Abstract:
:The 2015 Paediatric European Network for Treatment of AIDS (PENTA) guidelines provide practical recommendations on the management of HIV-1 infection in children in Europe and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of short-term morbidity and mortality to optimizing health status for adult life and minimizing the impact of chronic HIV infection on immune system development and health in general. Additionally, there is a greater need for increased awareness and minimization of long-term drug toxicity. The main updates to the previous guidelines include: an increase in the number of indications for antiretroviral therapy (ART) at all ages (higher CD4 thresholds for consideration of ART initiation and additional clinical indications), revised guidance on first- and second-line ART recommendations, including more recently available drug classes, expanded guidance on management of coinfections (including tuberculosis, hepatitis B and hepatitis C) and additional emphasis on the needs of adolescents as they approach transition to adult services. There is a new section on the current ART 'pipeline' of drug development, a comprehensive summary table of currently recommended ART with dosing recommendations. Differences between PENTA and current US and World Health Organization guidelines are highlighted and explained.
journal_name
HIV Medjournal_title
HIV medicineauthors
Bamford A,Turkova A,Lyall H,Foster C,Klein N,Bastiaans D,Burger D,Bernadi S,Butler K,Chiappini E,Clayden P,Della Negra M,Giacomet V,Giaquinto C,Gibb D,Galli L,Hainaut M,Koros M,Marques L,Nastouli E,Niehues T,Nogdoi
10.1111/hiv.12217subject
Has Abstractpub_date
2018-01-01 00:00:00pages
e1-e42issue
1eissn
1464-2662issn
1468-1293journal_volume
19pub_type
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