Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis.


:To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs were identified, including 1,803 upregulated and 42 downregulated genes. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein‑protein interaction (PPI) network analyses were performed. It was identified that the 'cell cycle' and 'progesterone‑mediated oocyte maturation' KEGG pathways were significantly enriched in the DEGs. In addition, the high expression of the hub genes from the PPI network (including cyclin dependent kinase 1, cyclin B1, cyclin B2, mitotic arrest deficient 2 like 1, BUB1 mitotic checkpoint serine/threonine kinase and cyclin A2; P=0.00116, 0.00021, 0.04889, 0.00222, 0.00015 and 0.00647, respectively) was associated with a decrease in overall survival for patients with HCC as identified using survival and expression data from The Cancer Genome Atlas. The identified hub genes and pathways may help to elucidate the molecular mechanisms of HCC progression from HBV‑positive liver cirrhosis. Additionally, they may be useful as therapeutic targets or serve as novel biomarkers for HCC prognosis prediction.


Mol Med Rep


Chen QF,Xia JG,Li W,Shen LJ,Huang T,Wu P




Has Abstract


2018-12-01 00:00:00












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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Gao Q,Ren H,Chen M,Niu Z,Tao H,Jia Y,Zhang J,Li W

    更新日期:2016-11-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Huang X,Li Y,He X,Chen Y,Wei W,Yang X,Ma K

    更新日期:2020-11-01 00:00:00

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    abstract::An increasing amount of evidence indicates that the inhibition of β adrenergic signaling can result in the inhibition of tumor growth. However, the role of propranolol in liver cancer and the underlying mechanism remain to be elucidated. The present study aimed to investigate the role of propranolol in liver cancer ce...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang F,Liu H,Wang F,Xu R,Wang P,Tang F,Zhang X,Zhu Z,Lv H,Han T

    更新日期:2018-04-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zuo Y,Yang D,Yu Y,Xiang M,Li H,Yang J,Li J,Jiang D,Zhou H,Xu Z,Yu Z

    更新日期:2018-03-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Yang Y,Zhao Y,Liu X,Chen Y,Liu P,Zhao L

    更新日期:2017-12-01 00:00:00

  • Protection against acute radiation-induced lung injury: a novel role for the anti-angiogenic agent Endostar.

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhang K,Yang S,Zhu Y,Mo A,Zhang D,Liu L

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    pub_type: 杂志文章


    authors: Yao J,Lu Y,Zhi M,Hu P,Wu W,Gao X

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    pub_type: 杂志文章


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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Yoon C,Koppula S,Yoo S,Yum M,Kim J,Lee J,Song M

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Magishi N,Yuikawa N,Kobayashi M,Taniuchi S

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    pub_type: 杂志文章


    authors: Li Q,Ma Y,Li L,Bao J,Zhang L

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章,评审


    authors: Zou J,Lei T,Guo P,Yu J,Xu Q,Luo Y,Ke R,Huang D

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu DL,Bu HQ,Jin HM,Zhao JF,Li Y,Huang H

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    pub_type: 杂志文章


    authors: Mueller CE,Birk R,Kramer B,Wenzel A,Sommer JU,Hörmann K,Stern-Straeter J,Weilbach C

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Diao YM,Hong J

    更新日期:2015-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

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    pub_type: 杂志文章


    authors: Zhao H,Zhao H,Xia X,Liu X

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    pub_type: 杂志文章


    authors: Hui H,Ma W,Cui J,Gong M,Wang Y,Zhang Y,He T,Bi Y,He Y

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    pub_type: 杂志文章


    authors: Jiang L,Wang Y,Zhu D,Xue Z,Mao H

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    pub_type: 杂志文章


    authors: Pan Y,Zhong S,Hu RM,Gong W

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    pub_type: 杂志文章


    authors: Xiang T,Ge S,Wen J,Xie J,Yang L,Wu X,Cheng N

    更新日期:2018-12-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Huang QY,Li XF,Liu SP

    更新日期:2012-03-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Du YX,Ye L,Song ZJ,Lv H,Liu Q,Li SG,Liu SS,Hong J,Gao Y,Schneider ME,Du WD

    更新日期:2020-12-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Song M,Zeng Q,Xiang Y,Gao L,Huang J,Huang J,Wu K,Lu J

    更新日期:2018-02-01 00:00:00

  • Differential long non‑coding RNA and mRNA expression in differentiated human glioblastoma stem cells.

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Li H,Li H,Hao Y,Jiao Y,Li Z,Yue H,Xu Z,Wang S,Cao Y,Zhao J

    更新日期:2016-09-01 00:00:00

  • Modulators of microglia activation and polarization in ischemic stroke (Review).

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Jiang CT,Wu WF,Deng YH,Ge JW

    更新日期:2020-05-01 00:00:00

  • miR‑494‑BAG‑1 axis is involved in cinobufacini‑induced cell proliferation and apoptosis in gastric cancer.

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Shen Z,Li Y,Zhao C,Wang F,Zhou R,Chen G

    更新日期:2018-05-01 00:00:00

  • Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts.

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Fukuda K,Miura Y,Maeda T,Hayashi S,Kurosaka M

    更新日期:2016-04-01 00:00:00

  • Grb2-associated binder 2 expression and its roles in uveal melanoma invasion.

    abstract::Uveal melanoma (UM) is characterized by high metastasis and poor prognosis. A more improved understanding of the metastatic mechanism in UM cells is essential for the design of molecular therapy. Grb2‑associated binder 2 (Gab2) has been reported to serve important roles in the progression of various types of human can...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Chen M,Li Y,Sun X,Zhang B,Li W,Wang S,Zhu X,Li F,Shi L

    更新日期:2017-10-01 00:00:00