Abstract：
:The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (~3-4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso- and macropore size distributions.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rosengren AM,Karlsson BC,Nicholls IAdoi
10.3390/ijms14011207subject
Has Abstractpub_date
2013-01-09 00:00:00pages
1207-17issue
1issn
1422-0067pii
ijms14011207journal_volume
14pub_type
杂志文章abstract：:Inorganic phosphate (Pi) is an essential nutrient for the maintenance of cells. In healthy mammals, extracellular Pi is maintained within a narrow concentration range of 0.70 to 1.55 mM. Mammalian cells depend on Na+/Pi cotransporters for Pi absorption, which have been well studied. However, a new type of sodium-indep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239298
更新日期：2020-12-06 00:00:00
abstract：:Platelet extracellular vesicles (PEVs) are potential new biomarkers of platelet activation which may allow us to predict and/or diagnose developing coronary thrombosis before myocardial necrosis occurs. The P2Y1 and P2Y12 receptors play a key role in platelet activation and aggregation. Whereas the P2Y1 antagonists ar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176065
更新日期：2020-08-23 00:00:00
abstract：:The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric environment. Wild-type AdiC from Escherichia coli, as well as its previously reported point mutants N22A and S26A, were overexpressed homologously and pur...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030918
更新日期：2018-03-20 00:00:00
abstract：:This paper reports the rapid melt quenching technique preparation for the new family of bismuth-lead germanate glass (BPG) systems in the form of (GeO(2))(60)-(PbO)(40-) (x)-(½Bi(2)O(3))(x) where x = 0 to 40 mol%. Their densities with respect of Bi(2)O(3) concentration were determined using Archimedes' method with ace...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044632
更新日期：2012-01-01 00:00:00
abstract：:In mammals, leptin is a peripheral satiety factor that inhibits feeding by regulating a variety of appetite-related hormones in the brain. However, most of the previous studies examining leptin in fish feeding were performed with mammalian leptins, which share very low sequence homologies with fish leptins. To elucida...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17060783
更新日期：2016-05-30 00:00:00
abstract：:Gibberellin (GA) is a key signal molecule inducing differentiation of tracheary elements, fibers, and xylogenesis. However the molecular mechanisms underlying the effect of GA on xylem elongation and secondary wall development in tree species remain to be determined. In this study, Betula platyphylla (birch) seeds wer...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160922960
更新日期：2015-09-23 00:00:00
abstract：:Strigolactones (SLs), a group of plant hormones, induce germination of root-parasitic plants and inhibit shoot branching in many plants. Shoot branching is an important trait that affects the number and quality of flowers and fruits. Root-parasitic plants, such as Phelipanche spp., infect tomato roots and cause econom...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092645
更新日期：2018-09-06 00:00:00
abstract：INTRODUCTION:Studies have shown that long-term positive behavioural and physiological changes are induced in connection with vaginal, physiological birth, and skin-to-skin contact after birth in mothers and babies. Some of these effects are consistent with the effect profile of oxytocin. This scoping review explores wh...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21249503
更新日期：2020-12-14 00:00:00
abstract：:This study aims to reveal the potential relationship between 5-HT and oxidative stress in the organism. Our in vitro experiments in RIN-14B cells showed that anoxia leads the cells to the state of oxidative stress. Administration of exogenous 5-HT exacerbated this effect, whereas the inhibition of Tph1, LP533401 allev...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061364
更新日期：2019-03-18 00:00:00
abstract：:Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress. In recent years, MTs ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102197
更新日期：2017-10-23 00:00:00
abstract：:Windup, a progressive increase in spinal response to repetitive stimulations of nociceptive peripheral fibers, is a useful model to study central sensitization to pain. Windup is expressed by neurons in both the dorsal and ventral horn of the spinal cord. In juvenile rats, it has been demonstrated both in vivo and in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246146
更新日期：2019-12-05 00:00:00
abstract：:Simulated-microgravity (SMG) promotes cell-apoptosis. We demonstrated that SMG inhibited cell proliferation/metastasis via FAK/RhoA-regulated mTORC1 pathway. Since mTORC1, NF-κB, and ERK1/2 signaling are important in cell apoptosis, we examined whether SMG-enhanced apoptosis is regulated via these signals controlled b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071994
更新日期：2018-07-08 00:00:00
abstract：:MCP-1-induced protein (MCPIP, also known as Zc3h12a or Regnase-1), a newly identified suppressor of cytokine signaling, is expressed in endothelial cells (ECs). To investigate the role of endothelial MCPIP in vascular homeostasis and function, we deleted the MCPIP gene specifically in ECs using the Cre-LoxP system. EC...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010172
更新日期：2019-01-05 00:00:00
abstract：:Systemic sclerosis is an auto-immune disease characterized by skin involvement that often affects multiple organ systems. Pulmonary hypertension is a common finding that can significantly impact prognosis. Molecular pathophysiological mechanisms underlying pulmonary hypertension in systemic sclerosis can be extremely ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124430
更新日期：2020-06-22 00:00:00
abstract：:Staphylococcus aureus is able to rapidly develop mechanisms of resistance to various drugs and to form strong biofilms, which makes it necessary to develop new antibacterial drugs. The essential oil of Melaleuca alternifolia is used as an antibacterial, a property believed to be mainly due to the presence of terpinen-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124531
更新日期：2020-06-25 00:00:00
abstract：:High levels of docosahexaenoic acid (DHA) in the phospholipids of mammalian brain have generated increasing interest in the search for its role in regulating brain functions. Recent studies have provided evidence for enhanced protective effects when DHA is administered in combination with phytochemicals, such as querc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040932
更新日期：2019-02-21 00:00:00
abstract：:Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown metformin to improve mortality rates in diabetes patients, and recent studies suggest metformin has additional effects in treating cancer, obesity, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19102863
更新日期：2018-09-21 00:00:00
abstract：:Molecular chaperones are key components of the protein homeostasis system against protein misfolding and aggregation. It has been recently shown that these molecules can be rationally modified to have an enhanced activity against specific amyloidogenic substrates. The resulting molecular chaperone variants can be effe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051443
更新日期：2018-05-12 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblasts activation, ECM accumulation, and diffused alveolar inflammation. The role of inflammation in IPF is still controversial and its involvement may follow nontraditional mechanisms. It is seen that a pathological microenvironment may af...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218140
更新日期：2020-10-30 00:00:00
abstract：:HD-Zip proteins are unique to plants, and contain a homeodomain closely linked to a leucine zipper motif, which are involved in dimerization and DNA binding. Based on homology in the HD-Zip domain, gene structure and the presence of additional motifs, HD-Zips are divided into four families, HD-Zip I⁻IV. Phylogenetic a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19124047
更新日期：2018-12-14 00:00:00
abstract：:Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-blocked clone. Pediatri...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17040461
更新日期：2016-03-29 00:00:00
abstract：:Diabetic complications are the major cause of mortality for the patients with diabetes. Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases. Seve...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17101629
更新日期：2016-09-24 00:00:00
abstract：:Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes. USP15 har...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18030483
更新日期：2017-02-24 00:00:00
abstract：:Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural antimicrobial peptides. FV7 (FRIRVRV-NH₂), a consensus amphiphilic sequence was identified as being analogous to host d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020339
更新日期：2017-02-06 00:00:00
abstract：:The Prostate Health Index (PHI) has been used increasingly in the context of prostate cancer (PCa) diagnostics since 2010. Previous studies have shown an association between PHI and a tumor volume of >0.5 cm³. The aim of this study was to investigate the correlation between PHI and tumor volume as well as the Gleason ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030488
更新日期：2017-02-24 00:00:00
abstract：:The aim of the present study was to determine whether preoperative three-dimensional (3D) fast spin-echo (FSE) T1-weighted magnetic resonance (MR) plaque imaging for severely stenotic cervical carotid arteries could accurately predict the development of artery-to-artery emboli during exposure of the carotid arteries i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17111791
更新日期：2016-10-27 00:00:00
abstract：:Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural functions are increasingly recognized. The machinery of TGF-β signaling, including the serine kinase type transmembrane receptors, is present in the central nervous system. However, the 3 mammalian TGF-β subtypes have distinct ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13078219
更新日期：2012-01-01 00:00:00
abstract：:The introduction of Clearfield technology allows the use of imidazolinone (IMI) herbicides to control weedy rice. Imidazolinone herbicides stop the acetolactate synthase (ALS) enzyme from synthesizing branched-chain amino acids, resulting in the death of the plant. Since the launch of Clearfield technology in Malaysia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22030982
更新日期：2021-01-20 00:00:00
abstract：:The main objective of this study is to explore the influence of ion composition on the trans-membrane potential across the ion exchange membrane (IEM), and thus offers a reference for the deep insight of "reverse electrodialysis heat engine" running in the composite systems. In comparison to the natural system (river ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235860
更新日期：2019-11-22 00:00:00
abstract：:The small abalone, Haliotis diversicolor supertexta, of the family Haliotidae, is one of the most important species of marine shellfish in eastern Asia. Over the past few decades, this species has drastically declined in Korea. Thus, hatchery-bred seeds have been released into natural coastal areas to compensate for t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms130910750
更新日期：2012-01-01 00:00:00
