Abstract:
:An HIV-infected man presented with a pneumonic illness following an episode of treated Pneumocystis carinii pneumonia (PCP). He had a rise in his CD4 count from 4 to 125 cells/microL on antiretroviral therapy prior to the onset of the second respiratory event. Bronchoalveolar lavage (BAL) revealed no pathogen, although a CD4 lymphocytosis in addition to a highly unusual population of rapidly proliferating CD8 cells was demonstrated. Following 2 weeks of steroid and anti-pneumocystis therapy, a repeat bronchoscopy demonstrated that the expression of these markers had returned to low values. This second respiratory illness, which may have arisen as a consequence of the regenerating immune response reacting to residual P. carinii antigen in the lung, is apparently not rare. When we reviewed our case notes, five further individuals were identified that had started antiretroviral therapy following an episode of PCP and subsequently developed a self-limiting pneumonitis for which no pathogen was identified on bronchoscopy.
journal_name
HIV Medjournal_title
HIV medicineauthors
Barry SM,Lipman MC,Deery AR,Johnson MA,Janossy Gdoi
10.1046/j.1468-1293.2002.00115.xkeywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
207-11issue
3eissn
1464-2662issn
1468-1293pii
0115journal_volume
3pub_type
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