Abstract:
:β-amyloid (Aβ)-mediated neuronal apoptosis is an important pathological feature of Alzheimer's disease (AD). Inhibiting apoptosis induced by Aβ may lead to the development of a potential therapeutic target for AD treatment. κ‑carrageenan‑derived pentasaccharide (KCP) extracted from marine red algae is involved in a variety of biological activities and may be an effective in the treatment of AD. The present study aimed to investigate the neuroprotective effect of KCP against Aβ25‑35‑induced neurotoxicity in SH‑SY5Y cells, and to examine the potential underlying mechanisms. The results of the present study revealed that pretreatment with KCP significantly attenuated Aβ25‑35‑induced loss of cell viability and apoptosis, as evaluated by MTT assays and annexin V/propidium iodide staining, respectively, in a dose‑dependent manner. Furthermore, KCP downregulated the protein expression levels of Aβ25‑35‑induced cleavage caspase 3 by inhibiting the overactivation of the JNK signaling pathway. The results of the present study indicated that KCP attenuated Aβ25‑35‑induced neuroblastoma cell cytotoxicity, suggesting that KCP may be a potential therapeutic agent for the treatment of AD.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Liu Y,Jiang L,Li Xdoi
10.3892/mmr.2016.6006subject
Has Abstractpub_date
2017-01-01 00:00:00pages
285-290issue
1eissn
1791-2997issn
1791-3004journal_volume
15pub_type
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