Abstract:
OBJECTIVES:In the case of coinfection with HIV and hepatitis B virus (HBV) and/or hepatitis C virus (HCV), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver-related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface antigen (HBsAg) and anti-HCV among HIV-infected patients in Guinea-Bissau. METHODS:Blood samples from HIV-infected patients in Guinea-Bissau were stored after testing for HBsAg and anti-HCV with rapid tests. Samples were subsequently re-tested for HBsAg and anti-HCV in Denmark. RESULTS:Two rapid tests were used in Guinea-Bissau: HBsAg Strip Ref 2034 (VEDA.LAB, Alençon, France; sensitivity 62.3%; specificity 99.2%) and HEPA-SCAN (Bhat Bio-Tech, Bangalore, India; sensitivity 57.1%; specificity 99.7%). In the two tests the ability to obtain the correct outcome depended on the antigen and antibody concentrations, respectively. Sex, age, CD4 cell count and antiretroviral therapy status did not differ between false negative and true positive samples in either of the tests. The study is limited by a low number of anti-HCV positive samples. CONCLUSIONS:New diagnostic rapid tests should always be evaluated in the setting in which they will be used before implementation.
journal_name
HIV Medjournal_title
HIV medicineauthors
Hønge B,Jespersen S,Medina C,Té D,da Silva Z,Ostergaard L,Laursen A,Wejse C,Krarup H,Erikstrup C,Bissau HIV cohort study group.doi
10.1111/hiv.12158subject
Has Abstractpub_date
2014-10-01 00:00:00pages
571-6issue
9eissn
1464-2662issn
1468-1293journal_volume
15pub_type
杂志文章相关文献
HIV MEDICINE文献大全abstract:OBJECTIVES:We evaluated the efficacy and tolerability of lamivudine + dolutegravir in a cohort of HIV-1 infected, treatment-experienced patients with undetectable HIV-RNA. METHODS:Time to treatment discontinuation (TD) and virological failure (VF) and their predictors were assessed in a multicenter cohort of HIV-1 inf...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12611
更新日期:2018-03-24 00:00:00
abstract:OBJECTIVES:Outbreaks of shigellosis have been documented in men who have sex with men (MSM), associated with interpersonal transmission and underlying HIV infection. We observed a rise in Shigella flexneri isolates identified in a downtown tertiary-care hospital laboratory located within the city centre community healt...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12191
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The toxicities, cost and complexity of triple combinations warrant the search for other treatment options, such as boosted protease inhibitor (PI) monotherapy. MONotherapy AntiRetroviral Kaletra (MONARK) is the first randomized trial comparing lopinavir/ritonavir monotherapy to triple combination therapy wit...
journal_title:HIV medicine
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1293.2009.00752.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:To study the impact of highly active antiretroviral therapy (HAART) on isotype switching and avidity maturation of HIV-1-specific immunoglobulin G (IgG) in patients with primary HIV-1 infection (PHI). METHODS:We studied the emergence and the evolution of anti-HIV IgG antibodies by quantitative immunoblottin...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2006.00406.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:As more HIV-positive individuals receive antiretroviral therapy (ART), payers are seeking options for covering these increased and sustained drug costs. Strategic use of available generic antiretroviral (ARV) formulations may be feasible. De-simplifying a single-tablet co-formulation (STF) into two or more t...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12701
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:Involvement of people living with HIV (PLHIV) in the design of HIV cure studies is important, given the potential risks to participants. We present results of an international survey of PLHIV to define these issues and inform cure research. METHODS:PLHIV were recruited in June-November 2014 through HIV webs...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12391
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:Dyslipidaemic effects of antiretrovirals (ARVs) may contribute to increased cardiovascular risk (CR) in HIV-1-infected patients. The ARTEN (atazanavir/ritonavir on a background of tenofovir and emtricitabine vs. nevirapine on the same background, in naïve HIV-1-infected patients) study compared prospectively...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1293.2011.00917.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:The Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 goals propose that 90% of all people living with HIV should know their HIV status, 90% of those diagnosed should receive antiretroviral therapy (ART), and 90% of those should have durable viral suppression. We ha...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12431
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:In the debate about legalization of euthanasia very little attention has so far been given to the opinion of the patient. OBJECTIVE:To assess the opinion of persons with HIV infection in Europe. METHODS:A cross-sectional survey of persons with HIV infection attending HIV/AIDS treatment centres or HIV suppo...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1046/j.1468-1293.2001.00053.x
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to characterize and compare insulin resistance (IR) in hepatitis C virus (HCV)-antibody (Ab)-positive and HCV-Ab-negative patients with HIV infection. METHODS:This was a single-centre cross-sectional study of 1041 HIV-infected patients (373 HCV-Ab-positive; 167 with detectable plasma...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2007.00539.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:Rapid HIV testing (RHT) is well established in many countries, but it is new in Australia since a policy change in 2011. We assessed service provider acceptability of RHT before and after its implementation in four Sydney public sexual health clinics. METHODS:Service providers were surveyed immediately afte...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12209
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to identify and describe the characteristics of persons born in the UK who acquire HIV infection abroad. METHODS:Analyses using case reports and follow-up data from the national HIV database held at the Health Protection Agency were performed. RESULTS:Fifteen per cent (2066 of 13 8...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2011.00983.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:HIV-associated neurocognitive disorders are highly prevalent, and physical activity (PA) is a modifiable behaviour that may affect neurocognitive function. Our objective was to determine the association between PA and neurocognitive function and the effect of HIV on this association. METHODS:PA was assessed...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/hiv.12490
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:Few studies have explored the optimal dosing for efavirenz in individuals from China. We investigated plasma efavirenz concentrations and their association with efficacy and tolerance of efavirenz 600 mg daily in Chinese HIV-infected adults. METHODS:An analysis was performed using plasma samples from 455 pa...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12607
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:Dried sample spots have molecular applications, but few data are available on conditions of HIV-1 RNA amplification. OBJECTIVES:To determine the impact of (i) the sample type (plasma or serum), (ii) various storage periods, (iii) transfer at ambient temperature of the dried spots via postal mail, and (iv) t...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2008.00604.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Three-drug nonoccupational post-exposure prophylaxis (NPEP) typically includes co-formulated emtricitabine-tenofovir (FTC-TDF) and a protease inhibitor. However, protease inhibitors can cause significant toxicities, can interact with prescribed and illicit drugs, and work late in the viral cycle. Agents that...
journal_title:HIV medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/hiv.12075
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz desp...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2011.00943.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:In recent years, new technologies and new approaches to scale up HIV testing have emerged. The objective of this paper was to synthesize the body of recent evidence on strategies aimed at increasing the uptake and coverage of HIV testing outside of health care settings in the European Union (EU)/European Eco...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12807
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, is a drug that is frequently included in highly active antiretroviral therapy for treatment of HIV infection. Decreased bioavailability and increased toxicity limit its use. We report a formulation of efavirenz-loaded lactoferrin nanoparticle...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12475
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To establish the prevalence, severity and factors associated with the HIV lipodystrophy syndrome. METHODS:Cross-sectional study of lipodystrophy conducted in high HIV caseload primary care sites and HIV outpatient clinics. A subset of patients was examined using dual energy X-ray absorptiometry (DEXA) and si...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1468-1293.2003.00159.x
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:We describe the management of a cohort of eight HIV-positive patients on antiretroviral medication with evidence of pancreatic insufficiency consisting of chronic diarrhoea and a low faecal elastase measurement. PATIENTS AND METHODS:Twenty-two patients with chronic diarrhoea for whom a faecal elastase measu...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2005.00263.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To assess the effect of chronic hepatitis B on survival and clinical complexity among people living with HIV following antiretroviral therapy (ART) initiation. METHODS:We evaluated mortality and single-drug substitutions up to 3 years from ART initiation (median follow-up 2.75 years; interquartile range 2-3...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12367
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:We provide the first estimate of HIV prevalence among trans and gender-diverse people living in England and compare outcomes of people living with HIV according to gender identity. METHODS:We analysed a comprehensive national HIV cohort and a nationally representative self-reported survey of people accessin...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12987
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Highly active antiretroviral therapy (HAART) has increased longevity. Currently, women comprise >50% of HIV-infected individuals worldwide. It is not known if there are differences between the sexes in the immunological and virological responses to HAART across the age strata. METHODS:Immunological reconsti...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/j.1468-1293.2007.00485.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to evaluate prospectively the usefulness of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in investigation of fever of unknown origin (FUO) in HIV-positive patients and to determine whether HIV viraemia impacts on FDG-PET/CT performance. METHODS:Th...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12030
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:GB virus type C (GBV-C) viraemia is associated with a beneficial outcome in HIV-infected individuals in several though not all studies. GBV-C viraemia was examined in a matched case-control study of 133 HIV-infected pregnant women who transmitted HIV to their infants ('cases') and 266 non-transmitting contro...
journal_title:HIV medicine
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1293.2007.00510.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:The relationship between marijuana use and markers of chronic lung disease in people living with HIV (PLWH) is poorly understood. METHODS:We performed a cross-sectional analysis of the Examinations of HIV-Associated Lung Emphysema (EXHALE) study, including 162 HIV-positive patients and 138 participants with...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12966
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS:In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Cli...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12679
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of "spit hoods" by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmissio...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12625
更新日期:2018-04-23 00:00:00
abstract:OBJECTIVES:The World Health Organization (WHO) recommends screening HIV-infected people for cryptococcal antigens to identify cryptococcosis, a major cause of AIDS-related deaths. As the burden of cryptococcosis is unknown in South Africa's KwaZulu-Natal province, we assessed the cryptococcal antigenuria prevalence amo...
journal_title:HIV medicine
pub_type: 杂志文章
doi:10.1111/hiv.12263
更新日期:2015-11-01 00:00:00