Abstract:
:Kaposi's sarcoma (KS) is the most prevalent AIDS-associated tumour, occurring in 20-30% of HIV-1-infected individuals in the early 1980s. The introduction of highly active antiretroviral therapy (HAART) has dramatically reduced the incidence of the disease and might therefore support the concept of 'opportunistic malignancies' requiring immune impairments to occur. The relationship between the immune system and the epidemiology of this virus-induced tumour is of importance in order to identify new therapeutic approaches for treating or preventing its occurrence. As a model of impaired angiogenesis, therapeutic options for treating AIDS patients with KS should therefore target cell division, anti-angiogenic processes, immune modulators, cytokines and potentially antiviral drugs.
journal_name
HIV Medjournal_title
HIV medicineauthors
Hermans Pdoi
10.1046/j.1468-1293.2000.00027.xkeywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
137-42issue
3eissn
1464-2662issn
1468-1293pii
hiv027journal_volume
1pub_type
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