Evodiamine inhibits PDGF‑BB‑induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress.

abstract：:The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following the onset of symptoms. Inflammation is one of the main mechanisms of autoimmune disorders and is a common feature of se...

journal_title：Molecular medicine reports

authors： Li T,Zhang J,Feng J,Li Q,Wu L,Ye Q,Sun J,Lin Y,Zhang M,Huang R,Cheng J,Cao Y,Xiang G,Zhang J,Wu Q

更新日期：2013-06-01 00:00:00

abstract：:The oral fluoropyrimidine S-1 has marked efficacy in treating metastatic colorectal cancer patients. In the present study, we explored the therapeutic potential of combined in vivo treatment in the human colon cancer cell lines COL-1, KM12C and KM20C with consecutive oral S-1 and leucovorin (LV) in 2-week therapeutic ...

journal_title：Molecular medicine reports

authors： Tsukioka S,Uchida J,Tsujimoto H,Nakagawa F,Sugimoto Y,Oka T,Kiniwa M

更新日期：2009-05-01 00:00:00

abstract：:Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staphylococcus aureus (MRSA), is a challenge in clinical practice. Ozone therapy ha...

journal_title：Molecular medicine reports

authors： Song M,Zeng Q,Xiang Y,Gao L,Huang J,Huang J,Wu K,Lu J

更新日期：2018-02-01 00:00:00

abstract：:Macrophages are involved in the progression of atherosclerosis by releasing pro-inflammatory cytokines. High levels of interleukin (IL)-18 are associated with an increased risk of developing diabetes and atherosclerosis. The present study aimed to investigate the association between IL-18, and high and fluctuating glu...

journal_title：Molecular medicine reports

authors： Zhang C,Bi Y,Jin G,Gan H,Yu L

更新日期：2015-08-01 00:00:00

abstract：:As well-known regulators of gene expression, microRNAs (miRNAs) are important not only in cell proliferation and differentiation, but also in tumorigenesis and organ development. It has been estimated that miRNAs may be responsible for regulating the expression of almost one third of the human genome. Simultaneously, ...

journal_title：Molecular medicine reports

authors： Kan Q,Ding S,Yang Y,Zhou X

更新日期：2015-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL)-induced macrophage pyroptosis is critical in atherosclerosis inflammation and plaque instability. It has been reported that mitochondrial (mt)DNA-depleted (rho0) cells demonstrate resistance to apoptosis. However, little is known about the susceptibility of rho0 cells to Ox-LD...

journal_title：Molecular medicine reports

authors： Yan H,Li Y,Peng X,Huang D,Gui L,Huang B

更新日期：2016-05-01 00:00:00

abstract：:Repair of cartilage defects remains a challenge for surgeons, owing to its poor self‑repairing capacity. Cartilage tissue engineering, particularly marrow stem cell‑based cartilage regeneration, provides a promising option for the regeneration of damaged cartilage. Although producing tissue‑engineered cartilage from m...

journal_title：Molecular medicine reports

authors： Zhang X,Xue K,Zhou J,Xu P,Huang H,Liu K

更新日期：2015-10-01 00:00:00

abstract：:Insulin resistance is associated with a poor prognosis in non‑alcoholic fatty liver disease (NAFLD) patients. Isomaltulose, a naturally‑occurring disaccharide, is reported to improve glucose and lipid metabolisms in obese patients. The present study aimed to investigate the effects of isomaltulose on insulin resistanc...

journal_title：Molecular medicine reports

authors： Kawaguchi T,Nakano D,Oriishi T,Torimura T

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to investigate the protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase (iNOS) and inflammation in a mouse model of myocardial ischemia/reperfusion injury (MIRI). In addition, the study aimed to determine its underlying mechanisms. A mouse model of MIRI was us...

journal_title：Molecular medicine reports

authors： Sun N,Wang H,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Long non‑coding RNAs (lncRNAs), including terminal differentiation‑induced lncRNA (TINCR), myocardial infarction‑associated transcript (MIAT) and H19, serve a key role in the regulation of DC...

journal_title：Molecular medicine reports

authors： Chen K,Ma Y,Wu S,Zhuang Y,Liu X,Lv L,Zhang G

更新日期：2019-08-01 00:00:00

abstract：:The expression of Ferroportin (Fpn) was examined at different time points in rats following focal cerebral ischemia treated with or without the traditional Chinese medicine Naotaifang. Initially, rats were randomly divided into 2, 6, 12, 24 and 72 h groups following middle cerebral artery occlusion (MCAO) and the mRNA...

journal_title：Molecular medicine reports

authors： Liao J,Xia X,Wang GZ,Shi YM,Ge JW

更新日期：2015-06-01 00:00:00

abstract：:Recent advances in the treatment of non-small cell lung cancer (NSCLC) with new agents require accurate histological subtyping at diagnosis to avoid the higher risk of an adverse response and to obtain the maximum therapeutic response. However, interobserver variability, tumor heterogeneity and the degree of different...

journal_title：Molecular medicine reports

authors： Hamamoto J,Soejima K,Yoda S,Naoki K,Nakayama S,Satomi R,Terai H,Ikemura S,Sato T,Yasuda H,Hayashi Y,Sakamoto M,Takebayashi T,Betsuyaku T

更新日期：2013-08-01 00:00:00

abstract：:Nerve growth factor (NGF) is expressed in the human corneal epithelium and stroma. It is an efficient therapy for human corneal ulcers caused by neurotropic disease. However, little is known about the molecular mechanism of NGF in healing human corneal epithelial diseases. Numerous microRNAs (miRNAs) are expressed in ...

journal_title：Molecular medicine reports

authors： Wu D,Qian T,Hong J,Li G,Shi W,Xu J

更新日期：2017-10-01 00:00:00

abstract：:Ischemic brain damage remains the major cause of death and disability worldwide. Bone mesenchymal stem cell (BMSC) transplantation has been identified to serve important roles in cerebral infarction due to its multi‑directional differentiation and proliferative ability. However, the function of miR‑705 combined with B...

journal_title：Molecular medicine reports

authors： Ji M,Wang W,Li S,Hu W

更新日期：2017-12-01 00:00:00

abstract：:Glioma is one of the most common malignant tumors affecting the central nervous system. We screened active drugs from 12 classes to provide experimental data for the study of human glioma. Serum-free suspension clone formation was used to induce the formation of glioma stem‑like cel...

journal_title：Molecular medicine reports

authors： Feng X,Zhou Q,Liu C,Tao ML

更新日期：2012-11-01 00:00:00

abstract：:Antimycin A (AMA) is an inhibitor of the electron transport chain in mitochondria. In this study, we investigated the anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), superoxide dismutase (SOD) or catalase on AMA-induced HeLa cell death in relation to the cell cycle. Treatment with Z-VAD, SOD or catalase rescu...

journal_title：Molecular medicine reports

authors： Han YH,Kim SH,Kim SZ,Park WH

更新日期：2009-03-01 00:00:00

abstract：:Developing a thorough understanding of experimental methods of hepatic differentiation in hepatic progenitor cells (HPCs) should expand the knowledge of hepatocyte induction in vitro and may help to develop cell transplantation therapies for the clinical usage of HPCs in liver diseases. A previous induction method eff...

journal_title：Molecular medicine reports

authors： Hui H,Ma W,Cui J,Gong M,Wang Y,Zhang Y,He T,Bi Y,He Y

更新日期：2017-12-01 00:00:00

abstract：:Pregnancy complications are associated with abnormal cytotrophoblast differentiation and invasion. Hydrogen peroxide (H2O2) is an important mediator of oxidative ischemia/reperfusion stress in the placenta. Lycium barbarum polysaccharides (LBP) have been demonstrated to counteract oxidative free radicals. The effects ...

journal_title：Molecular medicine reports

authors： Li J,Ding Z,Yang Y,Mao B,Wang Y,Xu X

更新日期：2018-09-01 00:00:00

abstract：:Isorhamnetin (ISH) is a flavonoid primarily obtained from the fruit of Hippophae rhamnoides L., which possesses anti‑inflammatory properties. However, the effect of ISH on the expression of inflammatory mediators in response to interleukin (IL)‑1β stimulation has not been elucidated. The present study investigated the...

journal_title：Molecular medicine reports

authors： Li J,Wu R,Qin X,Liu D,Lin F,Feng Q

更新日期：2017-10-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

journal_title：Molecular medicine reports

authors： Liao X,Zhou Z,Zhang X

更新日期：2020-08-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated with a specific genetic lesion. The Philadelphia translocation, producing a BCR‑ABL hybrid oncogene, is the most common mechanism of CML development. However, in the present study, b3a2, b2a2 and ela2 fusion junctions of the breakpo...

journal_title：Molecular medicine reports

authors： Zhou JB,Zhang T,Wang BF,Gao HZ,Xu X

更新日期：2013-02-01 00:00:00

abstract：:Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compres...

journal_title：Molecular medicine reports

authors： Cui W,Wang H,Cheng Y,Ma X,Lei Y,Ruan X,Shi L,Lv M

更新日期：2019-01-01 00:00:00

abstract：:In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

journal_title：Molecular medicine reports

authors： Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

更新日期：2017-01-01 00:00:00

abstract：:The present study aimed to determine the role of arginase (Arg) in pulmonary arterial hypertension (PAH). In vitro, human pulmonary artery smooth muscle cells (HPASMCs) were cultured under hypoxic conditions with, or without, the Arg inhibitor, S‑(2‑boronoethyl)‑l‑cysteine (BEC), for 48 h, following which the prolifer...

journal_title：Molecular medicine reports

authors： Jiang W,Sun B,Song X,Zheng Y,Wang L,Wang T,Liu S

更新日期：2015-09-01 00:00:00

abstract：:Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy end...

journal_title：Molecular medicine reports

authors： Chen H,Tang QL,Wu XY,Xie LC,Lin LM,Ho GY,Ma L

更新日期：2015-07-01 00:00:00

abstract：:Cip1-interacting zinc finger protein 1 (CIZ1) is a nuclear protein that was observed to bind to p21Cip1/Waf1. p21Cip1/Waf1 regulates the cell cycle and is associated with colorectal cancer (CRC) progression. However, the effect of CIZ1 on CRC cells remains unclear. In the present study, CIZ1 was observed to be highly ...

journal_title：Molecular medicine reports

authors： Yin J,Wang C,Tang X,Sun H,Shao Q,Yang X,Qu X

更新日期：2013-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effect and mechanism of Astragaloside IV (ASIV) on myocardial injury induced by type 2 diabetes, with a focus on energy metabolism. Blood glucose, the hemodynamic index, left ventricular weight/heart weight (LVW/HW), the left ventricular systolic pressure (LV...

journal_title：Molecular medicine reports

authors： Zhang Z,Wang J,Zhu Y,Zhang H,Wang H

更新日期：2019-11-01 00:00:00

abstract：:The sonic hedgehog (SHH) morphogen regulates cell differentiation and controls a number of genes during renal morphogenesis. To date, the effects of SHH on fibroblast growth factors (Fgfs) in embryonic kidney development remain unclear. In the present study, explants of BALB/c mouse embryonic kidney tissues were used ...

journal_title：Molecular medicine reports

authors： Chen X,Hou XM,Fan YF,Jin YT,Wang YL

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to investigate Fas expression in tumor samples from patients with gastric cancer, in order to determine the involvement of the Fas signaling pathway. The protein expression levels of Fas, caspase-8, caspase‑3 and poly (adenosine diphosphate‑ribose) polymerase 1 (PARP1) were examined in...

journal_title：Molecular medicine reports

authors： Wang X,Fu Z,Chen Y,Liu L

更新日期：2017-02-01 00:00:00

abstract：:Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance. G6PD deficiency is a major cause of neonatal jaundice and acute hemolyticanemia, and recently, G6PD has been associated with diseases including inflam...

journal_title：Molecular medicine reports

authors： Chen L,Zhang C,Wang Y,Li Y,Han Q,Yang H,Zhu Y

更新日期：2017-08-01 00:00:00