Effects of apocynin on oxidative stress and expression of apoptosis-related genes in testes of diabetic rats.

abstract：:Inflammatory response is a major defense mechanism against pathogens and chemical or mechanical injury. Rhus verniciflua Stokes (RVS) has traditionally been used as an ingredient in East Asian medicine for the treatment of gastritis, stomach cancer and atherosclerosis. The aim of the current study was to analyze the e...

journal_title：Molecular medicine reports

authors： Choi HS,Seo HS,Kim SR,Choi YK,Jang BH,Shin YC,Ko SG

更新日期：2014-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of nano-microcapsule-basic fibroblast growth factor (bFGF) combined with hypoxia-inducible factor-1 (HIF-1) on the random skin flap survival of rats. Male Sprague-Dawley rats were used to establish the McFarlane flap model and subsequently, all model rats were randomly...

journal_title：Molecular medicine reports

authors： Chen GJ,Chen YH,Yang XQ,Li ZJ

更新日期：2016-02-01 00:00:00

abstract：:Benign thyroid nodules are among the most common endocrine disorders. Recent advances in diagnostic imaging and pathology have significantly contributed to better risk stratification of thyroid nodules. However, current treatment options, beyond surgical approaches are limited. The following placebo-controlled study p...

journal_title：Molecular medicine reports

authors： Stancioiu F,Mihai D,Papadakis GZ,Tsatsakis A,Spandidos DA,Badiu C

更新日期：2019-09-01 00:00:00

abstract：:An effective therapeutic strategy for suppressing liver fibrosis should improve the overall prognosis of patients with chronic liver diseases. Although enormous efforts are ongoing to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic agents for humans. Insulin resistance (IR) is reportedly...

journal_title：Molecular medicine reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Douhara A,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2012-02-01 00:00:00

abstract：:Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hu...

journal_title：Molecular medicine reports

authors： Du J,Wu X,Zhang H,Wang S,Tan W,Guo X

更新日期：2010-09-01 00:00:00

abstract：:Dehydrocostuslactone is a sesquiterpene lactone derived from Saussurea lappa, a plant used in traditional herbal medicines. The anti-proliferative activity of dehydrocostuslactone was investigated in human breast cancer (MDA-MB-231, MDA-MB-453 and SK-BR-3) and ovarian cancer (SK-OV-3 and OVCAR3) cell lines using the m...

journal_title：Molecular medicine reports

authors： Choi EJ,Kim GH

更新日期：2010-01-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a complex inherited cardiovascular disease. The present study investigated the long noncoding (lnc)RNA/microRNA (mi)RNA/mRNA expression pattern of patients with HCM and aimed to identify key molecules involved in the development of this condition. An integrated strategy was conduct...

journal_title：Molecular medicine reports

authors： Li J,Wu Z,Zheng D,Sun Y,Wang S,Yan Y

更新日期：2019-07-01 00:00:00

abstract：:Acupuncture has been demonstrated to be an effective treatment for various diseases. However, little attention has been paid to its physiological influences, especially on the changes in protein and mRNA levels following acupuncture treatment under normal conditions. In this study, we investigated the gene expression ...

journal_title：Molecular medicine reports

authors： Yin LM,Wang Y,Wang Y,Xu YD,Liu YY,Jin WR,Zhang QH,Yang YQ

更新日期：2012-08-01 00:00:00

abstract：:Low shear stress serves an important role in the initiation and progression of atherosclerotic lesions, with an impact on progression, but its detailed mechanisms are .not yet fully known. The present study aimed to investigate endothelial cell (EC) apoptosis, as well as monocyte adhesion induced by low shear stress a...

journal_title：Molecular medicine reports

authors： Xie X,Wang F,Zhu L,Yang H,Pan D,Liu Y,Qu X,Gu Y,Li X,Chen S

更新日期：2020-06-01 00:00:00

abstract：:Peripheral blood T lymphocytopenia has previously been identified in polymyositis/dermatomyositis (PM/DM) patients. Therefore, the present study aimed to examine the potential role of autophagy in peripheral blood T cell survival in PM/DM patients. Transmission electron microscopy was used to detect the formation of a...

journal_title：Molecular medicine reports

authors： Shu X,Chen F,Peng Q,Lu X,Tian X,Wang Y,Wang G

更新日期：2017-08-01 00:00:00

abstract：:The tumorigenesis and maintenance of a cancer cells is dependent upon the collaboration of multiple signaling pathways. Signal transducer and activator of transcription 3 (STAT3) and β-catenin are at the center of multiple cancer-associated signaling pathways; therefore, simultaneously targeting STAT3 and β-catenin ma...

journal_title：Molecular medicine reports

authors： Wang XH,Liu MN,Huang P,Xu J,Liu AY,Chen J,Lv CQ,Xu RL

更新日期：2015-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role ...

journal_title：Molecular medicine reports

authors： Zhu W,Zhuang P,Song W,Duan S,Xu Q,Peng M,Zhou J

更新日期：2017-10-01 00:00:00

abstract：:The dysregulation of renin-angiotensin system-signaling is a contributing factor to the development of atherosclerosis and cardiovascular disease. We studied the progression of angiotensin II (AngII)-induced arterial wall atherosclerosis after its induction. Atherosclerosis was accelerated in ApoE (-/-) C57B6 mice by ...

journal_title：Molecular medicine reports

authors： Cha J,Ivanov V,Ivanova S,Kalinovsky T,Rath M,Niedzwiecki A

更新日期：2010-07-01 00:00:00

abstract：:Inflammatory responses are vital in lung injury diseases, particularly acute respiratory distress syndrome (ARDS). Recombinant human brain natriuretic peptide (rhBNP) has been shown to exhibit anti‑inflammatory effects in vivo in our previous studies. The present study aimed to investigate the mechanisms underlying th...

journal_title：Molecular medicine reports

authors： Song Z,Zhao X,Liu M,Jin H,Cui Y,Hou M,Gao Y

更新日期：2016-08-01 00:00:00

abstract：:The present study aimed to identify the genes directly or indirectly correlated with the amplification of MYCN in neuroblastoma (NB). Microarray data (GSE53371) were downloaded from Gene Expression Omnibus, and included 10 NB cell lines with MYCN amplification and 10 NB cell lines with normal MYCN copy numbers. Differ...

journal_title：Molecular medicine reports

authors： Bao J,Qin L,Cui L,Wang X,Meng Q,Zhu L,Zhang S

更新日期：2015-11-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α)...

journal_title：Molecular medicine reports

authors： Zhang L,Liu J,Zhou F,Wang W,Chen N

更新日期：2018-03-01 00:00:00

abstract：:Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem ce...

journal_title：Molecular medicine reports

authors： Song K,Gu T,Shuang F,Tang J,Ren D,Qin J,Hou S

更新日期：2015-09-01 00:00:00

abstract：:Functional appliances correct dental malocclusion, partly by exerting an indirect mechanical stimulus on the condylar cartilage, initiating novel bone formation in the condyle. Angiopoietin is involved in the angiogenesis associated with novel bone formation. This study aimed to determine the expression of angiopoieti...

journal_title：Molecular medicine reports

authors： Jing Z,Gu Z,Feng J

更新日期：2013-10-01 00:00:00

abstract：:MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'‑untranslational region (UTR) of their target mRNAs. Deregulation of miR‑10b has been reported to be associated with chondrosarcoma. However, the role of miR‑10b in chondrosarcoma cell migration and invasion,...

journal_title：Molecular medicine reports

authors： Aili A,Chen Y,Zhang H

更新日期：2016-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and Angiotensin II (Ang-II) are important in glomerulosclerosis, which is one of the main causes of chronic kidney disease. Previous studies have demonstrated that angiotensin type 1 receptor blocker (ARB) can inhibit the synthesis of VEGF mediated by Ang‑II and can effectivel...

journal_title：Molecular medicine reports

authors： Liu X,Zhang H,Wang Q,Yu K,Wang R,Sun J

更新日期：2015-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are frequently dysregulated in human cancer and can act as either potent oncogenes or tumor suppressor genes. The aberrant expression of miRNA‑409 (miR‑409) has been found in certain types of cancer, however, its expression and potential biological role in endometrial cancer remain to be fully eluci...

journal_title：Molecular medicine reports

authors： Zhang C,Wang B,Wu L

更新日期：2019-01-01 00:00:00

abstract：:Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibrobla...

journal_title：Molecular medicine reports

authors： Zi F,He J,He D,Li Y,Yang L,Cai Z

更新日期：2015-05-01 00:00:00

abstract：:The aim of the study was to examine the expression of mammalian target of rapamycin (mTOR)/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol (Res) intervention. The mTOR and 70S6K in pathological scar and normal skin fibroblasts were detected by immunofluorescence following treatm...

journal_title：Molecular medicine reports

authors： Tang ZM,Zhai XX,Ding JC

更新日期：2017-05-01 00:00:00

abstract：:Brain metabolism is closely associated with neuronal activity and enables the accurate synthesis and function of neurotransmitters. Although previous studies have demonstrated that chronic stress is associated with the overproduction of reactive oxygen species (ROS), which leads to oxidative stress and the disruption ...

journal_title：Molecular medicine reports

authors： Herbet M,Natorska-Chomicka D,Korga A,Ostrowska M,Izdebska M,Gawrońska-Grzywacz M,Piątkowska-Chmiel I,Pawłowski K,Ślaska B,Poleszak E,Dudka J

更新日期：2019-03-01 00:00:00

abstract：:The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)‑induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antide...

journal_title：Molecular medicine reports

authors： Liu C,Wang J,Xu S,An S,Tang S,He J,Liu Y,Lee RJ,Wang D

更新日期：2017-08-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in...

journal_title：Molecular medicine reports

authors： Liu Y,Li F,Zhang L,Wu J,Wang Y,Yu H

更新日期：2017-11-01 00:00:00

abstract：:The β1‑adrenergic receptor (AR) is the primary β‑AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor β1 gene (Adrb1) promoter in the myocardium ...

journal_title：Molecular medicine reports

authors： Huang Y,Liu XL,Wen J,Huang LH,Lu Y,Miao RJ,Liu X,Li Y,Xing XW,Yuan H

更新日期：2017-02-01 00:00:00

abstract：:The present study aimed to identify potentially important biomarkers associated with polycystic ovary syndrome (PCOS) by integrating DNA methylation with transcriptome profiling. The transcription (E‑MTAB‑3768) and methylation (E‑MTAB‑3777) datasets were retrieved from ArrayExpress. Paired transcription and methylatio...

journal_title：Molecular medicine reports

authors： Liu L,He D,Wang Y,Sheng M

更新日期：2020-05-01 00:00:00

abstract：:Peripheral artery disease (PAD) is a common manifestation of atherosclerosis. A number of emerging risk factors, including oxidative stress biomarkers, free radicals and heat shock proteins, may add to the established risk factors for cardiovascular disease (CVD). The present study assessed surrogate markers of oxidat...

journal_title：Molecular medicine reports

authors： Signorelli SS,Li Volsi G,Fiore V,Mangiafico M,Barbagallo I,Parenti R,Rizzo M,Li Volti G

更新日期：2016-10-01 00:00:00

abstract：:Puerarin has attracted increasing attention because of its beneficial effects on anti‑osteoporosis, but the molecular mechanisms underlying its actions on osteoblasts are not fully understood. The current study aimed to investigate the effect of puerarin on the cell viability and differentiation of mouse MC3T3‑E1 oste...

journal_title：Molecular medicine reports

authors： Zhan XQ,Zeng XW,Zhang YY,Feng Q,Zhao FM,Jiang ZQ,Sun C

更新日期：2017-11-01 00:00:00