Effects of leptin on the expression of fatty acid-binding proteins in human placental cell cultures.

abstract：:Advances in the treatment of nasopharyngeal carcinoma (NPC) have significantly improved the local control rate; however, distant metastasis remains a principal cause of mortality. Previous studies have demonstrated that the expression levels of amyloid β precursor protein (APP) are increased in NPC. The present study ...

journal_title：Molecular medicine reports

authors： Xu J,Ying Y,Xiong G,Lai L,Wang Q,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among females and the adenosine triphosphate (ATP) binding cassette E1 (ABCE1) gene is a member of the ATP‑binding cassette (ABC) family. Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis. However, little...

journal_title：Molecular medicine reports

authors： Huang B,Zhou H,Lang X,Liu Z

更新日期：2014-10-01 00:00:00

abstract：:Graft‑vs.‑host disease (GvHD) is a major and lethal complication of allogeneic bone marrow transplantation (allo‑BMT). Although great development has been made, the treatment progress of this disorder is slow. Research has illustrated that STAT3 was critical for T cell alloactivation in GvHD. In the present study, the...

journal_title：Molecular medicine reports

authors： Jia H,Cui J,Jia X,Zhao J,Feng Y,Zhao P,Zang D,Yu J,Zhao T,Wang H,Xu K

更新日期：2017-12-01 00:00:00

abstract：:In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

journal_title：Molecular medicine reports

authors： Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

更新日期：2017-01-01 00:00:00

abstract：:Ilexonin A is a compound isolated from the root of a plant commonly used in traditional Chinese medicine. The aim of the present study was to investigate the possible protective mechanism of Ilexonin A in rats subjected to occlusion of the middle cerebral artery (MCAO). Transient focal cerebral ischemia was induced by...

journal_title：Molecular medicine reports

authors： Xu AL,Zheng GY,Wang ZJ,Chen XD,Jiang Q

更新日期：2016-04-01 00:00:00

abstract：:Protein 4.1N (4.1N) is a member of the protein 4.1 family and is essential for the regulation of cell adhesion, motility and signaling. Previous studies have suggested that 4.1N may serve a tumor suppressor role. However, the molecular mechanisms remain unclear. In the current study, the role of 4.1N in the downregula...

journal_title：Molecular medicine reports

authors： Zhang L,Hu A,Li M,Zhang H,Ren C,An X,Liu C

更新日期：2016-01-01 00:00:00

abstract：:In order to gain greater understanding of the mechanisms underlying the effect of epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in oral squamous cell carcinoma (OSCC), a genome‑wide methylation and mRNA expression screen was performed in the CAL‑27 cell line with and without EGC...

journal_title：Molecular medicine reports

authors： Chen LL,Han WF,Geng Y,Su JS

更新日期：2015-10-01 00:00:00

abstract：:The β1‑adrenergic receptor (AR) is the primary β‑AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor β1 gene (Adrb1) promoter in the myocardium ...

journal_title：Molecular medicine reports

authors： Huang Y,Liu XL,Wen J,Huang LH,Lu Y,Miao RJ,Liu X,Li Y,Xing XW,Yuan H

更新日期：2017-02-01 00:00:00

abstract：:The pathogenesis of hepatocellular carcinoma (HCC) is thought to involve the interaction of numerous genes. Identification of these genes and proteins which regulate liver carcinogenesis is critical for the exploration of novel targeted therapies. Yes‑associated protein (YAP) and large tumor suppressor 1 (LATS1) are a...

journal_title：Molecular medicine reports

authors： Wang C,Zhu ZM,Liu CL,He XJ,Zhang HY,Dong JH

更新日期：2015-06-01 00:00:00

abstract：:Human amniotic epithelial cells (hAECs) have recently been recognized as a potential source of stem cells. The present study was designed to investigate the effects of mechanical stretch on the osteogenic differentiation of hAECs. As it has been previously reported that the physical environment is an important factor ...

journal_title：Molecular medicine reports

authors： Luan F,Ma K,Mao J,Yang F,Zhang M,Luan H

更新日期：2018-12-01 00:00:00

abstract：:Erythropoietin (EPO) has been shown to be neuroprotective in various models of neuronal injury. The aim of the present study was to investigate the beneficial effect of recombinant human EPO (rhEPO) following intracerebral hemorrhage (ICH) and the underlying molecular and cellular mechanisms. ICH was induced using aut...

journal_title：Molecular medicine reports

authors： Yu Z,Tang L,Chen L,Li J,Wu W,Hu C

更新日期：2013-11-01 00:00:00

abstract：:A limited number of studies have revealed that adding kidneys to liver perfusion may maintain an improved physiological balance; however, the underlying mechanism remains to be elucidated. The preset study confirmed the protective role of this new model and investigated the underlying mechanisms. Methods: A total of 1...

journal_title：Molecular medicine reports

authors： Li J,Jia J,He N,Jiang L,Yu H,Li H,Peng Y,Xie H,Zhou L,Zheng S

更新日期：2019-08-01 00:00:00

abstract：:The splicing factor is important in cancer development, modulation numerous tumor suppressors and oncogenes, and regulation of multiple signaling pathways. Splicing factor 2/alternative splicing factor (SF2/ASF) is a proto‑oncogene, which has been implicated in the development of hepatocellular carcinoma. However, the...

journal_title：Molecular medicine reports

authors： Zhao Y,Zhu T,Zhang X,Wang Q,Zhang J,Ji W,Ma Y

更新日期：2015-09-01 00:00:00

abstract：:B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...

journal_title：Molecular medicine reports

authors： Jia R,Jiao Z,Xu X,Wang J,Zhou Y,Song X,Ge S,Fan X

更新日期：2011-01-01 00:00:00

abstract：:Quantitative polymerase chain reaction (qPCR) analysis is a commonly used method for the study of mRNA expression throughout the field of mesenchymal stem cell (MSC) research. This technology is simple and sensitive; however the results may vary significantly due to the use of various reference genes (RGs) as normaliz...

journal_title：Molecular medicine reports

authors： Li X,Yang Q,Bai J,Yang Y,Zhong L,Wang Y

更新日期：2015-02-01 00:00:00

abstract：:Prostate cancer (PCa) is the second most common cancer amongst males worldwide. In the current study, microarray datasets GSE3325 and GSE6919 from the Gene Expression Omnibus database were screened to identify candidate genes that are associated with the progression of PCa. A total of 273 differentially expressed gene...

journal_title：Molecular medicine reports

authors： Li S,Hou J,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Lipoid proteinosis (LP) is a rare form of dermatosis with autosomal recessive inheritance. The present study hypothesized that an extracellular matrix protein 1 (ECM1) gene mutation forms the pathological basis of LP. The association between ECM1 mutation and LP; however, requires further investigation and was thus in...

journal_title：Molecular medicine reports

authors： Gao D,Ma X,Lian P,Zhou S,Chen J

更新日期：2018-06-01 00:00:00

abstract：:Clara cell protein (CC16) is an anti-inflammatory protein, which is expressed in the airway epithelium. It is involved in the development of airway inflammatory diseases, including chronic obstructive pulmonary disease and asthma. However, the exact molecular mechanism underlying its anti‑inflammatory action remains t...

journal_title：Molecular medicine reports

authors： Pang M,Bai XY,Li Y,Bai JZ,Yuan LR,Ren SA,Hu XY,Zhang XR,Yu BF,Guo R,Wang HL

更新日期：2016-11-01 00:00:00

abstract：:Early reports suggest that nuclear factor IA (NFIA) is important in the pathogenesis of glioma. Our previous study demonstrated that the long non‑coding RNA (lncRNA), RP5‑833A20.1, suppressed the expression of NFIA in THP‑1 macrophage-derived foam cells. However, the effect and possible mechanism of RP5‑833A20.1 on gl...

journal_title：Molecular medicine reports

authors： Kang CM,Hu YW,Nie Y,Zhao JY,Li SF,Chu S,Li HX,Huang QS,Qiu YR

更新日期：2016-12-01 00:00:00

abstract：:Macrophage cholesterol efflux is important in maintaining cellular lipid homeostasis and preventing the formation of lipid‑laden foam cells. Although radioactive [3H]‑cholesterol is widely used as a tracer in cholesterol efflux assays, the lengthy and labor‑intensive assay procedure, and the radioactivity disposal pro...

journal_title：Molecular medicine reports

authors： Song W,Wang W,Wang Y,Dou L,Chen L,Yan X

更新日期：2015-10-01 00:00:00

abstract：:The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B and ZHX2, all of which are ...

journal_title：Molecular medicine reports

authors： Wang J,Liu D,Liang X,Gao L,Yue X,Yang Y,Ma C,Liu J

更新日期：2013-11-01 00:00:00

abstract：:The primary effect of the endoplasmic reticulum (ER) stress response or unfolded protein response (UPR) is to reduce the load of unfolded protein and promote survival. However, prolonged and severe ER stress leads to tissue injury and serious diseases. Thus, it is important to identify drugs that can attenuate ER stre...

journal_title：Molecular medicine reports

authors： Qin HS,Yu PP,Sun Y,Wang DF,Deng XF,Bao YL,Song J,Sun LG,Song ZB,Li YX

更新日期：2016-06-01 00:00:00

abstract：:MicroRNAs (miRs) are considered to be effective, post‑transcriptional regulators in the pathophysiology of type 2 diabetes (T2D) and promising treatment targets. However, the function of miR‑141 remains to be elucidated. In the present study, upregulation of miR‑141 was demonstrated in diabetic mice and elderly diabet...

journal_title：Molecular medicine reports

authors： Yu X,Zhong L

更新日期：2018-06-01 00:00:00

abstract：:In the present study, the expression of microRNA (miR)‑671‑3p in non‑small‑cell lung cancer (NSCLC) was detected via reverse transcription‑quantitative polymerase chain reaction analysis, and its role in cell proliferation, apoptosis, migration and invasion was investigated via Cell Counting Kit‑8, colony formation, f...

journal_title：Molecular medicine reports

authors： Li ZY,Zhang ZZ,Bi H,Zhang QD,Zhang SJ,Zhou L,Zhu XQ,Zhou J

更新日期：2019-10-01 00:00:00

abstract：:Derivatives of caffeoylquinic acid (CQA) have been studied and reported as potent bioactive molecules possessing various health benefits including antioxidant and anti‑inflammatory activities. In the present study, the protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid (DCEQA) isolated from Atriplex gmelinii on UVB‑i...

journal_title：Molecular medicine reports

authors： Oh JH,Karadeniz F,Lee JI,Seo Y,Kong CS

更新日期：2019-07-01 00:00:00

abstract：:CD44 is closely linked to breast cancer progression; however, the regulatory functions of microRNAs (miRs) in breast cancer have yet to be fully elucidated. In order to investigate the regulation of CD44 by miRs in breast cancer, the present study isolated CD44+ and CD44- breast cancer cells by flow cytometry, reveali...

journal_title：Molecular medicine reports

authors： Yang Z,Chen D,Nie J,Zhou S,Wang J,Tang Q,Yang X

更新日期：2016-06-01 00:00:00

abstract：:Full‑thickness and large area defects of articular cartilage are unable to completely repair themselves and require surgical intervention, including microfracture, autologous or allogeneic osteochondral grafts, and autologous chondrocyte implantation. A large proportion of regenerative cartilage exists as fibrocartila...

journal_title：Molecular medicine reports

authors： Li Z,Fei H,Wang Z,Zhu T

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of high mobility group protein B1 (HMGB1), which is expressed in the serum of patients with sepsis, on vascular endothelial permeability. Sera from patients with sepsis were used to treat endothelial cells (ECs), and the effect on endothelial permeability was...

journal_title：Molecular medicine reports

authors： Zheng YJ,Xu WP,Ding G,Gao YH,Wang HR,Pan SM

更新日期：2016-01-01 00:00:00

abstract：:Osteosarcoma is the most common type of primary malignant tumor of the bone. However, mechanisms underlying osteosarcoma cell proliferation are poorly understood. The present study shows that RBEL1, a newly identified Rab-like GTPase, may be a key regulator of osteosarcoma cell proliferation. Knockdown of RBEL1 in ost...

journal_title：Molecular medicine reports

authors： Tang H,Ji F,Sun J,Xie Y,Xu Y,Yue H

更新日期：2016-02-01 00:00:00

abstract：:Dbl-family guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, which are significantly associated with tumorigenesis and metastasis. The catalytic ability of the Dbl-family GEFs to activate Rho GTPases depends on their Dbl-homology domain followed by a pleckstrin-homology domain. In the...

journal_title：Molecular medicine reports

authors： Wang H,Li Y,Wang Y,Han ZG,Cai B

更新日期：2012-05-01 00:00:00