当前位置： SCI文献检索 > HIV MEDICINE期刊下所有文献 > Serum cryptococcal antigen titre as a diagnostic tool and a predictor of mortality in HIV-infected patients with cryptococcal meningitis.

Serum cryptococcal antigen titre as a diagnostic tool and a predictor of mortality in HIV-infected patients with cryptococcal meningitis.

Abstract：

OBJECTIVES:The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS:In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Clinical Center from 1 January 2014 to 31 August 2016 were screened for serum CrAg using the latex agglutination test. Serum CrAg-positive patients underwent lumbar puncture to confirm CM prior to the initiation of appropriate antifungal therapy and were followed up for at least 6 months. RESULTS:One hundred and four (7.1%) of the total of 1474 HIV-infected patients screened were serum CrAg-positive. CM was diagnosed in the majority of serum CrAg-positive patients (71.3%; 67 of 94) and was confirmed in all (46 of 46) of the patients with headache or coma and in 43.8% (21 of 48) of patients without neurological symptoms. CrAg titres ≥ 1:1024 showed a sensitivity of 82.5% and a specificity of 86.7% for the diagnosis of concurrent CM (P < 0.001). The positive predictive value for CM in this population was 94.3%. A total of 13 serum CrAg-positive patients [13.8%; 95% confidence interval (CI) 7.5-22.4%] died (11 as a result of CM and two others as a result of bacterial pneumonia) despite early antifungal treatment initiation. Serum CrAg titres ≥ 1:1024 predicted all-cause mortality (hazard ratio 3.69; P = 0.03). CONCLUSIONS:Serum CrAg titres ≥ 1:1024 not only were associated with concurrent CM but also predicted mortality. HIV-infected patients with a positive serum CrAg test during screening should receive lumbar punctures regardless of symptoms to rule out CM and patients with serum CrAg titres ≥ 1:1024 should be offered immediate care.

journal_name

HIV Med

journal_title

HIV medicine

authors

Chen J,Zhang R,Shen Y,Liu L,Qi T,Wang Z,Mehraj V,Routy JP,Lu H

doi

10.1111/hiv.12679

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

69-73

issue

1

eissn

1464-2662

issn

1468-1293

journal_volume

20

pub_type

杂志文章

相关文献

HIV MEDICINE文献大全
  • Changes in elevated cholesterol in the era of tenofovir in South Africa: risk factors, clinical management and outcomes.

    abstract：OBJECTIVES:Antiretroviral therapy (ART) has been associated with unfavourable lipid profile changes and increased risk of cardiovascular disease (CVD). With a growing population on ART in South Africa, there has been concern about the increase in noncommunicable diseases such as CVD. We determined risk factors associat...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12495

    authors： Jamieson L,Evans D,Brennan AT,Moyo F,Spencer D,Mahomed K,Maskew M,Long L,Rosen S,Fox MP

    更新日期：2017-09-01 00:00:00

  • Reported consent processes and demographics: a substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.

    abstract：OBJECTIVES:Efforts are needed to improve informed consent of participants in research. The Strategic Timing of AntiRetroviral Therapy (START) study provides a unique opportunity to study the effect of length and complexity of informed consent documents on understanding and satisfaction among geographically diverse part...

    journal_title：HIV medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/hiv.12230

    authors： Denning E,Sharma S,Smolskis M,Touloumi G,Walker S,Babiker A,Clewett M,Emanuel E,Florence E,Papadopoulos A,Sánchez A,Tavel J,Grady C,International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Grou

    更新日期：2015-04-01 00:00:00

  • Knowledge of their children's HIV status in HIV-positive mothers attending a genitourinary medicine clinic in the UK.

    abstract：OBJECTIVES:To determine whether HIV-infected mothers knew the HIV status of their children, enabling the offer of targeted testing of children at risk. METHODS:All HIV-positive women attending the genitourinary medicine clinic at a district general hospital in the United Kingdom were asked whether they had children an...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2008.00556.x

    authors： Eisenhut M,Sharma V,Kawsar M,Balachandran T

    更新日期：2008-04-01 00:00:00

  • The prevalence of reduced zidovudine susceptibility in zidovudine-naive, antiretroviral-experienced HIV-1-infected patients.

    abstract：OBJECTIVES:There is increasing in vitro and in vivo evidence that reduced zidovudine (ZDV) susceptibility is generated by the selective pressure conferred by other nucleoside reverse transcriptase inhibitors (NRTIs). However, the degree to which this occurs in clinical practice remains unclear. We assessed phenotypic a...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1046/j.1468-1293.2003.00163.x

    authors： Gilleece Y,Torti C,Mandalia S,Gazzard BG,Pillay D,Pozniak AL

    更新日期：2003-10-01 00:00:00

  • Safety of nevirapine-containing antiretroviral triple therapy regimens to prevent vertical transmission in an African cohort of HIV-1-infected pregnant women.

    abstract：OBJECTIVE:To assess the incidence and consequences of adverse reactions among African HIV-positive pregnant women treated with fixed-dose combinations of a nevirapine-containing antiretroviral (ARV) triple therapy. METHODS:A retrospective analysis of the clinical files of 703 HIV-1-positive pregnant women treated with...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2006.00386.x

    authors： Marazzi MC,Germano P,Liotta G,Guidotti G,Loureiro S,da Cruz Gomes A,Valls Blazquez MC,Narciso P,Perno CF,Mancinelli S,Palombi L

    更新日期：2006-07-01 00:00:00

  • Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily.

    abstract：OBJECTIVES:Antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission of HIV and for maternal care management. Physiological changes during pregnancy can affect pharmacokinetics, potentially altering pharmacological activity. We therefore evaluated the pharmacokinetics of ...

    journal_title：HIV medicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/hiv.12047

    authors： Zorrilla CD,Wright R,Osiyemi OO,Yasin S,Baugh B,Brown K,Coate B,Verboven P,Mrus J,Falcon R,Kakuda TN

    更新日期：2014-01-01 00:00:00

  • New mutations associated with resistance not detected following zidovudine monotherapy in pregnancy when used in accordance with British HIV Association guidelines.

    abstract：OBJECTIVES:To determine whether mutations conferring drug resistance are detectable after zidovudine monotherapy (ZDVm) in pregnancy, using both standard genotyping and more sensitive cloning assays. METHODS:Post-delivery samples from women meeting the British HIV Association guidelines criteria for the use of ZDVm in...

    journal_title：HIV medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1468-1293.2008.00594.x

    authors： Read P,Costelloe S,Mullen J,O'Shea S,Lyons F,Hay P,Welch J,Larbalestier N,Taylor G,de Ruiter A

    更新日期：2008-08-01 00:00:00

  • The association between physical activity and cognition in men with and without HIV infection.

    abstract：OBJECTIVES:HIV-associated neurocognitive disorders are highly prevalent, and physical activity (PA) is a modifiable behaviour that may affect neurocognitive function. Our objective was to determine the association between PA and neurocognitive function and the effect of HIV on this association. METHODS:PA was assessed...

    journal_title：HIV medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1111/hiv.12490

    authors： Monroe AK,Zhang L,Jacobson LP,Plankey MW,Brown TT,Miller EN,Martin E,Becker JT,Levine AJ,Ragin A,Sacktor NC

    更新日期：2017-09-01 00:00:00

  • Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.

    abstract：OBJECTIVES:Conflicting results have been reported regarding the ability of valproic acid (VPA) to reduce the size of HIV reservoirs in patients receiving suppressive highly active antiretroviral therapy (HAART). In a randomized multicentre, cross-over study, we assessed whether adding VPA to stable HAART could potentia...

    journal_title：HIV medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1468-1293.2011.00975.x

    authors： Routy JP,Tremblay CL,Angel JB,Trottier B,Rouleau D,Baril JG,Harris M,Trottier S,Singer J,Chomont N,Sékaly RP,Boulassel MR

    更新日期：2012-05-01 00:00:00

  • Subgroup analysis of virological response rates with once- and twice-daily darunavir/ritonavir in treatment-experienced patients without darunavir resistance-associated mutations in the ODIN trial.

    abstract：BACKGROUND:ODIN (once-daily darunavir in treatment-experienced patients) was a 48-week, phase III, randomized, open-label trial comparing once-daily (qd) darunavir/ritonavir (DRV/r) 800/100 mg with twice-daily (bid) DRV/r 600/100 mg, both with an optimized background regimen [OBR; at least two nucleoside reverse transc...

    journal_title：HIV medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/hiv.12024

    authors： Sension M,Cahn P,Domingo P,Hodder S,Opsomer M,Lathouwers E,Van de Casteele T,Tomaka F

    更新日期：2013-08-01 00:00:00

  • Successful switch to rilpivirine/tenofovir/emtricitabine in HIV-1-infected patients with an isolated K103N mutation acquired during prior nonnucleoside reverse transcriptase inhibitor therapy.

    abstract：OBJECTIVES:Whether treatment-experienced HIV-1-infected patients with an acquired K103N mutation after failing nonnucleoside reverse transcriptase inhibitor (NNRTI) regimens can be treated with rilpivirine is unknown. The aim of this pilot study was to evaluate the efficacy of rilpivirine/tenofovir/emtricitabine in HIV...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12157

    authors： Rokx C,Verbon A,Rijnders BJ

    更新日期：2014-11-01 00:00:00

  • Diagnosing HIV infection in patients presenting with glandular fever-like illness in primary care: are we missing primary HIV infection?

    abstract：OBJECTIVES:The aim of the study was to examine the prevalence of HIV infection in patients presenting in primary care with glandular fever (GF)-like illness. METHODS:Samples from primary care submitted for a GF screen between April 2009 and June 2010 were identified. Samples without an HIV request were anonymized and ...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2012.01023.x

    authors： Hsu DT,Ruf M,O'Shea S,Costelloe S,Peck J,Tong CY

    更新日期：2013-01-01 00:00:00

  • Monitoring the HIV continuum of care in key populations across Europe and Central Asia.

    abstract：OBJECTIVES:The aim of the study was to measure and compare national continuum of HIV care estimates in Europe and Central Asia in three key subpopulations: men who have sex with men (MSM), people who inject drugs (PWID) and migrants. METHODS:Responses to a 2016 European Centre for Disease Prevention and Control (ECDC)...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12603

    authors： Brown AE,Attawell K,Hales D,Rice BD,Pharris A,Supervie V,Van Beckhoven D,Delpech VC,An der Heiden M,Marcus U,Maly M,Noori T

    更新日期：2018-05-08 00:00:00

  • Pulmonary function in an international sample of HIV-positive, treatment-naïve adults with CD4 counts > 500 cells/μL: a substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.

    abstract：OBJECTIVES:The aim of the study was to describe the prevalence and correlates of chronic obstructive pulmonary disease (COPD) in a multicentre international cohort of persons living with HIV (PLWH). METHODS:We performed a cross-sectional analysis of adult PLWH, naïve to HIV treatment, with baseline CD4 cell count > 50...

    journal_title：HIV medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/hiv.12240

    authors： Kunisaki KM,Niewoehner DE,Collins G,Nixon DE,Tedaldi E,Akolo C,Kityo C,Klinker H,La Rosa A,Connett JE,International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group.

    更新日期：2015-04-01 00:00:00

  • Sweden, the first country to achieve the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 continuum of HIV care targets.

    abstract：OBJECTIVES:The Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 goals propose that 90% of all people living with HIV should know their HIV status, 90% of those diagnosed should receive antiretroviral therapy (ART), and 90% of those should have durable viral suppression. We ha...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12431

    authors： Gisslén M,Svedhem V,Lindborg L,Flamholc L,Norrgren H,Wendahl S,Axelsson M,Sönnerborg A

    更新日期：2017-04-01 00:00:00

  • Severe haematologic toxicity is rare in high risk HIV-exposed infants receiving combination neonatal prophylaxis.

    abstract：OBJECTIVES:Combination neonatal prophylaxis (CNP) is recommended in high-risk situations for the prevention of mother-to-child HIV transmission, although data on its safety are limited. The aim of the study was to identify whether neonatal prophylaxis (NP) type is associated with the risk of severe anaemia or neutropae...

    journal_title：HIV medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1111/hiv.12696

    authors： European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord.

    更新日期：2019-05-01 00:00:00

  • CD4:CD8 ratio in children with perinatally acquired HIV-1 infection.

    abstract：OBJECTIVES:In adults with horizontally acquired HIV infection, an inverted CD4:CD8 ratio is associated with persistent immune activation, size of HIV reservoir and predicts an increased risk of non-AIDS-defining adverse events. Normalization of this ratio with antiretroviral therapy (ART) is suboptimal in adults, despi...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12642

    authors： Seers T,Vassallo P,Pollock K,Thornhill JP,Fidler S,Foster C

    更新日期：2018-10-01 00:00:00

  • Clinical outcomes of first antiretroviral regimen in HIV/hepatitis C virus co-infection.

    abstract：OBJECTIVES:Despite the benefits of HAART, initiation of antiretroviral therapy in HIV-HCV co-infected patients is often delayed as a consequence of patient and physician concern pertaining to liver toxicity. It is unclear whether this is justified. METHODS:We retrospectively evaluated treatment duration and outcome in...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2005.00340.x

    authors： Cooper CL,Breau C,Laroche A,Lee C,Garber G

    更新日期：2006-01-01 00:00:00

  • Treatment initiation factors and cognitive outcome in youth with perinatally acquired HIV infection.

    abstract：OBJECTIVES:Although cognitive outcomes among perinatally infected youth have improved with highly active antiretroviral therapy (HAART), the impact of the age of initiation of treatment and the central nervous system (CNS) penetration effectiveness (CPE) of the regimen on cognitive outcomes is unknown. We aimed to desc...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12220

    authors： Lazarus JR,Rutstein RM,Lowenthal ED

    更新日期：2015-07-01 00:00:00

  • Quantifying the drivers of HIV transmission and prevention in men who have sex with men: a population model-based analysis in Switzerland.

    abstract：OBJECTIVES:Despite the huge success of antiretroviral therapy (ART), there is an ongoing HIV epidemic among men who have sex with men (MSM) in resource-rich countries. Understanding the driving factors underlying this process is important for curbing the epidemic. METHODS:We simulated the HIV epidemic in MSM in Switze...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12660

    authors： Kusejko K,Marzel A,Hampel B,Bachmann N,Nguyen H,Fehr J,Braun DL,Battegay M,Bernasconi E,Calmy A,Cavassini M,Hoffmann M,Böni J,Yerly S,Klimkait T,Perreau M,Rauch A,Günthard HF,Kouyos RD,Swiss HIV Cohort Study.

    更新日期：2018-11-01 00:00:00

  • Cerebrospinal fluid HIV RNA in persons living with HIV.

    abstract：OBJECTIVES:Despite adequate suppression of plasma HIV RNA, viral escape in cerebrospinal fluid (CSF) is widely reported. Rates of CSF HIV RNA escape vary in the literature. In persons living with HIV (PLWH) undergoing lumbar puncture examination for clinical reasons, we assessed rates of CSF HIV RNA escape. METHODS:Pe...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12594

    authors： Di Carlofelice M,Everitt A,Muir D,Winston A

    更新日期：2018-05-01 00:00:00

  • Neurological and psychiatric tolerability of rilpivirine (TMC278) vs. efavirenz in treatment-naïve, HIV-1-infected patients at 48 weeks.

    abstract：OBJECTIVES:The aim of the study was to compare the neuropsychiatric safety and tolerability of rilpivirine (TMC278) vs. efavirenz in a preplanned pooled analysis of data from the ECHO and THRIVE studies which compared the safety and efficacy of the two drugs in HIV-1 infected treatment naïve adults. METHODS:ECHO and T...

    journal_title：HIV medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/hiv.12012

    authors： Mills AM,Antinori A,Clotet B,Fourie J,Herrera G,Hicks C,Madruga JV,Vanveggel S,Stevens M,Boven K,ECHO and THRIVE study groups.

    更新日期：2013-08-01 00:00:00

  • GENOPHAR: a randomized study of plasma drug measurements in association with genotypic resistance testing and expert advice to optimize therapy in patients failing antiretroviral therapy.

    abstract：OBJECTIVES:To evaluate the benefits of therapeutic drug monitoring (TDM) in association with genotypic resistance testing and expert advice to optimize therapy in multiexperienced patients infected with HIV-1. METHODS:Patients with a viral load>1000 HIV-1 RNA copies/mL and an unchanged antiretroviral therapy regimen o...

    journal_title：HIV medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1468-1293.2004.00234.x

    authors： Bossi P,Peytavin G,Ait-Mohand H,Delaugerre C,Ktorza N,Paris L,Bonmarchand M,Cacace R,David DJ,Simon A,Lamotte C,Marcelin AG,Calvez V,Bricaire F,Costagliola D,Katlama C

    更新日期：2004-09-01 00:00:00

  • Evolution of bone mineral density in AIDS patients on treatment with zidovudine/lamivudine plus abacavir or lopinavir/ritonavir.

    abstract：OBJECTIVES:The aim of the study was to determine the factors that may contribute to decreases in bone mineral density (BMD) in patients with AIDS. METHODS:This was a prospective, non-randomized study. Dual X-ray absorptiometry (DXA) was used to determine the BMD of the lumbar spine, femoral neck and distal radius in t...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2007.00525.x

    authors： Rivas P,Górgolas M,García-Delgado R,Díaz-Curiel M,Goyenechea A,Fernández-Guerrero ML

    更新日期：2008-02-01 00:00:00

  • Proviral HIV-1 dynamics and evolution in patients receiving efficient long-term antiretroviral combination therapy.

    abstract：OBJECTIVES:Different experimental approaches have shown that, despite plasma viral loads under the threshold of detection, HIV-1 frequently continues to replicate in patients receiving potent antiretroviral therapy. However, whether this low-grade viral replication is sufficient for the generation of new major quasispe...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1046/j.1468-1293.2000.00030.x

    authors： Birk M,Aleman S,Visco-Comandini U,Sönnerborg A

    更新日期：2000-10-01 00:00:00

  • The role of brain biopsy in the clinical management of HIV-related focal brain lesions.

    abstract：OBJECTIVES:Up to 20% of HIV-related focal brain lesion (FBL) diagnoses cannot be determined without invasive procedures. In such cases, brain biopsy is an important step in the evaluation algorithm. The aims of this study were to describe the clinical outcomes of patients with FBL, the proportion of diagnoses confirmed...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12646

    authors： Acosta MC,Kundro M,Viloria G,Peressín Paz A,Morello F,Latorre F,Seoane E,Toibaro J,Losso M

    更新日期：2018-11-01 00:00:00

  • The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*.

    abstract：BACKGROUND:Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz desp...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2011.00943.x

    authors： Cozzi-Lepri A,Paredes,Phillips AN,Clotet B,Kjaer J,Von Wyl V,Kronborg G,Castagna A,Bogner JR,Lundgren JD,EuroSIDA in EuroCoord.

    更新日期：2012-01-01 00:00:00

  • High HIV prevalence in a southern semi-rural area of Mozambique: a community-based survey.

    abstract：BACKGROUND:Southern African countries have borne the brunt of the HIV/AIDS pandemic. Monitoring epidemiological dynamics is critical to identify the populations at greatest risk of infection and to guide control strategies. METHODS:A cross-sectional community-based study to determine age- and sex-specific HIV prevalen...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/j.1468-1293.2012.01018.x

    authors： González R,Munguambe K,Aponte J,Bavo C,Nhalungo D,Macete E,Alonso P,Menéndez C,Naniche D

    更新日期：2012-11-01 00:00:00

  • De-simplifying single-tablet antiretroviral treatments: uptake, risks and cost savings.

    abstract：OBJECTIVES:As more HIV-positive individuals receive antiretroviral therapy (ART), payers are seeking options for covering these increased and sustained drug costs. Strategic use of available generic antiretroviral (ARV) formulations may be feasible. De-simplifying a single-tablet co-formulation (STF) into two or more t...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12701

    authors： Krentz HB,Campbell S,Lahl M,Gill MJ

    更新日期：2019-03-01 00:00:00

  • Characterization of associations and development of atazanavir resistance after unplanned treatment interruptions.

    abstract：OBJECTIVES:Although current guidelines recommend resistance testing prior to antiretroviral therapy (ART) reinitiation after treatment interruptions, virological failure of first-line ritonavir-boosted, protease-inhibitor (PI/r)-containing ART is associated with low emergent PI resistance. In patients experiencing unsc...

    journal_title：HIV medicine

    pub_type： 杂志文章

    doi：10.1111/hiv.12107

    authors： Tinago W,O'Halloran JA,O'Halloran RM,Macken A,Lambert JS,Sheehan GJ,Mallon PW

    更新日期：2014-04-01 00:00:00