Abstract:
OBJECTIVES:Up to 20% of HIV-related focal brain lesion (FBL) diagnoses cannot be determined without invasive procedures. In such cases, brain biopsy is an important step in the evaluation algorithm. The aims of this study were to describe the clinical outcomes of patients with FBL, the proportion of diagnoses confirmed by brain biopsies and their aetiologies, and to analyse the proportion of patients in whom the biopsy motivated a change in therapeutic management. METHODS:A retrospective cohort study was performed. The data from clinical records of patients with HIV-related FBL admitted between January 2005 and December 2015 were reviewed. RESULTS:A total of 137 patients were included in the study. The median age was 39 years [interquartile range (IQR) 33-44.5 years]. The median CD4 count was 54 cells/μL (IQR 21-124 cells/μL). Cerebral brain biopsy was performed in 21.16% of patients (29 of 137); 68.9% of these individuals (20 of 29) were diagnosed by histology, with results of central nervous system (CNS) lymphoma in 20.6% (six of 29), progressive multifocal leucoencephalopathy in 6.8% (two of 29), toxoplasmosis in 6.8% (two of 29), tuberculoma in 6.8% (two of 29), and other diagnoses in 27.6% (eight of 29). In nine patients, the histology was nonspecific. In 75.8% of patients (22 of 29), the result of the biopsy led to a change in the therapeutic management. We did not observe higher rates of mortality related to the procedure. Overall mortality at 30 and 90 days was similar in patients who were and were not biopsied. CONCLUSIONS:In this retrospective cohort study, cerebral biopsy was associated with significant adjustments in therapeutic management for a high percentage of patients.
journal_name
HIV Medjournal_title
HIV medicineauthors
Acosta MC,Kundro M,Viloria G,Peressín Paz A,Morello F,Latorre F,Seoane E,Toibaro J,Losso Mdoi
10.1111/hiv.12646subject
Has Abstractpub_date
2018-11-01 00:00:00pages
673-678issue
10eissn
1464-2662issn
1468-1293journal_volume
19pub_type
杂志文章相关文献
HIV MEDICINE文献大全abstract:OBJECTIVE:Data from observational cohorts may be influenced by population structure and loss to follow-up (LTFU). Quality of care may be associated with participation in cohort networks. We aimed to study the participation, characteristics and retention rates of immigrants in the Swiss HIV Cohort Study (SHCS). METHODS...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2011.00949.x
更新日期:2012-02-01 00:00:00
abstract::Despite advances in the treatment of HIV disease, the incidence and mortality of invasive cryptococcal disease remain significant. A matched, case-control study was performed to examine the impact of highly active antiretroviral therapy (HAART) and azole use on the incidence of invasive cryptococcal disease in HIV-inf...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2005.00289.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To measure the evolution of proviral HIV-1 DNA levels in patients receiving highly active antiretroviral therapy (HAART) compared to those treated with HAART plus interleukin-2 (IL-2) and hydroxyurea. DESIGN:Prospective randomised trial. METHODS:Twenty-two HIV-1 infected patients were randomly assigned to a...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1468-1293.2001.00065.x
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:Antiretroviral therapy (ART) in HIV-infected patients is associated with increased cardiovascular risk. Circulating markers of endothelial dysfunction may be used to study early atherogenesis. The aim of our study was to investigate changes in such markers during initiation of ART. METHODS:In 115 HIV-positi...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00661.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:Abacavir (ABC) selects for four mutations (K65R, L74V, Y115F and M184V) in HIV-1 reverse transcriptase (RT), both in vitro and during monotherapy in vivo. The aim of this analysis was to compare the selection of these and other nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations by ABC-con...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2004.00243.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:Antiretroviral therapy (ART) has been associated with unfavourable lipid profile changes and increased risk of cardiovascular disease (CVD). With a growing population on ART in South Africa, there has been concern about the increase in noncommunicable diseases such as CVD. We determined risk factors associat...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12495
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:Although current guidelines recommend resistance testing prior to antiretroviral therapy (ART) reinitiation after treatment interruptions, virological failure of first-line ritonavir-boosted, protease-inhibitor (PI/r)-containing ART is associated with low emergent PI resistance. In patients experiencing unsc...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12107
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:For the last 10 years there has been an epidemic of hepatitis C virus (HCV) infection in men who have sex with men (MSM) in Europe, North America and Australia. The majority of those infected are also HIV-positive and it is unclear to what extent HIV-negative MSM are also at increased risk of infection with ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12050
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Study 903 was a 144-week, randomized, double-blind, active-controlled study of tenofovir disoproxil fumarate (TDF) therapy in treatment-naive HIV-1-infected patients. Patients received either TDF (n = 299) or stavudine (d4T) (n = 301) with lamivudine (3TC) and efavirenz (EFV). Resistance analyses were perform...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2006.00404.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to describe Veterans Healthcare Administration (VHA) system-wide uptake of three HIV protease inhibitors: atazanavir, darunavir and tipranavir. METHODS:This retrospective cohort study evaluated VHA uptake of three target antiretrovirals and lopinavir/ritonavir in each complete 90-day...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2009.00764.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. However, the pathogenic mechanisms involved are not well understood or documented using conventional lipid measurements. METHODS:Using a cross-sectional design, the prevalence of abnormal stan...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2005.00316.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:The World Health Organization (WHO) recommends screening HIV-infected people for cryptococcal antigens to identify cryptococcosis, a major cause of AIDS-related deaths. As the burden of cryptococcosis is unknown in South Africa's KwaZulu-Natal province, we assessed the cryptococcal antigenuria prevalence amo...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12263
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz desp...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2011.00943.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:The Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 goals propose that 90% of all people living with HIV should know their HIV status, 90% of those diagnosed should receive antiretroviral therapy (ART), and 90% of those should have durable viral suppression. We ha...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12431
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the predictive value of clinical and molecular risk factors, including peripheral blood mononuclear cell (PBMC) mitochondrial DNA (mtDNA) and mitochondrial RNA (mtRNA), for the development of lactic acidosis (LA) and symptomatic hyperlactataemia (SHL). METHODS:In a substu...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1293.2011.00934.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Three-drug nonoccupational post-exposure prophylaxis (NPEP) typically includes co-formulated emtricitabine-tenofovir (FTC-TDF) and a protease inhibitor. However, protease inhibitors can cause significant toxicities, can interact with prescribed and illicit drugs, and work late in the viral cycle. Agents that...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/hiv.12075
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:In recent years, new technologies and new approaches to scale up HIV testing have emerged. The objective of this paper was to synthesize the body of recent evidence on strategies aimed at increasing the uptake and coverage of HIV testing outside of health care settings in the European Union (EU)/European Eco...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12807
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Two-drug antiretroviral regimens based on lamivudine (3TC) plus either a protease inhibitor (PI) or dolutegravir (DTG) are becoming increasingly popular in switch strategies. Our goal was to derive a predictive score for virological failure (VF). METHODS:We retrospectively analysed data for a cohort of 587 ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12759
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:We describe the management of a cohort of eight HIV-positive patients on antiretroviral medication with evidence of pancreatic insufficiency consisting of chronic diarrhoea and a low faecal elastase measurement. PATIENTS AND METHODS:Twenty-two patients with chronic diarrhoea for whom a faecal elastase measu...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2005.00263.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:Community HIV testing represents an opportunity for diagnosing HIV infection among individuals who may not have contact with health services, especially in hard-to-reach groups. The aim of this review was to assess the evidence for feasibility, acceptability and effectiveness of HIV testing strategies in com...
journal_title:HIV medicine
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1293.2012.00992.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To assess the incidence and consequences of adverse reactions among African HIV-positive pregnant women treated with fixed-dose combinations of a nevirapine-containing antiretroviral (ARV) triple therapy. METHODS:A retrospective analysis of the clinical files of 703 HIV-1-positive pregnant women treated with...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2006.00386.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV-related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV-infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2006.00372.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:Human leukocyte antigen (HLA)-B(*)5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC) in White and Hispanic subjects. Across the UK, limited data exist on HLA-B(*)5701 prevalence in HIV-1-infected subjects. We determined HLA-B(*)5701 prevalence in the general HIV-1-infec...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2009.00762.x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Metabolic diseases are frequently observed in HIV-infected persons and, as the risk of contracting these diseases is age-related, their prevalence will increase in the future as a consequence of the benefits of antiretroviral therapy (ART). SUMMARY OF GUIDELINES:All HIV-infected persons should be screened a...
journal_title:HIV medicine
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1293.2007.00534.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. METHODS:We performed a cross-sectional analysis of the Examinations of HIV-Associated Lung Emphysema (EXHALE) study, including 162 HIV-positive patients and 138 participants with...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12966
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to describe growth and body composition changes in HIV-positive children after they had initiated or changed antiretroviral therapy (ART) and to correlate these with viral, immune and treatment parameters. METHODS:Ninety-seven prepubertal HIV-positive children were observed over 48 ...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2010.00823.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:To determine whether HIV-infected mothers knew the HIV status of their children, enabling the offer of targeted testing of children at risk. METHODS:All HIV-positive women attending the genitourinary medicine clinic at a district general hospital in the United Kingdom were asked whether they had children an...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00556.x
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:In the debate about legalization of euthanasia very little attention has so far been given to the opinion of the patient. OBJECTIVE:To assess the opinion of persons with HIV infection in Europe. METHODS:A cross-sectional survey of persons with HIV infection attending HIV/AIDS treatment centres or HIV suppo...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1046/j.1468-1293.2001.00053.x
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Many patients may believe that HIV screening is included in routine preoperative work-ups. We examined what proportion of patients undergoing preoperative blood testing believed that they had been tested for HIV. METHODS:All patients hospitalized for elective orthopaedic surgery between January and December...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2012.00993.x
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Direct-acting antiviral agents (DAAs) have become the standard of care for the treatment of chronic hepatitis C virus (HCV) infection. We aimed to assess treatment uptake and efficacy in routine clinical settings among HIV/HCV coinfected patients after the introduction of the first generation DAAs. METHODS:...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12269
更新日期:2015-11-01 00:00:00