Late presentation of HIV infection: a consensus definition.

abstract：OBJECTIVES:The aim of this national audit was to assess adherence of services providing HIV care in the UK to national standards and guidelines regarding psychological support and the assessment of alcohol and recreational drug use (including chemsex drugs) in people living with HIV (PLWH). METHODS:Participating sites...

journal_title：HIV medicine

authors： Parry S,Curtis H,Chadwick D,British HIV Association Audit and Standards Sub-Committee.

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:ODIN (once-daily darunavir in treatment-experienced patients) was a 48-week, phase III, randomized, open-label trial comparing once-daily (qd) darunavir/ritonavir (DRV/r) 800/100 mg with twice-daily (bid) DRV/r 600/100 mg, both with an optimized background regimen [OBR; at least two nucleoside reverse transc...

journal_title：HIV medicine

authors： Sension M,Cahn P,Domingo P,Hodder S,Opsomer M,Lathouwers E,Van de Casteele T,Tomaka F

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Involvement of people living with HIV (PLHIV) in the design of HIV cure studies is important, given the potential risks to participants. We present results of an international survey of PLHIV to define these issues and inform cure research. METHODS:PLHIV were recruited in June-November 2014 through HIV webs...

journal_title：HIV medicine

authors： Simmons R,Kall M,Collins S,Cairns G,Taylor S,Nelson M,Fidler S,Porter K,Fox J,Collaborative HIV Eradication of viral Reservoirs (CHERUB) Survey collaboration.

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to characterize and compare insulin resistance (IR) in hepatitis C virus (HCV)-antibody (Ab)-positive and HCV-Ab-negative patients with HIV infection. METHODS:This was a single-centre cross-sectional study of 1041 HIV-infected patients (373 HCV-Ab-positive; 167 with detectable plasma...

journal_title：HIV medicine

authors： Squillace N,Lapadula G,Torti C,Orlando G,Mandalia S,Nardini G,Beghetto B,Costarelli S,Guaraldi G

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:To evaluate plasma levels of dehydroepiandrosterone sulphate (DHEAS) in a cohort of HIV-infected patients and to analyse factors associated with DHEAS levels. METHODS:We conducted a cross-sectional survey in the Nîmes University Hospital cohort of HIV-infected patients in south-eastern France. All HIV-infec...

journal_title：HIV medicine

authors： Mauboussin JM,Mahamat A,Peyrière H,Rouanet I,Fabbro-Peray P,Daures JP,Vincent D

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz desp...

journal_title：HIV medicine

authors： Cozzi-Lepri A,Paredes,Phillips AN,Clotet B,Kjaer J,Von Wyl V,Kronborg G,Castagna A,Bogner JR,Lundgren JD,EuroSIDA in EuroCoord.

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to identify differences in infant outcomes, virological efficacy, and preterm delivery (PTD) outcome between women exposed to lopinavir/ritonavir (LPV/r) and those exposed to atazanavir/ritonavir (ATV/r). METHODS:A retrospective case note review was carried out. The case notes of 49...

journal_title：HIV medicine

authors： Perry ME,Taylor GP,Sabin CA,Conway K,Flanagan S,Dwyer E,Stevenson J,Mulka L,McKendry A,Williams E,Barbour A,Dermont S,Roedling S,Shah R,Anderson J,Rodgers M,Wood C,Sarner L,Hay P,Hawkins D,deRuiter A

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to compare the incidence of anaemia in patients treated with zidovudine (ZDV) with that in patients treated with highly active antiretroviral therapy (HAART) not including ZDV. METHODS:Using HIV Insight, a database of abstracted US HIV care centre medical charts, ZDV-naïve patients s...

journal_title：HIV medicine

authors： Curkendall SM,Richardson JT,Emons MF,Fisher AE,Everhard F

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:In the UK, free HIV care is provided through dedicated HIV clinics. Using the national cohort of men who have sex with men (MSM) with diagnosed HIV infection and estimates of the number of undiagnosed men, we assessed whether high retention in HIV care and treatment coverage is sufficient to reduce HIV trans...

journal_title：HIV medicine

authors： Brown AE,Gill ON,Delpech VC

更新日期：2013-10-01 00:00:00

abstract：:An HIV-infected man presented with a pneumonic illness following an episode of treated Pneumocystis carinii pneumonia (PCP). He had a rise in his CD4 count from 4 to 125 cells/microL on antiretroviral therapy prior to the onset of the second respiratory event. Bronchoalveolar lavage (BAL) revealed no pathogen, althoug...

journal_title：HIV medicine

authors： Barry SM,Lipman MC,Deery AR,Johnson MA,Janossy G

更新日期：2002-07-01 00:00:00

abstract：:Initiating antiretroviral therapy (ART) as early as the day of HIV diagnosis is a strategy of increasing global interest to control the HIV epidemic and optimize the health of people living with HIV (PLWH). No detrimental effects of rapid-start ART have been identified in randomized controlled trials undertaken in low...

journal_title：HIV medicine

authors： Boyd MA,Boffito M,Castagna A,Estrada V

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Abacavir (ABC) selects for four mutations (K65R, L74V, Y115F and M184V) in HIV-1 reverse transcriptase (RT), both in vitro and during monotherapy in vivo. The aim of this analysis was to compare the selection of these and other nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations by ABC-con...

journal_title：HIV medicine

authors： Lanier ER,Givens N,Stone C,Griffin P,Gibb D,Walker S,Tisdale M,Irlbeck D,Underwood M,St Clair M,Ait-Khaled M

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:To determine whether mutations conferring drug resistance are detectable after zidovudine monotherapy (ZDVm) in pregnancy, using both standard genotyping and more sensitive cloning assays. METHODS:Post-delivery samples from women meeting the British HIV Association guidelines criteria for the use of ZDVm in...

journal_title：HIV medicine

authors： Read P,Costelloe S,Mullen J,O'Shea S,Lyons F,Hay P,Welch J,Larbalestier N,Taylor G,de Ruiter A

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to measure and compare national continuum of HIV care estimates in Europe and Central Asia in three key subpopulations: men who have sex with men (MSM), people who inject drugs (PWID) and migrants. METHODS:Responses to a 2016 European Centre for Disease Prevention and Control (ECDC)...

journal_title：HIV medicine

authors： Brown AE,Attawell K,Hales D,Rice BD,Pharris A,Supervie V,Van Beckhoven D,Delpech VC,An der Heiden M,Marcus U,Maly M,Noori T

更新日期：2018-05-08 00:00:00

abstract：OBJECTIVES:Certain non-AIDS-related diseases have been associated with immunodeficiency and HIV RNA levels in HIV-infected patients on combination antiretroviral therapy (cART). We aimed to investigate these associations in patients not yet on cART, when potential antiretroviral-drug-related effects are absent and vari...

journal_title：HIV medicine

authors： Zhang S,van Sighem A,Kesselring A,Gras L,Prins JM,Hassink E,Kauffmann R,Richter C,de Wolf F,Reiss P,ATHENA national observational HIV cohort study.

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:In most lung screening programmes, only subjects ≥ 55 years old and smoking ≥ 30 pack-years are eligible to undergo chest low-dose computed tomography. Whether the same criteria should apply to people living with HIV (PLHIV) is uncertain, given the increased lung cancer risks associated with immunodeficiency...

journal_title：HIV medicine

authors： Makinson A,Tron L,Grabar S,Milleron B,Reynes J,Le Moing V,Morquin D,Lert F,Costagliola D,Guiguet M

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Tuberculosis (TB) is a common opportunistic infection among HIV-infected people, and rifampicin is an important drug for the treatment of TB. However, administration of rifampicin in combination with antiretroviral therapy, particularly protease inhibitors, is difficult because of drug-drug interactions. ME...

journal_title：HIV medicine

authors： Mallolas J,Sarasa M,Nomdedeu M,Soriano A,López-Púa Y,Blanco JL,Martínez E,Gatell JM

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:Renal disease is a common and serious complication in HIV-infected patients. METHODS:A retrospective cohort analysis for the period 1989-2010 was carried out to determine the prevalence, incidence and risk factors for end-stage renal disease (ESRD). ESRD was defined as initiation of renal replacement therap...

journal_title：HIV medicine

authors： Bickel M,Marben W,Betz C,Khaykin P,Stephan C,Gute P,Haberl A,Knecht G,Wolf T,Brodt HR,Geiger H,Herrmann E,Jung O

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:HIV infection and its treatment are associated with dyslipidaemia and increased risk of cardiovascular disease. Accurate high-density lipoprotein (HDL) cholesterol values are necessary for the management of these abnormalities, but current methods have not been properly assessed in these patients. The aim of...

journal_title：HIV medicine

authors： Aragonès G,Beltrán R,Rull A,Marsillach J,Rodríguez F,Alí SB,Fernández-Sender L,Camps J,Joven J,Alonso-Villaverde C

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To study the impact of effective highly active antiretroviral therapy (HAART) on the preservation of long-term CD4 memory cells induced by vaccines in HIV-1-infected patients. METHODS:Thirty HIV-1-positive patients on HAART with undetectable viral load were randomized into three groups: 10 received HIV-1 rgp...

journal_title：HIV medicine

authors： Hejdeman B,Leandersson AC,Fredriksson EL,Sandström E,Wahren B,Bratt G

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to compare the effects on lipids, body composition and renal function of once-daily ritonavir-boosted saquinavir (SQV/r) or atazanavir (ATV/r) in combination with tenofovir/emtricitabine (TDF/FTC) over 48 weeks. METHODS:An investigator-initiated, randomized, open-label, multinationa...

journal_title：HIV medicine

authors： Vrouenraets SM,Wit FW,Fernandez Garcia E,Moyle GJ,Jackson AG,Allavena C,Raffi F,Jayaweera DT,Mauss S,Katlama C,Fisher M,Slama L,Hardy WD,Dejesus E,van Eeden A,Reiss P,BASIC Study Group.

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:This study was designed to evaluate the effects of the HIV protease inhibitor lopinavir/ritonavir on gingival epithelium growth, integrity and differentiation. METHODS:Organotypic (raft) cultures of gingival keratinocytes were established and treated with a range of lopinavir/ritonavir concentrations. To exa...

journal_title：HIV medicine

authors： Israr M,Mitchell D,Alam S,Dinello D,Kishel JJ,Meyers C

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:More than 10 years after the introduction of combination antiretroviral therapy (cART), we examined the trend in the proportion of deaths caused by end-stage liver disease (ESLD) in HIV-infected adults in France between 1995 and 2005. DESIGN AND METHODS:In 2005, 34 departments prospectively recorded all dea...

journal_title：HIV medicine

authors： Rosenthal E,Salmon-Céron D,Lewden C,Bouteloup V,Pialoux G,Bonnet F,Karmochkine M,May T,François M,Burty C,Jougla E,Costagliola D,Morlat P,Chêne G,Cacoub P,Mortavic\/Mortalité 2005 Study Group.

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Hyperlipidaemia is a recognized complication of HIV antiretroviral therapy. The interactions among HIV, viral hepatitis, antiretroviral therapies and lipids are poorly understood. METHODS:Ontario HIV Treatment Network Cohort Study participants with at least one lipid level after highly active antiretrovir...

journal_title：HIV medicine

authors： Diong C,Raboud J,Li M,Cooper C,Ontario HIV Treatment Network Cohort Study Team.

更新日期：2011-08-01 00:00:00

abstract：:Risk factors for death in an HIV-infected cohort in French Guiana were studied in 1374 patients between 1996 and 2005. Of these patients, 48.5% were male and 76% were immigrants. Covariates were measured at the time of consultation. There were 223 deaths. Addictions [adjusted hazard ratio (HR)=13; 95% confidence inter...

journal_title：HIV medicine

authors： Nacher M,Huber F,El Guedj M,Vaz T,Magnien C,Djossou F,Randrianjohany A,Alvarez F,Couppié P

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To establish the prevalence, severity and factors associated with the HIV lipodystrophy syndrome. METHODS:Cross-sectional study of lipodystrophy conducted in high HIV caseload primary care sites and HIV outpatient clinics. A subset of patients was examined using dual energy X-ray absorptiometry (DEXA) and si...

journal_title：HIV medicine

authors： Miller J,Carr A,Emery S,Law M,Mallal S,Baker D,Smith D,Kaldor J,Cooper DA

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVES:Direct-acting antiviral agents (DAAs) have become the standard of care for the treatment of chronic hepatitis C virus (HCV) infection. We aimed to assess treatment uptake and efficacy in routine clinical settings among HIV/HCV coinfected patients after the introduction of the first generation DAAs. METHODS:...

journal_title：HIV medicine

authors： Schaerer V,Haubitz S,Kovari H,Ledergerber B,Ambrosioni J,Cavassini M,Stoeckle M,Schmid P,Decosterd L,Aouri M,Böni J,Günthard HF,Furrer H,Metzner KJ,Fehr J,Rauch A,Swiss HIV Cohort Study.

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Mortality in young people with perinatally acquired HIV infection (PHIV) following transfer to adult care has not been characterized in the UK. We conducted a multicentre audit to establish the number of deaths and associated factors. METHODS:Fourteen adult clinics caring for infected young people reported ...

journal_title：HIV medicine

authors： Fish R,Judd A,Jungmann E,O'Leary C,Foster C,HIV Young Persons Network (HYPNet).

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:Despite the huge success of antiretroviral therapy (ART), there is an ongoing HIV epidemic among men who have sex with men (MSM) in resource-rich countries. Understanding the driving factors underlying this process is important for curbing the epidemic. METHODS:We simulated the HIV epidemic in MSM in Switze...

journal_title：HIV medicine

authors： Kusejko K,Marzel A,Hampel B,Bachmann N,Nguyen H,Fehr J,Braun DL,Battegay M,Bernasconi E,Calmy A,Cavassini M,Hoffmann M,Böni J,Yerly S,Klimkait T,Perreau M,Rauch A,Günthard HF,Kouyos RD,Swiss HIV Cohort Study.

更新日期：2018-11-01 00:00:00

abstract：:One-half of the estimated 2.5 million people who now live with HIV in the World Health Organization (WHO) European Region are still diagnosed late. A central question is which clinical scenarios should trigger an HIV test recommendation in order to avoid late presentation. Drawing on the work of the HIV Indicator Dise...

journal_title：HIV medicine

authors： Lazarus JV,Hoekstra M,Raben D,Delpech V,Coenen T,Lundgren JD,HIV in Europe Initiative Steering Committee.

更新日期：2013-08-01 00:00:00