The changing demographics of new HIV diagnoses at a London centre from 1994 to 2000.


OBJECTIVE:To document the demographic changes in new HIV diagnoses at the Royal Free Hospital, London, UK, between 1994 and 2000. DESIGN:Retrospective case note review. METHODS:Data were extracted from the Royal Free HIV database identifying new diagnoses for 1994, 1997 and 2000. All case notes were reviewed and patients were included if they had their first positive HIV test at the Royal Free Hospital, or if they first tested positive elsewhere and attended the Royal Free HIV unit for their initial HIV care. Data extracted included sex, ethnicity, age, risk factor(s) for HIV, reason for test, clinical stage of disease, CD4 count and HIV RNA viral load at diagnosis. RESULTS:One hundred and forty-four patients were identified for 1994, 136 for 1997 and 110 for 2000. Over this time period the proportion of white patients dropped from 72% (n = 104) to 48% (n = 53), P = 0.0001, whilst the proportion of black Africans rose from 24% (n = 34) to 45% (n = 49), P = 0.0004. The median CD4 count at diagnosis of the white cohort was 475 cells/microL in 1994 and 286/microL in 2000, P = 0.005, whilst in the black African patients it was 240/microL and 230/microL for the same years. CONCLUSIONS:There has been a reduction in new HIV diagnoses among the white population and a rise in the black Africans at this centre between 1994 and 2000. The clinical and immunological parameters of HIV disease have worsened over this time period for the white group, but have remained stable in the black Africans.




HIV medicine


Barry SM,Lloyd-Owen SJ,Madge SJ,Cozzi-Lepri A,Evans AJ,Phillips AN,Johnson MA





Has Abstract


2002-04-01 00:00:00














  • The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily.

    abstract::Tenofovir (TDF) co-administered with didanosine (ddI) 400 mg increases ddI plasma concentrations by up to 60%, raising concerns over toxicity. To limit this interaction, the dosage of ddI may be reduced to 250 mg once daily when co-prescribed with TDF. In this clinical cohort, highly active antiretroviral therapy regi...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Tung MY,Mandalia S,Bower M,Gazzard B,Nelson M

    更新日期:2005-05-01 00:00:00

  • Blood Epstein-Barr virus DNA load and risk of progression to AIDS-related systemic B lymphoma.

    abstract:BACKGROUND:AIDS-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the combined antiretroviral therapy (cART) era. Although most ARLs are associated with the Epstein-Barr virus (EBV), whether patients with high EBV burden are more at risk of developing ARL is unknown. This study investigated the re...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Leruez-Ville M,Seng R,Morand P,Boufassa F,Boue F,Deveau C,Rouzioux C,Goujard C,Seigneurin JM,Meyer L

    更新日期:2012-09-01 00:00:00

  • Associations of marijuana with markers of chronic lung disease in people living with HIV.

    abstract:OBJECTIVES:The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. METHODS:We performed a cross-sectional analysis of the Examinations of HIV-Associated Lung Emphysema (EXHALE) study, including 162 HIV-positive patients and 138 participants with...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Wenger DS,Triplette M,Shahrir S,Akgun KM,Wongtrakool C,Brown ST,Kim JW,Soo Hoo GW,Rodriguez-Barradas MC,Huang L,Feemster LC,Zifodya J,Crothers K

    更新日期:2021-02-01 00:00:00

  • Euthanasia: from the perspective of HIV infected persons in Europe.

    abstract:BACKGROUND:In the debate about legalization of euthanasia very little attention has so far been given to the opinion of the patient. OBJECTIVE:To assess the opinion of persons with HIV infection in Europe. METHODS:A cross-sectional survey of persons with HIV infection attending HIV/AIDS treatment centres or HIV suppo...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Andraghetti R,Foran S,Colebunders R,Tomlinson D,Vyras P,Borleffs CJ,Fleerackers Y,Schrooten W,Borchert M

    更新日期:2001-01-01 00:00:00

  • Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV.

    abstract:OBJECTIVES:Cardiovascular risk is increased in people living with HIV (PLWH). In HIV-uninfected populations, total absolute monocyte count (AMC) has been shown to be predictive of future cardiovascular events (CVEs). We sought to determine whether AMC predicts CVEs in PLWH independent of established and HIV-related car...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Bogorodskaya M,Lyass A,Mahoney TF,Borowsky LH,Sen P,Swirski FK,Srinivasa S,Longenecker CT,Massaro JM,D'Agostino RB Sr,Triant VA

    更新日期:2020-12-08 00:00:00

  • The role of tenofovir alafenamide in future HIV management.

    abstract::HIV infection has become a chronic condition rather than an acute life-threatening disease in developed countries, thanks to consistent innovation and evolution of effective interventions. This has altered HIV management and created new challenges. People living with HIV (PLWHIV) are living longer and so encounter com...

    journal_title:HIV medicine

    pub_type: 杂志文章,评审


    authors: Antela A,Aguiar C,Compston J,Hendry BM,Boffito M,Mallon P,Pourcher-Martinez V,Di Perri G

    更新日期:2016-05-01 00:00:00

  • National review of maternity care for women with HIV infection.

    abstract:OBJECTIVE:To assess adherence to the British HIV Association (BHIVA) 2001 guidelines for the management of HIV-infected pregnant women. METHODS:A survey and a case note review were carried out using structured questionnaires sent to providers of adult HIV care in the UK and Ireland. Participants were women with HIV in...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究


    authors: McDonald C,Curtis H,de Ruiter A,Johnson MA,Welch J,British HIV Association (BHIVA) and the BHIVA audit subcommittee.

    更新日期:2006-07-01 00:00:00

  • Better preserved immune responses after immunization with rgp 160 in HIV-1 infected patients treated with highly active antiretroviral therapy than in untreated patients with similar CD4 levels during at 2 years' follow-up.

    abstract:OBJECTIVE:To study the impact of effective highly active antiretroviral therapy (HAART) on the preservation of long-term CD4 memory cells induced by vaccines in HIV-1-infected patients. METHODS:Thirty HIV-1-positive patients on HAART with undetectable viral load were randomized into three groups: 10 received HIV-1 rgp...

    journal_title:HIV medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hejdeman B,Leandersson AC,Fredriksson EL,Sandström E,Wahren B,Bratt G

    更新日期:2003-04-01 00:00:00

  • Risk of non-AIDS-defining events among HIV-infected patients not yet on antiretroviral therapy.

    abstract:OBJECTIVES:Certain non-AIDS-related diseases have been associated with immunodeficiency and HIV RNA levels in HIV-infected patients on combination antiretroviral therapy (cART). We aimed to investigate these associations in patients not yet on cART, when potential antiretroviral-drug-related effects are absent and vari...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Zhang S,van Sighem A,Kesselring A,Gras L,Prins JM,Hassink E,Kauffmann R,Richter C,de Wolf F,Reiss P,ATHENA national observational HIV cohort study.

    更新日期:2015-05-01 00:00:00

  • Financial stress is associated with reduced treatment adherence in HIV-infected adults in a resource-rich setting.

    abstract:OBJECTIVES:Financial stress has been identified as a barrier to antiretroviral adherence, but only in resource- limited settings. Almost half of HIV-infected Australian adults earn no regular income and, despite highly subsidised antiretroviral therapy and universal health care, 3% of HIV-infected Australians cease ant...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: McAllister J,Beardsworth G,Lavie E,MacRae K,Carr A

    更新日期:2013-02-01 00:00:00

  • HIV lipodystrophy: prevalence, severity and correlates of risk in Australia.

    abstract:OBJECTIVE:To establish the prevalence, severity and factors associated with the HIV lipodystrophy syndrome. METHODS:Cross-sectional study of lipodystrophy conducted in high HIV caseload primary care sites and HIV outpatient clinics. A subset of patients was examined using dual energy X-ray absorptiometry (DEXA) and si...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究


    authors: Miller J,Carr A,Emery S,Law M,Mallal S,Baker D,Smith D,Kaldor J,Cooper DA

    更新日期:2003-07-01 00:00:00

  • An analysis of patients' understanding of 'routine' preoperative blood tests and HIV screening. Is no news really good news?

    abstract:OBJECTIVES:Many patients may believe that HIV screening is included in routine preoperative work-ups. We examined what proportion of patients undergoing preoperative blood testing believed that they had been tested for HIV. METHODS:All patients hospitalized for elective orthopaedic surgery between January and December...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Albrecht E,Frascarolo P,Meystre-Agustoni G,Farron A,Gilliard N,Darling K,Cavassini M

    更新日期:2012-08-01 00:00:00

  • The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*.

    abstract:BACKGROUND:Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz desp...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Cozzi-Lepri A,Paredes,Phillips AN,Clotet B,Kjaer J,Von Wyl V,Kronborg G,Castagna A,Bogner JR,Lundgren JD,EuroSIDA in EuroCoord.

    更新日期:2012-01-01 00:00:00

  • Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.

    abstract:OBJECTIVES:Conflicting results have been reported regarding the ability of valproic acid (VPA) to reduce the size of HIV reservoirs in patients receiving suppressive highly active antiretroviral therapy (HAART). In a randomized multicentre, cross-over study, we assessed whether adding VPA to stable HAART could potentia...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Routy JP,Tremblay CL,Angel JB,Trottier B,Rouleau D,Baril JG,Harris M,Trottier S,Singer J,Chomont N,Sékaly RP,Boulassel MR

    更新日期:2012-05-01 00:00:00

  • Increasing HIV transmission through male homosexual and heterosexual contact in Australia: results from an extended back-projection approach.

    abstract:OBJECTIVES:The aim of the study was to reconstruct the HIV epidemic in Australia for selected populations categorized by exposure route; namely, transmission among men who have sex with men (MSM), transmission among injecting drug users (IDUs), and transmission among heterosexual men and women in Australia. DESIGN:Sta...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Wand H,Yan P,Wilson D,McDonald A,Middleton M,Kaldor J,Law M

    更新日期:2010-07-01 00:00:00

  • Immune reconstitution pneumonitis following Pneumocystis carinii pneumonia in HIV-infected subjects.

    abstract::An HIV-infected man presented with a pneumonic illness following an episode of treated Pneumocystis carinii pneumonia (PCP). He had a rise in his CD4 count from 4 to 125 cells/microL on antiretroviral therapy prior to the onset of the second respiratory event. Bronchoalveolar lavage (BAL) revealed no pathogen, althoug...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Barry SM,Lipman MC,Deery AR,Johnson MA,Janossy G

    更新日期:2002-07-01 00:00:00

  • The association between physical activity and cognition in men with and without HIV infection.

    abstract:OBJECTIVES:HIV-associated neurocognitive disorders are highly prevalent, and physical activity (PA) is a modifiable behaviour that may affect neurocognitive function. Our objective was to determine the association between PA and neurocognitive function and the effect of HIV on this association. METHODS:PA was assessed...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究


    authors: Monroe AK,Zhang L,Jacobson LP,Plankey MW,Brown TT,Miller EN,Martin E,Becker JT,Levine AJ,Ragin A,Sacktor NC

    更新日期:2017-09-01 00:00:00

  • Prevalence of cryptococcal antigenuria at initial HIV diagnosis in KwaZulu-Natal.

    abstract:OBJECTIVES:The World Health Organization (WHO) recommends screening HIV-infected people for cryptococcal antigens to identify cryptococcosis, a major cause of AIDS-related deaths. As the burden of cryptococcosis is unknown in South Africa's KwaZulu-Natal province, we assessed the cryptococcal antigenuria prevalence amo...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Drain PK,Kleene JM,Coleman SM,Losina E,Katz JN,Giddy J,Ross D,Freedberg KA,Bassett IV

    更新日期:2015-11-01 00:00:00

  • Incidence of anaemia among HIV-infected patients treated with highly active antiretroviral therapy.

    abstract:OBJECTIVE:The aim of the study was to compare the incidence of anaemia in patients treated with zidovudine (ZDV) with that in patients treated with highly active antiretroviral therapy (HAART) not including ZDV. METHODS:Using HIV Insight, a database of abstracted US HIV care centre medical charts, ZDV-naïve patients s...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Curkendall SM,Richardson JT,Emons MF,Fisher AE,Everhard F

    更新日期:2007-11-01 00:00:00

  • The case for indicator condition-guided HIV screening.

    abstract::One-half of the estimated 2.5 million people who now live with HIV in the World Health Organization (WHO) European Region are still diagnosed late. A central question is which clinical scenarios should trigger an HIV test recommendation in order to avoid late presentation. Drawing on the work of the HIV Indicator Dise...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Lazarus JV,Hoekstra M,Raben D,Delpech V,Coenen T,Lundgren JD,HIV in Europe Initiative Steering Committee.

    更新日期:2013-08-01 00:00:00

  • De-simplifying single-tablet antiretroviral treatments: uptake, risks and cost savings.

    abstract:OBJECTIVES:As more HIV-positive individuals receive antiretroviral therapy (ART), payers are seeking options for covering these increased and sustained drug costs. Strategic use of available generic antiretroviral (ARV) formulations may be feasible. De-simplifying a single-tablet co-formulation (STF) into two or more t...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Krentz HB,Campbell S,Lahl M,Gill MJ

    更新日期:2019-03-01 00:00:00

  • Coronavirus disease 2019 (COVID-19) outcomes in HIV/AIDS patients: a systematic review.

    abstract:OBJECTIVES:The aim of the study was to systematically review current studies reporting on clinical outcomes in people living with HIV (PLHIV) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS:We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews a...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Cooper TJ,Woodward BL,Alom S,Harky A

    更新日期:2020-10-01 00:00:00

  • Hepatitis C in men who have sex with men in London--a community survey.

    abstract:OBJECTIVES:For the last 10 years there has been an epidemic of hepatitis C virus (HCV) infection in men who have sex with men (MSM) in Europe, North America and Australia. The majority of those infected are also HIV-positive and it is unclear to what extent HIV-negative MSM are also at increased risk of infection with ...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Price H,Gilson R,Mercey D,Copas A,Parry J,Nardone A,Johnson A,Hart G

    更新日期:2013-10-01 00:00:00

  • Antiretroviral therapy in HIV-positive men is associated with increased apolipoprotein CIII in triglyceride-rich lipoproteins.

    abstract:OBJECTIVES:Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. However, the pathogenic mechanisms involved are not well understood or documented using conventional lipid measurements. METHODS:Using a cross-sectional design, the prevalence of abnormal stan...

    journal_title:HIV medicine

    pub_type: 杂志文章,多中心研究


    authors: Rimland D,Guest JL,Hernández I,Del Rio C,Le NA,Brown WV

    更新日期:2005-09-01 00:00:00

  • Knowledge of their children's HIV status in HIV-positive mothers attending a genitourinary medicine clinic in the UK.

    abstract:OBJECTIVES:To determine whether HIV-infected mothers knew the HIV status of their children, enabling the offer of targeted testing of children at risk. METHODS:All HIV-positive women attending the genitourinary medicine clinic at a district general hospital in the United Kingdom were asked whether they had children an...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Eisenhut M,Sharma V,Kawsar M,Balachandran T

    更新日期:2008-04-01 00:00:00

  • Prognostic implications of baseline anaemia and changes in haemoglobin concentrations with amphotericin B therapy for cryptococcal meningitis.

    abstract:OBJECTIVES:Anaemia represents a common toxicity with amphotericin B-based induction therapy in HIV-infected persons with cryptococcal meningitis. We sought to examine the impact of amphotericin-related anaemia on survival. METHODS:We used data from Ugandan and South African trial participants to characterize the varia...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Tugume L,Morawski BM,Abassi M,Bahr NC,Kiggundu R,Nabeta HW,Hullsiek KH,Taseera K,Musubire AK,Schutz C,Muzoora C,Williams DA,Rolfes MA,Meintjes G,Rhein J,Meya DB,Boulware DR

    更新日期:2017-01-01 00:00:00

  • Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily.

    abstract:OBJECTIVES:Antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission of HIV and for maternal care management. Physiological changes during pregnancy can affect pharmacokinetics, potentially altering pharmacological activity. We therefore evaluated the pharmacokinetics of ...

    journal_title:HIV medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Zorrilla CD,Wright R,Osiyemi OO,Yasin S,Baugh B,Brown K,Coate B,Verboven P,Mrus J,Falcon R,Kakuda TN

    更新日期:2014-01-01 00:00:00

  • Community-onset methicillin-resistant Staphylococcus aureus in an urban HIV clinic.

    abstract:OBJECTIVES:To determine the proportion of skin/soft tissue infections (SSTIs) and to determine risks for MRSA infection caused by methicillin-resistant Staphylococcus aureus (MRSA) in HIV-infected out-patients. METHODS:We conducted a prospective study of SSTIs in HIV-infected out-patients. A questionnaire was used to ...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Skiest D,Brown K,Hester J,Moore T,Crosby C,Mussa HR,Hoffman-Roberts H,Cooper T

    更新日期:2006-09-01 00:00:00

  • Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.

    abstract::The 2015 Paediatric European Network for Treatment of AIDS (PENTA) guidelines provide practical recommendations on the management of HIV-1 infection in children in Europe and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of ...

    journal_title:HIV medicine

    pub_type: 杂志文章,实务指引


    authors: Bamford A,Turkova A,Lyall H,Foster C,Klein N,Bastiaans D,Burger D,Bernadi S,Butler K,Chiappini E,Clayden P,Della Negra M,Giacomet V,Giaquinto C,Gibb D,Galli L,Hainaut M,Koros M,Marques L,Nastouli E,Niehues T,Nog

    更新日期:2018-01-01 00:00:00

  • The role of brain biopsy in the clinical management of HIV-related focal brain lesions.

    abstract:OBJECTIVES:Up to 20% of HIV-related focal brain lesion (FBL) diagnoses cannot be determined without invasive procedures. In such cases, brain biopsy is an important step in the evaluation algorithm. The aims of this study were to describe the clinical outcomes of patients with FBL, the proportion of diagnoses confirmed...

    journal_title:HIV medicine

    pub_type: 杂志文章


    authors: Acosta MC,Kundro M,Viloria G,Peressín Paz A,Morello F,Latorre F,Seoane E,Toibaro J,Losso M

    更新日期:2018-11-01 00:00:00