MYBL2 protects against H9c2 injury induced by hypoxia via AKT and NF‑κB pathways.

abstract：:B cells are critically important for the pathogenesis of IgA nephropathy (IgAN). The present study aimed to investigate the abundance of B cell activating factor (BAFF), which belongs to the tumor necrosis factor superfamily, in the peripheral blood of patients with IgAN. The different forms of BAFF in peripheral bloo...

journal_title：Molecular medicine reports

authors： Zheng N,Fan J,Wang B,Wang D,Feng P,Yang Q,Yu X

更新日期：2017-04-01 00:00:00

abstract：:Growing evidence indicates that cyclin dependent kinases regulatory subunit 2 (CKS2) serves an essential role in the regulation of multiple cellular processes in diverse human cancer types. The present study investigated the contribution of CKS2 to breast cancer (BC) progression. In the present study, CKS2 expression ...

journal_title：Molecular medicine reports

authors： Huang N,Wu Z,Hong H,Wang X,Yang F,Li H

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to determine the profile of differentially expressed circular RNAs (circRNAs) in infertile patients treated with acupuncture and moxibustion and verify the role of acupuncture and moxibustion in altering endometrial receptivity (ER). High‑throughput RNA sequencing and bioinformatics analysis of...

journal_title：Molecular medicine reports

authors： Shen J,Chen L,Cheng J,Jin X,Mu Y,Li Q,Xia L,Gao Y,Xia Y

更新日期：2019-08-01 00:00:00

abstract：:In the last 30 years, the 5-year-survival rate of patients with osteosarcoma has not improved as a result of the low prevalence and large tumor heterogeneity. Therefore, the development of novel drugs for the treatment of osteosarcoma is urgently required. The present study aimed to identify potential novel drugs for ...

journal_title：Molecular medicine reports

authors： Zou Y,Yang J,Jiang D

更新日期：2015-11-01 00:00:00

abstract：:Cardiomyopathies have been indicated to be one of the leading causes of heart failure. Though it was indicated that genetic defects, viral infection and trace element deficiency were among the causes of cardiomyopathy, the etiology has remained to be fully elucidated. Cardiomyocytes require large amounts of energy to ...

journal_title：Molecular medicine reports

authors： Liu Z,Cai H,Dang Y,Qiu C,Wang J

更新日期：2016-02-01 00:00:00

abstract：:Radix Polygalae is a traditional Chinese medicine that has been used as a sedative and to improve memory for a number of years. The impact of Radix Polygalae in patients with Alzheimer's disease has been investigated. However the mechanisms underlying its effects remain unclear. In the current study, the toxicity of v...

journal_title：Molecular medicine reports

authors： Zhao H,Wang ZC,Wang KF,Chen XY

更新日期：2015-08-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:Glucocorticoids (GCs) are important stress hormones, which are used as a concomitant medication during malignant tumor chemotherapy. Clinical and preclinical studies have linked GCs to melanoma growth and progression. However, the effects and mechanism of action of GCs on the adhesion and survival of melanoma cells ar...

journal_title：Molecular medicine reports

authors： Huang GX,Qi MF,Li XL,Tang F,Zhu L

更新日期：2018-02-01 00:00:00

abstract：:Isoniazid (INH) is a drug extensively used as a prophylactic and therapeutic agent for human tuberculosis (TB). INH is metabolized by the enzymatic activity of N-acetyltransferase 2 (NAT2). Human NAT2, encoded by a highly polymorphic gene, is involved in the biotransformation of xenobiotics, including drugs and certai...

journal_title：Molecular medicine reports

authors： Díaz-Molina R,Cornejo-Bravo JM,Ramos-Ibarra MA,Estrada-Guzmán JD,Morales-Arango O,Reyes-Báez R,Robinson-Navarro OM,Soria-Rodríguez CG

更新日期：2008-11-01 00:00:00

abstract：:Previous studies have indicated that interleukin (IL)‑1β has an important role in the development of allergic diseases. Therefore, the present study aimed to investigate the upstream pathway underlying IL‑1β production in an experimental model of allergy. BALB/c mice (female, 6‑8 weeks old) were sensitized to recombin...

journal_title：Molecular medicine reports

authors： Nouri HR,Karkhah A,Mohammadzadeh I,Sankian M

更新日期：2016-04-01 00:00:00

abstract：:Platelet‑rich plasma (PRP) is a promising strategy for intervertebral disc degeneration (IDD). However, the short half‑life of growth factors released from PRP cannot continuously stimulate the degenerated discs. Thus, the present study hypothesized that the combined use of PRP and bone marrow‑derived mesenchymal stem...

journal_title：Molecular medicine reports

authors： Wang SZ,Jin JY,Guo YD,Ma LY,Chang Q,Peng XG,Guo FF,Zhang HX,Hu XF,Wang C

更新日期：2016-04-01 00:00:00

abstract：:Sulforaphane (SFN) is a naturally occurring chemopreventive agent, which effectively inhibits proliferation of HepG2 human hepatocellular carcinoma cells via mitochondria‑mediated apoptosis. Endoplasmic reticulum stress is considered the most important cause of cell apoptosis; therefore, the present study aimed to det...

journal_title：Molecular medicine reports

authors： Zou X,Qu Z,Fang Y,Shi X,Ji Y

更新日期：2017-01-01 00:00:00

abstract：:The present study aimed to reveal the underlying mechanism of angiotensin II (AngII)‑induced cardiac remodeling and to identify potential therapeutic targets for prevention. Rat cardiac fibroblasts (CFs) were cultured with 10 nM AngII for 12 h, and CFs without AngII were used as the control. Following RNA isolation fr...

journal_title：Molecular medicine reports

authors： Shu J,Liu Z,Jin L,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Chronic administration of D‑galactose (D‑gal) is a useful method for establishing a model of natural aging in the auditory system. Previous studies have demonstrated that NADPH oxidases (NOXs) may be an important source of reactive oxygen species (ROS) in the peripheral auditory system (PAS) and cause an increase in m...

journal_title：Molecular medicine reports

authors： Du Z,Yang Q,Zhou T,Liu L,Li S,Chen S,Gao C

更新日期：2014-12-01 00:00:00

abstract：:Hepatic fibrosis (HF), one of the leading global health problems, is defined as aberrant and excess production of extracellular matrix components. The pathogenesis of HF is complex and poorly understood. Long non‑coding RNAs (LncRNAs) can interact with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) to regula...

journal_title：Molecular medicine reports

authors： Jiang H,Wu F,Jiang N,Gao J,Zhang J

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs...

journal_title：Molecular medicine reports

authors： Hu J,Yue X,Liu J,Kong D

更新日期：2018-12-01 00:00:00

abstract：:The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 ...

journal_title：Molecular medicine reports

authors： Jia G,Zao M,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

journal_title：Molecular medicine reports

authors： Song B,Zhang H,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pa...

journal_title：Molecular medicine reports

authors： Chen PL,Wang WJ,Rao YQ,Li J,Cheng MJ

更新日期：2018-04-01 00:00:00

abstract：:Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

journal_title：Molecular medicine reports

authors： Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

更新日期：2017-06-01 00:00:00

abstract：:β-amyloid (Aβ)-mediated neuronal apoptosis is an important pathological feature of Alzheimer's disease (AD). Inhibiting apoptosis induced by Aβ may lead to the development of a potential therapeutic target for AD treatment. κ‑carrageenan‑derived pentasaccharide (KCP) extracted from marine red algae is involved in a va...

journal_title：Molecular medicine reports

authors： Liu Y,Jiang L,Li X

更新日期：2017-01-01 00:00:00

abstract：:Human forkhead box P3 (FOXP3)+ cluster of differentiation (CD)25+CD4+ regulatory T cells (Tregs) are a type of T cell that express CD4, CD25 and FOXP3, which are critical for maintaining immune homeostasis. The present study aimed to determine the mechanisms underlying Treg function. The GSE11292 dataset was downloade...

journal_title：Molecular medicine reports

authors： Bai X,Shi H,Yang M,Wang Y,Sun Z,Xu S

更新日期：2018-03-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMCs) are an important component of arterial walls, and their dysfunction may serve an important role in the development of cardiovascular diseases, including atherosclerosis and restenosis. Paeoniflorin (PF) is a principal component of the commonly used traditional Chinese medicine, peo...

journal_title：Molecular medicine reports

authors： Guo Y,Zhao Y,Li L,Wei X,Gao P,Zhou Y,Liu Y,Yang H

更新日期：2017-12-01 00:00:00

abstract：:The aim of this study was to evaluate the feasibility and safety of porcine Descemet's membrane (DM) as a carrier for the generation of tissue-engineered corneal endothelium by analyzing porcine endogenous retroviruses (PERVs) and the α-gal epitope. The morphology of porcine and human DM was observed by hematoxylin an...

journal_title：Molecular medicine reports

authors： Diao YM,Hong J

更新日期：2015-08-01 00:00:00

abstract：:Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemo...

journal_title：Molecular medicine reports

authors： Kim JH,Jeon WY,Lee MY,Seo CS,Lim HS,Shin HK

更新日期：2014-12-01 00:00:00

abstract：:microRNA‑34a (miRNA‑34a) plays an important role in the pathogenesis of leukemia. This study aimed to explore its role in the proliferation of HL‑60 cells and the correlation with some of its predicted target genes: the cyclin‑dependent kinase 4 (CDK4), the oncogene MYB and the silent information regulator 1 (SIRT1). ...

journal_title：Molecular medicine reports

authors： Tang R,Li J,Yue M,Liu Z,Feng S,Tang S,Wang T

更新日期：2014-04-01 00:00:00

abstract：:The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported ...

journal_title：Molecular medicine reports

authors： Xu CW,Cai XY,Shao Y,Li Y,Shi MW,Zhang LY,Wang L,Zhang YP,Wang LP,Tian YW

更新日期：2015-09-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of mesenchymal stem cell (MSC) therapy in combination with p38 mitogen‑activated protein (MAPK) inhibition against myocardial infarction (MI) injury in rats, and to elucidate the underlying mechanisms. An MI model was established by ligation of the anterior ...

journal_title：Molecular medicine reports

authors： Zhang Z,Zhou S,Mei Z,Zhang M

更新日期：2017-09-01 00:00:00

abstract：:Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), le...

journal_title：Molecular medicine reports

authors： Kim HS,Park JW,Kwon OK,Kim JH,Oh SR,Lee HK,Bach TT,Quang BH,Ahn KS

更新日期：2014-04-01 00:00:00