Abstract:
OBJECTIVES:The aim of the study was to describe the prevalence and correlates of chronic obstructive pulmonary disease (COPD) in a multicentre international cohort of persons living with HIV (PLWH). METHODS:We performed a cross-sectional analysis of adult PLWH, naïve to HIV treatment, with baseline CD4 cell count > 500 cells/μL enrolled in the Pulmonary Substudy of the Strategic Timing of AntiRetroviral Treatment (START) trial. We collected standardized, quality-controlled spirometry. COPD was defined as forced expiratory volume in 1 s:forced vital capacity (FEV1 :FVC) ratio less than the lower limit of normal. RESULTS:Among 1026 participants from 80 sites and 20 countries, the median age was 36 [interquartile range (IQR) 30, 44] years, 29% were female, and the median time since HIV diagnosis was 1.2 (IQR 0.4, 3.5) years. Baseline median CD4 cell count was 648 (IQR 583, 767) cells/μL, median viral load was 4.2 (IQR 3.5, 4.7) log10 HIV-1 RNA copies/mL, and 10% had a viral load ≤ 400 copies/mL despite lack of HIV treatment. Current/former/never smokers comprised 28%/11%/61% of the cohort, respectively. COPD was present in 6.8% of participants, and varied by age, smoking status and region. Forty-eight per cent of those with COPD reported lifelong nonsmoking. In multivariable regression, age and pack-years of smoking had the strongest associations with FEV1 :FVC ratio (P < 0.0001). There was a significant effect of region on FEV1 :FVC ratio (P = 0.010). CONCLUSIONS:Our data suggest that, among PLWH who were naïve to HIV treatment and had CD4 cell counts > 500 cells/μL, smoking and age were important factors related to COPD. Smoking cessation should remain a high global priority for clinical care and research in PLWH.
journal_name
HIV Medjournal_title
HIV medicineauthors
Kunisaki KM,Niewoehner DE,Collins G,Nixon DE,Tedaldi E,Akolo C,Kityo C,Klinker H,La Rosa A,Connett JE,International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group.doi
10.1111/hiv.12240subject
Has Abstractpub_date
2015-04-01 00:00:00pages
119-28eissn
1464-2662issn
1468-1293journal_volume
16 Suppl 1pub_type
杂志文章,随机对照试验相关文献
HIV MEDICINE文献大全abstract:OBJECTIVES:People with HIV (PWHIV) are likely to need therapies for comorbidities as they age. We assessed risk of drug-drug interactions (DDIs) in PWHIV. METHODS:The Climate-HIV electronic recording system was used to cross-sectionally analyse records from PWHIV aged ≥ 18 years attending four UK HIV units with a curr...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12879
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV-related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV-infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2006.00372.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to compare the neuropsychiatric safety and tolerability of rilpivirine (TMC278) vs. efavirenz in a preplanned pooled analysis of data from the ECHO and THRIVE studies which compared the safety and efficacy of the two drugs in HIV-1 infected treatment naïve adults. METHODS:ECHO and T...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/hiv.12012
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to compare the effects on lipids, body composition and renal function of once-daily ritonavir-boosted saquinavir (SQV/r) or atazanavir (ATV/r) in combination with tenofovir/emtricitabine (TDF/FTC) over 48 weeks. METHODS:An investigator-initiated, randomized, open-label, multinationa...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2011.00941.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate the association of adiposity with longitudinal kidney function change in 544 HIV-infected persons in the Study of Fat Redistribution and Metabolic Change in HIV infection (FRAM) cohort over 5 years of follow-up. METHODS:The regional distribution of muscle and adipose ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12196
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Many patients may believe that HIV screening is included in routine preoperative work-ups. We examined what proportion of patients undergoing preoperative blood testing believed that they had been tested for HIV. METHODS:All patients hospitalized for elective orthopaedic surgery between January and December...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2012.00993.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Human leukocyte antigen (HLA)-B(*)5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC) in White and Hispanic subjects. Across the UK, limited data exist on HLA-B(*)5701 prevalence in HIV-1-infected subjects. We determined HLA-B(*)5701 prevalence in the general HIV-1-infec...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2009.00762.x
更新日期:2010-03-01 00:00:00
abstract::Risk factors for death in an HIV-infected cohort in French Guiana were studied in 1374 patients between 1996 and 2005. Of these patients, 48.5% were male and 76% were immigrants. Covariates were measured at the time of consultation. There were 223 deaths. Addictions [adjusted hazard ratio (HR)=13; 95% confidence inter...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2007.00492.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:With the prolonged survival time of AIDS patients, complications of various systems and organs of HIV infection are increasingly prominent. These diseases have become the major factors influencing the quality of life and prognosis of HIV-infected persons, and multidisciplinary cooperation treatment is urgent...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1111/hiv.13022
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Although cognitive outcomes among perinatally infected youth have improved with highly active antiretroviral therapy (HAART), the impact of the age of initiation of treatment and the central nervous system (CNS) penetration effectiveness (CPE) of the regimen on cognitive outcomes is unknown. We aimed to desc...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12220
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. METHODS:We performed a cross-sectional analysis of the Examinations of HIV-Associated Lung Emphysema (EXHALE) study, including 162 HIV-positive patients and 138 participants with...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12966
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. However, the pathogenic mechanisms involved are not well understood or documented using conventional lipid measurements. METHODS:Using a cross-sectional design, the prevalence of abnormal stan...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2005.00316.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to systematically review current studies reporting on clinical outcomes in people living with HIV (PLHIV) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS:We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews a...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12911
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To document the demographic changes in new HIV diagnoses at the Royal Free Hospital, London, UK, between 1994 and 2000. DESIGN:Retrospective case note review. METHODS:Data were extracted from the Royal Free HIV database identifying new diagnoses for 1994, 1997 and 2000. All case notes were reviewed and pati...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1046/j.1468-1293.2002.00103.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:Involvement of people living with HIV (PLHIV) in the design of HIV cure studies is important, given the potential risks to participants. We present results of an international survey of PLHIV to define these issues and inform cure research. METHODS:PLHIV were recruited in June-November 2014 through HIV webs...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12391
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To compare virological and immunological responses to nevirapine (NVP)-based and efavirenz (EFV)-based highly active antiretroviral therapy (HAART) regimens in antiretroviral-naïve patients with advanced HIV infection. METHODS:A retrospective observational cohort study was conducted on antiretroviral-naïve H...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2004.00195.x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to identify differences in infant outcomes, virological efficacy, and preterm delivery (PTD) outcome between women exposed to lopinavir/ritonavir (LPV/r) and those exposed to atazanavir/ritonavir (ATV/r). METHODS:A retrospective case note review was carried out. The case notes of 49...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12277
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Antiretroviral therapy has dramatically improved the survival of HIV-infected children. Nevertheless, side effects comparable to those found in adults have been encountered, such as facial lipoatrophy, which can have a negative impact on the self-esteem of otherwise healthy adolescents. Cosmetic surgical pro...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00682.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to describe a UK-wide process to assess adherence to guidelines for the routine investigation and monitoring of HIV-positive adults aged ≥ 50 years and provide clinical services with individual feedback to support improvement in quality of care. METHODS:The British HIV Association (...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12842
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the risk of vertical transmission. Here we describe atazanavir/rit...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12164
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Limited studies have suggested increased incidence rates and unusual clinical presentations of appendicitis among HIV-infected patients during the pre-highly active antiretroviral therapy (HAART) era. Data in the HAART era are sparse, and no study has evaluated potential HIV-related risk factors for the deve...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00577.x
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:ODIN (once-daily darunavir in treatment-experienced patients) was a 48-week, phase III, randomized, open-label trial comparing once-daily (qd) darunavir/ritonavir (DRV/r) 800/100 mg with twice-daily (bid) DRV/r 600/100 mg, both with an optimized background regimen [OBR; at least two nucleoside reverse transc...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/hiv.12024
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to assess the currently available evidence concerning the management of dyslipidaemias in HIV-infected individuals treated with antiretroviral therapy. METHODS:Randomized trials, published within the 5 years preceding 5 October 2005, were identified in PubMed Medline, Embase, and Th...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1293.2007.00480.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To study the impact of effective highly active antiretroviral therapy (HAART) on the preservation of long-term CD4 memory cells induced by vaccines in HIV-1-infected patients. METHODS:Thirty HIV-1-positive patients on HAART with undetectable viral load were randomized into three groups: 10 received HIV-1 rgp...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1468-1293.2003.00148.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS:In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Cli...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12679
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Despite the benefits of HAART, initiation of antiretroviral therapy in HIV-HCV co-infected patients is often delayed as a consequence of patient and physician concern pertaining to liver toxicity. It is unclear whether this is justified. METHODS:We retrospectively evaluated treatment duration and outcome in...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2005.00340.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:An article by the Swiss AIDS Commission states that patients with stably suppressed viraemia [i.e. several successive HIV-1 RNA plasma concentrations (viral loads, VL) below the limits of detection during 6 months or more of highly active antiretroviral therapy (HAART)] are unlikely to be infectious. Questio...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2009.00714.x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:People living with HIV infection are at increased risk for developing cardiovascular disease (CVD). Safe and effective interventions for lowering CVD risk in HIV infection are high priorities. We conducted a prospective, randomized, controlled study to evaluate whether a yoga lifestyle intervention improves C...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2009.00801.x
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Rapid HIV testing (RHT) is well established in many countries, but it is new in Australia since a policy change in 2011. We assessed service provider acceptability of RHT before and after its implementation in four Sydney public sexual health clinics. METHODS:Service providers were surveyed immediately afte...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12209
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to compare the metabolic and morphological effects of enfuvirtide plus an optimized background (OB) regimen vs. OB alone (control group) in treatment-experienced patients in the T-20 vs. Optimized Regimen Only (TORO) studies. METHODS:Body composition and metabolic changes were invest...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2010.00845.x
更新日期:2011-01-01 00:00:00