Abstract：
:Fertilization is a cell biological phenomenon of crucial importance for the birth of new life in a variety of multicellular and sexual reproduction species such as algae, animal and plants. Fertilization involves a sequence of events, in which the female gamete "egg" and the male gamete "spermatozoon (sperm)" develop, acquire their functions, meet and fuse with each other, to initiate embryonic and zygotic development. Here, it will be briefly reviewed how oocyte cytoplasmic components are orchestrated to undergo hormone-induced oocyte maturation and sperm-induced activation of development. I then review how sperm-egg membrane interaction/fusion and activation of development in the fertilized egg are accomplished and regulated through egg coat- or egg plasma membrane-associated components, highlighting recent findings and future directions in the studies using Xenopus laevis as a model experimental animal.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sato Kdoi
10.3390/ijms16010114subject
Has Abstractpub_date
2014-12-23 00:00:00pages
114-34issue
1issn
1422-0067pii
ijms16010114journal_volume
16pub_type
杂志文章,评审abstract：:B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescenc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020418
更新日期：2020-01-09 00:00:00
abstract：:Amino acid transporters alanine-serine-cysteine transporter 2 (ASCT2) and L-Type Amino Acid Transporter 1 (LAT1) are coordinately enhanced in human cancers where among other roles, they are thought to drive mechanistic target-of-rapamycin (mTOR) growth signaling. To assess ASCT2 and LAT1 as therapeutic targets, nine u...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072093
更新日期：2018-07-19 00:00:00
abstract：:Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17122059
更新日期：2016-12-08 00:00:00
abstract：:The excellent biocompatibility and biological effects of fullerenol and its derivatives make their biomedical application promising. The potential effects of fullerenol in mammals have been extensively studied, but little is known about its effects on female reproduction. Using canonical oocyte-granulosa cell complexe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030699
更新日期：2018-03-01 00:00:00
abstract：:Proliferation and apoptosis are important physiological processes of preadipocytes. Rev-erbα is a circadian clock gene, and its activity contributes to several physiological processes in various cells. Previous studies demonstrated that Rev-erbα promotes preadipocyte differentiation, but a role of Rev-erbα on preadipo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184524
更新日期：2019-09-12 00:00:00
abstract：:Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of the genetic disease ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031069
更新日期：2020-02-06 00:00:00
abstract：:To combat the escalating rise of antibacterial resistance, the development of antimicrobial peptides (AMPs) with a unique mode of action is considered an attractive strategy. However, proteolytic degradation of AMPs remains the greatest challenge in their transformation into therapeutics. Herein, we synthesized Fmoc-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103602
更新日期：2020-05-20 00:00:00
abstract：:The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtain...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14011207
更新日期：2013-01-09 00:00:00
abstract：:Although higher nuclear factor κB (NFκB) expression and activity is observed in preeclamptic placentas, its mechanism of activation is unknown. This is the first study to investigate whether the canonical, non-canonical, or atypical NFκB activation pathways may be responsible for the higher activation of NFκB observed...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155574
更新日期：2020-08-04 00:00:00
abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134781
更新日期：2020-07-06 00:00:00
abstract：:PCSK9 (Proprotein convertase subtilisin/kexin type 9) increases plasma cholesterol levels by promoting LDL receptor degradation. Current antibody inhibitors block the interaction between PCSK9 and LDL receptors, significantly decrease plasma cholesterol levels, and provide beneficial clinical outcomes. To reduce the a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020640
更新日期：2018-02-24 00:00:00
abstract：:Astaxanthin, a potent antioxidant carotenoid, plays a major role in modulating the immune response. In this study, we examined the immunomodulatory effects of astaxanthin on cytokine production in primary cultured lymphocytes both in vitro and ex vivo. Direct administration of astaxanthin (70-300 nM) did not produce c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010044
更新日期：2015-12-29 00:00:00
abstract：:An increase in intracellular Ca2+ concentration ([Ca2+]i) plays a key role in controlling endothelial functions; however, it is still unclear whether endothelial Ca2+ handling is altered by type 2 diabetes mellitus, which results in severe endothelial dysfunction. Herein, we analyzed for the first time the Ca2+ respon...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010250
更新日期：2019-12-30 00:00:00
abstract：:Aspartylglucosaminidase (AGA) is a lysosomal hydrolase that participates in the breakdown of glycoproteins. Defects in the AGA gene result in a lysosomal storage disorder, aspartylglucosaminuria (AGU), that manifests mainly as progressive mental retardation. A number of AGU missense mutations have been identified that...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040706
更新日期：2017-03-26 00:00:00
abstract：:The availability of osteoinductive biomaterials has encouraged new therapies in bone regeneration and has potentially triggered paradigmatic shifts in the development of new implants in orthopedics and dentistry. Among several available synthetic biomaterials, bioceramics have gained attention for their ability to ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174080
更新日期：2019-08-21 00:00:00
abstract：:Phytochelatins (PCs) play an important role in detoxification of heavy metals in plants. PCs are synthesized from glutathione by phytochelatin synthase (PCS), a dipeptidyltransferase. Sesbania rostrata is a tropical legume plant that can tolerate high concentrations of Cd and Zn. In this study, the S. rostrata PCS gen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10083269
更新日期：2009-07-24 00:00:00
abstract：:Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP-induced hepatotoxicity using rats based on M1/M2-macrophage functions in relation to damage-associated molecular patterns (DAMPs) and autophagy. L...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21238998
更新日期：2020-11-26 00:00:00
abstract：:Cytokine-induced killer (CIK) cells are heterogeneous, major histocompatibility complex (MHC)-unrestricted T lymphocytes that have acquired the expression of several natural killer (NK) cell surface markers following the addition of interferon gamma (IFN-γ), OKT3 and interleukin-2 (IL-2). Treatment with CIK cells demo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093078
更新日期：2020-04-27 00:00:00
abstract：:The number of diabetes mellitus (DM) patients is increasing, and stroke is deeply associated with DM. Recently, neuroprotective effects of glucagon-like peptide-1 (GLP-1) are reported. In this study, we explored whether liraglutide, a GLP-1 analogue exerts therapeutic effects on a rat stroke model. Wistar rats receive...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141121513
更新日期：2013-10-30 00:00:00
abstract：:Aging is a major risk factor of osteoarthritis, which is characterized by the degeneration of articular cartilage. CCN3, a member of the CCN family, is expressed in cartilage and has various physiological functions during chondrocyte development, differentiation, and regeneration. Here, we examine the role of CCN3 in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207556
更新日期：2020-10-13 00:00:00
abstract：:Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism that is altered by inhibitors of complex I and has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11114465
更新日期：2010-11-09 00:00:00
abstract：:CD4+T-lymphocytes are relevant in the pathogenesis of rheumatoid arthritis (RA), however, their potential involvement in early RA remains elusive. Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug (DMARD), but its mechanism has not been fully established. In 47 new-onset DMARD-naïve RA patient...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186847
更新日期：2020-09-18 00:00:00
abstract：:Extracellular vesicles (EVs) are lipid bilayer vesicles which are released from cells and play multifaceted roles in cellular communication in health and disease. EVs can be isolated from various body fluids, including serum and plasma, and are usable biomarkers as they can inform health status. Studies on EVs are an ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020875
更新日期：2021-01-16 00:00:00
abstract：:Genetic analysis of "InochinoIchi," an exceptionally large grain rice variety, was conducted through five continuous backcrosses with Koshihikari as a recurrent parent using the large grain F3 plant in Koshihikari × Inochinoichi as a nonrecurrent parent. Thorough the F2 and all BCnF2 generations, large, medium, and sm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215442
更新日期：2019-10-31 00:00:00
abstract：:Reduced forms of ascorbate (AsA) and glutathione (GSH) are among the most important non-enzymatic foliar antioxidants in maize (Zea mays L.). The survey was aimed to evaluate impact of bird cherry-oat aphid (Rhopalosiphum padi L.) or grain aphid (Sitobion avenae F.) herbivory on expression of genes related to ascorbat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030268
更新日期：2016-02-23 00:00:00
abstract：:Tooth enamel is formed in an extracellular environment. Amelogenin, the major component in the protein matrix of tooth enamel during the developing stage, could assemble into high molecular weight structures, regulating enamel formation. However, the molecular structure of amelogenin protein assembly at the functional...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082946
更新日期：2020-04-22 00:00:00
abstract：:Recessively-inherited NR2E3 gene mutations cause an unusual retinopathy with abnormally-increased short-wavelength sensitive cone (S-cone) function, in addition to reduced rod and long/middle-wavelength sensitive cone (L/M-cone) function. Progress toward clinical trials to treat patients with this otherwise incurable ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102497
更新日期：2019-05-21 00:00:00
abstract：:Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-artic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082304
更新日期：2018-08-06 00:00:00
abstract：:Apolipoprotein E (apoE) is mainly secreted by hepatocytes and incorporated into most plasma lipoproteins. Macrophages, which accumulate cholesterol and are critical for the development of the atherosclerotic plaque, are also an important, albeit smaller, apoE source. Distal regulatory elements control cell-specific ac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061471
更新日期：2019-03-23 00:00:00
abstract：:Weight regulation and the magnitude of weight loss after a Roux-en-Y gastric bypass (RYGB) can be genetically determined. DNA methylation patterns and the expression of some genes can be altered after weight loss interventions, including RYGB. The present study aimed to evaluate how the gene expression and DNA methyla...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124476
更新日期：2020-06-24 00:00:00
