Abstract:
OBJECTIVES:The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. METHODS:We performed a cross-sectional analysis of the Examinations of HIV-Associated Lung Emphysema (EXHALE) study, including 162 HIV-positive patients and 138 participants without HIV. We modelled marijuana exposure as: (i) current daily or weekly marijuana smoking vs. monthly or less often; or (ii) cumulative marijuana smoking (joint-years). Linear and logistic regression estimated associations between marijuana exposure and markers of lung disease, adjusted for tobacco smoking and other factors. RESULTS:In PLWH, current daily or weekly marijuana use was associated with a larger forced vital capacity (FVC), larger total lung capacity and increased odds of radiographic emphysema compared with marijuana non-smokers in adjusted models; these associations were not statistically significant in participants without HIV. Marijuana joint-years were associated with higher forced expiratory volume in 1 s and FVC in PLWH but not with emphysema. CONCLUSIONS:In PLWH, marijuana smoking was associated with higher lung volumes and potentially with radiographic emphysema. No consistently negative associations were observed between marijuana and measures of chronic lung health.
journal_name
HIV Medjournal_title
HIV medicineauthors
Wenger DS,Triplette M,Shahrir S,Akgun KM,Wongtrakool C,Brown ST,Kim JW,Soo Hoo GW,Rodriguez-Barradas MC,Huang L,Feemster LC,Zifodya J,Crothers Kdoi
10.1111/hiv.12966subject
Has Abstractpub_date
2021-02-01 00:00:00pages
92-101issue
2eissn
1464-2662issn
1468-1293journal_volume
22pub_type
杂志文章相关文献
HIV MEDICINE文献大全abstract:OBJECTIVE:This study was designed to evaluate the effects of the HIV protease inhibitor lopinavir/ritonavir on gingival epithelium growth, integrity and differentiation. METHODS:Organotypic (raft) cultures of gingival keratinocytes were established and treated with a range of lopinavir/ritonavir concentrations. To exa...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2010.00863.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of adefovir dipivoxil (ADV) added to stable background antiretroviral therapy (ART) in HIV-infected individuals with advanced HIV disease. METHODS:ADHOC was a randomized, double-blind, placebo-controlled, international multicentre trial. Three hundred and one individuals wi...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1046/j.1468-1293.2002.00111.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to examine the prevalence of HIV infection in patients presenting in primary care with glandular fever (GF)-like illness. METHODS:Samples from primary care submitted for a GF screen between April 2009 and June 2010 were identified. Samples without an HIV request were anonymized and ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2012.01023.x
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:People with HIV (PWHIV) are likely to need therapies for comorbidities as they age. We assessed risk of drug-drug interactions (DDIs) in PWHIV. METHODS:The Climate-HIV electronic recording system was used to cross-sectionally analyse records from PWHIV aged ≥ 18 years attending four UK HIV units with a curr...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12879
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Limited studies have suggested increased incidence rates and unusual clinical presentations of appendicitis among HIV-infected patients during the pre-highly active antiretroviral therapy (HAART) era. Data in the HAART era are sparse, and no study has evaluated potential HIV-related risk factors for the deve...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00577.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:HIV infection and its treatment are associated with dyslipidaemia and increased risk of cardiovascular disease. Accurate high-density lipoprotein (HDL) cholesterol values are necessary for the management of these abnormalities, but current methods have not been properly assessed in these patients. The aim of...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2009.00772.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to describe the prevalence of and examine the factors associated with immunosuppression (CD4 < 200 cells/microL) among HIV-infected patients attending two large inner London treatment centres. METHODS:Patients attending for care who had a CD4 count < 200 cells/microL during a 6-mont...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2009.00753.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate the prevalence of and risk factors for hepatitis C or B virus (HCV or HBV) coinfection among HIV-infected pregnant women, and to investigate their immunological and virological characteristics and antiretroviral therapy use. METHODS:Information on HBV surface antigen ...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2008.00599.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To compare virological and immunological responses to nevirapine (NVP)-based and efavirenz (EFV)-based highly active antiretroviral therapy (HAART) regimens in antiretroviral-naïve patients with advanced HIV infection. METHODS:A retrospective observational cohort study was conducted on antiretroviral-naïve H...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2004.00195.x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:A prospective study was carried out to assess HIV-1 and HIV-2 mother-to-child transmission (MTCT) rates in Portugal between 1999 and 2005 by analysing the proportion of diagnosed infected children born to HIV-positive mothers. MATERIALS AND METHODS:Serial blood samples were collected from 1315 children at ri...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2008.00669.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:In recent years, new technologies and new approaches to scale up HIV testing have emerged. The objective of this paper was to synthesize the body of recent evidence on strategies aimed at increasing the uptake and coverage of HIV testing outside of health care settings in the European Union (EU)/European Eco...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12807
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:We describe the management of a cohort of eight HIV-positive patients on antiretroviral medication with evidence of pancreatic insufficiency consisting of chronic diarrhoea and a low faecal elastase measurement. PATIENTS AND METHODS:Twenty-two patients with chronic diarrhoea for whom a faecal elastase measu...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2005.00263.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:ODIN (once-daily darunavir in treatment-experienced patients) was a 48-week, phase III, randomized, open-label trial comparing once-daily (qd) darunavir/ritonavir (DRV/r) 800/100 mg with twice-daily (bid) DRV/r 600/100 mg, both with an optimized background regimen [OBR; at least two nucleoside reverse transc...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/hiv.12024
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The addition of a low dose of ritonavir to protease inhibitors (PIs) has become a widespread strategy to improve PI pharmacokinetics. As resistance is a major barrier to long-term suppression, in salvage therapy genotype and/or phenotype scoring is currently used to predict the response. We evaluated the rel...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1468-1293.2007.00464.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:Certain non-AIDS-related diseases have been associated with immunodeficiency and HIV RNA levels in HIV-infected patients on combination antiretroviral therapy (cART). We aimed to investigate these associations in patients not yet on cART, when potential antiretroviral-drug-related effects are absent and vari...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12202
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Southern African countries have borne the brunt of the HIV/AIDS pandemic. Monitoring epidemiological dynamics is critical to identify the populations at greatest risk of infection and to guide control strategies. METHODS:A cross-sectional community-based study to determine age- and sex-specific HIV prevalen...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2012.01018.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to compare the effects on lipids, body composition and renal function of once-daily ritonavir-boosted saquinavir (SQV/r) or atazanavir (ATV/r) in combination with tenofovir/emtricitabine (TDF/FTC) over 48 weeks. METHODS:An investigator-initiated, randomized, open-label, multinationa...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2011.00941.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS:In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Cli...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12679
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Low-dose stavudine therapy may have a lower toxicity profile compared with standard dose. A randomized controlled trial comparing these two doses of stavudine with tenofovir disoproxil fumarate (tenofovir DF) was performed to assess the effects on anthropometry, markers of inflammation, and lipid and glucose...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/hiv.12074
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART). It is still unclear whether viral properties such as cell tropism play a major role in this incomplete immune response. This study therefore intended to follow ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12365
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Mucocutaneous manifestations such as oral candidiasis (OC) and seborrheic dermatitis (SD) are very common HIV-related opportunistic events and are usually initial markers of immunodeficiency. AIM:The purpose of this study was to evaluate the efficacy of highly active antiretroviral therapy (HAART) in the re...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1293.2004.00185.x
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:AIDS-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the combined antiretroviral therapy (cART) era. Although most ARLs are associated with the Epstein-Barr virus (EBV), whether patients with high EBV burden are more at risk of developing ARL is unknown. This study investigated the re...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2012.00998.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:The aim of this national audit was to assess adherence of services providing HIV care in the UK to national standards and guidelines regarding psychological support and the assessment of alcohol and recreational drug use (including chemsex drugs) in people living with HIV (PLWH). METHODS:Participating sites...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12744
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to compare the incidence of anaemia in patients treated with zidovudine (ZDV) with that in patients treated with highly active antiretroviral therapy (HAART) not including ZDV. METHODS:Using HIV Insight, a database of abstracted US HIV care centre medical charts, ZDV-naïve patients s...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2007.00500.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:Outbreaks of shigellosis have been documented in men who have sex with men (MSM), associated with interpersonal transmission and underlying HIV infection. We observed a rise in Shigella flexneri isolates identified in a downtown tertiary-care hospital laboratory located within the city centre community healt...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12191
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Different experimental approaches have shown that, despite plasma viral loads under the threshold of detection, HIV-1 frequently continues to replicate in patients receiving potent antiretroviral therapy. However, whether this low-grade viral replication is sufficient for the generation of new major quasispe...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1046/j.1468-1293.2000.00030.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:The Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 goals propose that 90% of all people living with HIV should know their HIV status, 90% of those diagnosed should receive antiretroviral therapy (ART), and 90% of those should have durable viral suppression. We ha...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12431
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to explore the awareness of rectal microbicides, the use of pre-exposure prophylaxis (PREP) and the willingness to participate in biomedical HIV prevention trials in a cohort of HIV-negative gay men. METHODS:In a community-based cohort study, HIV-negative homosexually active men in ...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2009.00777.x
更新日期:2010-04-01 00:00:00
abstract::Worldwide we have seen dramatic increases in HIV prevalence and decreases in life expectancy over the last decade. The aim of this study was to determine the association between HIV prevalence and life expectancy. A strong negative association between adult HIV prevalence and life expectancy was observed for 137 count...
journal_title:HIV medicine
pub_type: 信件
doi:10.1111/j.1468-1293.2005.00266.x
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is a common opportunistic infection among HIV-infected people, and rifampicin is an important drug for the treatment of TB. However, administration of rifampicin in combination with antiretroviral therapy, particularly protease inhibitors, is difficult because of drug-drug interactions. ME...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2007.00442.x
更新日期:2007-03-01 00:00:00