Examining the key genes and pathways in hepatocellular carcinoma development from hepatitis B virus‑positive cirrhosis.


:To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs were identified, including 1,803 upregulated and 42 downregulated genes. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein‑protein interaction (PPI) network analyses were performed. It was identified that the 'cell cycle' and 'progesterone‑mediated oocyte maturation' KEGG pathways were significantly enriched in the DEGs. In addition, the high expression of the hub genes from the PPI network (including cyclin dependent kinase 1, cyclin B1, cyclin B2, mitotic arrest deficient 2 like 1, BUB1 mitotic checkpoint serine/threonine kinase and cyclin A2; P=0.00116, 0.00021, 0.04889, 0.00222, 0.00015 and 0.00647, respectively) was associated with a decrease in overall survival for patients with HCC as identified using survival and expression data from The Cancer Genome Atlas. The identified hub genes and pathways may help to elucidate the molecular mechanisms of HCC progression from HBV‑positive liver cirrhosis. Additionally, they may be useful as therapeutic targets or serve as novel biomarkers for HCC prognosis prediction.


Mol Med Rep


Chen QF,Xia JG,Li W,Shen LJ,Huang T,Wu P




Has Abstract


2018-12-01 00:00:00












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    abstract::Cnidium monnieri (L.) Cusson is a frequently used traditional Chinese medicine that treats gynecological diseases and carbuncles. However, the mechanism of action of C. monnieri remains to be fully elucidated. The present study examined the cell cycle arrest and apoptotic effects resulting from ethanol extract of C. m...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Lim EG,Kim GT,Kim BM,Kim EJ,Kim SY,Kim YM

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang L,Liu Y,Song J

    更新日期:2018-03-01 00:00:00

  • BmK CT and 125I-BmK CT suppress the invasion of glioma cells in vitro via matrix metalloproteinase-2.

    abstract::Chlorotoxin (CTX) is an established blocker of small‑conductance Cl‑ channels and has previously been demonstrated to inhibit the invasion of glioma cells. Buthus martensii Karsch chlorotoxin‑like toxin (BmK CT) is the first chlorotoxin-like peptide. The present study aimed to determine the inhibitory effect of BmK CT...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Sun N,Zhao L,Qiao W,Xing Y,Zhao J

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    journal_title:Molecular medicine reports

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    authors: Chen L,Cheng MM,Li YP,Lin SF,Zheng QH,Liu QY

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  • NORAD regulates epithelial‑mesenchymal transition of non‑small cell lung cancer cells via miR‑422a.

    abstract::The poor prognosis of non‑small cell lung cancer (NSCLC) is related to epithelial‑mesenchymal transition (EMT). Recent studies demonstrated that non‑coding RNA activated by DNA damage (NORAD) displays a carcinogenic effect and targets microRNA (miR)‑422a, which may be involved in tumor cell migration and invasion. The...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Chen Z,Che Q,Xie C

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Lv XF,Hong HQ,Liu L,Cui SH,Ren CC,Li HY,Zhang XA,Zhang LD,Wei TX,Liu JJ,Xing WY,Fu H,Yan SJ

    更新日期:2018-07-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Jin X,Xu Z,Fan R,Wang C,Ji W,Ma Y,Cai W,Zhang Y,Yang N,Zou S,Zhou X,Li Y

    更新日期:2017-09-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


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    更新日期:2018-01-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zheng YJ,Xu WP,Ding G,Gao YH,Wang HR,Pan SM

    更新日期:2016-01-01 00:00:00

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    journal_title:Molecular medicine reports

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    authors: Jeong SO,Son Y,Lee JH,Cheong YK,Park SH,Chung HT,Pae HO

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    authors: Luo L,Li Y,Yang Y,He Y,Wang Y,Xu Z,Zhang Y

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    pub_type: 杂志文章


    authors: Wang B,Xu H,Li J,Gao HM,Xing YH,Lin Z,Li HJ,Wang YQ,Cao SH

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    pub_type: 杂志文章


    authors: Wu D,Qian T,Hong J,Li G,Shi W,Xu J

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Jiang CY,Wang W

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    pub_type: 杂志文章


    authors: Wang MM,Lu M,Zhang CL,Wu X,Chen JX,Lv WW,Sun T,Qiu H,Huang SH

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    pub_type: 杂志文章


    authors: Yang X,Cui Y,Yang F,Sun C,Gao X

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Ying S,He J,Yu M,Zhang Y,Deng S,Zhang L,Xie M,Hu S

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    abstract::Long non‑coding RNAs (lncRNAs) are a novel group of non‑coding RNAs that are associated with inflammation and tumorigenesis. At present, the diagnostic efficacy of lncRNAs in inflammatory bowel disease (IBD) is unclear. The present study aimed to identify lncRNAs that may be used as potential biomarkers for IBD. The m...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang S,Hou Y,Chen W,Wang J,Xie W,Zhang X,Zeng L

    更新日期:2018-02-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Bai YQ,Feng JK,Zhang QF,Wu HZ,Du YR,Wei W

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    abstract::To evaluate the effect of melatonin supplementation in maturation medium for human 'rescue IVM' and investigate differences in transcriptomic profile of blastocysts developed from oocytes matured in vitro with/without melatonin treatment and in vivo, a total of 314 GV oocytes and 320 MI oocytes were collected from 200...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Hao Y,Zhang Z,Han D,Cao Y,Zhou P,Wei Z,Lv M,Chen D

    更新日期:2017-08-01 00:00:00

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    abstract::Stroke is a leading cause of impairment and disability worldwide, and motor imagery (MI) has been used in stroke rehabilitation. Electroencephalography (EEG) has been used to study MI. However, the characteristic features of EEG during MI in stroke patients have not been established. The purpose of this study was to i...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Gong W,Zhang T,Shan L

    更新日期:2013-12-01 00:00:00

  • Long non-coding RNA RP5-833A20.1 inhibits proliferation, metastasis and cell cycle progression by suppressing the expression of NFIA in U251 cells.

    abstract::Early reports suggest that nuclear factor IA (NFIA) is important in the pathogenesis of glioma. Our previous study demonstrated that the long non‑coding RNA (lncRNA), RP5‑833A20.1, suppressed the expression of NFIA in THP‑1 macrophage-derived foam cells. However, the effect and possible mechanism of RP5‑833A20.1 on gl...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Kang CM,Hu YW,Nie Y,Zhao JY,Li SF,Chu S,Li HX,Huang QS,Qiu YR

    更新日期:2016-12-01 00:00:00

  • MG132 reverse the malignant characteristics of hypopharyngeal cancer.

    abstract::In order to reverse the malignant characteristics of hypopharyngeal cancer, the proteasome inhibitor MG132 was introduced into FaDu/T cells and the mechanisms underlying its effects were investigated. The multi-drug resistance (MDR) sensitivities of FaDu/T and FaDu/T-MG132 cancer cells to several chemotherapeutics wer...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Ma J,Yu L,Tian J,Mu Y,Lv Z,Zou J,Li J,Wang H,Xu W

    更新日期:2014-06-01 00:00:00

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    abstract::Glucocorticoid receptor (GR) function is essential for glucocorticoid action on various effector cells. The aim of the present study was to investigate the mRNA expression profiles of GRα and GRβ in peripheral blood mononuclear cells (PBMC) and examine the association between the expression levels of the GR isoforms a...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Mei B,Chen Y,Liu W,Li L,Wang C

    更新日期:2015-03-01 00:00:00

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    abstract::Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PD...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章,meta分析


    authors: Zheng B,Peng J,Mollayup A,Bakri A,Guo L,Zheng J,Xu H

    更新日期:2018-01-01 00:00:00

  • Angiotensin II promotes differentiation of mouse c-kit-positive cardiac stem cells into pacemaker-like cells.

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Xue C,Zhang J,Lv Z,Liu H,Huang C,Yang J,Wang T

    更新日期:2015-05-01 00:00:00

  • hNTCP‑expressing primary pig hepatocytes are a valuable tool for investigating hepatitis B virus infection and antiviral drugs.

    abstract::Primary human hepatocytes (PHHs) are the 'gold standard' for investigating hepatitis B virus (HBV) infection and antiviral drugs. However, poor availability, variation between batches and ethical issues regarding PHHs limit their applications. The discovery of human sodium taurocholate co‑transporting polypeptide (hNT...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhou M,Qin B,Deng XS,Zeng XL,Lu Y,Huang ZG,Wu CC,Mou LS

    更新日期:2019-10-01 00:00:00

  • 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells.

    abstract::Protein 4.1N (4.1N) is a member of the protein 4.1 family and is essential for the regulation of cell adhesion, motility and signaling. Previous studies have suggested that 4.1N may serve a tumor suppressor role. However, the molecular mechanisms remain unclear. In the current study, the role of 4.1N in the downregula...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhang L,Hu A,Li M,Zhang H,Ren C,An X,Liu C

    更新日期:2016-01-01 00:00:00

  • Icariside II ameliorates myocardial ischemia and reperfusion injury by attenuating inflammation and apoptosis through the regulation of the PI3K/AKT signaling pathway.

    abstract::Icariside II (ICAII) is a bioflavonoid compound which has demonstrated anti‑oxidative, anti‑inflammatory and anti‑apoptotic biological activities. However, to the best of our knowledge, whether ICAII can alleviate myocardial ischemia and reperfusion injury (MIRI) remains unknown. The aim of the present study was to de...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Guan BF,Dai XF,Huang QB,Zhao D,Shi JL,Chen C,Zhu Y,Ai F

    更新日期:2020-10-01 00:00:00

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Li Y,Hou X,Qi Q,Wang L,Luo L,Yang S,Zhang Y,Miao Z,Zhang Y,Wang F,Wang H,Huang W,Wang Z,Shen Y,Wang Y

    更新日期:2014-01-01 00:00:00