Kaposi's sarcoma in HIV-infected patients: treatment options.

Abstract:

:Kaposi's sarcoma (KS) is the most prevalent AIDS-associated tumour, occurring in 20-30% of HIV-1-infected individuals in the early 1980s. The introduction of highly active antiretroviral therapy (HAART) has dramatically reduced the incidence of the disease and might therefore support the concept of 'opportunistic malignancies' requiring immune impairments to occur. The relationship between the immune system and the epidemiology of this virus-induced tumour is of importance in order to identify new therapeutic approaches for treating or preventing its occurrence. As a model of impaired angiogenesis, therapeutic options for treating AIDS patients with KS should therefore target cell division, anti-angiogenic processes, immune modulators, cytokines and potentially antiviral drugs.

journal_name

HIV Med

journal_title

HIV medicine

authors

Hermans P

doi

10.1046/j.1468-1293.2000.00027.x

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

137-42

issue

3

eissn

1464-2662

issn

1468-1293

pii

hiv027

journal_volume

1

pub_type

杂志文章,评审
  • Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France.

    abstract:OBJECTIVES:The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV-infected adult patients and to investigate the associated factors. METHODS:A cross-sectional survey was conducted in a French hospital-based cohort. Clearance of creatinine (CC) was calculated using the Cockcrof...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2009.00780.x

    authors: Déti EK,Thiébaut R,Bonnet F,Lawson-Ayayi S,Dupon M,Neau D,Pellegrin JL,Malvy D,Tchamgoué S,Dabis F,Morlat P,Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.

    更新日期:2010-05-01 00:00:00

  • Assessment of mother-to-child HIV-1 and HIV-2 transmission: an AIDS reference laboratory collaborative study.

    abstract:OBJECTIVE:A prospective study was carried out to assess HIV-1 and HIV-2 mother-to-child transmission (MTCT) rates in Portugal between 1999 and 2005 by analysing the proportion of diagnosed infected children born to HIV-positive mothers. MATERIALS AND METHODS:Serial blood samples were collected from 1315 children at ri...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1468-1293.2008.00669.x

    authors: Pádua E,Almeida C,Nunes B,Cortes Martins H,Castela J,Neves C,Paixão MT

    更新日期:2009-03-01 00:00:00

  • Nevirapine- versus efavirenz-based highly active antiretroviral therapy regimens in antiretroviral-naïve patients with advanced HIV infection.

    abstract:OBJECTIVE:To compare virological and immunological responses to nevirapine (NVP)-based and efavirenz (EFV)-based highly active antiretroviral therapy (HAART) regimens in antiretroviral-naïve patients with advanced HIV infection. METHODS:A retrospective observational cohort study was conducted on antiretroviral-naïve H...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2004.00195.x

    authors: Manosuthi W,Sungkanuparph S,Vibhagool A,Rattanasiri S,Thakkinstian A

    更新日期:2004-03-01 00:00:00

  • Regulation of adiponectin in adipocytes upon exposure to HIV-1.

    abstract:OBJECTIVES:Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV-related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV-infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide ...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2006.00372.x

    authors: Sankalé JL,Tong Q,Hadigan CM,Tan G,Grinspoon SK,Kanki PJ,Hotamisligil GS

    更新日期:2006-05-01 00:00:00

  • Early changes in bone turnover and inflammatory biomarkers and clinically significant bone mineral density loss over 48 weeks among HIV-infected patients with virological failure of a standard first-line antiretroviral therapy regimen in the SECOND-LINE s

    abstract:OBJECTIVES:We assessed whether changes at week 12 in markers of bone turnover, inflammation, and immune activation were associated with clinically important (≥ 5%) bone mineral density (BMD) loss from baseline to week 48 at the proximal femur (hip) and lumbar spine in the SECOND-LINE study. METHODS:We measured concent...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12882

    authors: Mwasakifwa GE,Amin J,White CP,Center JR,Kelleher A,Boyd MA

    更新日期:2020-09-01 00:00:00

  • Serum cryptococcal antigen titre as a diagnostic tool and a predictor of mortality in HIV-infected patients with cryptococcal meningitis.

    abstract:OBJECTIVES:The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS:In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Cli...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12679

    authors: Chen J,Zhang R,Shen Y,Liu L,Qi T,Wang Z,Mehraj V,Routy JP,Lu H

    更新日期:2019-01-01 00:00:00

  • Correction of facial lipoatrophy using autologous fat transplants in HIV-infected adolescents.

    abstract:OBJECTIVES:Antiretroviral therapy has dramatically improved the survival of HIV-infected children. Nevertheless, side effects comparable to those found in adults have been encountered, such as facial lipoatrophy, which can have a negative impact on the self-esteem of otherwise healthy adolescents. Cosmetic surgical pro...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2008.00682.x

    authors: Dollfus C,Blanche S,Trocme N,Funck-Brentano I,Bonnet F,Levan P

    更新日期:2009-05-01 00:00:00

  • Correlating HIV tropism with immunological response under combination antiretroviral therapy.

    abstract:OBJECTIVES:A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART). It is still unclear whether viral properties such as cell tropism play a major role in this incomplete immune response. This study therefore intended to follow ...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12365

    authors: Bader J,Schöni-Affolter F,Böni J,Gorgievski-Hrisoho M,Martinetti G,Battegay M,Klimkait T,Swiss HIV Cohort Study.

    更新日期:2016-09-01 00:00:00

  • Prognostic implications of baseline anaemia and changes in haemoglobin concentrations with amphotericin B therapy for cryptococcal meningitis.

    abstract:OBJECTIVES:Anaemia represents a common toxicity with amphotericin B-based induction therapy in HIV-infected persons with cryptococcal meningitis. We sought to examine the impact of amphotericin-related anaemia on survival. METHODS:We used data from Ugandan and South African trial participants to characterize the varia...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12387

    authors: Tugume L,Morawski BM,Abassi M,Bahr NC,Kiggundu R,Nabeta HW,Hullsiek KH,Taseera K,Musubire AK,Schutz C,Muzoora C,Williams DA,Rolfes MA,Meintjes G,Rhein J,Meya DB,Boulware DR

    更新日期:2017-01-01 00:00:00

  • Clinical outcomes of first antiretroviral regimen in HIV/hepatitis C virus co-infection.

    abstract:OBJECTIVES:Despite the benefits of HAART, initiation of antiretroviral therapy in HIV-HCV co-infected patients is often delayed as a consequence of patient and physician concern pertaining to liver toxicity. It is unclear whether this is justified. METHODS:We retrospectively evaluated treatment duration and outcome in...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2005.00340.x

    authors: Cooper CL,Breau C,Laroche A,Lee C,Garber G

    更新日期:2006-01-01 00:00:00

  • Monitoring the HIV continuum of care in key populations across Europe and Central Asia.

    abstract:OBJECTIVES:The aim of the study was to measure and compare national continuum of HIV care estimates in Europe and Central Asia in three key subpopulations: men who have sex with men (MSM), people who inject drugs (PWID) and migrants. METHODS:Responses to a 2016 European Centre for Disease Prevention and Control (ECDC)...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12603

    authors: Brown AE,Attawell K,Hales D,Rice BD,Pharris A,Supervie V,Van Beckhoven D,Delpech VC,An der Heiden M,Marcus U,Maly M,Noori T

    更新日期:2018-05-08 00:00:00

  • Potential lung cancer screening outcomes using different age and smoking thresholds in the ANRS-CO4 French Hospital Database on HIV cohort.

    abstract:OBJECTIVES:In most lung screening programmes, only subjects ≥ 55 years old and smoking ≥ 30 pack-years are eligible to undergo chest low-dose computed tomography. Whether the same criteria should apply to people living with HIV (PLHIV) is uncertain, given the increased lung cancer risks associated with immunodeficiency...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12811

    authors: Makinson A,Tron L,Grabar S,Milleron B,Reynes J,Le Moing V,Morquin D,Lert F,Costagliola D,Guiguet M

    更新日期:2020-03-01 00:00:00

  • Effects of highly active antiretroviral therapy on vaccine-induced humoral immunity in HIV-infected adults.

    abstract:OBJECTIVES:The acquisition of adequate vaccine-induced humoral immunity is especially important in HIV-infected individuals, who are at increased risk of infections. The aim of the study was to assess the safety of administering a complete vaccination programme to successfully treated HIV-infected adults and to evaluat...

    journal_title:HIV medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1468-1293.2010.00830.x

    authors: González R,Castro P,García F,Plana M,Bayas JM,Lafuente S,Serrano B,Mora B,Argelich R,Gatell JM,Vilella A

    更新日期:2010-09-01 00:00:00

  • Mitochondrial DNA assessment in adipocytes and peripheral blood mononuclear cells of HIV-infected patients with lipodystrophy according to a validated case definition.

    abstract:BACKGROUND:Several studies have compared mitochondrial DNA (mtDNA) content in tissue from HIV-1-infected patients on highly active antiretroviral therapy with and without evidence of lipodystrophy, the diagnosis of which was based on subjective clinical assessment. OBJECTIVES:The aim of this study was to assess the ut...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2007.00428.x

    authors: Casula M,van der Valk M,Wit FW,Nievaard MA,Reiss P

    更新日期:2007-01-01 00:00:00

  • Neurological and psychiatric tolerability of rilpivirine (TMC278) vs. efavirenz in treatment-naïve, HIV-1-infected patients at 48 weeks.

    abstract:OBJECTIVES:The aim of the study was to compare the neuropsychiatric safety and tolerability of rilpivirine (TMC278) vs. efavirenz in a preplanned pooled analysis of data from the ECHO and THRIVE studies which compared the safety and efficacy of the two drugs in HIV-1 infected treatment naïve adults. METHODS:ECHO and T...

    journal_title:HIV medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/hiv.12012

    authors: Mills AM,Antinori A,Clotet B,Fourie J,Herrera G,Hicks C,Madruga JV,Vanveggel S,Stevens M,Boven K,ECHO and THRIVE study groups.

    更新日期:2013-08-01 00:00:00

  • Changes in elevated cholesterol in the era of tenofovir in South Africa: risk factors, clinical management and outcomes.

    abstract:OBJECTIVES:Antiretroviral therapy (ART) has been associated with unfavourable lipid profile changes and increased risk of cardiovascular disease (CVD). With a growing population on ART in South Africa, there has been concern about the increase in noncommunicable diseases such as CVD. We determined risk factors associat...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12495

    authors: Jamieson L,Evans D,Brennan AT,Moyo F,Spencer D,Mahomed K,Maskew M,Long L,Rosen S,Fox MP

    更新日期:2017-09-01 00:00:00

  • Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy.

    abstract:BACKGROUND:Mucocutaneous manifestations such as oral candidiasis (OC) and seborrheic dermatitis (SD) are very common HIV-related opportunistic events and are usually initial markers of immunodeficiency. AIM:The purpose of this study was to evaluate the efficacy of highly active antiretroviral therapy (HAART) in the re...

    journal_title:HIV medicine

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1468-1293.2004.00185.x

    authors: Dunic I,Vesic S,Jevtovic DJ

    更新日期:2004-01-01 00:00:00

  • Cushing's syndrome secondary to inhaled corticosteroids mimicking HIV-associated lipodystrophy.

    abstract::We report the case of an asthmatic man with HIV infection who was initially diagnosed with HIV treatment-associated lipodystrophy. Further investigations showed he had Cushing's syndrome secondary to 1600 microg of budesonide dry powder inhaler. Cushing's syndrome has not been reported previously on this normal dose o...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1046/j.1468-1293.2001.00058.x

    authors: le Roux CW,Beckles MA,Besser GM,Pinching AJ,Davison AG

    更新日期:2001-04-01 00:00:00

  • The role of tenofovir alafenamide in future HIV management.

    abstract::HIV infection has become a chronic condition rather than an acute life-threatening disease in developed countries, thanks to consistent innovation and evolution of effective interventions. This has altered HIV management and created new challenges. People living with HIV (PLWHIV) are living longer and so encounter com...

    journal_title:HIV medicine

    pub_type: 杂志文章,评审

    doi:10.1111/hiv.12401

    authors: Antela A,Aguiar C,Compston J,Hendry BM,Boffito M,Mallon P,Pourcher-Martinez V,Di Perri G

    更新日期:2016-05-01 00:00:00

  • Antiretroviral therapy in HIV-positive men is associated with increased apolipoprotein CIII in triglyceride-rich lipoproteins.

    abstract:OBJECTIVES:Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. However, the pathogenic mechanisms involved are not well understood or documented using conventional lipid measurements. METHODS:Using a cross-sectional design, the prevalence of abnormal stan...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1468-1293.2005.00316.x

    authors: Rimland D,Guest JL,Hernández I,Del Rio C,Le NA,Brown WV

    更新日期:2005-09-01 00:00:00

  • Impact of immune interventions on proviral HIV-1 DNA decay in patients receiving highly active antiretroviral therapy.

    abstract:OBJECTIVE:To measure the evolution of proviral HIV-1 DNA levels in patients receiving highly active antiretroviral therapy (HAART) compared to those treated with HAART plus interleukin-2 (IL-2) and hydroxyurea. DESIGN:Prospective randomised trial. METHODS:Twenty-two HIV-1 infected patients were randomly assigned to a...

    journal_title:HIV medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1468-1293.2001.00065.x

    authors: Lafeuillade A,Poggi C,Chadapaud S,Hittinger G,Khiri H,Halfon P

    更新日期:2001-07-01 00:00:00

  • Euthanasia: from the perspective of HIV infected persons in Europe.

    abstract:BACKGROUND:In the debate about legalization of euthanasia very little attention has so far been given to the opinion of the patient. OBJECTIVE:To assess the opinion of persons with HIV infection in Europe. METHODS:A cross-sectional survey of persons with HIV infection attending HIV/AIDS treatment centres or HIV suppo...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1046/j.1468-1293.2001.00053.x

    authors: Andraghetti R,Foran S,Colebunders R,Tomlinson D,Vyras P,Borleffs CJ,Fleerackers Y,Schrooten W,Borchert M

    更新日期:2001-01-01 00:00:00

  • Paediatric antiretroviral therapy audit in South London.

    abstract:OBJECTIVES:To audit clinical and surrogate marker outcome data following the introduction of combination antiretroviral therapy to HIV-infected children in South London. METHODS:We performed a retrospective cohort study of 110 HIV-infected children under the care of the Paediatric HIV in South London Network (PHILS-NE...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1046/j.1464-2662.2001.00098.x

    authors: Doerholt K,Sharland M,Ball C,DuMont G

    更新日期:2002-01-01 00:00:00

  • Inhibitory quotient as a prognostic factor of response to a salvage antiretroviral therapy containing ritonavir-boosted saquinavir. The CIVSA Study.

    abstract:BACKGROUND:The addition of a low dose of ritonavir to protease inhibitors (PIs) has become a widespread strategy to improve PI pharmacokinetics. As resistance is a major barrier to long-term suppression, in salvage therapy genotype and/or phenotype scoring is currently used to predict the response. We evaluated the rel...

    journal_title:HIV medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1468-1293.2007.00464.x

    authors: Mallolas J,Blanco J,Labarga P,Vergara A,Ocampo A,Sarasa M,Arnedo M,López-Púa Y,García J,Juega J,Guelar A,Terrón A,Dalmau D,García I,Zárraga M,Martínez E,Carné X,Pumarola T,Escayola R,Gatell J

    更新日期:2007-05-01 00:00:00

  • Appendicitis in HIV-infected patients during the era of highly active antiretroviral therapy.

    abstract:BACKGROUND:Limited studies have suggested increased incidence rates and unusual clinical presentations of appendicitis among HIV-infected patients during the pre-highly active antiretroviral therapy (HAART) era. Data in the HAART era are sparse, and no study has evaluated potential HIV-related risk factors for the deve...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2008.00577.x

    authors: Crum-Cianflone N,Weekes J,Bavaro M

    更新日期:2008-07-01 00:00:00

  • An oral formulation of efavirenz-loaded lactoferrin nanoparticles with improved biodistribution and pharmacokinetic profile.

    abstract:OBJECTIVES:Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, is a drug that is frequently included in highly active antiretroviral therapy for treatment of HIV infection. Decreased bioavailability and increased toxicity limit its use. We report a formulation of efavirenz-loaded lactoferrin nanoparticle...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12475

    authors: Kumar P,Lakshmi YS,Kondapi AK

    更新日期:2017-08-01 00:00:00

  • HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.

    abstract::The advent of potent highly active antiretroviral therapy (HAART) for persons infected with HIV-1 has led to a "new" chronic disease with complications including cardiovascular disease (CVD). CVD is a significant cause of morbidity and mortality in persons with HIV infection. In addition to traditional risk factors su...

    journal_title:HIV medicine

    pub_type: 杂志文章,评审

    doi:10.1111/hiv.12346

    authors: Lambert CT,Sandesara PB,Hirsh B,Shaw LJ,Lewis W,Quyyumi AA,Schinazi RF,Post WS,Sperling L

    更新日期:2016-06-01 00:00:00

  • Polypharmacy and potential drug-drug interactions for people with HIV in the UK from the Climate-HIV database.

    abstract:OBJECTIVES:People with HIV (PWHIV) are likely to need therapies for comorbidities as they age. We assessed risk of drug-drug interactions (DDIs) in PWHIV. METHODS:The Climate-HIV electronic recording system was used to cross-sectionally analyse records from PWHIV aged ≥ 18 years attending four UK HIV units with a curr...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/hiv.12879

    authors: Okoli C,Schwenk A,Radford M,Myland M,Taylor S,Darley A,Barnes J,Fox A,Grimson F,Reeves I,Munshi S,Croucher A,Boxall N,Benn P,Paice A,van Wyk J,Khoo S

    更新日期:2020-09-01 00:00:00

  • Trends in uptake of recently approved antiretrovirals within a national healthcare system.

    abstract:OBJECTIVE:The aim of the study was to describe Veterans Healthcare Administration (VHA) system-wide uptake of three HIV protease inhibitors: atazanavir, darunavir and tipranavir. METHODS:This retrospective cohort study evaluated VHA uptake of three target antiretrovirals and lopinavir/ritonavir in each complete 90-day...

    journal_title:HIV medicine

    pub_type: 杂志文章

    doi:10.1111/j.1468-1293.2009.00764.x

    authors: Belperio PS,Mole LA,Boothroyd DB,Backus LI

    更新日期:2010-03-01 00:00:00

  • Randomized comparison of metabolic and renal effects of saquinavir/r or atazanavir/r plus tenofovir/emtricitabine in treatment-naïve HIV-1-infected patients.

    abstract:OBJECTIVES:The aim of the study was to compare the effects on lipids, body composition and renal function of once-daily ritonavir-boosted saquinavir (SQV/r) or atazanavir (ATV/r) in combination with tenofovir/emtricitabine (TDF/FTC) over 48 weeks. METHODS:An investigator-initiated, randomized, open-label, multinationa...

    journal_title:HIV medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1468-1293.2011.00941.x

    authors: Vrouenraets SM,Wit FW,Fernandez Garcia E,Moyle GJ,Jackson AG,Allavena C,Raffi F,Jayaweera DT,Mauss S,Katlama C,Fisher M,Slama L,Hardy WD,Dejesus E,van Eeden A,Reiss P,BASIC Study Group.

    更新日期:2011-11-01 00:00:00