Naotaifang extract treatment results in increased ferroportin expression in the hippocampus of rats subjected to cerebral ischemia.

abstract：:Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulat...

journal_title：Molecular medicine reports

authors： Jia Z,Lin L,Huang S,Zhu Z,Huang W,Huang Z

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to investigate the effect of SOX2 on odontoblast differentiation of dental pulp stem cells (DPSCs), and to examine the potential application of DPSCs on dental restoration. SRY‑box 2 (SOX2) overexpression in human DPSCs (DPSCs‑SOX2) was established by retroviral infection. The empty vector‑infe...

journal_title：Molecular medicine reports

authors： Yang Y,Zhao Y,Liu X,Chen Y,Liu P,Zhao L

更新日期：2017-12-01 00:00:00

abstract：:The corticotropin-releasing factor (CRF) family is involved in modulating gastrointestinal motility, sensitivity and inflammation. CRF signalling exerts an important role in inflammatory bowel disease (IBD), predominantly by activating CRF receptors. The aim of the present study was to investigate the function of CRF ...

journal_title：Molecular medicine reports

authors： Chen H,Shi H,Liu Y,Ren X,He S,Chang X,Yin Y

更新日期：2018-01-01 00:00:00

abstract：:Derivatives of caffeoylquinic acid (CQA) have been studied and reported as potent bioactive molecules possessing various health benefits including antioxidant and anti‑inflammatory activities. In the present study, the protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid (DCEQA) isolated from Atriplex gmelinii on UVB‑i...

journal_title：Molecular medicine reports

authors： Oh JH,Karadeniz F,Lee JI,Seo Y,Kong CS

更新日期：2019-07-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) affect atherosclerosis by regulating the physiological and pathological processes of endothelial cells; however, the role of lncRNA WEE2 antisense RNA 1 (WEE2‑AS1) in arteriosclerosis obliterans (ASO) is not completely understood. The present study aimed to explore the function of lncRNA...

journal_title：Molecular medicine reports

authors： Jiang B,Wang R,Lin Z,Ma J,Cui J,Wang M,Liu R,Wu W,Zhang C,Li W,Wang S

更新日期：2020-12-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:β-amyloid (Aβ)-mediated neuronal apoptosis is an important pathological feature of Alzheimer's disease (AD). Inhibiting apoptosis induced by Aβ may lead to the development of a potential therapeutic target for AD treatment. κ‑carrageenan‑derived pentasaccharide (KCP) extracted from marine red algae is involved in a va...

journal_title：Molecular medicine reports

authors： Liu Y,Jiang L,Li X

更新日期：2017-01-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non‑coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogen...

journal_title：Molecular medicine reports

authors： Tao R,Li YX,Liu YK,Liu F,Zhou ZY

更新日期：2019-04-01 00:00:00

abstract：:Clara cell protein (CC16) is an anti-inflammatory protein, which is expressed in the airway epithelium. It is involved in the development of airway inflammatory diseases, including chronic obstructive pulmonary disease and asthma. However, the exact molecular mechanism underlying its anti‑inflammatory action remains t...

journal_title：Molecular medicine reports

authors： Pang M,Bai XY,Li Y,Bai JZ,Yuan LR,Ren SA,Hu XY,Zhang XR,Yu BF,Guo R,Wang HL

更新日期：2016-11-01 00:00:00

abstract：:In the present study, we report the mutation of the 3β-hydroxysteroid dehydrogenase (3β-HSD) gene in a family suffering from adrenocortical insufficiency. The index patient was clinically diagnosed with adrenocortical insufficiency. Peripheral venous blood (5 ml) was collected from ...

journal_title：Molecular medicine reports

authors： Pan Y,Zhong S,Hu RM,Gong W

更新日期：2012-12-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. TBMS1 has been reported to induce apoptosis in human glioma cells, however the mechanism remains to be elucidated. The present study explored TBMS1‑induced PI3K/A...

journal_title：Molecular medicine reports

authors： Cao LJ,Xie HT,Chu ZX,Ma Y,Wang MM,Shi Z

更新日期：2020-08-01 00:00:00

abstract：:Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen...

journal_title：Molecular medicine reports

authors： Ding H,Luo Y,Hu K,Huang H,Liu P,Xiong M,Zhu L,Yi J,Xu Y

更新日期：2020-11-01 00:00:00

abstract：:Cheonggukjang (CKJ), a fermented soybean product, has been reported to have beneficial effects on various chronic diseases, including cardiovascular disease, cancer and immune diseases. To investigate whether CKJ induces growth sensitivity in mammals, alterations of key parameters related to their growth were analyzed...

journal_title：Molecular medicine reports

authors： Hwang IS,Kim JE,Lee YJ,Kwak MH,Lee HG,Kim HS,Lee HS,Hwang DY

更新日期：2014-01-01 00:00:00

abstract：:Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy end...

journal_title：Molecular medicine reports

authors： Chen H,Tang QL,Wu XY,Xie LC,Lin LM,Ho GY,Ma L

更新日期：2015-07-01 00:00:00

abstract：:The association of the peripheral lymphocyte‑to‑monocyte ratio (LMR) with α‑fetoprotein (AFP) status in patients with AFP‑positive and AFP‑negative hepatocellular carcinoma (HCC) has not been investigated in detail. The aim of the present study was to examine the association between the LMR and AFP status in these pat...

journal_title：Molecular medicine reports

authors： Wang H,Xiang Y,Li X,Liu S,Liu L

更新日期：2020-10-01 00:00:00

abstract：:The advanced glycosylation end product-specific receptor (RAGE) has been demonstrated to be an important mediator of asthma pathogenesis. The soluble isoform of RAGE (sRAGE) acts as a 'decoy' to sequester RAGE ligands, and thus prevents their binding to the receptor. A number of reports have linked deficiency of sRAGE...

journal_title：Molecular medicine reports

authors： Lyu Y,Zhao H,Ye Y,Liu L,Zhu S,Xia Y,Zou F,Cai S

更新日期：2018-03-01 00:00:00

abstract：:Advances in the treatment of nasopharyngeal carcinoma (NPC) have significantly improved the local control rate; however, distant metastasis remains a principal cause of mortality. Previous studies have demonstrated that the expression levels of amyloid β precursor protein (APP) are increased in NPC. The present study ...

journal_title：Molecular medicine reports

authors： Xu J,Ying Y,Xiong G,Lai L,Wang Q,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:MicroRNAs (miRs) are considered to be effective, post‑transcriptional regulators in the pathophysiology of type 2 diabetes (T2D) and promising treatment targets. However, the function of miR‑141 remains to be elucidated. In the present study, upregulation of miR‑141 was demonstrated in diabetic mice and elderly diabet...

journal_title：Molecular medicine reports

authors： Yu X,Zhong L

更新日期：2018-06-01 00:00:00

abstract：:Aberrant DNA methylation is the most common type of epigenetic alteration and is associated with many types of cancer. Although previous studies have provided a few novel DNA methylation markers in hepatocellular carcinoma (HCC), specific DNA methylation patterns and comparisons of the aberrant alterations in methylat...

journal_title：Molecular medicine reports

authors： Sun N,Zhang J,Zhang C,Shi Y,Zhao B,Jiao A,Chen B

更新日期：2018-11-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is toxic against transformed tumor cells. Cornification is the terminal differentiation of keratinocytes and a specific form of programmed cell death caused by TRAIL that occurs in keratinocytes. Apoptosis can also be triggered when TRAIL induces expressi...

journal_title：Molecular medicine reports

authors： Kim SW,Park SY

更新日期：2016-01-01 00:00:00

abstract：:Cholelithiasis is a common medical condition whose incidence rate is increasing yearly, while its pathogenesis has yet to be elucidated. The present study assessed the expression of Rho-kinase (ROCK) in gallbladder smooth muscles and its effect on the contractile function of gallbladder smooth muscles during gallstone...

journal_title：Molecular medicine reports

authors： Wang B,Ding YM,Wang CT,Wang WX

更新日期：2015-08-01 00:00:00

abstract：:It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. ...

journal_title：Molecular medicine reports

authors： Falzone L,Marconi A,Loreto C,Franco S,Spandidos DA,Libra M

更新日期：2016-11-01 00:00:00

abstract：:The mammalian target of rapamycin/eukaryotic translation inititiation factor 4E binding protein 1 (mTOR/4E-BP1) transduction pathway is activated in a range of malignant cancers, but its role in human gastric cardiac adenocarcinoma (GCA) has not been well defined. The present study used western blotting and reverse tr...

journal_title：Molecular medicine reports

authors： Yang HY,Xue LY,Xing LX,Wang J,Wang JL,Yan X,Zhang XH

更新日期：2013-02-01 00:00:00

abstract：:Benign thyroid nodules are among the most common endocrine disorders. Recent advances in diagnostic imaging and pathology have significantly contributed to better risk stratification of thyroid nodules. However, current treatment options, beyond surgical approaches are limited. The following placebo-controlled study p...

journal_title：Molecular medicine reports

authors： Stancioiu F,Mihai D,Papadakis GZ,Tsatsakis A,Spandidos DA,Badiu C

更新日期：2019-09-01 00:00:00

abstract：:Mossy fiber sprouting (MFS) is a pathological phenomenon that is commonly observed in temporal lobe epilepsy (TLE). However, the molecular mechanisms underlying MFS remain unclear. It has been demonstrated that the tau protein is important in the progression of MFS by the regulation of microtubule dynamics and axonal ...

journal_title：Molecular medicine reports

authors： Huang WJ,Tian FF,Chen JM,Guo TH,Ma YF,Fang J,Dang J,Song MY

更新日期：2013-11-01 00:00:00

abstract：:Transgelin 2 (TAGLN2) is a cytoskeletal protein of the calponin family. Abnormal expression of TAGLN2 was observed in various types of cancer. Our previous study reported that TAGLN2 expression was reduced in lymph node‑positive breast cancer patients; however, the role of TAGLN2 in breast cancer metastasis remains un...

journal_title：Molecular medicine reports

authors： Yang L,Hong Q,Xu SG,Kuang XY,Di GH,Liu GY,Wu J,Shao ZM,Yu SJ

更新日期：2019-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Although numerous studies have suggested the potentially oncogenic roles of wild‑type or mutant hepatitis B virus X (HBx) protein in hepatocarcinogenesis, their exact mechanism remains unclear. Increasing evidence suggests that microRNAs ...

journal_title：Molecular medicine reports

authors： Fu X,Tan D,Hou Z,Hu Z,Liu G,Ouyang Y,Liu F

更新日期：2013-02-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP2) is a growth factor that is involved in the development and progression of various types of cancer. However, the epigenetic regulation of the expression of BMP2 and the association between BMP2 expression and drug resistance in breast cancer remains to be elucidated. The present stud...

journal_title：Molecular medicine reports

authors： Du M,Su XM,Zhang T,Xing YJ

更新日期：2014-08-01 00:00:00

abstract：:Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. It has been reported that pyrrolidine dithiocarbamate (PDTC), an inhibi...

journal_title：Molecular medicine reports

authors： He X,Song Y,Wang L,Xu J

更新日期：2020-01-01 00:00:00