Abstract:
BACKGROUND:Mucocutaneous manifestations such as oral candidiasis (OC) and seborrheic dermatitis (SD) are very common HIV-related opportunistic events and are usually initial markers of immunodeficiency. AIM:The purpose of this study was to evaluate the efficacy of highly active antiretroviral therapy (HAART) in the regression of HIV-associated OC and SD. METHODS:In a prospective study, 120 HIV-infected patients with OC and SD were divided into two groups: HAART-treated patients (group 1, n=76) and non-HAART-treated patients (group 2, n=44). Non-HAART-treated patients were given antimicrobial therapy. Study subjects were matched for sex, age, risk, and stage of HIV infection. The results were analysed by chi2 test and the Kaplan-Meier method. RESULTS:At baseline, OC was evident in 59 (77.7%) of the HAART-treated patients and in 34 (77.3%) of the non-HAART-treated patients, while SD was present in 19 (25.0%) of the HAART-treated patients and in 17 (38.6%) of the non-HAART-treated patients. After a median follow-up period of 22 months, regression of OC and SD occurred in 49 (83.1%) and 16 (84.2%) of the HAART-treated patients, respectively. In the control group, regression of OC and SD occurred in only five (14.7%) and seven (41.2%) patients, respectively, during the same period. CONCLUSIONS:HAART showed greater efficacy than standard antimicrobial therapy for the treatment of OC and SD in HIV-infected patients.
journal_name
HIV Medjournal_title
HIV medicineauthors
Dunic I,Vesic S,Jevtovic DJdoi
10.1111/j.1468-1293.2004.00185.xkeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
50-4issue
1eissn
1464-2662issn
1468-1293pii
185journal_volume
5pub_type
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