation have been considered as potential therapeutic candidates to reduce the risk of neurodegeneration associated with inflammation. Uncaria ...

journal_title：Molecular medicine reports

authors： Jung HY,Nam KN,Woo BC,Kim KP,Kim SO,Lee EH

更新日期：2013-01-01 00:00:00

abstract：:Centromere protein M (CENPM), a protein required for chromosome separation, is involved in in mitosis. However, little has been reported about the roles of CENPM in various types of cancer. The present study identified that the mRNA expression levels of CENPM were significantly upregulated in 14 types of human cancer ...

journal_title：Molecular medicine reports

authors： Liu Y,Yu W,Ren P,Zhang T

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in...

journal_title：Molecular medicine reports

authors： Liu Y,Li F,Zhang L,Wu J,Wang Y,Yu H

更新日期：2017-11-01 00:00:00

abstract：:Cerebral ischemic stroke (IS) is a disease presenting high morbidity and mortality rates worldwide. Understanding of the pathogenesis underlying IS may facilitate the development of effective clinical therapeutic strategies and improve the prevention of this disease, decreasing its occurrence rate. Epigenetic alterati...

journal_title：Molecular medicine reports

authors： Wei Y,Sun Z,Wang Y,Xie Z,Xu S,Xu Y,Zhou X,Bi J,Zhu Z

更新日期：2019-08-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is one of the highly malignant tumors and a serious threat to human health. The aim of the present study was to explore the underlying molecular mechanisms of SCLC. mRNA microarray datasets GSE6044 and GSE11969 were downloaded from Gene Expression Omnibus database, and the differentially ...

journal_title：Molecular medicine reports

authors： Wen P,Chidanguro T,Shi Z,Gu H,Wang N,Wang T,Li Y,Gao J

更新日期：2018-08-01 00:00:00

abstract：:Circadian rhythms comprise of daily oscillations in a variety of biological processes and are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer progression, and understanding natural oscillations in cellular growth control, tumor suppression and cancer treatment, may reveal ...

journal_title：Molecular medicine reports

authors： Couto P,Miranda D,Vieira R,Vilhena A,De Marco L,Bastos-Rodrigues L

更新日期：2014-07-01 00:00:00

abstract：:Hepatic glycoprotein (gp78), a membrane-anchored E3 ubiquitin ligase, has been reported to be involved in regulating lipid and energy metabolism in animals, and cell death‑inducing DFFA‑like effector c (cidec) has emerged as an important regulator of metabolism, which has been implicated in the process of fat differen...

journal_title：Molecular medicine reports

authors： Li J,Liu G,Zhang F,Zhang Z,Xu Y,Li Q

更新日期：2017-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly metastatic malignancy, which is highly prevalent in Southeast Asia and North Africa. Recent studies implicated the critical role of nemo‑like kinase (NLK) in tumor biology. However, the functional role of NLK in NPC has yet to be elucidated. In the present study, the signific...

journal_title：Molecular medicine reports

authors： Chen S,Ma Z,Chen X,Zhang J

更新日期：2014-07-01 00:00:00

abstract：:Spinal cord injury (SCI) is a cause of disability. The present study aimed to investigate the molecular mechanisms involved in traumatic SCI. Transcriptome data under accession no. GSE5296, including 96 chips, were downloaded from the Gene Expression Omnibus database. The raw data were normalized and differentially ex...

journal_title：Molecular medicine reports

authors： Zhao SJ,Zhou W,Chen J,Luo YJ,Yin GY

更新日期：2018-06-01 00:00:00

abstract：:The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on the differentiation of endothelial progenitor cells (EPCs) to endothelial cells (ECs) induced by shear stress, and to investigate the corresponding mechanisms. Cultured rat late EPCs were exposed to shear stress (12 dyn/cm2) for differe...

journal_title：Molecular medicine reports

authors： Chu HR,Sun YC,Gao Y,Guan XM,Yan H,Cui XD,Zhang XY,Li X,Li H,Cheng M

更新日期：2019-03-01 00:00:00

abstract：:Lactate is an important metabolite in cellular metabolism and fluctuates in certain disease conditions including cancer and immune diseases. It was hypothesized that a decrease in lactate would modulate the inflammatory response elicited by lipopolysaccharides (LPS) in macrophages. When RAW 264.7 macrophages were trea...

journal_title：Molecular medicine reports

authors： Song YJ,Kim A,Kim GT,Yu HY,Lee ES,Park MJ,Kim YJ,Shim SM,Park TS

更新日期：2019-01-01 00:00:00

abstract：:The use of small molecule compounds to inhibit cell proliferation is one of the most promising approaches in cancer therapy. In the present study, a cell viability assay, flow cytometry analysis, western blotting and mouse xenograft models were used to investigate the anticancer activities of #2714 and its underlying ...

journal_title：Molecular medicine reports

authors： Lu W,Sun Q,Chen B,Li Y,Xu Y,Wang S

更新日期：2019-06-01 00:00:00

abstract：:The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. The aim of the present study was to investigate the potential effect of naringenin on HS and its underlying mechanisms. The mouse model of HS was prepared by a mechanical stretch device and then treated with naringenin at various co...

journal_title：Molecular medicine reports

authors： Shan S,Zhang Y,Wu M,Yi B,Wang J,Li Q

更新日期：2017-10-01 00:00:00

abstract：:IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein, which is aberrantly expressed in several tumor types and is closely associated with the development, metastasis and prognosis of cancer. Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research o...

journal_title：Molecular medicine reports

authors： Diao B,Liu Y,Zhang Y,Yu J,Xie J,Xu GZ

更新日期：2017-04-01 00:00:00

abstract：:As one of the first-established negative feedback regulators of angiogenesis, mesenchymal vasohibin-1 (VASH1) serves important roles in the progression and prognosis of various types of tumor. However, the clinical implications of VASH1 in esophageal carcinoma (EC) cells have not been reported and the direct effects o...

journal_title：Molecular medicine reports

authors： Ma D,Li J,Wang J,Sun Z,Wang K

更新日期：2017-08-01 00:00:00

abstract：:Single nucleotide polymorphisms associated with lipid metabolism and energy balance are implicated in the weight loss response caused by nutritional interventions. Diet‑induced weight loss is also associated with differential global DNA methylation. DNA methylation has been proposed as a predictive biomarker for weigh...

journal_title：Molecular medicine reports

authors： Pirini F,Rodriguez-Torres S,Ayandibu BG,Orera-Clemente M,Gonzalez-de la Vega A,Lawson F,Thorpe RJ Jr,Sidransky D,Guerrero-Preston R

更新日期：2018-01-01 00:00:00

abstract：:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological char...

journal_title：Molecular medicine reports

authors： Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BH

更新日期：2018-12-01 00:00:00

abstract：:To identify novel candidate genes associated with osteoporosis, RNA‑sequence analysis of human mesenchymal stem cells (hMSCs) from patients with osteoporosis (G3) and osteopenia (G2), and healthy controls (G1) was performed. Differentially expressed genes (DEGs) from among the three groups were identified. DEGs were s...

journal_title：Molecular medicine reports

authors： Song I,Choi YJ,Jin Y,Kim JW,Koh JT,Ji HM,Jeong SY,Won YY,Kim W,Chung YS

更新日期：2017-10-01 00:00:00