Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis.

abstract：:The present study aimed to determine the potential molecular mechanisms underlying p21 (RAC1)‑activated kinase 7 (PAK7) expression in glioblastoma (GBM) and evaluate candidate prognosis biomarkers for GBM. Gene expression data from patients with GBM, including 144 tumor samples and 5 normal brain samples, were downloa...

journal_title：Molecular medicine reports

authors： Wang X,Liu S,Shao Z,Zhang P

更新日期：2020-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL)-induced macrophage pyroptosis is critical in atherosclerosis inflammation and plaque instability. It has been reported that mitochondrial (mt)DNA-depleted (rho0) cells demonstrate resistance to apoptosis. However, little is known about the susceptibility of rho0 cells to Ox-LD...

journal_title：Molecular medicine reports

authors： Yan H,Li Y,Peng X,Huang D,Gui L,Huang B

更新日期：2016-05-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PA) is a leading cause of adult cancer mortality, and surgery is still the best available treatment strategy. However, PA can recur at any time and has limited prognosis. It is therefore necessary to explore novel serum biomarkers of PA to allow the early diagnosis of PA. Soluble a-prolifera...

journal_title：Molecular medicine reports

authors： Han L,Zhang W,Song F,Guo Y,Guo K,Zhou W

更新日期：2014-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miR‑222 has been revealed to play important roles in various physiological and pathological process...

journal_title：Molecular medicine reports

authors： Bai YY,Niu JZ

更新日期：2020-03-01 00:00:00

abstract：:The aim of the present study was to investigate the combination of certain serological markers (Forns' index; FI), FibroScan® and acoustic radiation force impulse elastography (ARFI) in the assessment of liver fibrosis in patients with hepatitis B, and to explore the impact of inflammatory activity and steatosis on th...

journal_title：Molecular medicine reports

authors： Dong DR,Hao MN,Li C,Peng Z,Liu X,Wang GP,Ma AL

更新日期：2015-06-01 00:00:00

abstract：:Obesity has a negative effect on ovarian functions, which is reported to increase the risk of infertility. The mechanism underlying obesity‑induced infertility is not yet clear. The present study established a high‑fat diet (HFD)‑induced obesity mouse model to elucidate the mechanisms underlying the effect of HFD‑indu...

journal_title：Molecular medicine reports

authors： Wu Y,Zhang Z,Liao X,Qi L,Liu Y,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Low‑density lipoprotein receptors (LDLRs) may serve a role in the diabetogenic effect of statins; however, the effects of statins on LDLR expression and its regulation in the pancreas and islets have yet to be determined. To exclude the long‑term effects of treatment with atorvastatin, which allows mice to adapt, male...

journal_title：Molecular medicine reports

authors： Yu Q,Wang F,Meng X,Gong Y,Wang Y,Xu C,Wang S

更新日期：2018-09-01 00:00:00

abstract：:Mossy fiber sprouting (MFS) is a pathological phenomenon that is commonly observed in temporal lobe epilepsy (TLE). However, the molecular mechanisms underlying MFS remain unclear. It has been demonstrated that the tau protein is important in the progression of MFS by the regulation of microtubule dynamics and axonal ...

journal_title：Molecular medicine reports

authors： Huang WJ,Tian FF,Chen JM,Guo TH,Ma YF,Fang J,Dang J,Song MY

更新日期：2013-11-01 00:00:00

abstract：:Neural stem cells (NSCs) have the potential to give rise to offspring cells and hypoxic injury can impair the function of NSCs. The present study investigated the effects of mesenchymal stem cell (MSC)‑derived extracellular vesicles (EVs) on NSC injury, as well as the underlying mechanisms. MSC‑EVs were isolated and i...

journal_title：Molecular medicine reports

authors： Li F,Zhang J,Liao R,Duan Y,Tao L,Xu Y,Chen A

更新日期：2020-11-01 00:00:00

abstract：:Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticanc...

journal_title：Molecular medicine reports

authors： Dexheimer GM,Becker Delving LKO,de Oliveira HS,Biolchi V,Goettert MI,Pozzobon A

更新日期：2017-05-01 00:00:00

abstract：:The early diagnosis of acute rejection is crucial for graft survival after kidney transplantation. The interferon-γ (IFNγ)-CXCR3-chemokine-dependent inflammatory loop plays a pivotal role in the recruitment of T lymphocytes during acute rejection. Previously published studies have typically focused on the CXCR3 recept...

journal_title：Molecular medicine reports

authors： Huang H,Xu X,Yao C,Cai M,Qian Y,Wang X,Shi B

更新日期：2014-01-01 00:00:00

abstract：:The interaction between the host and human cytomegalovirus (HCMV) is important in determining the outcome of a viral infection. The HCMV RL13 gene product exerts independent, inhibitory effects on viral growth in fibroblasts and epithelial cells. At present, there are few reports on the interactions between the HCMV R...

journal_title：Molecular medicine reports

authors： Wang G,Ren G,Cui X,Lu Z,Ma Y,Qi Y,Huang Y,Liu Z,Sun Z,Ruan Q

更新日期：2016-03-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades its own long-lived proteins and damaged organelles. Ataxia telangiectasia mutated (ATM) has recently been shown to upregulate the process of autophagy. Previous studies showed...

journal_title：Molecular medicine reports

authors： Qased AB,Yi H,Liang N,Ma S,Qiao S,Liu X

更新日期：2013-02-01 00:00:00

abstract：:Nuclear respiratory factor 1 (NRF-1) has important roles in the regulation of several key metabolic genes required for cellular growth and respiration. A previous study by our group indicated that NRF‑1 is involved in mitochondrial dysfunction induced by the environmental pollutant benzo[a]pyrene in the 16HBE human br...

journal_title：Molecular medicine reports

authors： Wu J,Wang Y,Wo D,Zhang L,Li J

更新日期：2016-05-01 00:00:00

abstract：:Due to the rising abuse of ketamine usage in recent years, ketamine‑induced urinary tract syndrome has received increasing attention. The present study aimed to investigate the molecular mechanism underlying ketamine‑associated cystitis in a mouse model. Female C57BL/6 mice were randomly divided into two groups: One g...

journal_title：Molecular medicine reports

authors： Shen CH,Wang ST,Wang SC,Lin SM,Lin LC,Dai YC,Liu YW

更新日期：2019-04-01 00:00:00

abstract：:Circular RNAs (circRNAs) are class of endogenous RNAs that have a role in the regulation of gene expression. The present study aimed to investigate the diagnostic value and role of circRNA in the pathogenesis of leukoaraiosis (LA). The present study performed Arraystar Human circRNA Array analysis of 6 samples from LA...

journal_title：Molecular medicine reports

authors： Mi T,Luo C,Hu Y,Qu C,Wang X,Guo S,Du Y

更新日期：2017-09-01 00:00:00

abstract：:Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent. The present meta‑analysis aimed to evaluate the precise result by searching the PubMed databas...

journal_title：Molecular medicine reports

authors： Tian GX,Zeng XT,Wang XB,Zhang L,Zhang W,Wei WL

更新日期：2013-04-01 00:00:00

abstract：:Although imatinib is effective in chronic myeloid leukemia treatment, imatinib resistance due to the T315I mutation and/or other mutations is a challenge to be overcome. However, how DNA mutation occurs, particularly the T315I mutation, remains unclear. In the current study, the mutagenesis of BCR‑ABL was analyzed via...

journal_title：Molecular medicine reports

authors： Dong Y,Gao X,Zhao Y,Wei M,Xu L,Yang G,Liu L

更新日期：2017-12-01 00:00:00

abstract：:The primary aim of the present study was to examine the effects of microRNA‑21 (miR‑21) on the proliferation and differentiation of rat primary neural stem cells (NSCs) in vitro. miR‑21 was overexpressed in NSCs by transfection with a miR‑21 mimic. The effects of miR‑21 overexpression on NSC proliferation were reveale...

journal_title：Molecular medicine reports

authors： Zhang WM,Zhang ZR,Yang XT,Zhang YG,Gao YS

更新日期：2018-01-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role ...

journal_title：Molecular medicine reports

authors： Zhu W,Zhuang P,Song W,Duan S,Xu Q,Peng M,Zhou J

更新日期：2017-10-01 00:00:00

abstract：:An abundance of studies has demonstrated that disruption of circadian rhythms is one of the factors that may contribute to the initiation and development of human colorectal carcinomas (CRCs). Recently, microRNA‑124 has been demonstrated to suppress tumor growth or metastasis of CRCs. However, the mechanisms of cross‑...

journal_title：Molecular medicine reports

authors： Yu JZ,Sun N,Bei YB,Li XB,Lu C,Hua LC

更新日期：2017-09-25 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. MicroRNAs (miRNAs) are a group of endogenous small non‑coding RNAs that regulate target genes, and play a critical role in many biological processes. However, the underlying mechanism of specific miRNA, miR‑130a‑3p, in AS remains largely unknown....

journal_title：Molecular medicine reports

authors： Li F,Si D,Guo X,Guo N,Li D,Zhang L,Jian X,Ma J

更新日期：2019-10-01 00:00:00

abstract：:Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. However, its effect on proliferation and clinical parameters in HCC require further elucidation. The present study aimed to investigate LOXL2 expression in HCC from in vitro and clinical asp...

journal_title：Molecular medicine reports

authors： Wu L,Zhang Y,Zhu Y,Cong Q,Xiang Y,Fu L

更新日期：2016-09-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore considered a drug discovery target for IBD. The well‑known traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent for t...

journal_title：Molecular medicine reports

authors： Fang W,Zhao P,Shen A,Liu L,Chen H,Chen Y,Peng J,Sferra TJ,Sankararaman S,Luo Y,Ke X

更新日期：2021-03-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:The present study investigated the effect of certain 1,3,5‑triazine derivatives on epidermal growth factor receptor‑tyrosine kinase (EGFR‑TK). The results suggested that 1,3,5‑triazine derivatives exhibited optimal drug likeness via molinspiration and proved to be effective drug candidates as potential anticancer agen...

journal_title：Molecular medicine reports

authors： Yan W,Zhao Y,He J

更新日期：2018-11-01 00:00:00

abstract：:B cells are critically important for the pathogenesis of IgA nephropathy (IgAN). The present study aimed to investigate the abundance of B cell activating factor (BAFF), which belongs to the tumor necrosis factor superfamily, in the peripheral blood of patients with IgAN. The different forms of BAFF in peripheral bloo...

journal_title：Molecular medicine reports

authors： Zheng N,Fan J,Wang B,Wang D,Feng P,Yang Q,Yu X

更新日期：2017-04-01 00:00:00

abstract：:Androgens are essential for the development of the prostate and prostate cancer. We examined androgen-regulated gene expression in the human prostate. Samples from benign and malignant prostate tissue and samples containing prostate tissue obtained from prostate cancer patients thre...

journal_title：Molecular medicine reports

authors： Vaarala MH,Hirvikoski P,Kauppila S,Paavonen TK

更新日期：2012-09-01 00:00:00

abstract：:The p38 pathway, which is important in mitogen-activated protein kinase (MAPK) family protein signaling, leads to mitochondrial dysfunction and activation of caspase-3. B-cell lymphoma 2 (Bcl‑2) family members are involved in the regulation of activities associated with the survival and death of neurons through apopto...

journal_title：Molecular medicine reports

authors： Liu XW,Ji EF,He P,Xing RX,Tian BX,Li XD

更新日期：2014-10-01 00:00:00