Ethanol extract from Cnidium monnieri (L.) Cusson induces cell cycle arrest and apoptosis via regulation of the p53‑independent pathway in HepG2 and Hep3B hepatocellular carcinoma cells.

abstract：:The tumor suppressor gene CD82, also known as KAI1, may act as a general suppressor of metastasis in numerous types of cancer. It is hypothesized that downregulation of CD82 gene expression may be an important factor in the induction of hepatocellular carcinoma (HCC), however the mechanism for this requires further st...

journal_title：Molecular medicine reports

authors： Yu G,Bing Y,Li W,Xia L,Liu Z

更新日期：2014-11-01 00:00:00

abstract：:The aim of the present study was to investigate the role of microRNA (miR)‑34a expression in the proliferation, invasion and metastasis of colon cancer and its underlying mechanisms. HCT116 cells were cultured in high‑sugar Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum and 1000 U/ml penic...

journal_title：Molecular medicine reports

authors： Li C,Lu S,Wang Y,Guo S,Zhao T,Wang X,Song B

更新日期：2017-02-01 00:00:00

abstract：:Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction...

journal_title：Molecular medicine reports

authors： Zhou G,Jiang H,Ma L

更新日期：2018-09-01 00:00:00

abstract：:Tilianin, the main effective flavonoid monomer enriched from Dracocephalum moldavuca L., has been shown to have cardioprotective effects. However, the mechanism of tilianin cardioprotection remains largely unknown. The present study aimed to investigate the effects of tilianin preconditioning on myocardial ischemia/re...

journal_title：Molecular medicine reports

authors： Guo X,Cao W,Yao J,Yuan Y,Hong Y,Wang X,Xing J

更新日期：2015-03-01 00:00:00

abstract：:The hepatitis C virus (HCV) alternate reading frame protein (ARFP or F protein) of the HCV 1b genotype is a double-frameshift product of the HCV core protein (Core). The discovery of HCV F protein challenges various biological functions attributed to Core. However, the specific characteristics of the host cellular imm...

journal_title：Molecular medicine reports

authors： Xu X,Yu X,Deng X,Yue M,Zhang J,Zhu D,Zhou Z,Zhai X,Xu K,Zhang Y

更新日期：2014-02-01 00:00:00

abstract：:Curcumin is characterized by anti‑inflammatory, anti‑oxidative, antiviral, antifibrotic, anticoagulation and glucose regulatory functions. However, whether it is protective in diabetes mellitus‑associated cerebral infarction remains to be fully elucidated. In the present study, it was demonstrated for the first time, ...

journal_title：Molecular medicine reports

authors： Xia M,Ye Z,Shi Y,Zhou L,Hua Y

更新日期：2018-01-01 00:00:00

abstract：:Vacquinol‑1 (Vacq), a quinolone derivative, has recently been reported to display potent antitumor effects in glioblastomas by inducing cellular massive vacuolization and cell death. However, whether Vacq induces cytotoxicities in other types of cancers, and the potential underlying mechanism, remain to be investigate...

journal_title：Molecular medicine reports

authors： Sun SL,Li X,Su N,Chen S,Gao X,Zhang G,Piao H

更新日期：2018-07-01 00:00:00

abstract：:The expression of Ferroportin (Fpn) was examined at different time points in rats following focal cerebral ischemia treated with or without the traditional Chinese medicine Naotaifang. Initially, rats were randomly divided into 2, 6, 12, 24 and 72 h groups following middle cerebral artery occlusion (MCAO) and the mRNA...

journal_title：Molecular medicine reports

authors： Liao J,Xia X,Wang GZ,Shi YM,Ge JW

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to identify differentially expressed genes and biological processes associated with periodontitis. In this study, the most significant 200 differentially expressed genes associated with periodontitis were identified using integrated analysis of multiple microarray data in combination w...

journal_title：Molecular medicine reports

authors： Guo X,Wang Y,Wang C,Chen J

更新日期：2015-04-01 00:00:00

abstract：:Long non-coding RNA (lncRNA), transcripts of >200 bp in length that do not appear to exhibit any coding capacity, are important in the occurrence and development of cancer, cardiovascular and neurological diseases. However, effects of lncRNAs on photo‑aging remain to be elucidated. To explore the potential effects of ...

journal_title：Molecular medicine reports

authors： Lei L,Zeng Q,Lu J,Ding S,Xia F,Kang J,Tan L,Gao L,Kang L,Cao K,Zhou J,Xiao R,Chen J,Huang J

更新日期：2017-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated mortality in the 21st century. microRNA (miR)‑23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR‑23b in HCC remains unclear. The present study revealed a neg...

journal_title：Molecular medicine reports

authors： Jiang T,Huang Z,Zhang S,Zou W,Xiang L,Wu X,Shen Y,Liu W,Zeng Z,Zhao A,Zhou S,Zeng Q

更新日期：2018-08-01 00:00:00

abstract：:Family with sequence similarity 172, member A (FAM172A), was cloned from human aortic tissues and confirmed in our previous study in 2009, however, its functions remain to be fully elucidated. In our previous studies, the protein expression of FAM172A in human aortic smooth muscle cells was found to be upregulated by ...

journal_title：Molecular medicine reports

authors： Li MF,Zhang R,Guo MG,Li LX,Lu HK,Lu JX,Jia WP

更新日期：2016-01-01 00:00:00

abstract：:According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the...

journal_title：Molecular medicine reports

authors： Wang X,Ma J,Ma J,Wen Y,Meng L,Yang H,Zhang R,Hao D

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to identify the mutation causing an atypical syndrome. High-resolution single nucleotide polymorphism (SNP) arrays are considered to be a major detection method for submicroscopic chromosomal rearrangements smaller than 5 Mb in size. Genomic DNA samples of the patient and his parents were conve...

journal_title：Molecular medicine reports

authors： Hu S,Yang Y,Liu L,Tan Z,Zhao T

更新日期：2017-05-01 00:00:00

abstract：:Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PD...

journal_title：Molecular medicine reports

authors： Zheng B,Peng J,Mollayup A,Bakri A,Guo L,Zheng J,Xu H

更新日期：2018-01-01 00:00:00

abstract：:The present study was designed to elucidate the expression levels and the proliferative effect of flotillin-1, an integral membrane protein encoded by the FLOT1 gene, in human clear-cell renal cell carcinoma (RCC). Flotillin has been implicated in other types of cancer, but the role of flotillin in RCC has not been es...

journal_title：Molecular medicine reports

authors： Zhang Y,Li J,Song Y,Chen F,Pei Y,Yao F

更新日期：2014-08-01 00:00:00

abstract：:Progressive cardiac conduction defect (PCCD) is an inherited autosomal dominant cardiac disorder characterized by an age‑dependent cardiac electrical conduction block. Several genes have been associated with the genetic pathogenesis of PCCD. The present study aimed to identify the causal mutation of PCCD and to invest...

journal_title：Molecular medicine reports

authors： Fan P,Zhang D,Yang KQ,Tian T,Luo F,Liu YX,Wang LP,Zhou XL

更新日期：2020-06-01 00:00:00

abstract：:Erythropoietin (EPO) has been shown to be neuroprotective in various models of neuronal injury. The aim of the present study was to investigate the beneficial effect of recombinant human EPO (rhEPO) following intracerebral hemorrhage (ICH) and the underlying molecular and cellular mechanisms. ICH was induced using aut...

journal_title：Molecular medicine reports

authors： Yu Z,Tang L,Chen L,Li J,Wu W,Hu C

更新日期：2013-11-01 00:00:00

abstract：:Human forkhead box P3 (FOXP3)+ cluster of differentiation (CD)25+CD4+ regulatory T cells (Tregs) are a type of T cell that express CD4, CD25 and FOXP3, which are critical for maintaining immune homeostasis. The present study aimed to determine the mechanisms underlying Treg function. The GSE11292 dataset was downloade...

journal_title：Molecular medicine reports

authors： Bai X,Shi H,Yang M,Wang Y,Sun Z,Xu S

更新日期：2018-03-01 00:00:00

abstract：:The differentiation of pluripotent mesenchymal stem cells to mature osteoblasts is crucial for the maintenance of the adult skeleton. In rheumatic arthritis, osteoblast differentiation is impaired by the overproduction of cytokine tumor necrosis factor (TNF)‑α. It has been demonstrated that TNF-α is able to inhibit os...

journal_title：Molecular medicine reports

authors： Wang G,Zhang X,Yu B,Ren K

更新日期：2015-07-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) is known to increase the survival of skin flaps by promoting neovascularization; however, the detailed mechanisms involved are not fully understood. In the present study, we aimed to characterize the effects of HBO treatment on neovascularization and skin flap survival. We also analyzed the mec...

journal_title：Molecular medicine reports

authors： Liu X,Liang F,Yang J,Li Z,Hou X,Wang Y,Gao C

更新日期：2013-10-01 00:00:00

abstract：:Soy milk, which is produced from whole soybeans, contains a variety of biologically active components. Isoflavones are a class of soy-derived phytoestrogens with beneficial effects, among which genistein (GEN) has been previously indicated to reduce the risk of prostate cancer. The present study evaluated the effects ...

journal_title：Molecular medicine reports

authors： Kang NH,Shin HC,Oh S,Lee KH,Lee YB,Choi KC

更新日期：2016-08-01 00:00:00

abstract：:The dopamine precursor 3,4‑dihydroxyphenyl‑ l‑alanine (L‑DOPA) is the most widely used symptomatic treatment for Parkinson's disease (PD); however, its prolonged use is associated with L‑DOPA‑induced dyskinesia in more than half of patients after 10 years of treatment. The present study investigated whether co‑treatme...

journal_title：Molecular medicine reports

authors： Ryu YK,Park HY,Go J,Lee IB,Choi YK,Lee CH,Kim KS

更新日期：2021-03-01 00:00:00

abstract：:The aim of this study was to evaluate the feasibility and safety of porcine Descemet's membrane (DM) as a carrier for the generation of tissue-engineered corneal endothelium by analyzing porcine endogenous retroviruses (PERVs) and the α-gal epitope. The morphology of porcine and human DM was observed by hematoxylin an...

journal_title：Molecular medicine reports

authors： Diao YM,Hong J

更新日期：2015-08-01 00:00:00

abstract：:Apoptosis serves a pivotal role in the pathogenesis of osteoarthritis (OA). Increasing evidence has demonstrated that paeoniflorin exerts key properties (including anticancer, anti-inflammation and neuroprotective) for clinical applications. However, the precise role of paeoniflorin in articular cartilage apoptosis re...

journal_title：Molecular medicine reports

authors： Hu PF,Chen WP,Bao JP,Wu LD

更新日期：2018-04-01 00:00:00

abstract：:Inflammatory and immune responses, as well as melatonin secretion, are affected by circadian regulation. Abnormal circadian rhythm of melatonin release has been reported to be associated with the later stages of sepsis; however, its role in the early stages of sepsis is unclear. We studied 11 septic and 11 non-septic ...

journal_title：Molecular medicine reports

authors： Li CX,Liang DD,Xie GH,Cheng BL,Chen QX,Wu SJ,Wang JL,Cho W,Fang XM

更新日期：2013-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers. A hypoxic microenvironment is a common feature of HCC, and is associated with malignant invasion, metastasis and epithelial-mesenchymal transition (EMT) changes. Curcumin is a botanical agent derived from the dried rhizome of Curcuma longa. Alt...

journal_title：Molecular medicine reports

authors： Duan W,Chang Y,Li R,Xu Q,Lei J,Yin C,Li T,Wu Y,Ma Q,Li X

更新日期：2014-11-01 00:00:00

abstract：:The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and sec...

journal_title：Molecular medicine reports

authors： Zheng W,Guan J

更新日期：2018-09-01 00:00:00

abstract：:Glucosamine is a possible cause of vascular endothelial injury in the initial stages of atherosclerosis, through endoplasmic reticulum (ER) stress resulting in fatty streaks in the vascular wall. Quercetin is an anti‑diabetic and cardiovascular protective agent that has previously been demonstrated to reduce ER stress...

journal_title：Molecular medicine reports

authors： Cai X,Bao L,Ding Y,Dai X,Zhang Z,Li Y

更新日期：2017-02-01 00:00:00

abstract：:The present study was designed to determine the association between atrial fibrillation (AF) and inflammation in a goat sterile pericarditis model and to assess the effect of atorvastatin, a cholesterol‑reducing drug, on AF. A total of 15 adult male goats were randomly divided into control, untreated pericarditis and ...

journal_title：Molecular medicine reports

authors： Zhang Y,Wang YT,Shan ZL,Guo HY,Guan Y,Yuan HT

更新日期：2015-04-01 00:00:00