Abstract:
OBJECTIVES:The acquisition of adequate vaccine-induced humoral immunity is especially important in HIV-infected individuals, who are at increased risk of infections. The aim of the study was to assess the safety of administering a complete vaccination programme to successfully treated HIV-infected adults and to evaluate specific humoral responses and the effect of highly active antiretroviral therapy (HAART) interruption on these responses. METHODS:A placebo-controlled, double-blind clinical trial was designed and 26 HIV-infected adults enrolled. Study participants were randomized to receive either a complete immunization schedule with commercial vaccines or placebo for 12 months. HAART was then discontinued for 6 months. Specific humoral responses were evaluated at baseline, at month 12 and after HAART interruption and compared between groups. RESULTS:There were neither local nor systemic secondary effects related to vaccination. Specific humoral responses to vaccines were adequate, but a loss of immunoglobulin G titres was observed after HAART interruption in 12 study participants. CONCLUSIONS:HAART interruption may cause impairment of previously acquired vaccine-induced immunity in HIV-infected adults.
journal_name
HIV Medjournal_title
HIV medicineauthors
González R,Castro P,García F,Plana M,Bayas JM,Lafuente S,Serrano B,Mora B,Argelich R,Gatell JM,Vilella Adoi
10.1111/j.1468-1293.2010.00830.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
535-9issue
8eissn
1464-2662issn
1468-1293pii
HIV830journal_volume
11pub_type
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