mRNA expression of interleukins and Th1/Th2 imbalance in patients with pulmonary embolism.

abstract：:Cerebral ischemic stroke (IS) is a disease presenting high morbidity and mortality rates worldwide. Understanding of the pathogenesis underlying IS may facilitate the development of effective clinical therapeutic strategies and improve the prevention of this disease, decreasing its occurrence rate. Epigenetic alterati...

journal_title：Molecular medicine reports

authors： Wei Y,Sun Z,Wang Y,Xie Z,Xu S,Xu Y,Zhou X,Bi J,Zhu Z

更新日期：2019-08-01 00:00:00

abstract：:Human mucin 1 (MUC1) is a target for immunotherapy. The major problem associated with MUC1‑based cancer vaccines is the weakness of the immunogenicity of MUC1. The present study aimed to develop an efficient cancer vaccine through generating a recombinant fusion protein consisting of MUC1 and maltose‑binding protein (...

journal_title：Molecular medicine reports

authors： Fang F,Ma J,Ni W,Wang F,Sun X,Li Y,Li Q,Xie F,Wang J,Zhai R,Liu Z,Gao S,Tai G

更新日期：2014-08-01 00:00:00

abstract：:The use of human bone marrow mesenchymal stem cells (hBMSCs) as a tissue engineering application for individuals affected by osteoporosis and other types of bone loss diseases has been well studied in recent years. The osteogenic differentiation of hBMSCs can be regulated by a number of cues. MicroRNAs (miRNAs/miRs) s...

journal_title：Molecular medicine reports

authors： Zhang Y,Zhou L,Zhang Z,Ren F,Chen L,Lan Z

更新日期：2020-07-01 00:00:00

abstract：:The present study aimed to investigate functional networks underlying brain‑activity alterations in patients with acute unilateral open globe injury (OGI) and associations with their clinical features using the voxel‑wise degree centrality (DC) method. In total, 18 patients with acute OGI (16 males and 2 females), and...

journal_title：Molecular medicine reports

authors： Wang H,Chen T,Ye L,Yang QC,Wei R,Zhang Y,Jiang N,Shao Y

更新日期：2017-12-01 00:00:00

abstract：:Osteosarcoma is a malignant bone tumor which is found most commonly in adolescents and young adults. Local perfusion thermochemotherapy has long been proposed as an alternative strategy for the treatment of osteosarcoma. As a standard anticancer drug, paclitaxel plays a significant ...

journal_title：Molecular medicine reports

authors： Huang T,Gong WH,Li XC,Zou CP,Jiang GJ,Li XH,Feng DP

更新日期：2012-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been discovered to have pivotal roles in regulating the drug resistance of various types of human cancer, including cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Fewer studies have explored the roles of miR-106a in NSCLC-cell resistance to DDP and its precise molecular mecha...

journal_title：Molecular medicine reports

authors： Ma Y,Li X,Cheng S,Wei W,Li Y

更新日期：2015-01-01 00:00:00

abstract：:The splicing factor is important in cancer development, modulation numerous tumor suppressors and oncogenes, and regulation of multiple signaling pathways. Splicing factor 2/alternative splicing factor (SF2/ASF) is a proto‑oncogene, which has been implicated in the development of hepatocellular carcinoma. However, the...

journal_title：Molecular medicine reports

authors： Zhao Y,Zhu T,Zhang X,Wang Q,Zhang J,Ji W,Ma Y

更新日期：2015-09-01 00:00:00

abstract：:The poor prognosis of non‑small cell lung cancer (NSCLC) is related to epithelial‑mesenchymal transition (EMT). Recent studies demonstrated that non‑coding RNA activated by DNA damage (NORAD) displays a carcinogenic effect and targets microRNA (miR)‑422a, which may be involved in tumor cell migration and invasion. The...

journal_title：Molecular medicine reports

authors： Chen Z,Che Q,Xie C

更新日期：2021-02-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among females and the adenosine triphosphate (ATP) binding cassette E1 (ABCE1) gene is a member of the ATP‑binding cassette (ABC) family. Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis. However, little...

journal_title：Molecular medicine reports

authors： Huang B,Zhou H,Lang X,Liu Z

更新日期：2014-10-01 00:00:00

abstract：:Hypoxemia and hypercarbia resulting from a lack of surfactant is considered to be the primary mechanism underlying neonatal respiratory distress syndrome (NRDS). Surfactant replacement therapy may mitigate the symptoms of the disease by decreasing the surface tension of alveoli and facilitating inflation. However, sur...

journal_title：Molecular medicine reports

authors： Mei H,Zhang Y,Liu C,Zhang Y,Liu C,Song D,Xin C,Wang J,Josephs-Spaulding J,Zhu Y,Tang F

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of a variety of biological processes and their dysregulation is closely related to cancer formation and progression. Therefore, examination of aberrantly expressed miRNAs in oral squamous cell carcinoma (OSCC) may provide important clues for the diagnosis and treatment of pa...

journal_title：Molecular medicine reports

authors： Wang Q,Lv L,Li Y,Ji H

更新日期：2018-09-01 00:00:00

abstract：:Allergen extracts are commonly utilized for diagnosis and immunotherapy; however, the stability of protease‑rich extracts is important for a precise diagnosis and treatment efficacy. The present study determines the optimal conditions for the storage of German cockroach allergen extract. Cockroach extracts were recons...

journal_title：Molecular medicine reports

authors： Jeong KY,Lee J,Yuk JE,Park KH,Lee JH,Kim JD,Park JW

更新日期：2020-02-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:Pseudomonas aeruginosa continues to be a predominant cause of infections with high intrinsic resistance to antibiotics, resulting in treatment failure. P. aeruginosa is the leading cause of respiratory infections among cystic fibrosis (CF) patients. Resistance to carbapenem antibiotics among P. aeruginosa has been rep...

journal_title：Molecular medicine reports

authors： Li Y,Zhang X,Wang C,Hu Y,Niu X,Pei D,He Z,Bi Y

更新日期：2015-01-01 00:00:00

abstract：:Scavenger receptor class A, member 5 (SCARA5) is a member of the scavenger receptor family, and is involved in several types of human malignancy; however, its roles in osteosarcoma (OS) remain to be fully elucidated. Therefore, in the present study, the biological functions of SCARA5 in OS, and the potential underlyin...

journal_title：Molecular medicine reports

authors： Wen X,Wang N,Zhang F,Dong C

更新日期：2016-03-01 00:00:00

abstract：:B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...

journal_title：Molecular medicine reports

authors： Jia R,Jiao Z,Xu X,Wang J,Zhou Y,Song X,Ge S,Fan X

更新日期：2011-01-01 00:00:00

abstract：:Accumulating evidence has revealed that the mammalian heart possesses a measurable capacity for renewal. Neonatal mice retain a regenerative capacity over a short time-frame (≤6 days), but this capacity is lost by 7 days of age. In the present study, differential gene expression profiling of mouse cardiac tissue was p...

journal_title：Molecular medicine reports

authors： Liu M,Zhu JG,Yu ZB,Song GX,Shen YH,Liu YQ,Zhu C,Qian LM

更新日期：2014-06-01 00:00:00

abstract：:The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels of molecules such as stromal cell‑derived factor‑...

journal_title：Molecular medicine reports

authors： Xue Y,Li Z,Wang Y,Zhu X,Hu R,Xu W

更新日期：2020-10-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of the serum of patients with secondary hyperparathyroidism (SHPT) on endothelial cells and to examine the protective effect and the possible mechanism of Klotho. A total of three types of mixed serum from 15 patients with SHPT scheduled for parathyroidectomy,...

journal_title：Molecular medicine reports

authors： Chen C,Mao H,Yu X,Sun B,Zeng M,Zhao X,Qian J,Liu J,Xing C

更新日期：2015-08-01 00:00:00

abstract：:Liver-intestine cadherin (LI-cadherin), a novel member of the cadherin family, has been associated with the ability of a tumor to acquire an aggressive phenotype in several types of cancer. However, the exact function of LI-cadherin in the process of tumor invasion and metastasis remains predominantly unknown. To expl...

journal_title：Molecular medicine reports

authors： Yu Q,Shen W,Zhou H,Dong W,Gao D

更新日期：2016-05-01 00:00:00

abstract：:The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑bu...

journal_title：Molecular medicine reports

authors： Duan Y,Sun N,Xue M,Wang X,Yang H

更新日期：2017-12-01 00:00:00

abstract：:Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. However, the effect of PKE as a cancer drug ...

journal_title：Molecular medicine reports

authors： Park BH,Jung KH,Son MK,Seo JH,Lee HS,Lee JH,Hong SS

更新日期：2013-01-01 00:00:00

abstract：:The aims of the current study were to systematically analyze the regulation of the expression of NALP3 by the P2X7 receptor in P388D1 murine macrophage‑like cells, and to investigate the association between the P2X7 receptor and the NALP3 at the molecular level. Cell culture, RNA transfection, adenosine triphosphate (...

journal_title：Molecular medicine reports

authors： Chen Z,Jin H,Hou Y,Wang B,Chen C,Yang Z,Ding D,Zuo Y,Ren S

更新日期：2015-02-01 00:00:00

abstract：:To evaluate the effect of melatonin supplementation in maturation medium for human 'rescue IVM' and investigate differences in transcriptomic profile of blastocysts developed from oocytes matured in vitro with/without melatonin treatment and in vivo, a total of 314 GV oocytes and 320 MI oocytes were collected from 200...

journal_title：Molecular medicine reports

authors： Hao Y,Zhang Z,Han D,Cao Y,Zhou P,Wei Z,Lv M,Chen D

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to determine the role of arginase (Arg) in pulmonary arterial hypertension (PAH). In vitro, human pulmonary artery smooth muscle cells (HPASMCs) were cultured under hypoxic conditions with, or without, the Arg inhibitor, S‑(2‑boronoethyl)‑l‑cysteine (BEC), for 48 h, following which the prolifer...

journal_title：Molecular medicine reports

authors： Jiang W,Sun B,Song X,Zheng Y,Wang L,Wang T,Liu S

更新日期：2015-09-01 00:00:00

abstract：:Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rat...

journal_title：Molecular medicine reports

authors： Lufrano M,Jacob A,Zhou M,Wang P

更新日期：2013-08-01 00:00:00

abstract：:A subset of cancer stem cells termed 'side population' (SP) cells has been identified in several types of solid tumor and is known to be responsible for the failure of chemotherapy and for cancer relapse. In the present study, the oral squamous cell carcinoma (OSCC) cell line SCC‑55 was used for analysis of the SP cel...

journal_title：Molecular medicine reports

authors： Liu Y,Cui P,Chen J,Li W

更新日期：2015-05-01 00:00:00

abstract：:Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the baldin...

journal_title：Molecular medicine reports

authors： Lim KM,An S,Lee OK,Lee MJ,Lee JP,Lee KS,Lee GT,Lee KK,Bae S

更新日期：2015-08-01 00:00:00

abstract：:Gastric cancer (GC) has one of the highest mortality rates among all types of cancer in the world. At present, an efficient treatment for GC remains elusive. Studies have demonstrated that microRNAs (miRs) are abnormally expressed in cancer, and that these serve important roles in the development and metastasis of var...

journal_title：Molecular medicine reports

authors： Yin Y,Li X,Guo Z,Zhou F

更新日期：2019-11-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis-inducing ligand (TRAIL) is well known as a transmembrane cytokine and has been proposed as one of the most effective anti‑cancer therapeutic agents, owing to its efficiency to selectively induce cell death in a variety of tumor cells. Suppression of autophagy flux has been incre...

journal_title：Molecular medicine reports

authors： Nazim UM,Yin H,Park SY

更新日期：2019-02-01 00:00:00