Resistance of mitochondrial DNA-depleted cells against oxidized low-density lipoprotein-induced macrophage pyroptosis.

abstract：:Cryoinjury, or injury caused by extremely low temperatures, can occur in corneal endothelial cells (CECs) and lead to visual impairment. However, the mechanism of cryoinjury in CECs is not clear. The Stk11‑p53 signaling pathway regulates the proliferation and division of cells. Activity of the Stk11‑p53 signaling path...

journal_title：Molecular medicine reports

authors： Zhao S,Fei X,Liu T,Liu Y

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to investigate the potential effect of hematoporphyrin monomethyl ether-sonodynamic therapy (HMME-SDT) on MG-63 osteosarcoma cells. The HMME concentration was kept constant at 20 µg/ml and the MG-63 osteosarcoma cell line was exposed to ultrasound with an intensity of 1.0 W/cm2 for 30 ...

journal_title：Molecular medicine reports

authors： Liu X,Li W,Geng S,Meng QG,Bi ZG

更新日期：2015-07-01 00:00:00

abstract：:microRNAs (miRNAs) have been reported to be involved in various human diseases. They may have uses in diagnosis and as therapeutic targets, thus the discovery of novel miRNAs has the potential to provide clinical tools or shed light on novel mechanisms. In the current study, miR‑107 was revealed to be downregulated in...

journal_title：Molecular medicine reports

authors： Ruan J,Liu X,Xiong X,Zhang C,Li J,Zheng H,Huang C,Shi Q,Weng Y

更新日期：2015-02-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:Subsequent to the publication of the above paper, the authors have realized that there were errors in Fig. 1 on page 902; essentially, the experimental data described as being 'Preterm' and 'Infected preterm' should have been labelled as 'Full‑term without labor' and 'Preterm', respectively. Note that these errors in ...

journal_title：Molecular medicine reports

authors： Chen J,Zheng D,Cui H,Liu S,Zhang L,Liu C

更新日期：2018-04-01 00:00:00

abstract：:MicroRNA (miR)-22 has previously been reported to be frequently downregulated in certain types of cancer. The present study examined the expression and effects of miR-22 in renal cell carcinoma (RCC). The results indicated that miR‑22 was downregulated in tumor tissue from patients with RCC. In addition, lower miR‑22 ...

journal_title：Molecular medicine reports

authors： Fan W,Huang J,Xiao H,Liang Z

更新日期：2016-06-01 00:00:00

abstract：:Radix Salviae miltiorrhizae (SM) and Lignum Dalbergiae odoriferae (DO) are traditional Chinese medicinal herbs used to treat ischemic heart disease and other cardiovascular diseases; however, to the best of our knowledge, there are currently few studies regarding their effects. The present study aimed to investigate t...

journal_title：Molecular medicine reports

authors： Mu F,Duan J,Bian H,Yin Y,Zhu Y,Wei G,Guan Y,Wang Y,Guo C,Wen A,Yang Y,Xi M

更新日期：2017-08-01 00:00:00

abstract：:Ubiquitin‑specific‑processing protease 34 (USP34) is a deubiquitinase that is involved in the pathogenesis of various cancers. Its roles in diffuse large B‑cell lymphoma (DLBCL) are unknown. The present study aimed to determine the level of USP34 expression and to explore its association with clinicopathological featu...

journal_title：Molecular medicine reports

authors： Li C,Huang L,Lu H,Wang W,Chen G,Gu Y,Zhou Q,Peng Z,Feng Z

更新日期：2018-11-01 00:00:00

abstract：:Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative, anti-inflammatory and immunoregulatory bioactivities. The present study was performed to examine the effect of quercetin on hu...

journal_title：Molecular medicine reports

authors： Chen FY,Cao LF,Wan HX,Zhang MY,Cai JY,Shen LJ,Zhong JH,Zhong H

更新日期：2015-01-01 00:00:00

abstract：:A subset of cancer stem cells termed 'side population' (SP) cells has been identified in several types of solid tumor and is known to be responsible for the failure of chemotherapy and for cancer relapse. In the present study, the oral squamous cell carcinoma (OSCC) cell line SCC‑55 was used for analysis of the SP cel...

journal_title：Molecular medicine reports

authors： Liu Y,Cui P,Chen J,Li W

更新日期：2015-05-01 00:00:00

abstract：:Tilianin, the main effective flavonoid monomer enriched from Dracocephalum moldavuca L., has been shown to have cardioprotective effects. However, the mechanism of tilianin cardioprotection remains largely unknown. The present study aimed to investigate the effects of tilianin preconditioning on myocardial ischemia/re...

journal_title：Molecular medicine reports

authors： Guo X,Cao W,Yao J,Yuan Y,Hong Y,Wang X,Xing J

更新日期：2015-03-01 00:00:00

abstract：:Glucocorticoids (GCs) are important stress hormones, which are used as a concomitant medication during malignant tumor chemotherapy. Clinical and preclinical studies have linked GCs to melanoma growth and progression. However, the effects and mechanism of action of GCs on the adhesion and survival of melanoma cells ar...

journal_title：Molecular medicine reports

authors： Huang GX,Qi MF,Li XL,Tang F,Zhu L

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to examine the status and clinical significance of cluster of differentiation (CD) 19+CD24highCD38high regulatory B cells (Bregs), serum interleukin (IL)‑10, serum transforming growth factor (TGF)‑β and IL‑10 receptor (IL‑10R) expression in peripheral blood from patients with systemic lupus ery...

journal_title：Molecular medicine reports

authors： Wang T,Li Z,Li X,Chen L,Zhao H,Jiang C,Song L

更新日期：2017-11-01 00:00:00

abstract：:Obesity may induce end‑organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the present study was to define the roles of autophagy and mitophagy in high fat diet (HFD)‑induced cardiomyopathy. Male, 8 week‑old C57BL/6 mice were fed either a...

journal_title：Molecular medicine reports

authors： Che Y,Wang ZP,Yuan Y,Zhang N,Jin YG,Wan CX,Tang QZ

更新日期：2018-09-01 00:00:00

abstract：:Liver-intestine cadherin (LI-cadherin), a novel member of the cadherin family, has been associated with the ability of a tumor to acquire an aggressive phenotype in several types of cancer. However, the exact function of LI-cadherin in the process of tumor invasion and metastasis remains predominantly unknown. To expl...

journal_title：Molecular medicine reports

authors： Yu Q,Shen W,Zhou H,Dong W,Gao D

更新日期：2016-05-01 00:00:00

abstract：:Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compres...

journal_title：Molecular medicine reports

authors： Cui W,Wang H,Cheng Y,Ma X,Lei Y,Ruan X,Shi L,Lv M

更新日期：2019-01-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major impediment to cancer therapy. MG‑132 has been identified to be effective against MDR in several types of cancer. However, the mechanism of MG‑132 in head and neck squamous cell carcinomas remains unknown. Based on our previous study, the present detected P‑gp and P‑gp expression i...

journal_title：Molecular medicine reports

authors： Ma J,Lv Z,Liu X,Liu X,Xu W

更新日期：2018-08-01 00:00:00

abstract：:Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may generate different quantities of sonosensitizer, protoporphyrin IX (...

journal_title：Molecular medicine reports

authors： Li N,Sun M,Wang Y,Lv Y,Hu Z,Cao W,Zheng J,Jiao X

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present was to evaluate the effects of DNA methylation and histone acetylation on 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD)‑induced cleft palate in fetal mice. Pregnant mice (n=10) were randomly divided into two groups: i) TCDD group, mice were treated with 28 µg/kg TCDD on gestation day (GD) 10 by ora...

journal_title：Molecular medicine reports

authors： Yuan X,Qiu L,Pu Y,Liu C,Zhang X,Wang C,Pu W,Fu Y

更新日期：2016-08-01 00:00:00

abstract：:This study investigated the role of microRNA-21 (miR-21) and microRNA-24 (miR-24) in the pathological processes that follow cerebral ischemic injury and examined the potential use of miR-21 and -24 in stroke diagnostics as sensitive plasma biomarkers. An oxygen-glucose deprivation (OGD) model was constructed using mou...

journal_title：Molecular medicine reports

authors： Zhou J,Zhang J

更新日期：2014-08-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non‑coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogen...

journal_title：Molecular medicine reports

authors： Tao R,Li YX,Liu YK,Liu F,Zhou ZY

更新日期：2019-04-01 00:00:00

abstract：:Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a perm...

journal_title：Molecular medicine reports

authors： Perletti G,Skerk V,Magri V,Markotic A,Mazzoli S,Parnham MJ,Wagenlehner FM,Naber KG

更新日期：2011-11-01 00:00:00

abstract：:Pseudomonas aeruginosa continues to be a predominant cause of infections with high intrinsic resistance to antibiotics, resulting in treatment failure. P. aeruginosa is the leading cause of respiratory infections among cystic fibrosis (CF) patients. Resistance to carbapenem antibiotics among P. aeruginosa has been rep...

journal_title：Molecular medicine reports

authors： Li Y,Zhang X,Wang C,Hu Y,Niu X,Pei D,He Z,Bi Y

更新日期：2015-01-01 00:00:00

abstract：:Vitiligo is a polygenic autoimmune disorder characterized by loss of pigmentation due to melanocyte destruction. Hydroxychloroquine (HCQ) is an effective immunosuppressant widely used in the treatment of autoimmune disorders. As generalized vitiligo (GV) is commonly considered to be a T cell and autoantibody-induced i...

journal_title：Molecular medicine reports

authors： Li DG,Hu WZ,Ma HJ,Liu W,Yang QQ,Zhao G

更新日期：2016-08-01 00:00:00

abstract：:Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), le...

journal_title：Molecular medicine reports

authors： Kim HS,Park JW,Kwon OK,Kim JH,Oh SR,Lee HK,Bach TT,Quang BH,Ahn KS

更新日期：2014-04-01 00:00:00

abstract：:Rhus javanica Linn, a traditional medicinal herb from the family Anacardiaceae, has been used in the treatment of liver diseases, cancer, parasitic infections, malaria and respiratory diseases in China, Korea and other Asian countries for centuries. In the present study, the protective effects of R. javanica ethanolic...

journal_title：Molecular medicine reports

authors： Yoon C,Koppula S,Yoo S,Yum M,Kim J,Lee J,Song M

更新日期：2016-01-01 00:00:00

abstract：:Inflammation is a potent promoter of tumor metastasis. The aim of the present study was to explore the function of systemic inflammation in the formation of lung metastasis of breast cancer cells in a mouse model. BALB/c mice were injected intraperitoneally with lipopolysaccharide (LPS) in order to establish an inflam...

journal_title：Molecular medicine reports

authors： Li S,Xu X,Jiang M,Bi Y,Xu J,Han M

更新日期：2015-06-01 00:00:00

abstract：:The present study aimed to compare the expression levels of excitatory amino acid transporters (EAATs) and growth status of piglets weaned at 10‑20 days after birth with suckling piglets. A total of 40 hybrid piglets (Landrace x Large White x Duroc) born to 40 different sows, with similar body weight were selected for...

journal_title：Molecular medicine reports

authors： Wang QJ,Cui YZ,Zhang XY,Su J

更新日期：2017-11-01 00:00:00

abstract：:The mortality rate of ovarian cancer is the highest of all gynecological malignancies. Telmisartan is a commonly used clinical angiotensin receptor blocker, which has antihypertensive, anti‑inflammatory and antithrombotic effects. In the present study, it was investigated whether telmisartan could exert anticancer eff...

journal_title：Molecular medicine reports

authors： Pu Z,Zhu M,Kong F

更新日期：2016-01-01 00:00:00