The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease.

Abstract:

:We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four-yr-old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed with multicentric CD, a non-malignant lymphoproliferative disorder fueled by excessive IL-6 production. Treatment with IL-6 blockade (tocilizumab) every two wk and methylprednisolone had no effect on his lymph nodes or cardiac function while on temporary RotaFlow. A Berlin LVAD was placed for treatment with rituximab, COP, vincristine, and methylprednisolone. After three courses of chemotherapy, his inflammatory markers normalized and his lymphadenopathy decreased but cardiac function remained severely depressed. He tolerated chemotherapy on the Berlin but required frequent titrations of his anti-coagulation regimen and he did suffer a hemorrhagic stroke. His clinical status improved significantly with rehabilitation, and he tolerated heart transplantation without further complications. MCS is a feasible option as a bridge to recovery or heart transplant eligibility for patients with hemodynamic collapse requiring chemotherapy but it does necessitate close titration of the anti-coagulation regimen to coincide with changes in the inflammatory state.

journal_name

Pediatr Transplant

authors

Thomas TO,Chandrakasan S,O'Brien M,Jefferies JL,Ryan TD,Wilmot I,Baker ML,Madueme PC,Morales D,Lorts A

doi

10.1111/petr.12398

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

E15-8

issue

1

eissn

1397-3142

issn

1399-3046

journal_volume

19

pub_type

杂志文章
  • A typology of non-adherence in pediatric renal transplant recipients.

    abstract::We reviewed 112 pediatric renal transplant recipients to document the rate of medication non-adherence (NA) and to examine the relationships between NA, comorbid psychiatric illness, and the outcome variables of acute and chronic rejection and graft loss. A total of 32.5% of subjects had clinically significant NA with...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00117.x

    authors: Shaw RJ,Palmer L,Blasey C,Sarwal M

    更新日期:2003-12-01 00:00:00

  • Prevalence and outcomes of renal transplantation in children with intellectual disability.

    abstract::To describe the prevalence and outcomes of renal transplantation in children with ID we performed a retrospective cohort analysis of all children receiving a first kidney-alone transplant in the UNOS dataset from 2008 to 2011. Recipients with definite, probable, and without ID were compared using chi-square tests. Kap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12339

    authors: Wightman A,Young B,Bradford M,Dick A,Healey P,McDonald R,Smith J

    更新日期:2014-11-01 00:00:00

  • Resistance to growth hormone in children with chronic liver disease.

    abstract::Malnutrition adversely affects mortality and morbidity before and after liver transplantation. Outcome might be improved if liver transplant recipients were in a better nutritional state at the time of transplantation. In this review, we will examine the potential use of GH and IGF-I to improve nutritional status in p...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Bucuvalas JC,Horn JA,Chernausek SD

    更新日期:1997-08-01 00:00:00

  • Frequency of urinary tract infection in pediatric liver transplantation candidates.

    abstract::An increased frequency of infections has been reported in patients with chronic liver disease. The tendency of patients in this population to acquire UTI is not completely understood. We aimed at investigating the incidence of UTI in children with cirrhosis, before liver transplantation. Twenty-six children (9 girls, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00674.x

    authors: Baskin E,Ozçay F,Sakalli H,Agras PI,Karakayali H,Canan O,Haberal M

    更新日期:2007-06-01 00:00:00

  • Minimum mycophenolic acid levels are associated with donor-specific antibody formation.

    abstract::Although de novo DSA are associated with inferior graft survival, there are no effective strategies to prevent their formation. Underexposure to MPA (prodrug: MMF) also contributes to rejection rates early after transplantation, but the effect of this phenomenon on the formation of DSA long-term post-transplantation i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12637

    authors: Filler G,Todorova EK,Bax K,Alvarez-Elías AC,Huang SH,Kobrzynski MC

    更新日期:2016-02-01 00:00:00

  • The reduced left lateral segment in pediatric liver transplantation: an alternative to the monosegment graft.

    abstract::Tailoring graft size to small paediatric recipients is a challenge. We have developed a reduced left lateral segment as an alternative to monosegment transplantation for small size recipients. Since November 2000, 89 children have been transplanted with 100 deceased donor liver grafts in our unit. Our median patient a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00882.x

    authors: Attia MS,Stringer MD,McClean P,Prasad KR

    更新日期:2008-09-01 00:00:00

  • Unexpectedly high prevalence of pretransplant abnormal glucose tolerance in pediatric kidney transplant recipients.

    abstract::Several studies suggested that the incidence of new-onset diabetes following pediatric kidney transplantation has increased markedly in recent years, with reported incidence of up to 20%. However, limited information is available regarding the incidence and features of pretransplant status of abnormal glucose toleranc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00459.x

    authors: Shishido S,Sato H,Asanuma H,Shindo M,Hataya H,Ishikura K,Hamasaki Y,Goto M,Ikeda M,Honda M

    更新日期:2006-02-01 00:00:00

  • C2 blood concentrations of orally administered cyclosporine in pediatric liver graft recipients with a body weight below 10 kg.

    abstract::Pharmacokinetic studies in adult and pediatric liver transplant recipients have shown that the C(2) monitoring is superior to the traditional determination of CsA trough levels (C(0)) as an estimate of CsA exposure. However, target reference values for C(2) in very small infants have not been established yet. The obje...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-3046.2003.00138.x

    authors: Ganschow R,Richter A,Grabhorn E,Schulz A,von Hugo A,Mir TS,Broering DC,Rogiers X,Hinrichs B,Burdelski M

    更新日期:2004-04-01 00:00:00

  • Renal injury and recovery in pediatric patients after ventricular assist device implantation and cardiac transplant.

    abstract:BACKGROUND:The use of ventricular assist devices (VADs) in children with heart failure may be of particular benefit to those with accompanying renal failure, as improved renal function is seen in some, but not all recipients. We hypothesized that persistent renal dysfunction at 7 days and/or 1 month after VAD implantat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13477

    authors: Hollander SA,Cantor RS,Sutherland SM,Koehl DA,Pruitt E,McDonald N,Kirklin JK,Ravekes WJ,Ameduri R,Chrisant M,Hoffman TM,Lytrivi ID,Conway J

    更新日期:2019-08-01 00:00:00

  • Chronic Mycoplasma pneumoniae infection in a child after renal transplantation.

    abstract::Mycoplasma pneumoniae has rarely been reported in renal transplant recipients. We present the case of a 10-yr-old boy with a six-month history of chronic cough, recurrent pyrexia, and weight loss three yr after RTx. The patient's post-transplant course was complicated by recurrence of NS that resolved with plasmaphere...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01130.x

    authors: Schwerk N,Hartmann C,Baumann U,Pape L,Ehrich JH,Hansen G

    更新日期:2010-05-01 00:00:00

  • Inter-rater reliability of the Pediatric Transplant Rating Instrument (P-TRI): challenges to reliably identifying adherence risk factors during pediatric pre-transplant evaluations.

    abstract::The purpose of this study was to assess the inter-rater reliability of the P-TRI, a 17-item instrument developed to identify risk factors associated with poor treatment adherence in pediatric solid organ transplant candidates. Because factors influencing treatment adherence may vary with age, the 89 subject samples we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01428.x

    authors: Fisher M,Storfer-Isser A,Shaw RJ,Bernard RS,Drury S,Ularntinon S,Horwitz SM

    更新日期:2011-03-01 00:00:00

  • Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.

    abstract::Impact of pretransplant splenectomy in patients with beta-thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty-seven class III patients (29 transplants) had a pretransplant splenectomy. The outcome of these 29 transplants was compared with 76 transplants in class III who did not have a splen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00953.x

    authors: Mathews V,George B,Lakshmi KM,Viswabandya A,John JM,Sitaram U,Daniel D,Chandy M,Srivastava A

    更新日期:2009-03-01 00:00:00

  • Allograft rejection in pediatric liver transplantation: Comparison between cadaveric and living related donors.

    abstract::The aim of this study was to determine whether living related liver transplantation has an immunological advantage compared with cadaveric liver transplants in children. The records of 100 pediatric primary liver transplant recipients performed between January 1992 and December 1998 at the University of California, Sa...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.02013.x

    authors: Toyoki Y,Renz JF,Mudge C,Ascher NL,Roberts JP,Rosenthal P

    更新日期:2002-08-01 00:00:00

  • Squamous cell carcinoma development in Fanconi anemia patients who underwent hematopoietic stem cell transplantation.

    abstract::We examined SCC development of 24 FA patients, who received HSCT from HLA-matched relatives. In our BMT center, we applied low-dose CY + LFI + ATG (n:13) as conditioning regimen for FA patients between 1992 and 1999, and CY + BU + ATG (n:11) between 1999 and 2002. The aim of this study was to investigate SCC developme...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13706

    authors: Anak S,Yalman N,Bilgen H,Sepet E,Deviren A,Gürtekin B,Tunca F,Başaran B

    更新日期:2020-06-01 00:00:00

  • Grading acute graft-versus-host disease: time to reconsider.

    abstract::Acute graft-versus-host disease (GVHD) is a common and serious complication of allogeneic blood and marrow transplantation. Acute GVHD is commonly graded according to modified Glucksberg criteria. There is considerable within-grade heterogeneity with different patterns of skin, liver, or gut involvement. In this comme...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12433

    authors: Goyal RK,Goyal M,Sankaranarayan K

    更新日期:2015-05-01 00:00:00

  • Pediatric renal transplantation in the Nordic countries: a report of the Nordic Pediatric Renal Transplant Study Group.

    abstract::The Nordic Pediatric Renal Transplant Study Group was organized in 1994 to register and follow children under 16 years of age who receive renal allografts in the Nordic countries. It comprises all transplant centers in Scandinavia, four in Sweden, three in Denmark and one each in Norway and Finland. The following repo...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Tydén G,Berg U

    更新日期:1998-08-01 00:00:00

  • The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: A single-center report from Brazil.

    abstract::With the number of long-term HSCT survivors steadily increasing, attention needs to be focused on the late complications and quality of life. We therefore analyzed the outcome of 101 pediatric patients (<18 years old at the time of HSCT) transplanted for acute leukemia between 1981 and 2015 at Complexo Hospital de Clí...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13691

    authors: Marinho DH,Ribeiro LL,Nichele S,Loth G,Koliski A,Mousquer RTG,Funke VAM,Page K,Fasth A,Pasquini R,Boguszewski MCDS,Bonfim C

    更新日期:2020-06-01 00:00:00

  • A clinical description of children with solid organ transplants who present with feeding disorder.

    abstract::Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young childr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13389

    authors: Lerret SM,Erato G,Goday PS,Silverman AH

    更新日期:2019-05-01 00:00:00

  • Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

    abstract::In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left latera...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13384

    authors: Ocwieja KE,Vargas SO,Elisofon SA,Shulman DS,Lee CK,Fawaz R,Collins N,Vakili K,Sharma TS

    更新日期:2019-05-01 00:00:00

  • De novo development of antibodies to kidney-associated self-antigens angiotensin II receptor type I, collagen IV, and fibronectin occurs at early time points after kidney transplantation in children.

    abstract::Chronic rejection is the leading cause of graft loss following pediatric kidney transplantation. Our group and others have demonstrated an association between the development of Abs to self-antigens and chronic rejection following adult lung and heart transplantation. The goal of this study was to determine whether Ab...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12531

    authors: Hesemann LE,Subramanian V,Mohanakumar T,Dharnidharka VR

    更新日期:2015-08-01 00:00:00

  • Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation.

    abstract::The clinical significance of parvovirus B19 infection in pediatric solid-organ and bone marrow transplanted patients is unclear. The overall prevalence of parvovirus B19 infection in these patients is about 1-2% during the first year after transplantation. The most common symptom is anemia, but leukopenia and thromboc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2001.00035.x

    authors: Broliden K

    更新日期:2001-10-01 00:00:00

  • The significance of a defect on DMSA scan in children with renal transplants.

    abstract::Since December 1995, pediatric renal transplant recipients in our unit have received a DMSA scan as soon as possible post-transplant in order to provide a baseline for comparison in the event of subsequent complications. We retrospectively reviewed the case notes and DMSA scans of the 45 patients who underwent a scan ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-3046.2003.00073.x

    authors: Hutchinson C,Beckett M,Kiratli P,Gordon I,Trompeter RS,Rees L

    更新日期:2003-12-01 00:00:00

  • Plasmapheresis-resistant acute humoral rejection successfully treated with anti-C5 antibody.

    abstract::Even if kidney graft survival has improved during the last decades, sensitized pediatric patients are an emerging problem. We describe a 17-yr-old male who lost his first graft due to chronic rejection becoming hyperimmunized (CDC PRA 99.61%). A desensitization protocol based on high-dose IVIG, PP, and two Mabthera(®)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12187

    authors: Ghirardo G,Benetti E,Poli F,Vidal E,Della Vella M,Cozzi E,Murer L

    更新日期:2014-02-01 00:00:00

  • Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning.

    abstract::Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is challenging. Recently, umbilical cord blood transplantation (CBT) after non-myeloablative therapy has been reported in adult but not in childhood SAA. However, most cas...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00486.x

    authors: Ohga S,Ichino K,Goto K,Hattori S,Nomura A,Takada H,Nakamura K,Hara T

    更新日期:2006-06-01 00:00:00

  • Health-related quality of life changes following renal transplantation in children.

    abstract:BACKGROUND:Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL. METHODS:We performed a retrospective study using the PedsQL3.0ESRD module during dialysis and at 3 and 12 months following kidney transplant in 56 recipients. For the enti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13333

    authors: Wightman A,Bradford MC,Smith J

    更新日期:2019-03-01 00:00:00

  • Pleural disease in patients undergoing lung transplantation for cystic fibrosis.

    abstract::Cystic fibrosis (CF) is associated with varying degrees of pleural inflammatory reaction that occurs as a result of chronic pulmonary infections and intervention to pleural space. The amount of pleural reaction is associated with the difficulty involved when performing the pneumonectomy at the time of lung replacement...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Dosanjh A,Jones L,Yuh D,Robbins RC

    更新日期:1998-11-01 00:00:00

  • Nocturnal hypertension and left ventricular hypertrophy in pediatric renal transplant recipients in South India.

    abstract::HTN after renal transplantation is associated with cardiovascular morbidity. ABPM allows diagnosis of masked HTN and isolated nocturnal HTN. Longitudinal ABPM data in children post-transplant are limited. ABPM was performed in children post-transplant and repeated in 6-12 months. BP indices were used to determine the ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13710

    authors: Pais P,Dello Strologo L,Iyengar A,Velusamy V,Greenbaum LA

    更新日期:2020-06-01 00:00:00

  • En bloc kidney transplantation from infant donors younger than 10 months into pediatric recipients.

    abstract::Early graft loss and poor graft function limit the use of kidneys from infant donors. Six en bloc kidney transplantations were performed from infant donors younger than 10 months into pediatric recipients between November 2012 and September 2015 at our center. We retrospectively analyzed recipient and donor demographi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12845

    authors: Wang HY,Li J,Liu LS,Deng RH,Fu Q,Ko DS,Zhang HX,Deng SX,Wang CX

    更新日期:2017-03-01 00:00:00

  • Sequential liver-kidney transplantation in a boy with congenital hepatic fibrosis and nephronophthisis from a living donor.

    abstract::A five-yr-old boy developed chronic liver failure and ESKD because of CHF and juvenile NPHP. He underwent sequential liver and kidney transplantation with a compatible blood type from his father, at five yr, seven months and five yr, 11 months old, respectively. Because the patient was not in ESKD, we initially perfor...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01611.x

    authors: Udagawa T,Kamei K,Ogura M,Tsutsumi A,Noda S,Kasahara M,Fukuda A,Sakamoto S,Shigeta S,Tanaka H,Kuroda T,Matsuoka K,Nakazawa A,Nagai T,Uemura O,Ito S

    更新日期:2012-11-01 00:00:00

  • Transplantation of adult-size kidneys in small pediatric recipients: A single-center experience.

    abstract::RTx of adult-size kidneys presents a size mismatch in small pediatric recipients, and there are potential surgical complications. This study reveals the outcomes of intra- and extraperitoneal RTx in low-weight (less than 15 kg) pediatric recipients. We studied 51 pediatric patients weighing less than 15 kg who receive...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13401

    authors: Muramatsu M,Mizutani T,Hamasaki Y,Takahashi Y,Itabashi Y,Kubota M,Hashimoto J,Oguchi H,Sakurabayashi K,Hyodo Y,Shinoda K,Kawamura T,Sakai K,Shishido S

    更新日期:2019-06-01 00:00:00