Abstract:
:B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways can be both beneficial or detrimental depending on the circumstances. Thus, targeting BCL-xL would in turn be a "double-edge sword" and therefore, additional studies are needed to better comprehend this dual and apparently contradictory role of BCL-XL in longevity.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Borrás C,Mas-Bargues C,Román-Domínguez A,Sanz-Ros J,Gimeno-Mallench L,Inglés M,Gambini J,Viña Jdoi
10.3390/ijms21020418subject
Has Abstractpub_date
2020-01-09 00:00:00issue
2issn
1422-0067pii
ijms21020418journal_volume
21pub_type
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