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Chronic hepatitis B increases mortality and complexity among HIV-coinfected patients in South Africa: a cohort study.

Abstract：

OBJECTIVES:To assess the effect of chronic hepatitis B on survival and clinical complexity among people living with HIV following antiretroviral therapy (ART) initiation. METHODS:We evaluated mortality and single-drug substitutions up to 3 years from ART initiation (median follow-up 2.75 years; interquartile range 2-3 years) among patients with and without chronic hepatitis B (CHB) enrolled in a workplace HIV care programme in South Africa. RESULTS:Mortality was increased for CHB patients with hepatitis B virus (HBV) DNA levels > 10 000 copies/mL (adjusted hazard ratio 3.1; 95% confidence interval 1.2-8.0) compared with non-CHB patients. We did not observe a similar difference between non-CHB patients and those with CHB and HBV DNA < 10 000 copies/mL (adjusted hazard ratio 0.70; 95% confidence interval 0.2-2.3). Single-drug substitutions occurred more frequently among coinfected patients regardless of HBV DNA level. CONCLUSIONS:Our findings suggest that CHB may increase mortality and complicate ART management.

journal_name

HIV Med

journal_title

HIV medicine

authors

Velen K,Charalambous S,Innes C,Churchyard GJ,Hoffmann CJ

doi

10.1111/hiv.12367

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

702-7

issue

9

eissn

1464-2662

issn

1468-1293

journal_volume

17

pub_type

杂志文章

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