GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway.

abstract：:We have recently described an immune system-released activating agent (ISRAA) as a nervous system-induced factor that stimulates immune responses in the mouse spleen. However, the human ISRAA has not yet been identified. In this study, we examined the effects of the mouse ISRAA protein on human peripheral blood mononu...

journal_title：Molecular medicine reports

authors： Taha S,Fathallah MD,Bakhiet M

更新日期：2014-07-01 00:00:00

abstract：:Cochlear progenitor cells are considered as one of the best candidates for hair cell regeneration, thus, the regulation of cochlear progenitor cell proliferation has become a focus in this field. Several genes expressed in the inner ear during postnatal development have been demonstrated to be involved in maintaining ...

journal_title：Molecular medicine reports

authors： Song YL,Tian KY,Mi WJ,Ding ZJ,Qiu Y,Chen FQ,Zha DJ,Qiu JH

更新日期：2018-04-01 00:00:00

abstract：:Electroacupuncture (EA) has been documented as a form of therapy for chronic sinusitis (CRS). The present study aimed to assess the effects of EA combined with interleukin‑10 (IL‑10) overexpression on CRS in mice, and to investigate the associated mechanisms. A mouse model of CRS was established by the administration ...

journal_title：Molecular medicine reports

authors： Zhou L,Hong J,Wan Z,Lu X,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:The primary aim of the present study was to examine the effects of microRNA‑21 (miR‑21) on the proliferation and differentiation of rat primary neural stem cells (NSCs) in vitro. miR‑21 was overexpressed in NSCs by transfection with a miR‑21 mimic. The effects of miR‑21 overexpression on NSC proliferation were reveale...

journal_title：Molecular medicine reports

authors： Zhang WM,Zhang ZR,Yang XT,Zhang YG,Gao YS

更新日期：2018-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are critical to vascular smooth muscle cell migration in vivo. The dysregulation of MMPs is involved in the pathogenesis of abnormal arterial remodeling, aneurysm formation and atherosclerotic plaque instability. It has been confirmed that lipopolysa...

journal_title：Molecular medicine reports

authors： Li H,Xu H,Sun B

更新日期：2012-10-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMCs) are an important component of arterial walls, and their dysfunction may serve an important role in the development of cardiovascular diseases, including atherosclerosis and restenosis. Paeoniflorin (PF) is a principal component of the commonly used traditional Chinese medicine, peo...

journal_title：Molecular medicine reports

authors： Guo Y,Zhao Y,Li L,Wei X,Gao P,Zhou Y,Liu Y,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the most common fatty liver disease in developed countries, in which fat accumulation in the liver is induced by non‑alcoholic factors. The present study was conducted to identify NAFLD‑associated long non‑coding RNAs (lncRNAs), mRNAs and microRNAs (miRNAs). The microarray ...

journal_title：Molecular medicine reports

authors： Wu H,Song X,Ling Y,Zhou J,Tao Z,Shen Y

更新日期：2019-04-01 00:00:00

abstract：:SRY-box 9 (SOX9) is an important transcription factor required for development, which has additionally been reported to be an independent prognostic indicator for the survival of patients with non‑small cell lung cancer (NSCLC). Accumulating evidence has indicated that dysregulation of microRNAs (miRNAs/miRs) may cont...

journal_title：Molecular medicine reports

authors： Lei Z,Shi H,Li W,Yu D,Shen F,Yu X,Lu D,Sun C,Liao K

更新日期：2018-01-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a triterpenoid saponin isolated from the tuber of Bolbostemma paniculatum (Maxim) Franquet, serves an universal suppressive role in multiple cancer types, including lung cancer. However, the mechanism involved in non‑small cell lung cancer (NSCLC) cells by which TBMS1 elicits its antitumor effec...

journal_title：Molecular medicine reports

authors： Shi H,Bi H,Sun X,Dong H,Jiang Y,Mu H,Liu G,Kong W,Gao R,Su J

更新日期：2018-03-01 00:00:00

abstract：:Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the...

journal_title：Molecular medicine reports

authors： Huang F,Zhang RY,Song L

更新日期：2017-10-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of death and nervous system damage in neonates. The aim of the present study was to investigate the effect of the Toll‑like receptor 4 (TLR4) antagonist TAK‑242 on HIE. The Rice‑Vannucci method was used for ligation of the left common carotid art...

journal_title：Molecular medicine reports

authors： Jiang L,Xu Z,Li H,Wu M,Wang F,Liu S,Tao J,Feng X

更新日期：2020-08-01 00:00:00

abstract：:It has been reported that sevoflurane induces neurotoxicity in the developing brain. Dexmedetomidine is an α2 adrenoceptor agonist used for the prevention of sevoflurane‑induced agitation in children in clinical practice. The aim of the present study was to determine whether dexmedetomidine could prevent sevoflurane‑i...

journal_title：Molecular medicine reports

authors： Zhang Y,Li M,Cui E,Zhang H,Zhu X,Zhou J,Yan M,Sun J

更新日期：2021-01-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with a poor prognosis due to difficulties in early detection. The aims of the present study were to construct a recurrence risk prediction model and to reveal important OC genes or pathways. RNA sequencing data was obtained for 307 OC samples, and the corresponding clinical data were ...

journal_title：Molecular medicine reports

authors： Cheng L,Li L,Wang L,Li X,Xing H,Zhou J

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to evaluate the protein expression of the transmembrane translocase FAT/CD36 and cytoplasmic H-FABP and L-FABP in human trophoblast tissue and evaluate the effects of exogenous leptin upon differential expression of each biomolecule; consequently, it aimed to derive information regarding the ef...

journal_title：Molecular medicine reports

authors： Mousiolis AV,Kollia P,Skentou C,Messinis IE

更新日期：2012-02-01 00:00:00

abstract：:To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs ...

journal_title：Molecular medicine reports

authors： Chen QF,Xia JG,Li W,Shen LJ,Huang T,Wu P

更新日期：2018-12-01 00:00:00

abstract：:β-elemene, a plant-derived drug extracted from Curcuma wenyujin, has demonstrated marked antiproliferative effects on glioblastoma, while toxicity remains low. However, the underlying molecular mechanisms of the antitumor activity of β-elemene remain to be elucidated. Previously, it was identified that the glia matura...

journal_title：Molecular medicine reports

authors： Zhu TZ,Li XM,Luo LH,Xu YH,Cao P,Liu Y,Liang GB

更新日期：2014-08-01 00:00:00

abstract：:Caudal type homeobox transcription factor 2 (CDX2) is important in intestinal cell fate specification and multiple lines of evidence have substantiated that CDX2 is important in carcinogenesis of the digestive tract. The CDX2 regulatory network is intricate and remains to be fully elucidated in gastric cancer. The aim...

journal_title：Molecular medicine reports

authors： Wei W,Li L,Wang X,Yan L,Cao W,Zhan Z,Zhang X,Yu H,Xie Y,Xiao Q

更新日期：2015-07-01 00:00:00

abstract：:The aim of the present study was to investigate the molecular mechanism of nasopharyngeal carcinoma (NPC) primary tumor development through the identification of key genes using bioinformatics approaches. Using the GSE53819 microarray dataset, acquired from the Gene Expression Omnibus database, differentially expresse...

journal_title：Molecular medicine reports

authors： An F,Zhang Z,Xia M

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs...

journal_title：Molecular medicine reports

authors： Hu J,Yue X,Liu J,Kong D

更新日期：2018-12-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present study developed a dendrimer‑based protein biochip for rapid, sensitive ...

journal_title：Molecular medicine reports

authors： Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

更新日期：2020-12-01 00:00:00

abstract：:Different sources of mesenchymal stem cells (MSCs) may differ in their biological characteristics, which are important for their clinical application. In the present study, MSCs were isolated from human exfoliated deciduous teeth (SHED), bone marrow, gingival tissue and umbilical cord tissue, and their biological char...

journal_title：Molecular medicine reports

authors： Li J,Xu SQ,Zhao YM,Yu S,Ge LH,Xu BH

更新日期：2018-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurological disorder that results from brain cell death; however, not all brain regions are simultaneously affected to the same extent. Despite single biomarkers for AD having been determined on a genome‑wide scale, the differential co‑expression in gene pairs betwe...

journal_title：Molecular medicine reports

authors： Yu L,Qian S,Wei S

更新日期：2018-08-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress plays a key role in the development of neurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF) is a natural drug derived from isothiocyanate found in cruciferous vegetables. Although there are reports indicating that SF is ...

journal_title：Molecular medicine reports

authors： Deng C,Tao R,Yu SZ,Jin H

更新日期：2012-07-01 00:00:00

abstract：:Mineralized bone matrix constituted with collagenous and non-collagenous proteins was synthesized by osteoblasts differentiated from mesenchymal stem cells. Secretory leukocyte protease inhibitor (SLPI), a serine protease inhibitor, promotes cell migration and proliferation, and suppresses the inflammatory response. R...

journal_title：Molecular medicine reports

authors： Choi BD,Lee SY,Jeong SJ,Lim DS,Cha HJ,Chung WG,Jeong MJ

更新日期：2016-08-01 00:00:00

abstract：:Molecular biologists have identified a number of genes and microRNAs (miRs) associated with chronic myelogenous leukemia (CML). However, their underlying mechanisms in CML remain unclear. In the present study, three regulatory networks of genes and miRs were constructed to elucidate the underlying mechanisms of CML. T...

journal_title：Molecular medicine reports

authors： Wang K,Xu Z,Wang N,Tian Y,Sun X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:Hydroxyapatite scaffolds (HASs) are widely studied as suitable materials for bone replacement scaffolds due to their chemical similarities to organic materials. In our previous study, a novel HAS with a 25‑30‑µm groove structure (HAS‑G) exhibited enhanced osteogenesis of bone mesenchymal stromal cells (BMSCs) compared...

journal_title：Molecular medicine reports

authors： Li C,Yang L,Ren X,Lin M,Shen D,Li Y,Zhang X,Liu C,Mu Y

更新日期：2020-10-01 00:00:00

abstract：:The present study aimed to evaluate the effects of Krüppel‑like factor 2 (KLF2) on the differentiation of endothelial progenitor cells (EPCs) to endothelial cells (ECs) induced by shear stress, and to investigate the corresponding mechanisms. Cultured rat late EPCs were exposed to shear stress (12 dyn/cm2) for differe...

journal_title：Molecular medicine reports

authors： Chu HR,Sun YC,Gao Y,Guan XM,Yan H,Cui XD,Zhang XY,Li X,Li H,Cheng M

更新日期：2019-03-01 00:00:00

abstract：:Diabetes has been identified to be a risk factor for Alzheimer's disease (AD). Vildagliptin, a novel oral hypoglycemic agent, has been demonstrated to exert protective effects on the pancreas and cardiovascular system. The present study examined the potential protective effects of vildagliptin on neurons in an AD rat ...

journal_title：Molecular medicine reports

authors： Ma QH,Jiang LF,Mao JL,Xu WX,Huang M

更新日期：2018-03-01 00:00:00

abstract：:The mechanisms underlying cancer radioresistance remain unclear. Several studies have found that increased glucose transporter‑1 (GLUT‑1) expression is associated with radioresistance. Recently, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway was reported to be involved in the control of GLUT‑1...

journal_title：Molecular medicine reports

authors： Fang J,Zhou SH,Fan J,Yan SX

更新日期：2015-03-01 00:00:00

abstract：:Elevated plasma homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is an independent risk factor for neurodegenerative diseases. Hcy, even at a low concentration, can promote free radical formation and increase oxidative stress, leading to neuronal death, which may be an important mechanism underlying the patho...

journal_title：Molecular medicine reports

authors： Tian X,Gong L,Jin A,Wang Y,Zhou X,Tan Y

更新日期：2019-09-01 00:00:00