Abstract:
:Based on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon sample loop (4 mm o.d. and 2.4 mm i.d., 150 cm length) were both theoretically and experimentally investigated. The prominent absorption differences between propofol and moisture on the inwall of the sample loop allowed their concentrations to be time-resolved during the injection process, realizing sensitive measurement of end-tidal propofol with a response time of 2 s. At the optimized carrier gas flow rate of 700 mL min(-1), the linear response range for propofol was achieved to be 0.2 to 20 ppbv with a limit of detection (LOD) of 65 pptv. Finally, this method was performed on a patient undergoing mastectomy surgery to continuously monitor the end-tidal propofol with an interval of five respirations and the result nicely demonstrated its fast response to the propofol changes.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Zhou Q,Li E,Wang Z,Gong Y,Wang C,Guo L,Li Hdoi
10.1088/1752-7155/9/1/016002subject
Has Abstractpub_date
2015-01-05 00:00:00pages
016002issue
1eissn
1752-7155issn
1752-7163journal_volume
9pub_type
杂志文章abstract::Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, including fatty acids and their derivatives (e.g. hydrocarbons, aliphatic al...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/6/2/024001
更新日期:2012-06-01 00:00:00
abstract::Arterial lactate concentrations, taken as indicators of physical fitness, in athletes as well as in patients with cardio-respiratory or metabolic diseases, are measured invasively from arterialized ear lobe blood. Currently developed micro enzyme detectors permit a non-invasive measurement of hypoxia-related metabolit...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/4/1/017105
更新日期:2010-03-01 00:00:00
abstract::Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation incre...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046008
更新日期:2016-10-12 00:00:00
abstract::Since the ancient discovery of the 'sweet odor' in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the 'smell' of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advanceme...
journal_title:Journal of breath research
pub_type: 历史文章,杂志文章,评审
doi:10.1088/1752-7155/7/3/037109
更新日期:2013-09-01 00:00:00
abstract::There are many respiratory infections such as influenza that cause epidemics. These respiratory infection epidemics can be effectively prevented by determining the presence or absence of infections in patients using frequent tests. We think that self-diagnosis may be possible using a system that can collect and detect...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/3/036009
更新日期:2016-07-22 00:00:00
abstract::Oxidative stress is associated with numerous health conditions and disorders, and aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in exhaled human breath. Few studies report breath aldehyde levels in human populations, and none claim participant numbers in the hundreds or more. F...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab8865
更新日期:2020-07-21 00:00:00
abstract::Experimental studies using trained dogs to identify breath odour markers of human cancer, published in the recent decade, have been analyzed and compared with the authors' own results. Particular published studies differ as regards the experimental setup, kind of odour samples (breath, urine, tumor tissue, serum), sam...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/9/2/027001
更新日期:2015-05-06 00:00:00
abstract::Aircraft engine exhaust increases the number concentration of nanoparticles (NP) in the surrounding environment. Health concerns related to NP raise the question of the exposure and health monitoring of airport workers. No biological monitoring study on this profession has been reported to date. The aim was to evaluat...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/3/036006
更新日期:2016-07-13 00:00:00
abstract::There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research the sensor responses (i.e. resistance changes w.r.t. concentration of ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa8efe
更新日期:2017-12-06 00:00:00
abstract::Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current che...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046009
更新日期:2016-10-18 00:00:00
abstract::Selected volatile organic compounds (VOCs) in breath may be considered biomarkers if they are indicative of distinct diseases or disease states. Given the inherent molecular selectivity of vibrational spectroscopy, infrared sensing technologies appear ideally suitable for the determination of endogenous VOCs in breath...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/2/026003
更新日期:2014-06-01 00:00:00
abstract::Nitrative stress is thought to be involved in the inflammatory process in COPD airways, and the alveolar nitric oxide concentration (CAlv) has been reported to be increased. However, the CAlv levels are also regulated by gas diffusion at alveolar sites. The aim of the study was to assess the relationship between the C...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/4/046002
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Asthma control does not yet meet the goals of asthma management guidelines. Non-invasive monitoring of airway inflammation may help to improve the level of asthma control in children. OBJECTIVES:(1) To identify a set of exhaled volatile organic compounds (VOCs) that is most predictive for an asthma exacerba...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa5a8b
更新日期:2017-03-01 00:00:00
abstract::The data obtained for the concentration distributions of the most abundant volatile metabolites in exhaled breath determined in two independent studies are reviewed, the first limited study involving five healthy volunteers providing daily breath samples over a month, and the subsequent study involving 30 healthy volu...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/1/1/014004
更新日期:2007-09-01 00:00:00
abstract::The forehead was studied as a possible sampling site for capturing changes in volatile organic compound (VOC) profiles associated with psychological-stress. Skin-VOCs were sampled with a polydimethylsilicone (PDMS)-coupon and the resulting VOCs were recovered and analysed with two-stage thermal desorption gas chromato...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046012
更新日期:2016-11-21 00:00:00
abstract::In this article, a database of blood:air and fat:air partition coefficients (λ b:a and λ f:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/017103
更新日期:2016-01-27 00:00:00
abstract:BACKGROUND:Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation. OBJECTIVES:The aim of the study was to evaluate th...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa61c5
更新日期:2017-09-27 00:00:00
abstract::Early detection of lung cancer (LC) is a priority since LC is characterized by symptoms mimicking other respiratory conditions, but it remains the leading cause of oncological disease death. Properly trained dogs can perceive the volatile organic compounds (VOCs) related to cancer thanks to their acute sense of smell....
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab716e
更新日期:2020-03-11 00:00:00
abstract::Concentrations of exhaled volatile organic compounds (VOCs) may depend not only on biochemical or pathologic processes but also on physiological parameters. As breath sampling may be done in different body positions, effects of the sampling position on exhaled VOC concentrations were investigated by means of real-time...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/9/4/047105
更新日期:2015-11-19 00:00:00
abstract::This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after period...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017006
更新日期:2008-03-01 00:00:00
abstract::Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessing malabsorption of sugars in the small intestine. However, there are...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/7/2/024001
更新日期:2013-06-01 00:00:00
abstract::Methods for breath sampling and analysis require robust quality assessment to minimise the risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies also requires careful consideration of systematic and random variation as a result of sampling and analysis techniques. In this study...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aae557
更新日期:2018-10-30 00:00:00
abstract::Tongue coating (TC) mainly consists of protein mostly from exfoliated epithelial cells. Until now, to reduce TC accumulation, only mechanical measures have been available, and the procedure involves unpleasant side effects, such as gagging reflex or carcinogenesis related to mechanical stimulation. We expected that pr...
journal_title:Journal of breath research
pub_type: 杂志文章,随机对照试验
doi:10.1088/1752-7155/6/1/017107
更新日期:2012-03-01 00:00:00
abstract::Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...
journal_title:Journal of breath research
pub_type: 杂志文章,多中心研究
doi:10.1088/1752-7155/7/2/026008
更新日期:2013-06-01 00:00:00
abstract::Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/016005
更新日期:2016-02-01 00:00:00
abstract::In the current pilot study we aimed to determine whether breath analysis could be used to help recognise intra-abdominal infection, using acute appendicitis as an exemplar condition. Our study included 53 patients (aged 18-88 years) divided into three groups: appendix group, 26 (13 male) patients suffering from acute ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/abba88
更新日期:2020-10-22 00:00:00
abstract::Exhaled nitric oxide (eNO) has been suggested to be a marker of small airway injury. We investigated the effects of different ventilation strategies on eNO. Sixty-nine patients who received elective open abdominal surgery under general anesthesia with more than 2 h of surgery duration were randomly divided into three ...
journal_title:Journal of breath research
pub_type: 杂志文章,随机对照试验
doi:10.1088/1752-7155/9/1/016006
更新日期:2015-02-26 00:00:00
abstract::Biogenic amines are interesting compounds which may be of use for medical diagnosis or therapeutic monitoring. The present paper deals with the problems that occur with concentration determination of dimethylamine (DMA) and trimethylamine (TMA). These occur in the breath of people suffering from renal disease. The mea...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/4/2/026002
更新日期:2010-06-01 00:00:00
abstract::Profiling the body chemistry by means of volatile organic compounds (VOCs) in the breath opens exciting new avenues in medical diagnostics. Gas sensors could provide ideal platforms for realizing portable, hand-held breath testing devices in the near future. This review summarizes the latest developments and applicati...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/8/2/027103
更新日期:2014-06-01 00:00:00
abstract::Exhaled breath collection is used to identify and monitor inflammatory or oxidative components in breath. Exhaled breath sample collection is noninvasive and would greatly benefit human pollutant exposure research. We demonstrate the efficacy of exhaled breath collection and analysis in two human exposure studies to o...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/3/037019
更新日期:2008-09-01 00:00:00