Abstract:
OBJECTIVES:Efforts are needed to improve informed consent of participants in research. The Strategic Timing of AntiRetroviral Therapy (START) study provides a unique opportunity to study the effect of length and complexity of informed consent documents on understanding and satisfaction among geographically diverse participants. METHODS:Interested START sites were randomized to use either the standard consent form or the concise consent form for all of the site's participants. RESULTS:A total of 4473 HIV-positive participants at 154 sites world-wide took part in the Informed Consent Substudy, with consent given in 11 primary languages. Most sites sent written information to potential participants in advance of clinic visits, usually including the consent form. At about half the sites, staff reported spending less than an hour per participant in the consent process. The vast majority of sites assessed participant understanding using informal nonspecific questions or clinical judgment. CONCLUSIONS:These data reflect the interest of START research staff in evaluating the consent process and improving informed consent. The START Informed Consent Substudy is by far the largest study of informed consent intervention ever conducted. Its results have the potential to impact how consent forms are written around the world.
journal_name
HIV Medjournal_title
HIV medicineauthors
Denning E,Sharma S,Smolskis M,Touloumi G,Walker S,Babiker A,Clewett M,Emanuel E,Florence E,Papadopoulos A,Sánchez A,Tavel J,Grady C,International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Groudoi
10.1111/hiv.12230subject
Has Abstractpub_date
2015-04-01 00:00:00pages
24-9eissn
1464-2662issn
1468-1293journal_volume
16 Suppl 1pub_type
杂志文章,随机对照试验相关文献
HIV MEDICINE文献大全abstract::HIV infection has become a chronic condition rather than an acute life-threatening disease in developed countries, thanks to consistent innovation and evolution of effective interventions. This has altered HIV management and created new challenges. People living with HIV (PLWHIV) are living longer and so encounter com...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1111/hiv.12401
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:Certain non-AIDS-related diseases have been associated with immunodeficiency and HIV RNA levels in HIV-infected patients on combination antiretroviral therapy (cART). We aimed to investigate these associations in patients not yet on cART, when potential antiretroviral-drug-related effects are absent and vari...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12202
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. METHODS:We performed a cross-sectional analysis of the Examinations of HIV-Associated Lung Emphysema (EXHALE) study, including 162 HIV-positive patients and 138 participants with...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12966
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS:In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Cli...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12679
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:In the case of coinfection with HIV and hepatitis B virus (HBV) and/or hepatitis C virus (HCV), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver-related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface anti...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12158
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To compare virological and immunological responses to nevirapine (NVP)-based and efavirenz (EFV)-based highly active antiretroviral therapy (HAART) regimens in antiretroviral-naïve patients with advanced HIV infection. METHODS:A retrospective observational cohort study was conducted on antiretroviral-naïve H...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2004.00195.x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To compare the safety and efficacy of amprenavir [APV/j Agenerase trade mark; GlaxoSmithKline, [Ware, UK; 600 mg twice a day (bid)] boosted with low-dose ritonavir (RTV, 100 mg bid) with those of other protease inhibitors (PIs) in PI-experienced HIV-infected patients. STUDY DESIGN:Parallel-group, randomized...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1293.2004.00224.x
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:Socio-economic factors and lifestyle are known to differ across geographies and populations, which may result in distinct risk profiles for cardiovascular disease (CVD). This study assessed carotid intima-media thickness (CIMT), a proxy for CVD, and its determinants in two groups of people living with HIV (P...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12831
更新日期:2020-07-01 00:00:00
abstract::Tenofovir (TDF) co-administered with didanosine (ddI) 400 mg increases ddI plasma concentrations by up to 60%, raising concerns over toxicity. To limit this interaction, the dosage of ddI may be reduced to 250 mg once daily when co-prescribed with TDF. In this clinical cohort, highly active antiretroviral therapy regi...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2005.00279.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:Across Europe, almost a third of individuals infected with HIV do not enter health care until late in the course of their infection. Surveillance to identify the extent to which late presentation occurs remains inadequate across Europe and is further complicated by the lack of a common clinical definition of...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2010.00857.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Study 903 was a 144-week, randomized, double-blind, active-controlled study of tenofovir disoproxil fumarate (TDF) therapy in treatment-naive HIV-1-infected patients. Patients received either TDF (n = 299) or stavudine (d4T) (n = 301) with lamivudine (3TC) and efavirenz (EFV). Resistance analyses were perform...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2006.00404.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:In recent years, new technologies and new approaches to scale up HIV testing have emerged. The objective of this paper was to synthesize the body of recent evidence on strategies aimed at increasing the uptake and coverage of HIV testing outside of health care settings in the European Union (EU)/European Eco...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12807
更新日期:2020-03-01 00:00:00
abstract::An HIV-infected man presented with a pneumonic illness following an episode of treated Pneumocystis carinii pneumonia (PCP). He had a rise in his CD4 count from 4 to 125 cells/microL on antiretroviral therapy prior to the onset of the second respiratory event. Bronchoalveolar lavage (BAL) revealed no pathogen, althoug...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1046/j.1468-1293.2002.00115.x
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:To determine the proportion of skin/soft tissue infections (SSTIs) and to determine risks for MRSA infection caused by methicillin-resistant Staphylococcus aureus (MRSA) in HIV-infected out-patients. METHODS:We conducted a prospective study of SSTIs in HIV-infected out-patients. A questionnaire was used to ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2006.00394.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to assess the currently available evidence concerning the management of dyslipidaemias in HIV-infected individuals treated with antiretroviral therapy. METHODS:Randomized trials, published within the 5 years preceding 5 October 2005, were identified in PubMed Medline, Embase, and Th...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1293.2007.00480.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission of HIV and for maternal care management. Physiological changes during pregnancy can affect pharmacokinetics, potentially altering pharmacological activity. We therefore evaluated the pharmacokinetics of ...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/hiv.12047
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To assess adherence to the British HIV Association (BHIVA) 2001 guidelines for the management of HIV-infected pregnant women. METHODS:A survey and a case note review were carried out using structured questionnaires sent to providers of adult HIV care in the UK and Ireland. Participants were women with HIV in...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2006.00385.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV-related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV-infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2006.00372.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the predictive value of clinical and molecular risk factors, including peripheral blood mononuclear cell (PBMC) mitochondrial DNA (mtDNA) and mitochondrial RNA (mtRNA), for the development of lactic acidosis (LA) and symptomatic hyperlactataemia (SHL). METHODS:In a substu...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1293.2011.00934.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Low-dose stavudine therapy may have a lower toxicity profile compared with standard dose. A randomized controlled trial comparing these two doses of stavudine with tenofovir disoproxil fumarate (tenofovir DF) was performed to assess the effects on anthropometry, markers of inflammation, and lipid and glucose...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/hiv.12074
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To study the impact of effective highly active antiretroviral therapy (HAART) on the preservation of long-term CD4 memory cells induced by vaccines in HIV-1-infected patients. METHODS:Thirty HIV-1-positive patients on HAART with undetectable viral load were randomized into three groups: 10 received HIV-1 rgp...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1468-1293.2003.00148.x
更新日期:2003-04-01 00:00:00
abstract::Kaposi's sarcoma (KS) is the most prevalent AIDS-associated tumour, occurring in 20-30% of HIV-1-infected individuals in the early 1980s. The introduction of highly active antiretroviral therapy (HAART) has dramatically reduced the incidence of the disease and might therefore support the concept of 'opportunistic mali...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1046/j.1468-1293.2000.00027.x
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Several studies have compared mitochondrial DNA (mtDNA) content in tissue from HIV-1-infected patients on highly active antiretroviral therapy with and without evidence of lipodystrophy, the diagnosis of which was based on subjective clinical assessment. OBJECTIVES:The aim of this study was to assess the ut...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2007.00428.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Community HIV testing represents an opportunity for diagnosing HIV infection among individuals who may not have contact with health services, especially in hard-to-reach groups. The aim of this review was to assess the evidence for feasibility, acceptability and effectiveness of HIV testing strategies in com...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1293.2012.00992.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the risk of vertical transmission. Here we describe atazanavir/rit...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12164
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to compare the effects on lipids, body composition and renal function of once-daily ritonavir-boosted saquinavir (SQV/r) or atazanavir (ATV/r) in combination with tenofovir/emtricitabine (TDF/FTC) over 48 weeks. METHODS:An investigator-initiated, randomized, open-label, multinationa...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2011.00941.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Although cognitive outcomes among perinatally infected youth have improved with highly active antiretroviral therapy (HAART), the impact of the age of initiation of treatment and the central nervous system (CNS) penetration effectiveness (CPE) of the regimen on cognitive outcomes is unknown. We aimed to desc...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12220
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Metabolic diseases are frequently observed in HIV-infected persons and, as the risk of contracting these diseases is age-related, their prevalence will increase in the future as a consequence of the benefits of antiretroviral therapy (ART). SUMMARY OF GUIDELINES:All HIV-infected persons should be screened a...
journal_title:HIV medicine
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1293.2007.00534.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:Antiretroviral therapy has dramatically improved the survival of HIV-infected children. Nevertheless, side effects comparable to those found in adults have been encountered, such as facial lipoatrophy, which can have a negative impact on the self-esteem of otherwise healthy adolescents. Cosmetic surgical pro...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00682.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:An article by the Swiss AIDS Commission states that patients with stably suppressed viraemia [i.e. several successive HIV-1 RNA plasma concentrations (viral loads, VL) below the limits of detection during 6 months or more of highly active antiretroviral therapy (HAART)] are unlikely to be infectious. Questio...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2009.00714.x
更新日期:2009-09-01 00:00:00